Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

8C5V

Chemotaxis core signalling unit from E protein lysed E. coli cells

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000155	molecular_function	phosphorelay sensor kinase activity
A	0000160	biological_process	phosphorelay signal transduction system
A	0004673	molecular_function	protein histidine kinase activity
A	0005737	cellular_component	cytoplasm
A	0006935	biological_process	chemotaxis
A	0007165	biological_process	signal transduction
A	0016310	biological_process	phosphorylation
A	0016772	molecular_function	transferase activity, transferring phosphorus-containing groups
B	0000155	molecular_function	phosphorelay sensor kinase activity
B	0000160	biological_process	phosphorelay signal transduction system
B	0004673	molecular_function	protein histidine kinase activity
B	0005737	cellular_component	cytoplasm
B	0006935	biological_process	chemotaxis
B	0007165	biological_process	signal transduction
B	0016310	biological_process	phosphorylation
B	0016772	molecular_function	transferase activity, transferring phosphorus-containing groups
C	0000160	biological_process	phosphorelay signal transduction system
D	0000160	biological_process	phosphorelay signal transduction system
E	0006935	biological_process	chemotaxis
E	0007165	biological_process	signal transduction
F	0006935	biological_process	chemotaxis
F	0007165	biological_process	signal transduction
G	0006935	biological_process	chemotaxis
G	0007165	biological_process	signal transduction
H	0006935	biological_process	chemotaxis
H	0007165	biological_process	signal transduction
I	0004888	molecular_function	transmembrane signaling receptor activity
I	0005515	molecular_function	protein binding
I	0005886	cellular_component	plasma membrane
I	0006935	biological_process	chemotaxis
I	0007165	biological_process	signal transduction
I	0009593	biological_process	detection of chemical stimulus
I	0016020	cellular_component	membrane
I	0042802	molecular_function	identical protein binding
I	0048870	biological_process	cell motility
I	0071230	biological_process	cellular response to amino acid stimulus
I	0098561	cellular_component	methyl accepting chemotaxis protein complex
I	1902021	biological_process	regulation of bacterial-type flagellum-dependent cell motility
J	0004888	molecular_function	transmembrane signaling receptor activity
J	0005515	molecular_function	protein binding
J	0005886	cellular_component	plasma membrane
J	0006935	biological_process	chemotaxis
J	0007165	biological_process	signal transduction
J	0009593	biological_process	detection of chemical stimulus
J	0016020	cellular_component	membrane
J	0042802	molecular_function	identical protein binding
J	0048870	biological_process	cell motility
J	0071230	biological_process	cellular response to amino acid stimulus
J	0098561	cellular_component	methyl accepting chemotaxis protein complex
J	1902021	biological_process	regulation of bacterial-type flagellum-dependent cell motility
K	0004888	molecular_function	transmembrane signaling receptor activity
K	0005515	molecular_function	protein binding
K	0005886	cellular_component	plasma membrane
K	0006935	biological_process	chemotaxis
K	0007165	biological_process	signal transduction
K	0009593	biological_process	detection of chemical stimulus
K	0016020	cellular_component	membrane
K	0042802	molecular_function	identical protein binding
K	0048870	biological_process	cell motility
K	0071230	biological_process	cellular response to amino acid stimulus
K	0098561	cellular_component	methyl accepting chemotaxis protein complex
K	1902021	biological_process	regulation of bacterial-type flagellum-dependent cell motility
L	0004888	molecular_function	transmembrane signaling receptor activity
L	0005515	molecular_function	protein binding
L	0005886	cellular_component	plasma membrane
L	0006935	biological_process	chemotaxis
L	0007165	biological_process	signal transduction
L	0009593	biological_process	detection of chemical stimulus
L	0016020	cellular_component	membrane
L	0042802	molecular_function	identical protein binding
L	0048870	biological_process	cell motility
L	0071230	biological_process	cellular response to amino acid stimulus
L	0098561	cellular_component	methyl accepting chemotaxis protein complex
L	1902021	biological_process	regulation of bacterial-type flagellum-dependent cell motility
M	0004888	molecular_function	transmembrane signaling receptor activity
M	0005515	molecular_function	protein binding
M	0005886	cellular_component	plasma membrane
M	0006935	biological_process	chemotaxis
M	0007165	biological_process	signal transduction
M	0009593	biological_process	detection of chemical stimulus
M	0016020	cellular_component	membrane
M	0042802	molecular_function	identical protein binding
M	0048870	biological_process	cell motility
M	0071230	biological_process	cellular response to amino acid stimulus
M	0098561	cellular_component	methyl accepting chemotaxis protein complex
