8BYP
Botulinum neurotoxin serotype X in complex with NTNH/X
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| N | 0004222 | molecular_function | metalloendopeptidase activity |
| N | 0005576 | cellular_component | extracellular region |
| N | 0006508 | biological_process | proteolysis |
| N | 0008270 | molecular_function | zinc ion binding |
| X | 0004222 | molecular_function | metalloendopeptidase activity |
| X | 0005576 | cellular_component | extracellular region |
| X | 0006508 | biological_process | proteolysis |
| X | 0008233 | molecular_function | peptidase activity |
| X | 0008237 | molecular_function | metallopeptidase activity |
| X | 0008270 | molecular_function | zinc ion binding |
| X | 0008320 | molecular_function | protein transmembrane transporter activity |
| X | 0016787 | molecular_function | hydrolase activity |
| X | 0035821 | biological_process | modulation of process of another organism |
| X | 0044161 | cellular_component | host cell cytoplasmic vesicle |
| X | 0044164 | cellular_component | host cell cytosol |
| X | 0044231 | cellular_component | host cell presynaptic membrane |
| X | 0046872 | molecular_function | metal ion binding |
| X | 0071806 | biological_process | protein transmembrane transport |
| X | 0090729 | molecular_function | toxin activity |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI3 |
| Number of Residues | 50 |
| Details | Region: {"description":"Belt; not required for channel formation","evidences":[{"source":"UniProtKB","id":"P0DPI0","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 213 |
| Details | Region: {"description":"N-terminus of receptor binding domain (N-RBD)","evidences":[{"source":"UniProtKB","id":"P0DPI0","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 202 |
| Details | Region: {"description":"C-terminus of receptor binding domain (C-RBD)","evidences":[{"source":"UniProtKB","id":"P0DPI0","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 3 |
| Details | Motif: {"description":"Host ganglioside-binding motif","evidences":[{"source":"UniProtKB","id":"P0DPI0","evidenceCode":"ECO:0000250"},{"source":"PubMed","id":"28770820","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI7 |
| Number of Residues | 1 |
| Details | Active site: {"evidences":[{"source":"UniProtKB","id":"P0DPI0","evidenceCode":"ECO:0000250"},{"source":"PROSITE-ProRule","id":"PRU10095","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI8 |
| Number of Residues | 2 |
| Details | Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU10095","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"29540745","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6F47","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI9 |
| Number of Residues | 1 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"29540745","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6F47","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
