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SummaryStructural detailsExperimental detailsFunctional detailsSequence NeighborHistoryDownloads

8BQS

Cryo-EM structure of the I-II-III2-IV2 respiratory supercomplex from Tetrahymena thermophila

This is a non-PDB format compatible entry.
Functional Information from GO Data
ChainGOidnamespacecontents
A0005739cellular_componentmitochondrion
A0046872molecular_functionmetal ion binding
A00005543molecular_functionphospholipid binding
A00008915molecular_functionlipid-A-disaccharide synthase activity
A00009245biological_processlipid A biosynthetic process
A00016757molecular_functionglycosyltransferase activity
A10005739cellular_componentmitochondrion
A10044877molecular_functionprotein-containing complex binding
A11901006biological_processubiquinone-6 biosynthetic process
A30006631biological_processfatty acid metabolic process
A30016874molecular_functionligase activity
A30031956molecular_functionmedium-chain fatty acid-CoA ligase activity
A60016020cellular_componentmembrane
A90016020cellular_componentmembrane
AA0003954molecular_functionNADH dehydrogenase activity
AA0005739cellular_componentmitochondrion
AA0008137molecular_functionNADH dehydrogenase (ubiquinone) activity
AA0015990biological_processelectron transport coupled proton transport
AA0016020cellular_componentmembrane
AA0016491molecular_functionoxidoreductase activity
AA0042773biological_processATP synthesis coupled electron transport
AB0003954molecular_functionNADH dehydrogenase activity
AB0008137molecular_functionNADH dehydrogenase (ubiquinone) activity
AB0016020cellular_componentmembrane
AB0016491molecular_functionoxidoreductase activity
AB0016651molecular_functionoxidoreductase activity, acting on NAD(P)H
AB0042773biological_processATP synthesis coupled electron transport
AB0045333biological_processcellular respiration
AB0046872molecular_functionmetal ion binding
AB0051536molecular_functioniron-sulfur cluster binding
AB0051539molecular_function4 iron, 4 sulfur cluster binding
AB1902600biological_processproton transmembrane transport
AC0003954molecular_functionNADH dehydrogenase activity
AC0005739cellular_componentmitochondrion
AC0008137molecular_functionNADH dehydrogenase (ubiquinone) activity
AC0009060biological_processaerobic respiration
AC0015990biological_processelectron transport coupled proton transport
AC0016020cellular_componentmembrane
AC0016491molecular_functionoxidoreductase activity
AC0031966cellular_componentmitochondrial membrane
AC0042773biological_processATP synthesis coupled electron transport
AC0045271cellular_componentrespiratory chain complex I
AC0048039molecular_functionubiquinone binding
AD0005739cellular_componentmitochondrion
AD0005743cellular_componentmitochondrial inner membrane
AD0006120biological_processmitochondrial electron transport, NADH to ubiquinone
AD0008137molecular_functionNADH dehydrogenase (ubiquinone) activity
AD0010181molecular_functionFMN binding
AD0045271cellular_componentrespiratory chain complex I
AD0046872molecular_functionmetal ion binding
AD0051287molecular_functionNAD binding
AD0051539molecular_function4 iron, 4 sulfur cluster binding
AD1902600biological_processproton transmembrane transport
AE0005739cellular_componentmitochondrion
AE0006120biological_processmitochondrial electron transport, NADH to ubiquinone
AE0016491molecular_functionoxidoreductase activity
AE0016651molecular_functionoxidoreductase activity, acting on NAD(P)H
AE0048038molecular_functionquinone binding
AE0051287molecular_functionNAD binding
AF0005739cellular_componentmitochondrion
AF0016020cellular_componentmembrane
AH0003954molecular_functionNADH dehydrogenase activity
AH0005739cellular_componentmitochondrion
AH0005743cellular_componentmitochondrial inner membrane
AH0008137molecular_functionNADH dehydrogenase (ubiquinone) activity