M	1902021	biological_process	regulation of bacterial-type flagellum-dependent cell motility
N	0004888	molecular_function	transmembrane signaling receptor activity
N	0005515	molecular_function	protein binding
N	0005886	cellular_component	plasma membrane
N	0006935	biological_process	chemotaxis
N	0007165	biological_process	signal transduction
N	0009593	biological_process	detection of chemical stimulus
N	0016020	cellular_component	membrane
N	0042802	molecular_function	identical protein binding
N	0048870	biological_process	cell motility
N	0071230	biological_process	cellular response to amino acid stimulus
N	0098561	cellular_component	methyl accepting chemotaxis protein complex
N	1902021	biological_process	regulation of bacterial-type flagellum-dependent cell motility
O	0004888	molecular_function	transmembrane signaling receptor activity
O	0005515	molecular_function	protein binding
O	0005886	cellular_component	plasma membrane
O	0006935	biological_process	chemotaxis
O	0007165	biological_process	signal transduction
O	0009593	biological_process	detection of chemical stimulus
O	0016020	cellular_component	membrane
O	0042802	molecular_function	identical protein binding
O	0048870	biological_process	cell motility
O	0071230	biological_process	cellular response to amino acid stimulus
O	0098561	cellular_component	methyl accepting chemotaxis protein complex
O	1902021	biological_process	regulation of bacterial-type flagellum-dependent cell motility
P	0004888	molecular_function	transmembrane signaling receptor activity
P	0005515	molecular_function	protein binding
P	0005886	cellular_component	plasma membrane
P	0006935	biological_process	chemotaxis
P	0007165	biological_process	signal transduction
P	0009593	biological_process	detection of chemical stimulus
P	0016020	cellular_component	membrane
P	0042802	molecular_function	identical protein binding
P	0048870	biological_process	cell motility
P	0071230	biological_process	cellular response to amino acid stimulus
P	0098561	cellular_component	methyl accepting chemotaxis protein complex
P	1902021	biological_process	regulation of bacterial-type flagellum-dependent cell motility
Q	0004888	molecular_function	transmembrane signaling receptor activity
Q	0005515	molecular_function	protein binding
Q	0005886	cellular_component	plasma membrane
Q	0006935	biological_process	chemotaxis
Q	0007165	biological_process	signal transduction
Q	0009593	biological_process	detection of chemical stimulus
Q	0016020	cellular_component	membrane
Q	0042802	molecular_function	identical protein binding
Q	0048870	biological_process	cell motility
Q	0071230	biological_process	cellular response to amino acid stimulus
Q	0098561	cellular_component	methyl accepting chemotaxis protein complex
Q	1902021	biological_process	regulation of bacterial-type flagellum-dependent cell motility
R	0004888	molecular_function	transmembrane signaling receptor activity
R	0005515	molecular_function	protein binding
R	0005886	cellular_component	plasma membrane
R	0006935	biological_process	chemotaxis
R	0007165	biological_process	signal transduction
R	0009593	biological_process	detection of chemical stimulus
R	0016020	cellular_component	membrane
R	0042802	molecular_function	identical protein binding
R	0048870	biological_process	cell motility
R	0071230	biological_process	cellular response to amino acid stimulus
R	0098561	cellular_component	methyl accepting chemotaxis protein complex
R	1902021	biological_process	regulation of bacterial-type flagellum-dependent cell motility
S	0004888	molecular_function	transmembrane signaling receptor activity
S	0005515	molecular_function	protein binding
S	0005886	cellular_component	plasma membrane
S	0006935	biological_process	chemotaxis
S	0007165	biological_process	signal transduction
S	0009593	biological_process	detection of chemical stimulus
S	0016020	cellular_component	membrane
S	0042802	molecular_function	identical protein binding
S	0048870	biological_process	cell motility
S	0071230	biological_process	cellular response to amino acid stimulus
S	0098561	cellular_component	methyl accepting chemotaxis protein complex
S	1902021	biological_process	regulation of bacterial-type flagellum-dependent cell motility
T	0004888	molecular_function	transmembrane signaling receptor activity
T	0005515	molecular_function	protein binding
T	0005886	cellular_component	plasma membrane
T	0006935	biological_process	chemotaxis
T	0007165	biological_process	signal transduction
T	0009593	biological_process	detection of chemical stimulus
T	0016020	cellular_component	membrane
T	0042802	molecular_function	identical protein binding
T	0048870	biological_process	cell motility
T	0071230	biological_process	cellular response to amino acid stimulus
T	0098561	cellular_component	methyl accepting chemotaxis protein complex
T	1902021	biological_process	regulation of bacterial-type flagellum-dependent cell motility

