8BQS

Cryo-EM structure of the I-II-III2-IV2 respiratory supercomplex from Tetrahymena thermophila

This is a non-PDB format compatible entry.

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005739	cellular_component	mitochondrion
A	0006508	biological_process	proteolysis
A	0008233	molecular_function	peptidase activity
A	0008237	molecular_function	metallopeptidase activity
A	0016787	molecular_function	hydrolase activity
A	0046872	molecular_function	metal ion binding
A0	0000166	molecular_function	nucleotide binding
A0	0005543	molecular_function	phospholipid binding
A0	0006629	biological_process	lipid metabolic process
A0	0008915	molecular_function	lipid-A-disaccharide synthase activity
A0	0009245	biological_process	lipid A biosynthetic process
A0	0016020	cellular_component	membrane
A0	0016740	molecular_function	transferase activity
A0	0016757	molecular_function	glycosyltransferase activity
A0	0046872	molecular_function	metal ion binding
A1	0000166	molecular_function	nucleotide binding
A1	0005739	cellular_component	mitochondrion
A1	0044877	molecular_function	protein-containing complex binding
A1	0046872	molecular_function	metal ion binding
A2	0005737	cellular_component	cytoplasm
A2	0006457	biological_process	protein folding
A2	0044183	molecular_function	protein folding chaperone
A2	0051082	molecular_function	unfolded protein binding
A2	0051087	molecular_function	protein-folding chaperone binding
A3	0016874	molecular_function	ligase activity
A5	0000166	molecular_function	nucleotide binding
A9	0046872	molecular_function	metal ion binding
AA	0003954	molecular_function	NADH dehydrogenase activity
AA	0008137	molecular_function	NADH dehydrogenase (ubiquinone) activity
AA	0015990	biological_process	electron transport coupled proton transport
AA	0016020	cellular_component	membrane
AA	0016491	molecular_function	oxidoreductase activity
AA	0042773	biological_process	ATP synthesis coupled electron transport
AB	0008137	molecular_function	NADH dehydrogenase (ubiquinone) activity
AB	0016020	cellular_component	membrane
AB	0016491	molecular_function	oxidoreductase activity
AB	0016651	molecular_function	oxidoreductase activity, acting on NAD(P)H
AB	0042773	biological_process	ATP synthesis coupled electron transport
AB	0046872	molecular_function	metal ion binding
AB	0051536	molecular_function	iron-sulfur cluster binding
AB	0051537	molecular_function	2 iron, 2 sulfur cluster binding
AB	0051539	molecular_function	4 iron, 4 sulfur cluster binding
AB	1902600	biological_process	proton transmembrane transport
AC	0005886	cellular_component	plasma membrane
AC	0008137	molecular_function	NADH dehydrogenase (ubiquinone) activity
AC	0016491	molecular_function	oxidoreductase activity
AC	0022904	biological_process	respiratory electron transport chain
AC	0031966	cellular_component	mitochondrial membrane
AC	0042773	biological_process	ATP synthesis coupled electron transport
AC	1902600	biological_process	proton transmembrane transport
AD	0000166	molecular_function	nucleotide binding
AD	0005739	cellular_component	mitochondrion
AD	0005743	cellular_component	mitochondrial inner membrane
AD	0006120	biological_process	mitochondrial electron transport, NADH to ubiquinone
AD	0008137	molecular_function	NADH dehydrogenase (ubiquinone) activity
AD	0010181	molecular_function	FMN binding
AD	0022904	biological_process	respiratory electron transport chain
AD	0046872	molecular_function	metal ion binding
AD	0051287	molecular_function	NAD binding
AD	0051536	molecular_function	iron-sulfur cluster binding
AD	0051539	molecular_function	4 iron, 4 sulfur cluster binding
AD	1902600	biological_process	proton transmembrane transport
AE	0005739	cellular_component	mitochondrion
AE	0006120	biological_process	mitochondrial electron transport, NADH to ubiquinone
AE	0016491	molecular_function	oxidoreductase activity
AE	0016651	molecular_function	oxidoreductase activity, acting on NAD(P)H
AE	0048038	molecular_function	quinone binding
AE	0051287	molecular_function	NAD binding
AH	0003954	molecular_function	NADH dehydrogenase activity
AH	0005743	cellular_component	mitochondrial inner membrane
AH	0008137	molecular_function	NADH dehydrogenase (ubiquinone) activity
AH	0009060	biological_process	aerobic respiration
