8BRJ

Escherichia coli anaerobic fatty acid beta oxidation trifunctional enzyme (anEcTFE) trimeric complex

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003857	molecular_function	3-hydroxyacyl-CoA dehydrogenase activity
A	0003988	molecular_function	acetyl-CoA C-acyltransferase activity
A	0004300	molecular_function	enoyl-CoA hydratase activity
A	0005737	cellular_component	cytoplasm
A	0005829	cellular_component	cytosol
A	0006631	biological_process	fatty acid metabolic process
A	0006635	biological_process	fatty acid beta-oxidation
A	0016042	biological_process	lipid catabolic process
A	0016746	molecular_function	acyltransferase activity
A	0016747	molecular_function	acyltransferase activity, transferring groups other than amino-acyl groups
A	0033542	biological_process	fatty acid beta-oxidation, unsaturated, even number
A	0036125	cellular_component	fatty acid beta-oxidation multienzyme complex
A	0044281	biological_process	small molecule metabolic process
B	0003857	molecular_function	3-hydroxyacyl-CoA dehydrogenase activity
B	0003988	molecular_function	acetyl-CoA C-acyltransferase activity
B	0004300	molecular_function	enoyl-CoA hydratase activity
B	0005737	cellular_component	cytoplasm
B	0005829	cellular_component	cytosol
B	0006631	biological_process	fatty acid metabolic process
B	0006635	biological_process	fatty acid beta-oxidation
B	0016042	biological_process	lipid catabolic process
B	0016746	molecular_function	acyltransferase activity
B	0016747	molecular_function	acyltransferase activity, transferring groups other than amino-acyl groups
B	0033542	biological_process	fatty acid beta-oxidation, unsaturated, even number
B	0036125	cellular_component	fatty acid beta-oxidation multienzyme complex
B	0044281	biological_process	small molecule metabolic process
C	0003857	molecular_function	3-hydroxyacyl-CoA dehydrogenase activity
C	0004300	molecular_function	enoyl-CoA hydratase activity
C	0005515	molecular_function	protein binding
C	0005737	cellular_component	cytoplasm
C	0006631	biological_process	fatty acid metabolic process
C	0006635	biological_process	fatty acid beta-oxidation
C	0008692	molecular_function	3-hydroxybutyryl-CoA epimerase activity
C	0016042	biological_process	lipid catabolic process
C	0016491	molecular_function	oxidoreductase activity
C	0016509	molecular_function	long-chain-3-hydroxyacyl-CoA dehydrogenase activity
C	0016616	molecular_function	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
C	0016829	molecular_function	lyase activity
C	0016853	molecular_function	isomerase activity
C	0036125	cellular_component	fatty acid beta-oxidation multienzyme complex
C	0044248	biological_process	cellular catabolic process
C	0051287	molecular_function	NAD binding
C	0070403	molecular_function	NAD+ binding

Functional Information from PROSITE/UniProt

site_id	PS00067
Number of Residues	25
Details	3HCDH 3-hydroxyacyl-CoA dehydrogenase signature. DkaGFYvNRilaPYIneair.MLtqG

Chain	Residue	Details
C	ASP489-GLY513

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site_id	PS00098
Number of Residues	19
Details	THIOLASE_1 Thiolases acyl-enzyme intermediate signature. VSRaCATSFqAVanvaesL

Chain	Residue	Details
A	VAL95-LEU113

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site_id	PS00099
Number of Residues	14
Details	THIOLASE_3 Thiolases active site. GLVTACAAgGlGaA

Chain	Residue	Details
A	GLY417-ALA430

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site_id	PS00737
Number of Residues	17
Details	THIOLASE_2 Thiolases signature 2. NvlGGsIAyGHPfAaTG

Chain	Residue	Details
A	ASN382-GLY398

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	2
Details	SITE: Important for catalytic activity => ECO:0000250

Chain	Residue	Details
C	GLU118
C	GLU140

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site_id	SWS_FT_FI2
Number of Residues	4
Details	ACT_SITE: Proton acceptor => ECO:0000250

Chain	Residue	Details
A	HIS392
A	CYS422
B	HIS392
B	CYS422

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