AH0009060biological_processaerobic respiration
AH0016020cellular_componentmembrane
AH0016491molecular_functionoxidoreductase activity
AH1902600biological_processproton transmembrane transport
AI0003954molecular_functionNADH dehydrogenase activity
AI0005739cellular_componentmitochondrion
AI0006120biological_processmitochondrial electron transport, NADH to ubiquinone
AI0016491molecular_functionoxidoreductase activity
AI0045271cellular_componentrespiratory chain complex I
AI0046872molecular_functionmetal ion binding
AI0051537molecular_function2 iron, 2 sulfur cluster binding
AJ0005739cellular_componentmitochondrion
AJ0016020cellular_componentmembrane
AL0003954molecular_functionNADH dehydrogenase activity
AL0005739cellular_componentmitochondrion
AL0006120biological_processmitochondrial electron transport, NADH to ubiquinone
AL0016020cellular_componentmembrane
AL0016651molecular_functionoxidoreductase activity, acting on NAD(P)H
AL0032981biological_processmitochondrial respiratory chain complex I assembly
AL0051539molecular_function4 iron, 4 sulfur cluster binding
AN0005739cellular_componentmitochondrion
AN0005743cellular_componentmitochondrial inner membrane
AN0022904biological_processrespiratory electron transport chain
AO0005739cellular_componentmitochondrion
AO0008137molecular_functionNADH dehydrogenase (ubiquinone) activity
AO0016491molecular_functionoxidoreductase activity
AO0016651molecular_functionoxidoreductase activity, acting on NAD(P)H
AO1902600biological_processproton transmembrane transport
AP0005739cellular_componentmitochondrion
AP0005743cellular_componentmitochondrial inner membrane
AP0006979biological_processresponse to oxidative stress
AP0016020cellular_componentmembrane
AP0032981biological_processmitochondrial respiratory chain complex I assembly
AR0005739cellular_componentmitochondrion
AR0005743cellular_componentmitochondrial inner membrane
AR0022900biological_processelectron transport chain
AS0005739cellular_componentmitochondrion
AS0005743cellular_componentmitochondrial inner membrane
AS0006979biological_processresponse to oxidative stress
AT0005739cellular_componentmitochondrion
AT0008137molecular_functionNADH dehydrogenase (ubiquinone) activity
AT0009060biological_processaerobic respiration
AT0015990biological_processelectron transport coupled proton transport
AT0016491molecular_functionoxidoreductase activity
AT0046872molecular_functionmetal ion binding
AT0048038molecular_functionquinone binding
AT0051536molecular_functioniron-sulfur cluster binding
AT0051539molecular_function4 iron, 4 sulfur cluster binding
AU0016020cellular_componentmembrane
AV0000035molecular_functionacyl binding
AV0000036molecular_functionacyl carrier activity
AV0005739cellular_componentmitochondrion
AV0006633biological_processfatty acid biosynthetic process
AV1902494cellular_componentcatalytic complex
AW0000035molecular_functionacyl binding
AW0000036molecular_functionacyl carrier activity
AW0005739cellular_componentmitochondrion
AW0006633biological_processfatty acid biosynthetic process
AW1902494cellular_componentcatalytic complex
AX0005739cellular_componentmitochondrion
AX0008137molecular_functionNADH dehydrogenase (ubiquinone) activity
AX0016020cellular_componentmembrane
AX0016491molecular_functionoxidoreductase activity
AX0030964cellular_componentNADH dehydrogenase complex
AX0031966cellular_componentmitochondrial membrane
AX1902600biological_processproton transmembrane transport
AY0005739cellular_componentmitochondrion
AY0016020cellular_componentmembrane
AZ0005739cellular_componentmitochondrion
AZ0005743cellular_componentmitochondrial inner membrane
AZ0005840cellular_componentribosome
B0005739cellular_componentmitochondrion
B0046872molecular_functionmetal ion binding
B00016020cellular_componentmembrane
B40016020cellular_componentmembrane