Functional Information from PROSITE/UniProt

site_id	PS00039
Number of Residues	9
Details	DEAD_ATP_HELICASE DEAD-box subfamily ATP-dependent helicases signature. FFDEADElL

Chain	Residue	Details
C	PHE12-LEU20

site_id	PS00538
Number of Residues	23
Details	CHEMOTAXIS_TRANSDUC_1 Bacterial chemotaxis sensory transducers signature. RTEQQaaSLeETAASMEQLTATV

Chain	Residue	Details
I	ARG294-VAL316

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	504
Details	Domain: {"description":"Histidine kinase","evidences":[{"source":"PROSITE-ProRule","id":"PRU00107","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI2
Number of Residues	830
Details	Domain: {"description":"CheW-like","evidences":[{"source":"PROSITE-ProRule","id":"PRU00052","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI3
Number of Residues	208
Details	Domain: {"description":"HPt","evidences":[{"source":"PROSITE-ProRule","id":"PRU00110","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI4
Number of Residues	2
Details	Modified residue: {"description":"Phosphohistidine; by autocatalysis","evidences":[{"source":"PROSITE-ProRule","id":"PRU00107","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"2832069","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI5
Number of Residues	60
Details	Topological domain: {"description":"Cytoplasmic","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI6
Number of Residues	504
Details	Transmembrane: {"description":"Helical","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI7
Number of Residues	1908
Details	Topological domain: {"description":"Periplasmic","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI8
Number of Residues	624
Details	Domain: {"description":"HAMP","evidences":[{"source":"PROSITE-ProRule","id":"PRU00102","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI9
Number of Residues	2748
Details	Domain: {"description":"Methyl-accepting transducer","evidences":[{"source":"PROSITE-ProRule","id":"PRU00284","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI10
Number of Residues	108
Details	Region: {"description":"The 3 Arg may form a positively charged pocket, which binds the alpha-carboxyl group of the attractant AA"}

Chain

Residue

Details

site_id	SWS_FT_FI11
Number of Residues	24
Details	Modified residue: {"description":"Glutamate methyl ester (Gln)","evidences":[{"source":"PubMed","id":"2033064","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"6402709","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI12
Number of Residues	24
Details	Modified residue: {"description":"Glutamate methyl ester (Glu)","evidences":[{"source":"PubMed","id":"2033064","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"6402709","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI13
Number of Residues	12
Details	Modified residue: {"description":"Glutamate methyl ester (Glu)","evidences":[{"source":"PubMed","id":"2033064","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)