8C1Z
Tetrameric 5-HT3aR in Salipro (apo state, symmetric)
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004888 | molecular_function | transmembrane signaling receptor activity |
| A | 0005216 | molecular_function | monoatomic ion channel activity |
| A | 0005230 | molecular_function | extracellular ligand-gated monoatomic ion channel activity |
| A | 0006811 | biological_process | monoatomic ion transport |
| A | 0015276 | molecular_function | ligand-gated monoatomic ion channel activity |
| A | 0016020 | cellular_component | membrane |
| A | 0034220 | biological_process | monoatomic ion transmembrane transport |
| A | 0045211 | cellular_component | postsynaptic membrane |
| B | 0004888 | molecular_function | transmembrane signaling receptor activity |
| B | 0005216 | molecular_function | monoatomic ion channel activity |
| B | 0005230 | molecular_function | extracellular ligand-gated monoatomic ion channel activity |
| B | 0006811 | biological_process | monoatomic ion transport |
| B | 0015276 | molecular_function | ligand-gated monoatomic ion channel activity |
| B | 0016020 | cellular_component | membrane |
| B | 0034220 | biological_process | monoatomic ion transmembrane transport |
| B | 0045211 | cellular_component | postsynaptic membrane |
| C | 0004888 | molecular_function | transmembrane signaling receptor activity |
| C | 0005216 | molecular_function | monoatomic ion channel activity |
| C | 0005230 | molecular_function | extracellular ligand-gated monoatomic ion channel activity |
| C | 0006811 | biological_process | monoatomic ion transport |
| C | 0015276 | molecular_function | ligand-gated monoatomic ion channel activity |
| C | 0016020 | cellular_component | membrane |
| C | 0034220 | biological_process | monoatomic ion transmembrane transport |
| C | 0045211 | cellular_component | postsynaptic membrane |
| D | 0004888 | molecular_function | transmembrane signaling receptor activity |
| D | 0005216 | molecular_function | monoatomic ion channel activity |
| D | 0005230 | molecular_function | extracellular ligand-gated monoatomic ion channel activity |
| D | 0006811 | biological_process | monoatomic ion transport |
| D | 0015276 | molecular_function | ligand-gated monoatomic ion channel activity |
| D | 0016020 | cellular_component | membrane |
| D | 0034220 | biological_process | monoatomic ion transmembrane transport |
| D | 0045211 | cellular_component | postsynaptic membrane |
Functional Information from PROSITE/UniProt
| site_id | PS00236 |
| Number of Residues | 15 |
| Details | NEUROTR_ION_CHANNEL Neurotransmitter-gated ion-channels signature. CsLdIynFPfDvqnC |
| Chain | Residue | Details |
| A | CYS135-CYS149 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 104 |
| Details | TRANSMEM: Helical; Name=1 => ECO:0000255 |
| Chain | Residue | Details |
| A | LEU221-ASP247 | |
| B | LEU221-ASP247 | |
| C | LEU221-ASP247 | |
| D | LEU221-ASP247 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 572 |
| Details | TOPO_DOM: Cytoplasmic => ECO:0000305|PubMed:25119048 |
| Chain | Residue | Details |
| A | SER248-VAL252 | |
| A | GLU300-ARG439 | |
| B | SER248-VAL252 | |
| B | GLU300-ARG439 | |
| C | SER248-VAL252 | |
| C | GLU300-ARG439 | |
| D | SER248-VAL252 | |
| D | GLU300-ARG439 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 72 |
| Details | TRANSMEM: Helical; Name=2 => ECO:0000255 |
| Chain | Residue | Details |
| A | SER253-ASP271 | |
| B | SER253-ASP271 | |
| C | SER253-ASP271 | |
| D | SER253-ASP271 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 44 |
| Details | TOPO_DOM: Extracellular => ECO:0000305|PubMed:25119048 |
| Chain | Residue | Details |
| A | THR272-PRO281 | |
| A | HIS460-SER462 | |
| B | THR272-PRO281 | |
| B | HIS460-SER462 | |
| C | THR272-PRO281 | |
| C | HIS460-SER462 | |
| D | THR272-PRO281 | |
| D | HIS460-SER462 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 72 |
| Details | TRANSMEM: Helical; Name=3 => ECO:0000255 |
| Chain | Residue | Details |
| A | PRO281-ALA299 | |
| B | PRO281-ALA299 | |
| C | PRO281-ALA299 | |
| D | PRO281-ALA299 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 76 |
| Details | TRANSMEM: Helical; Name=4 => ECO:0000255 |
| Chain | Residue | Details |
| A | ILE440-TRP459 | |
| B | ILE440-TRP459 | |
| C | ILE440-TRP459 | |
| D | ILE440-TRP459 |
| site_id | SWS_FT_FI7 |
| Number of Residues | 12 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255 |
| Chain | Residue | Details |
| A | VAL83 | |
| D | VAL83 | |
| D | CYS149 | |
| D | ILE165 | |
| A | CYS149 | |
| A | ILE165 | |
| B | VAL83 | |
| B | CYS149 | |
| B | ILE165 | |
| C | VAL83 | |
| C | CYS149 | |
| C | ILE165 |