AH	0016020	cellular_component	membrane
AH	0016491	molecular_function	oxidoreductase activity
AH	1902600	biological_process	proton transmembrane transport
AI	0003954	molecular_function	NADH dehydrogenase activity
AI	0005743	cellular_component	mitochondrial inner membrane
AI	0006120	biological_process	mitochondrial electron transport, NADH to ubiquinone
AI	0008137	molecular_function	NADH dehydrogenase (ubiquinone) activity
AI	0016491	molecular_function	oxidoreductase activity
AI	0046872	molecular_function	metal ion binding
AI	0051536	molecular_function	iron-sulfur cluster binding
AI	0051537	molecular_function	2 iron, 2 sulfur cluster binding
AI	0098796	cellular_component	membrane protein complex
AI	1902494	cellular_component	catalytic complex
AI	1902600	biological_process	proton transmembrane transport
AL	0003954	molecular_function	NADH dehydrogenase activity
AL	0005739	cellular_component	mitochondrion
AL	0006120	biological_process	mitochondrial electron transport, NADH to ubiquinone
AL	0009060	biological_process	aerobic respiration
AL	0016020	cellular_component	membrane
AL	0016651	molecular_function	oxidoreductase activity, acting on NAD(P)H
AL	0032981	biological_process	mitochondrial respiratory chain complex I assembly
AL	0046872	molecular_function	metal ion binding
AL	0051536	molecular_function	iron-sulfur cluster binding
AL	0051539	molecular_function	4 iron, 4 sulfur cluster binding
AN	0005743	cellular_component	mitochondrial inner membrane
AN	0022904	biological_process	respiratory electron transport chain
AO	0008137	molecular_function	NADH dehydrogenase (ubiquinone) activity
AO	0016491	molecular_function	oxidoreductase activity
AO	0016651	molecular_function	oxidoreductase activity, acting on NAD(P)H
AO	1902600	biological_process	proton transmembrane transport
AP	0005743	cellular_component	mitochondrial inner membrane
AP	0006979	biological_process	response to oxidative stress
AP	0016020	cellular_component	membrane
AP	0022904	biological_process	respiratory electron transport chain
AP	0045271	cellular_component	respiratory chain complex I
AQ	0000166	molecular_function	nucleotide binding
AR	0005743	cellular_component	mitochondrial inner membrane
AR	0022900	biological_process	electron transport chain
AR	0022904	biological_process	respiratory electron transport chain
AS	0005743	cellular_component	mitochondrial inner membrane
AS	0006979	biological_process	response to oxidative stress
AS	0022904	biological_process	respiratory electron transport chain
AT	0008137	molecular_function	NADH dehydrogenase (ubiquinone) activity
AT	0009060	biological_process	aerobic respiration
AT	0015990	biological_process	electron transport coupled proton transport
AT	0016491	molecular_function	oxidoreductase activity
AT	0045271	cellular_component	respiratory chain complex I
AT	0046872	molecular_function	metal ion binding
AT	0048038	molecular_function	quinone binding
AT	0051536	molecular_function	iron-sulfur cluster binding
AT	0051539	molecular_function	4 iron, 4 sulfur cluster binding
AV	0000035	molecular_function	acyl binding
AV	0000036	molecular_function	acyl carrier activity
AV	0005739	cellular_component	mitochondrion
AV	0006629	biological_process	lipid metabolic process
AV	0006631	biological_process	fatty acid metabolic process
AV	0006633	biological_process	fatty acid biosynthetic process
AW	0000035	molecular_function	acyl binding
AW	0000036	molecular_function	acyl carrier activity
AW	0005739	cellular_component	mitochondrion
AW	0006629	biological_process	lipid metabolic process
AW	0006631	biological_process	fatty acid metabolic process
AW	0006633	biological_process	fatty acid biosynthetic process
AX	0008137	molecular_function	NADH dehydrogenase (ubiquinone) activity
AX	0016020	cellular_component	membrane
AX	0016491	molecular_function	oxidoreductase activity
AX	0022904	biological_process	respiratory electron transport chain
AX	0030964	cellular_component	NADH dehydrogenase complex
AX	0031966	cellular_component	mitochondrial membrane
AX	1902600	biological_process	proton transmembrane transport
AZ	0005743	cellular_component	mitochondrial inner membrane
AZ	0005840	cellular_component	ribosome
AZ	0022904	biological_process	respiratory electron transport chain
B	0005739	cellular_component	mitochondrion
