Loading
PDBj
MenuPDBj@FacebookPDBj@X(formerly Twitter)PDBj@BlueSkyPDBj@YouTubewwPDB FoundationwwPDBDonate
RCSB PDBPDBeBMRBAdv. SearchSearch help

8BVX

Structure of the mouse 8-oxoguanine DNA Glycosylase mOGG1 in complex with ligand TH13264

Functional Information from GO Data
ChainGOidnamespacecontents
A0000702molecular_functionoxidized base lesion DNA N-glycosylase activity
A0000978molecular_functionRNA polymerase II cis-regulatory region sequence-specific DNA binding
A0003677molecular_functionDNA binding
A0003684molecular_functiondamaged DNA binding
A0003824molecular_functioncatalytic activity
A0005634cellular_componentnucleus
A0005654cellular_componentnucleoplasm
A0005739cellular_componentmitochondrion
A0006281biological_processDNA repair
A0006284biological_processbase-excision repair
A0006285biological_processbase-excision repair, AP site formation
A0006289biological_processnucleotide-excision repair
A0006355biological_processregulation of DNA-templated transcription
A0006974biological_processDNA damage response
A0006979biological_processresponse to oxidative stress
A0008017molecular_functionmicrotubule binding
A0008534molecular_functionoxidized purine nucleobase lesion DNA N-glycosylase activity
A0009314biological_processresponse to radiation
A0016363cellular_componentnuclear matrix
A0016607cellular_componentnuclear speck
A0016787molecular_functionhydrolase activity
A0016798molecular_functionhydrolase activity, acting on glycosyl bonds
A0016829molecular_functionlyase activity
A0019104molecular_functionDNA N-glycosylase activity
A0019899molecular_functionenzyme binding
A0032357molecular_functionoxidized purine DNA binding
A0032991cellular_componentprotein-containing complex
A0034039molecular_function8-oxo-7,8-dihydroguanine DNA N-glycosylase activity
A0034614biological_processcellular response to reactive oxygen species
A0044029biological_processpositive regulation of gene expression via chromosomal CpG island demethylation
A0045944biological_processpositive regulation of transcription by RNA polymerase II
A0140078molecular_functionclass I DNA-(apurinic or apyrimidinic site) endonuclease activity
A1901291biological_processnegative regulation of double-strand break repair via single-strand annealing
B0000702molecular_functionoxidized base lesion DNA N-glycosylase activity
B0000978molecular_functionRNA polymerase II cis-regulatory region sequence-specific DNA binding
B0003677molecular_functionDNA binding
B0003684molecular_functiondamaged DNA binding
B0003824molecular_functioncatalytic activity
B0005634cellular_componentnucleus
B0005654cellular_componentnucleoplasm
B0005739cellular_componentmitochondrion
B0006281biological_processDNA repair
B0006284biological_processbase-excision repair
B0006285biological_processbase-excision repair, AP site formation
B0006289biological_processnucleotide-excision repair
B0006355biological_processregulation of DNA-templated transcription
B0006974biological_processDNA damage response
B0006979biological_processresponse to oxidative stress
B0008017molecular_functionmicrotubule binding
B0008534molecular_functionoxidized purine nucleobase lesion DNA N-glycosylase activity
B0009314biological_processresponse to radiation
B0016363cellular_componentnuclear matrix
B0016607cellular_componentnuclear speck
B0016787molecular_functionhydrolase activity
B0016798molecular_functionhydrolase activity, acting on glycosyl bonds
B0016829molecular_functionlyase activity
B0019104molecular_functionDNA N-glycosylase activity
B0019899molecular_functionenzyme binding
B0032357molecular_functionoxidized purine DNA binding
B0032991cellular_componentprotein-containing complex
B0034039molecular_function8-oxo-7,8-dihydroguanine DNA N-glycosylase activity
B0034614biological_processcellular response to reactive oxygen species
B0044029biological_processpositive regulation of gene expression via chromosomal CpG island demethylation
B0045944biological_processpositive regulation of transcription by RNA polymerase II
B0140078molecular_functionclass I DNA-(apurinic or apyrimidinic site) endonuclease activity
B1901291biological_processnegative regulation of double-strand break repair via single-strand annealing
C0000702molecular_functionoxidized base lesion DNA N-glycosylase activity
C0000978molecular_functionRNA polymerase II cis-regulatory region sequence-specific DNA binding
C0003677molecular_functionDNA binding
C0003684molecular_functiondamaged DNA binding
C0003824molecular_functioncatalytic activity
C0005634cellular_componentnucleus
C0005654cellular_componentnucleoplasm
C0005739cellular_componentmitochondrion
C0006281biological_processDNA repair
C0006284biological_processbase-excision repair
C0006285biological_processbase-excision repair, AP site formation
C0006289biological_processnucleotide-excision repair
C0006355biological_processregulation of DNA-templated transcription
C0006974biological_processDNA damage response
C0006979biological_processresponse to oxidative stress
C0008017molecular_functionmicrotubule binding
C0008534molecular_functionoxidized purine nucleobase lesion DNA N-glycosylase activity
C0009314biological_processresponse to radiation
C0016363cellular_componentnuclear matrix
C0016607cellular_componentnuclear speck
C0016787molecular_functionhydrolase activity
C0016798molecular_functionhydrolase activity, acting on glycosyl bonds
C0016829molecular_functionlyase activity
C0019104molecular_functionDNA N-glycosylase activity
C0019899molecular_functionenzyme binding
C0032357molecular_functionoxidized purine DNA binding
C0032991cellular_componentprotein-containing complex
C0034039molecular_function8-oxo-7,8-dihydroguanine DNA N-glycosylase activity
C0034614biological_processcellular response to reactive oxygen species
C0044029biological_processpositive regulation of gene expression via chromosomal CpG island demethylation
C0045944biological_processpositive regulation of transcription by RNA polymerase II
C0140078molecular_functionclass I DNA-(apurinic or apyrimidinic site) endonuclease activity
C1901291biological_processnegative regulation of double-strand break repair via single-strand annealing
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues3
DetailsACT_SITE: Schiff-base intermediate with DNA => ECO:0000250
ChainResidueDetails
ALYS249
BLYS249
CLYS249

site_idSWS_FT_FI2
Number of Residues27
DetailsBINDING: BINDING => ECO:0000250
ChainResidueDetails
AASN149
BASN149
BARG154
BARG204
BPRO266
BASP268
BHIS270
BGLN287
BGLN315
BPHE319
CASN149
AARG154
CARG154
CARG204
CPRO266
CASP268
CHIS270
CGLN287
CGLN315
CPHE319
AARG204
APRO266
AASP268
AHIS270
AGLN287
AGLN315
APHE319

236620

PDB entries from 2025-05-28

PDB statisticsPDBj update infoContact PDBjnumon