B50016020cellular_componentmembrane
B60016020cellular_componentmembrane
BB0016020cellular_componentmembrane
BD0016020cellular_componentmembrane
BH0005739cellular_componentmitochondrion
BH0016020cellular_componentmembrane
BH0016491molecular_functionoxidoreductase activity
BI0051536molecular_functioniron-sulfur cluster binding
BI0051537molecular_function2 iron, 2 sulfur cluster binding
BI0140647biological_processP450-containing electron transport chain
BL0016020cellular_componentmembrane
BM0016020cellular_componentmembrane
BR0005739cellular_componentmitochondrion
BR0006120biological_processmitochondrial electron transport, NADH to ubiquinone
BX0016020cellular_componentmembrane
BY0005739cellular_componentmitochondrion
BY0016020cellular_componentmembrane
C0005739cellular_componentmitochondrion
C0009055molecular_functionelectron transfer activity
C0016020cellular_componentmembrane
C0016491molecular_functionoxidoreductase activity
C0022904biological_processrespiratory electron transport chain
CA0005743cellular_componentmitochondrial inner membrane
CA0006099biological_processtricarboxylic acid cycle
CA0006121biological_processmitochondrial electron transport, succinate to ubiquinone
CA0008177molecular_functionsuccinate dehydrogenase (quinone) activity
CA0009055molecular_functionelectron transfer activity
CA0016020cellular_componentmembrane
CA0016491molecular_functionoxidoreductase activity
CA0016627molecular_functionoxidoreductase activity, acting on the CH-CH group of donors
CA0022900biological_processelectron transport chain
CA0050660molecular_functionflavin adenine dinucleotide binding
CB0005743cellular_componentmitochondrial inner membrane
CB0006099biological_processtricarboxylic acid cycle
CB0008177molecular_functionsuccinate dehydrogenase (quinone) activity
CB0009055molecular_functionelectron transfer activity
CB0009060biological_processaerobic respiration
CB0016491molecular_functionoxidoreductase activity
CB0022904biological_processrespiratory electron transport chain
CB0051536molecular_functioniron-sulfur cluster binding
CB0051537molecular_function2 iron, 2 sulfur cluster binding
CB0051538molecular_function3 iron, 4 sulfur cluster binding
CF0016020cellular_componentmembrane
CJ0016020cellular_componentmembrane
CK0016020cellular_componentmembrane
CM0016020cellular_componentmembrane
CN0016020cellular_componentmembrane
D0005739cellular_componentmitochondrion
D0006122biological_processmitochondrial electron transport, ubiquinol to cytochrome c
D0009055molecular_functionelectron transfer activity
D0016020cellular_componentmembrane
D0020037molecular_functionheme binding
D0046872molecular_functionmetal ion binding
DA0004129molecular_functioncytochrome-c oxidase activity
DA0005739cellular_componentmitochondrion
DA0005743cellular_componentmitochondrial inner membrane
DA0006119biological_processoxidative phosphorylation
DA0006123biological_processmitochondrial electron transport, cytochrome c to oxygen
DA0009060biological_processaerobic respiration
DA0015990biological_processelectron transport coupled proton transport
DA0016020cellular_componentmembrane
DA0016491molecular_functionoxidoreductase activity
DA0020037molecular_functionheme binding
DA0046872molecular_functionmetal ion binding
DB0004129molecular_functioncytochrome-c oxidase activity
DB0005507molecular_functioncopper ion binding
DB0005739cellular_componentmitochondrion
DB0016020cellular_componentmembrane
DB0016491molecular_functionoxidoreductase activity
DB0042773biological_processATP synthesis coupled electron transport
DB1902600biological_processproton transmembrane transport
DC0005739cellular_componentmitochondrion
DC0016020cellular_componentmembrane
DD0005740cellular_componentmitochondrial envelope
DD0006123biological_processmitochondrial electron transport, cytochrome c to oxygen
