8BTG

Cryo-EM structure of the bacterial replication origin opening basal unwinding system

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000166	molecular_function	nucleotide binding
A	0003677	molecular_function	DNA binding
A	0003688	molecular_function	DNA replication origin binding
A	0005515	molecular_function	protein binding
A	0005524	molecular_function	ATP binding
A	0005737	cellular_component	cytoplasm
A	0005886	cellular_component	plasma membrane
A	0006260	biological_process	DNA replication
A	0006270	biological_process	DNA replication initiation
A	0006275	biological_process	regulation of DNA replication
A	0008289	molecular_function	lipid binding
A	0009295	cellular_component	nucleoid
A	0016787	molecular_function	hydrolase activity
A	0042802	molecular_function	identical protein binding
A	0043565	molecular_function	sequence-specific DNA binding
A	1990101	cellular_component	DnaA-oriC complex
B	0000166	molecular_function	nucleotide binding
B	0003677	molecular_function	DNA binding
B	0003688	molecular_function	DNA replication origin binding
B	0005515	molecular_function	protein binding
B	0005524	molecular_function	ATP binding
B	0005737	cellular_component	cytoplasm
B	0005886	cellular_component	plasma membrane
B	0006260	biological_process	DNA replication
B	0006270	biological_process	DNA replication initiation
B	0006275	biological_process	regulation of DNA replication
B	0008289	molecular_function	lipid binding
B	0009295	cellular_component	nucleoid
B	0016787	molecular_function	hydrolase activity
B	0042802	molecular_function	identical protein binding
B	0043565	molecular_function	sequence-specific DNA binding
B	1990101	cellular_component	DnaA-oriC complex
C	0000166	molecular_function	nucleotide binding
C	0003677	molecular_function	DNA binding
C	0003688	molecular_function	DNA replication origin binding
C	0005515	molecular_function	protein binding
C	0005524	molecular_function	ATP binding
C	0005737	cellular_component	cytoplasm
C	0005886	cellular_component	plasma membrane
C	0006260	biological_process	DNA replication
C	0006270	biological_process	DNA replication initiation
C	0006275	biological_process	regulation of DNA replication
C	0008289	molecular_function	lipid binding
C	0009295	cellular_component	nucleoid
C	0016787	molecular_function	hydrolase activity
C	0042802	molecular_function	identical protein binding
C	0043565	molecular_function	sequence-specific DNA binding
C	1990101	cellular_component	DnaA-oriC complex
D	0000166	molecular_function	nucleotide binding
D	0003677	molecular_function	DNA binding
D	0003688	molecular_function	DNA replication origin binding
D	0005515	molecular_function	protein binding
D	0005524	molecular_function	ATP binding
D	0005737	cellular_component	cytoplasm
D	0005886	cellular_component	plasma membrane
D	0006260	biological_process	DNA replication
D	0006270	biological_process	DNA replication initiation
D	0006275	biological_process	regulation of DNA replication
D	0008289	molecular_function	lipid binding
D	0009295	cellular_component	nucleoid
D	0016787	molecular_function	hydrolase activity
D	0042802	molecular_function	identical protein binding
D	0043565	molecular_function	sequence-specific DNA binding
D	1990101	cellular_component	DnaA-oriC complex
E	0000166	molecular_function	nucleotide binding
E	0003677	molecular_function	DNA binding
E	0003688	molecular_function	DNA replication origin binding
E	0005515	molecular_function	protein binding
E	0005524	molecular_function	ATP binding
E	0005737	cellular_component	cytoplasm
E	0005886	cellular_component	plasma membrane
E	0006260	biological_process	DNA replication
E	0006270	biological_process	DNA replication initiation
E	0006275	biological_process	regulation of DNA replication
E	0008289	molecular_function	lipid binding
E	0009295	cellular_component	nucleoid
E	0016787	molecular_function	hydrolase activity
E	0042802	molecular_function	identical protein binding
E	0043565	molecular_function	sequence-specific DNA binding
E	1990101	cellular_component	DnaA-oriC complex
F	0000166	molecular_function	nucleotide binding
F	0003677	molecular_function	DNA binding
F	0003688	molecular_function	DNA replication origin binding
F	0005515	molecular_function	protein binding
F	0005524	molecular_function	ATP binding
F	0005737	cellular_component	cytoplasm
F	0005886	cellular_component	plasma membrane
F	0006260	biological_process	DNA replication
F	0006270	biological_process	DNA replication initiation
F	0006275	biological_process	regulation of DNA replication
F	0008289	molecular_function	lipid binding
F	0009295	cellular_component	nucleoid
F	0016787	molecular_function	hydrolase activity
F	0042802	molecular_function	identical protein binding
F	0043565	molecular_function	sequence-specific DNA binding
F	1990101	cellular_component	DnaA-oriC complex
G	0000166	molecular_function	nucleotide binding
G	0003677	molecular_function	DNA binding
G	0003688	molecular_function	DNA replication origin binding
G	0005515	molecular_function	protein binding
G	0005524	molecular_function	ATP binding
G	0005737	cellular_component	cytoplasm
G	0005886	cellular_component	plasma membrane
G	0006260	biological_process	DNA replication
G	0006270	biological_process	DNA replication initiation
G	0006275	biological_process	regulation of DNA replication
G	0008289	molecular_function	lipid binding
G	0009295	cellular_component	nucleoid
G	0016787	molecular_function	hydrolase activity
G	0042802	molecular_function	identical protein binding
G	0043565	molecular_function	sequence-specific DNA binding
G	1990101	cellular_component	DnaA-oriC complex

Functional Information from PROSITE/UniProt

site_id	PS01008
Number of Residues	20
Details	DNAA DnaA protein signature. IGeeFGgRdHTTVihAhekI

Chain	Residue	Details
A	ILE405-ILE424

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI4
Number of Residues	14
Details	Binding site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_00377","evidenceCode":"ECO:0000255"},{"source":"PDB","id":"8BTG","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8BV3","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	7
Details	Binding site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_00377","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	21
Details	Binding site: {"evidences":[{"source":"PDB","id":"8BV3","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	168
Details	Motif: {"description":"Initiator specific motif (ISM)","evidences":[{"source":"PubMed","id":"38097584","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"34197592","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI8
Number of Residues	7
Details	Binding site: {"evidences":[{"source":"PDB","id":"8BTG","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8BV3","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI9
Number of Residues	65
Details	Region: {"description":"linker","evidences":[{"source":"PubMed","id":"38097584","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

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