8C3O
Crystal structure of autotaxin gamma and compound MEY-003
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0003676 | molecular_function | nucleic acid binding |
| A | 0005044 | molecular_function | scavenger receptor activity |
| A | 0006955 | biological_process | immune response |
| A | 0016787 | molecular_function | hydrolase activity |
| A | 0030247 | molecular_function | polysaccharide binding |
| A | 0046872 | molecular_function | metal ion binding |
| B | 0003676 | molecular_function | nucleic acid binding |
| B | 0005044 | molecular_function | scavenger receptor activity |
| B | 0006955 | biological_process | immune response |
| B | 0016787 | molecular_function | hydrolase activity |
| B | 0030247 | molecular_function | polysaccharide binding |
| B | 0046872 | molecular_function | metal ion binding |
Functional Information from PROSITE/UniProt
| site_id | PS00524 |
| Number of Residues | 21 |
| Details | SMB_1 Somatomedin B domain (SMB) signature. CrCdnlCksyts.CChDFdelC |
| Chain | Residue | Details |
| A | CYS74-CYS94 | |
| A | CYS118-CYS138 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 2 |
| Details | ACT_SITE: Nucleophile => ECO:0000250|UniProtKB:Q9R1E6 |
| Chain | Residue | Details |
| A | THR210 | |
| B | THR210 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 8 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:26371182, ECO:0000269|PubMed:27754931, ECO:0007744|PDB:4ZG6, ECO:0007744|PDB:4ZG7, ECO:0007744|PDB:4ZG9, ECO:0007744|PDB:5KXA |
| Chain | Residue | Details |
| A | ASP172 | |
| A | THR210 | |
| A | ASP359 | |
| A | HIS360 | |
| B | ASP172 | |
| B | THR210 | |
| B | ASP359 | |
| B | HIS360 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 6 |
| Details | BINDING: BINDING => ECO:0000250|UniProtKB:Q9R1E6 |
| Chain | Residue | Details |
| A | PHE211 | |
| A | LEU244 | |
| A | TYR307 | |
| B | PHE211 | |
| B | LEU244 | |
| B | TYR307 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 2 |
| Details | BINDING: BINDING => ECO:0000305|PubMed:26371182, ECO:0007744|PDB:4ZG7 |
| Chain | Residue | Details |
| A | ASN231 | |
| B | ASN231 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 8 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:26371182, ECO:0007744|PDB:4ZG6, ECO:0007744|PDB:4ZG7, ECO:0007744|PDB:4ZG9, ECO:0007744|PDB:4ZGA |
| Chain | Residue | Details |
| A | ASP312 | |
| A | HIS316 | |
| A | HIS475 | |
| A | ASP769 | |
| B | ASP312 | |
| B | HIS316 | |
| B | HIS475 | |
| B | ASP769 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 8 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:26371182, ECO:0000269|PubMed:27754931, ECO:0007744|PDB:4ZG6, ECO:0007744|PDB:4ZG7, ECO:0007744|PDB:4ZG9, ECO:0007744|PDB:4ZGA, ECO:0007744|PDB:5KXA |
| Chain | Residue | Details |
| A | ASP765 | |
| A | ASP767 | |
| A | LEU771 | |
| A | ASP773 | |
| B | ASP765 | |
| B | ASP767 | |
| B | LEU771 | |
| B | ASP773 |
| site_id | SWS_FT_FI7 |
| Number of Residues | 2 |
| Details | SITE: Essential for catalytic activity => ECO:0000250|UniProtKB:Q9R1E6 |
| Chain | Residue | Details |
| A | LYS878 | |
| B | LYS878 |
| site_id | SWS_FT_FI8 |
| Number of Residues | 6 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255 |
| Chain | Residue | Details |
| A | ALA54 | |
| A | ALA411 | |
| A | ASN832 | |
| B | ALA54 | |
| B | ALA411 | |
| B | ASN832 |
| site_id | SWS_FT_FI9 |
| Number of Residues | 2 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:26371182, ECO:0007744|PDB:4ZG6, ECO:0007744|PDB:4ZG7, ECO:0007744|PDB:4ZG9, ECO:0007744|PDB:4ZGA |
| Chain | Residue | Details |
| A | ASN525 | |
| B | ASN525 |