DD0045277cellular_componentrespiratory chain complex IV
DD0046872molecular_functionmetal ion binding
DE0016020cellular_componentmembrane
DG0016020cellular_componentmembrane
DH0016020cellular_componentmembrane
DJ0016020cellular_componentmembrane
DK0003700molecular_functionDNA-binding transcription factor activity
DK0005634cellular_componentnucleus
DK0006355biological_processregulation of DNA-templated transcription
DK0010468biological_processregulation of gene expression
DM0016020cellular_componentmembrane
DN0005739cellular_componentmitochondrion
DN0016020cellular_componentmembrane
DP0005739cellular_componentmitochondrion
DP0005743cellular_componentmitochondrial inner membrane
DP0016020cellular_componentmembrane
DR0016020cellular_componentmembrane
DS0016020cellular_componentmembrane
DS0022857molecular_functiontransmembrane transporter activity
DS0055085biological_processtransmembrane transport
DU0016020cellular_componentmembrane
DV0005310molecular_functiondicarboxylic acid transmembrane transporter activity
DV0008272biological_processobsolete sulfate transport
DV0015116molecular_functionsulfate transmembrane transporter activity
DV0015117molecular_functionthiosulfate transmembrane transporter activity
DV0015131molecular_functionoxaloacetate transmembrane transporter activity
DV0015140molecular_functionmalate transmembrane transporter activity
DV0015141molecular_functionsuccinate transmembrane transporter activity
DV0015297molecular_functionantiporter activity
DV0015709biological_processthiosulfate transport
DV0015729biological_processoxaloacetate transport
DV0016020cellular_componentmembrane
DV0035435biological_processphosphate ion transmembrane transport
DV0071422biological_processsuccinate transmembrane transport
DV0071423biological_processmalate transmembrane transport
DV1902356biological_processoxaloacetate(2-) transmembrane transport
DV1902358biological_processsulfate transmembrane transport
DW0005739cellular_componentmitochondrion
DW0005743cellular_componentmitochondrial inner membrane
DW0016020cellular_componentmembrane
Da0004129molecular_functioncytochrome-c oxidase activity
Da0005739cellular_componentmitochondrion
Da0005743cellular_componentmitochondrial inner membrane
Da0006119biological_processoxidative phosphorylation
Da0006123biological_processmitochondrial electron transport, cytochrome c to oxygen
Da0009060biological_processaerobic respiration
Da0015990biological_processelectron transport coupled proton transport
Da0016020cellular_componentmembrane
Da0016491molecular_functionoxidoreductase activity
Da0020037molecular_functionheme binding
Da0046872molecular_functionmetal ion binding
Db0004129molecular_functioncytochrome-c oxidase activity
Db0005507molecular_functioncopper ion binding
Db0005739cellular_componentmitochondrion
Db0016020cellular_componentmembrane
Db0016491molecular_functionoxidoreductase activity
Db0042773biological_processATP synthesis coupled electron transport
Db1902600biological_processproton transmembrane transport
Dc0005739cellular_componentmitochondrion
Dc0016020cellular_componentmembrane
Dd0005740cellular_componentmitochondrial envelope
Dd0006123biological_processmitochondrial electron transport, cytochrome c to oxygen
Dd0045277cellular_componentrespiratory chain complex IV
Dd0046872molecular_functionmetal ion binding
De0016020cellular_componentmembrane
Dg0016020cellular_componentmembrane
Dh0016020cellular_componentmembrane
Dj0016020cellular_componentmembrane
Dk0003700molecular_functionDNA-binding transcription factor activity
Dk0005634cellular_componentnucleus
Dk0006355biological_processregulation of DNA-templated transcription
Dk0010468biological_processregulation of gene expression
Dm0016020cellular_componentmembrane
Dn0005739cellular_componentmitochondrion
Dn0016020cellular_componentmembrane
Dp0005739cellular_componentmitochondrion