B	0046872	molecular_function	metal ion binding
B6	0016020	cellular_component	membrane
BC	0000166	molecular_function	nucleotide binding
BH	0016491	molecular_function	oxidoreductase activity
BI	0005739	cellular_component	mitochondrion
BI	0009055	molecular_function	electron transfer activity
BI	0022900	biological_process	electron transport chain
BI	0046872	molecular_function	metal ion binding
BI	0051536	molecular_function	iron-sulfur cluster binding
BI	0051537	molecular_function	2 iron, 2 sulfur cluster binding
BI	0140647	biological_process	P450-containing electron transport chain
BR	0005739	cellular_component	mitochondrion
BR	0006120	biological_process	mitochondrial electron transport, NADH to ubiquinone
BR	0008270	molecular_function	zinc ion binding
BR	0046872	molecular_function	metal ion binding
C	0009055	molecular_function	electron transfer activity
C	0016020	cellular_component	membrane
C	0016491	molecular_function	oxidoreductase activity
C	0022904	biological_process	respiratory electron transport chain
C	0046872	molecular_function	metal ion binding
CA	0000104	molecular_function	succinate dehydrogenase activity
CA	0000166	molecular_function	nucleotide binding
CA	0005743	cellular_component	mitochondrial inner membrane
CA	0006099	biological_process	tricarboxylic acid cycle
CA	0006121	biological_process	mitochondrial electron transport, succinate to ubiquinone
CA	0008177	molecular_function	succinate dehydrogenase (quinone) activity
CA	0009055	molecular_function	electron transfer activity
CA	0016491	molecular_function	oxidoreductase activity
CA	0016627	molecular_function	oxidoreductase activity, acting on the CH-CH group of donors
CA	0022900	biological_process	electron transport chain
CA	0046872	molecular_function	metal ion binding
CA	0050660	molecular_function	flavin adenine dinucleotide binding
CB	0005743	cellular_component	mitochondrial inner membrane
CB	0006099	biological_process	tricarboxylic acid cycle
CB	0008177	molecular_function	succinate dehydrogenase (quinone) activity
CB	0009055	molecular_function	electron transfer activity
CB	0009060	biological_process	aerobic respiration
CB	0016491	molecular_function	oxidoreductase activity
CB	0022904	biological_process	respiratory electron transport chain
CB	0046872	molecular_function	metal ion binding
CB	0051536	molecular_function	iron-sulfur cluster binding
CB	0051537	molecular_function	2 iron, 2 sulfur cluster binding
CB	0051538	molecular_function	3 iron, 4 sulfur cluster binding
CB	0051539	molecular_function	4 iron, 4 sulfur cluster binding
CE	0046872	molecular_function	metal ion binding
D	0005739	cellular_component	mitochondrion
D	0006122	biological_process	mitochondrial electron transport, ubiquinol to cytochrome c
D	0009055	molecular_function	electron transfer activity
D	0016020	cellular_component	membrane
D	0020037	molecular_function	heme binding
D	0046872	molecular_function	metal ion binding
DA	0004129	molecular_function	cytochrome-c oxidase activity
DA	0005743	cellular_component	mitochondrial inner membrane
DA	0006119	biological_process	oxidative phosphorylation
DA	0006123	biological_process	mitochondrial electron transport, cytochrome c to oxygen
DA	0009060	biological_process	aerobic respiration
DA	0015990	biological_process	electron transport coupled proton transport
DA	0016020	cellular_component	membrane
DA	0016491	molecular_function	oxidoreductase activity
DA	0020037	molecular_function	heme binding
DA	0022904	biological_process	respiratory electron transport chain
DA	0046872	molecular_function	metal ion binding
DB	0004129	molecular_function	cytochrome-c oxidase activity
DB	0005507	molecular_function	copper ion binding
DB	0016020	cellular_component	membrane
DB	0016491	molecular_function	oxidoreductase activity
DB	0042773	biological_process	ATP synthesis coupled electron transport
DB	0046872	molecular_function	metal ion binding
DB	1902600	biological_process	proton transmembrane transport
DD	0005740	cellular_component	mitochondrial envelope
DD	0006123	biological_process	mitochondrial electron transport, cytochrome c to oxygen
DD	0045277	cellular_component	respiratory chain complex IV
DD	0046872	molecular_function	metal ion binding
DF	0000166	molecular_function	nucleotide binding
DF	0005524	molecular_function	ATP binding
