8C02

Structure of SLC40/ferroportin in complex with synthetic nanobody Sy3 in occluded conformation

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0002260	biological_process	lymphocyte homeostasis
A	0003158	biological_process	endothelium development
A	0005381	molecular_function	iron ion transmembrane transporter activity
A	0005515	molecular_function	protein binding
A	0005654	cellular_component	nucleoplasm
A	0005737	cellular_component	cytoplasm
A	0005829	cellular_component	cytosol
A	0005886	cellular_component	plasma membrane
A	0006366	biological_process	transcription by RNA polymerase II
A	0006811	biological_process	monoatomic ion transport
A	0006826	biological_process	iron ion transport
A	0006879	biological_process	intracellular iron ion homeostasis
A	0006915	biological_process	apoptotic process
A	0008021	cellular_component	synaptic vesicle
A	0015093	molecular_function	ferrous iron transmembrane transporter activity
A	0016020	cellular_component	membrane
A	0016323	cellular_component	basolateral plasma membrane
A	0017046	molecular_function	peptide hormone binding
A	0034755	biological_process	iron ion transmembrane transport
A	0042802	molecular_function	identical protein binding
A	0043066	biological_process	negative regulation of apoptotic process
A	0045944	biological_process	positive regulation of transcription by RNA polymerase II
A	0046872	molecular_function	metal ion binding
A	0048536	biological_process	spleen development
A	0051649	biological_process	establishment of localization in cell
A	0055085	biological_process	transmembrane transport
A	0060345	biological_process	spleen trabecula formation
A	0060586	biological_process	multicellular organismal-level iron ion homeostasis
A	1903988	biological_process	iron ion export across plasma membrane

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	329
Details	Transmembrane: {"description":"Helical","evidences":[{"source":"PubMed","id":"32814342","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6W4S","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	22
Details	Topological domain: {"description":"Extracellular","evidences":[{"source":"PubMed","id":"32814342","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	8
Details	Topological domain: {"description":"Cytoplasmic","evidences":[{"source":"PubMed","id":"32814342","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI4
Number of Residues	4
Details	Binding site: {"evidences":[{"source":"PubMed","id":"32814342","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

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