Dp0005743cellular_componentmitochondrial inner membrane
Dp0016020cellular_componentmembrane
Dr0016020cellular_componentmembrane
Ds0016020cellular_componentmembrane
Ds0022857molecular_functiontransmembrane transporter activity
Ds0055085biological_processtransmembrane transport
Du0016020cellular_componentmembrane
Dv0005310molecular_functiondicarboxylic acid transmembrane transporter activity
Dv0008272biological_processobsolete sulfate transport
Dv0015116molecular_functionsulfate transmembrane transporter activity
Dv0015117molecular_functionthiosulfate transmembrane transporter activity
Dv0015131molecular_functionoxaloacetate transmembrane transporter activity
Dv0015140molecular_functionmalate transmembrane transporter activity
Dv0015141molecular_functionsuccinate transmembrane transporter activity
Dv0015297molecular_functionantiporter activity
Dv0015709biological_processthiosulfate transport
Dv0015729biological_processoxaloacetate transport
Dv0016020cellular_componentmembrane
Dv0035435biological_processphosphate ion transmembrane transport
Dv0071422biological_processsuccinate transmembrane transport
Dv0071423biological_processmalate transmembrane transport
Dv1902356biological_processoxaloacetate(2-) transmembrane transport
Dv1902358biological_processsulfate transmembrane transport
Dw0005739cellular_componentmitochondrion
Dw0005743cellular_componentmitochondrial inner membrane
Dw0016020cellular_componentmembrane
E0005739cellular_componentmitochondrion
E0006122biological_processmitochondrial electron transport, ubiquinol to cytochrome c
E0016020cellular_componentmembrane
E0016491molecular_functionoxidoreductase activity
E0046872molecular_functionmetal ion binding
E0051537molecular_function2 iron, 2 sulfur cluster binding
EB0016020cellular_componentmembrane
ED0005739cellular_componentmitochondrion
ED0016020cellular_componentmembrane
EF0005737cellular_componentcytoplasm
EF0005739cellular_componentmitochondrion
EF0016020cellular_componentmembrane
EF0043231cellular_componentintracellular membrane-bounded organelle
EF0046872molecular_functionmetal ion binding
EF0051537molecular_function2 iron, 2 sulfur cluster binding
EF0106034biological_processprotein maturation by [2Fe-2S] cluster transfer
EH0016020cellular_componentmembrane
EL0016020cellular_componentmembrane
EM0016020cellular_componentmembrane
EQ0016020cellular_componentmembrane
ES0005739cellular_componentmitochondrion
ES0016020cellular_componentmembrane
Eb0016020cellular_componentmembrane
Ed0005739cellular_componentmitochondrion
Ed0016020cellular_componentmembrane
Ef0005737cellular_componentcytoplasm
Ef0005739cellular_componentmitochondrion
Ef0016020cellular_componentmembrane
Ef0043231cellular_componentintracellular membrane-bounded organelle
Ef0046872molecular_functionmetal ion binding
Ef0051537molecular_function2 iron, 2 sulfur cluster binding
Ef0106034biological_processprotein maturation by [2Fe-2S] cluster transfer
Eh0016020cellular_componentmembrane
El0016020cellular_componentmembrane
Em0016020cellular_componentmembrane
Eq0016020cellular_componentmembrane
Es0005739cellular_componentmitochondrion
Es0016020cellular_componentmembrane
F0005739cellular_componentmitochondrion
F0005743cellular_componentmitochondrial inner membrane
FA0005739cellular_componentmitochondrion
FA0005743cellular_componentmitochondrial inner membrane
FA0015031biological_processprotein transport
Fa0005739cellular_componentmitochondrion
Fa0005743cellular_componentmitochondrial inner membrane
Fa0015031biological_processprotein transport
I0016020cellular_componentmembrane
K0016020cellular_componentmembrane
a0005739cellular_componentmitochondrion
a0046872molecular_functionmetal ion binding
b0005739cellular_componentmitochondrion
b0046872molecular_functionmetal ion binding
c0005739cellular_componentmitochondrion
c0009055molecular_functionelectron transfer activity
