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8BVX

Structure of the mouse 8-oxoguanine DNA Glycosylase mOGG1 in complex with ligand TH13264

Functional Information from GO Data
ChainGOidnamespacecontents
A0000702molecular_functionoxidized base lesion DNA N-glycosylase activity
A0000978molecular_functionRNA polymerase II cis-regulatory region sequence-specific DNA binding
A0003677molecular_functionDNA binding
A0003684molecular_functiondamaged DNA binding
A0003824molecular_functioncatalytic activity
A0005634cellular_componentnucleus
A0005654cellular_componentnucleoplasm
A0005739cellular_componentmitochondrion
A0006281biological_processDNA repair
A0006284biological_processbase-excision repair
A0006285biological_processbase-excision repair, AP site formation
A0006289biological_processnucleotide-excision repair
A0006355biological_processregulation of DNA-templated transcription
A0006974biological_processDNA damage response
A0006979biological_processresponse to oxidative stress
A0008017molecular_functionmicrotubule binding
A0008534molecular_functionoxidized purine nucleobase lesion DNA N-glycosylase activity
A0009314biological_processresponse to radiation
A0016363cellular_componentnuclear matrix
A0016607cellular_componentnuclear speck
A0016787molecular_functionhydrolase activity
A0016798molecular_functionhydrolase activity, acting on glycosyl bonds
A0016829molecular_functionlyase activity
A0019104molecular_functionDNA N-glycosylase activity
A0019899molecular_functionenzyme binding
A0032357molecular_functionoxidized purine DNA binding
A0032991cellular_componentprotein-containing complex
A0034039molecular_function8-oxo-7,8-dihydroguanine DNA N-glycosylase activity
A0034614biological_processcellular response to reactive oxygen species
A0044029biological_processpositive regulation of gene expression via chromosomal CpG island demethylation
A0045944biological_processpositive regulation of transcription by RNA polymerase II
A0140078molecular_functionclass I DNA-(apurinic or apyrimidinic site) endonuclease activity
A1901291biological_processnegative regulation of double-strand break repair via single-strand annealing
B0000702molecular_functionoxidized base lesion DNA N-glycosylase activity
B0000978molecular_functionRNA polymerase II cis-regulatory region sequence-specific DNA binding
B0003677molecular_functionDNA binding
B0003684molecular_functiondamaged DNA binding
B0003824molecular_functioncatalytic activity
B0005634cellular_componentnucleus
B0005654cellular_componentnucleoplasm
B0005739cellular_componentmitochondrion
B0006281biological_processDNA repair
B0006284biological_processbase-excision repair
B0006285biological_processbase-excision repair, AP site formation
B0006289biological_processnucleotide-excision repair
B0006355biological_processregulation of DNA-templated transcription
B0006974biological_processDNA damage response
B0006979biological_processresponse to oxidative stress
B0008017molecular_functionmicrotubule binding
B0008534molecular_functionoxidized purine nucleobase lesion DNA N-glycosylase activity
B0009314biological_processresponse to radiation
B0016363cellular_componentnuclear matrix
B0016607cellular_componentnuclear speck
B0016787molecular_functionhydrolase activity
B0016798molecular_functionhydrolase activity, acting on glycosyl bonds
B0016829molecular_functionlyase activity
B0019104molecular_functionDNA N-glycosylase activity
B0019899molecular_functionenzyme binding
B0032357molecular_functionoxidized purine DNA binding
B0032991cellular_componentprotein-containing complex
B0034039molecular_function8-oxo-7,8-dihydroguanine DNA N-glycosylase activity
B0034614biological_processcellular response to reactive oxygen species
B0044029biological_processpositive regulation of gene expression via chromosomal CpG island demethylation
B0045944biological_processpositive regulation of transcription by RNA polymerase II
B0140078molecular_functionclass I DNA-(apurinic or apyrimidinic site) endonuclease activity
B1901291biological_processnegative regulation of double-strand break repair via single-strand annealing
C0000702molecular_functionoxidized base lesion DNA N-glycosylase activity
C0000978molecular_functionRNA polymerase II cis-regulatory region sequence-specific DNA binding
C0003677molecular_functionDNA binding
C0003684molecular_functiondamaged DNA binding
C0003824molecular_functioncatalytic activity
C0005634cellular_componentnucleus
C0005654cellular_componentnucleoplasm
C0005739cellular_componentmitochondrion
C0006281biological_processDNA repair
C0006284biological_processbase-excision repair
C0006285biological_processbase-excision repair, AP site formation
C0006289biological_processnucleotide-excision repair
C0006355biological_processregulation of DNA-templated transcription
C0006974biological_processDNA damage response
C0006979biological_processresponse to oxidative stress
C0008017molecular_functionmicrotubule binding
C0008534molecular_functionoxidized purine nucleobase lesion DNA N-glycosylase activity
C0009314biological_processresponse to radiation
C0016363cellular_componentnuclear matrix
C0016607cellular_componentnuclear speck
C0016787molecular_functionhydrolase activity
C0016798molecular_functionhydrolase activity, acting on glycosyl bonds
C0016829molecular_functionlyase activity
C0019104molecular_functionDNA N-glycosylase activity
C0019899molecular_functionenzyme binding
C0032357molecular_functionoxidized purine DNA binding
C0032991cellular_componentprotein-containing complex
C0034039molecular_function8-oxo-7,8-dihydroguanine DNA N-glycosylase activity
C0034614biological_processcellular response to reactive oxygen species
C0044029biological_processpositive regulation of gene expression via chromosomal CpG island demethylation
C0045944biological_processpositive regulation of transcription by RNA polymerase II
C0140078molecular_functionclass I DNA-(apurinic or apyrimidinic site) endonuclease activity
C1901291biological_processnegative regulation of double-strand break repair via single-strand annealing
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues3
DetailsActive site: {"description":"Schiff-base intermediate with DNA","evidences":[{"evidenceCode":"ECO:0000250"}]}
ChainResidueDetails

site_idSWS_FT_FI2
Number of Residues26
DetailsBinding site: {"evidences":[{"evidenceCode":"ECO:0000250"}]}
ChainResidueDetails

238895

PDB entries from 2025-07-16

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