c0016020cellular_componentmembrane
c0016491molecular_functionoxidoreductase activity
c0022904biological_processrespiratory electron transport chain
d0005739cellular_componentmitochondrion
d0006122biological_processmitochondrial electron transport, ubiquinol to cytochrome c
d0009055molecular_functionelectron transfer activity
d0016020cellular_componentmembrane
d0020037molecular_functionheme binding
d0046872molecular_functionmetal ion binding
e0005739cellular_componentmitochondrion
e0006122biological_processmitochondrial electron transport, ubiquinol to cytochrome c
e0016020cellular_componentmembrane
e0016491molecular_functionoxidoreductase activity
e0046872molecular_functionmetal ion binding
e0051537molecular_function2 iron, 2 sulfur cluster binding
f0005739cellular_componentmitochondrion
f0005743cellular_componentmitochondrial inner membrane
i0016020cellular_componentmembrane
k0016020cellular_componentmembrane
Functional Information from PROSITE/UniProt
site_idPS00012
Number of Residues16
DetailsPHOSPHOPANTETHEINE Phosphopantetheine attachment site. KLGLDSLDQTALLASI
ChainResidueDetails
AVLYS90-ILE105
site_idPS00022
Number of Residues12
DetailsEGF_1 EGF-like domain signature 1. CsCgiSqsGPwC
ChainResidueDetails
EFCYS99-CYS110
site_idPS00077
Number of Residues55
DetailsCOX1_CUB Heme-copper oxidase catalytic subunit, copper B binding region signature. WFFGHPeVyvliiptfgfinmivphnntrrvaskhhmiwaiyvmaymgylvwg..HH
ChainResidueDetails
DATRP387-HIS441
site_idPS00197
Number of Residues9
Details2FE2S_FER_1 2Fe-2S ferredoxin-type iron-sulfur binding region signature. CREGICGSC
ChainResidueDetails
CBCYS122-CYS130
site_idPS00198
Number of Residues12
Details4FE4S_FER_1 4Fe-4S ferredoxin-type iron-sulfur binding region signature. CvLCAaCStSCP
ChainResidueDetails
CBCYS215-PRO226
ALCYS136-PRO147
ALCYS175-PRO186
site_idPS00213
Number of Residues13
DetailsLIPOCALIN Lipocalin signature. NWEy.QYDGQWWSM
ChainResidueDetails
BTASN81-MET93
site_idPS00504
Number of Residues10
DetailsFRD_SDH_FAD_BINDING Fumarate reductase / succinate dehydrogenase FAD-binding site. RSHTvaAqGG
ChainResidueDetails
CAARG84-GLY93
site_idPS00535
Number of Residues12
DetailsCOMPLEX1_49K Respiratory chain NADH dehydrogenase 49 Kd subunit signature. LHRGsEKLiEdR
ChainResidueDetails
AELEU62-ARG73
site_idPS00542
Number of Residues22
DetailsCOMPLEX1_30K Respiratory chain NADH dehydrogenase 30 Kd subunit signature. EREtsEMYginykwKidtRkLL
ChainResidueDetails
AOGLU136-LEU157
site_idPS00641
Number of Residues18
DetailsCOMPLEX1_75K_1 Respiratory-chain NADH dehydrogenase 75 Kd subunit signature 1. PrfCYherlsvaGnCRmC
ChainResidueDetails
ABPRO62-CYS79
site_idPS00642
Number of Residues13
DetailsCOMPLEX1_75K_2 Respiratory-chain NADH dehydrogenase 75 Kd subunit signature 2. CPiCDqGGeCdLQ
ChainResidueDetails
ABCYS129-GLN141
site_idPS00643
Number of Residues11
DetailsCOMPLEX1_75K_3 Respiratory-chain NADH dehydrogenase 75 Kd subunit signature 3. RCIhCtRCVrF
ChainResidueDetails
ABARG176-PHE186
site_idPS00645
Number of Residues12
DetailsCOMPLEX1_51K_2 Respiratory-chain NADH dehydrogenase 51 Kd subunit signature 2. ESCGqCtPCReG
ChainResidueDetails
ADGLU378-GLY389
site_idPS00667
Number of Residues16
DetailsCOMPLEX1_ND1_1 Respiratory-chain NADH dehydrogenase subunit 1 signature 1. GRLQyIaDALKLFiKG
ChainResidueDetails
AHGLY63-GLY78
site_idPS00668
Number of Residues14
DetailsCOMPLEX1_ND1_2 Respiratory-chain NADH dehydrogenase subunit 1 signature 2. PFDLAEAEseLVt.G
ChainResidueDetails
AHPRO218-GLY231
site_idPS00848
Number of Residues23
DetailsCOX5B_1 Cytochrome c oxidase subunit Vb, zinc binding region signature. LLFfllregslqrCmgCGqvFKL
ChainResidueDetails
DDLEU175-LEU197

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PDB entries from 2024-10-16

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