DJ	0046872	molecular_function	metal ion binding
DK	0003700	molecular_function	DNA-binding transcription factor activity
DK	0005634	cellular_component	nucleus
DK	0006355	biological_process	regulation of DNA-templated transcription
DP	0005743	cellular_component	mitochondrial inner membrane
DP	0016020	cellular_component	membrane
DS	0016020	cellular_component	membrane
DU	0016020	cellular_component	membrane
DV	0016020	cellular_component	membrane
DW	0005743	cellular_component	mitochondrial inner membrane
DW	0016020	cellular_component	membrane
Da	0004129	molecular_function	cytochrome-c oxidase activity
Da	0005743	cellular_component	mitochondrial inner membrane
Da	0006119	biological_process	oxidative phosphorylation
Da	0006123	biological_process	mitochondrial electron transport, cytochrome c to oxygen
Da	0009060	biological_process	aerobic respiration
Da	0015990	biological_process	electron transport coupled proton transport
Da	0016020	cellular_component	membrane
Da	0016491	molecular_function	oxidoreductase activity
Da	0020037	molecular_function	heme binding
Da	0022904	biological_process	respiratory electron transport chain
Da	0046872	molecular_function	metal ion binding
Db	0004129	molecular_function	cytochrome-c oxidase activity
Db	0005507	molecular_function	copper ion binding
Db	0016020	cellular_component	membrane
Db	0016491	molecular_function	oxidoreductase activity
Db	0042773	biological_process	ATP synthesis coupled electron transport
Db	0046872	molecular_function	metal ion binding
Db	1902600	biological_process	proton transmembrane transport
Dd	0005740	cellular_component	mitochondrial envelope
Dd	0006123	biological_process	mitochondrial electron transport, cytochrome c to oxygen
Dd	0045277	cellular_component	respiratory chain complex IV
Dd	0046872	molecular_function	metal ion binding
Df	0000166	molecular_function	nucleotide binding
Df	0005524	molecular_function	ATP binding
Dj	0046872	molecular_function	metal ion binding
Dk	0003700	molecular_function	DNA-binding transcription factor activity
Dk	0005634	cellular_component	nucleus
Dk	0006355	biological_process	regulation of DNA-templated transcription
Dp	0005743	cellular_component	mitochondrial inner membrane
Dp	0016020	cellular_component	membrane
Ds	0016020	cellular_component	membrane
Du	0016020	cellular_component	membrane
Dv	0016020	cellular_component	membrane
Dw	0005743	cellular_component	mitochondrial inner membrane
Dw	0016020	cellular_component	membrane
E	0016020	cellular_component	membrane
E	0046872	molecular_function	metal ion binding
E	0051536	molecular_function	iron-sulfur cluster binding
E	0051537	molecular_function	2 iron, 2 sulfur cluster binding
ED	0046872	molecular_function	metal ion binding
EF	0005737	cellular_component	cytoplasm
EF	0005739	cellular_component	mitochondrion
EF	0043231	cellular_component	intracellular membrane-bounded organelle
EF	0046872	molecular_function	metal ion binding
EF	0051536	molecular_function	iron-sulfur cluster binding
EF	0051537	molecular_function	2 iron, 2 sulfur cluster binding
ER	0000166	molecular_function	nucleotide binding
ER	0005524	molecular_function	ATP binding
Ed	0046872	molecular_function	metal ion binding
Ef	0005737	cellular_component	cytoplasm
Ef	0005739	cellular_component	mitochondrion
Ef	0043231	cellular_component	intracellular membrane-bounded organelle
Ef	0046872	molecular_function	metal ion binding
Ef	0051536	molecular_function	iron-sulfur cluster binding
Ef	0051537	molecular_function	2 iron, 2 sulfur cluster binding
Er	0000166	molecular_function	nucleotide binding
Er	0005524	molecular_function	ATP binding
F	0005743	cellular_component	mitochondrial inner membrane
F	0016020	cellular_component	membrane
F	0022904	biological_process	respiratory electron transport chain
FA	0005743	cellular_component	mitochondrial inner membrane
FA	0015031	biological_process	protein transport
Fa	0005743	cellular_component	mitochondrial inner membrane
Fa	0015031	biological_process	protein transport
a	0005739	cellular_component	mitochondrion
a	0006508	biological_process	proteolysis
a	0008233	molecular_function	peptidase activity
a	0008237	molecular_function	metallopeptidase activity
a	0016787	molecular_function	hydrolase activity
a	0046872	molecular_function	metal ion binding
b	0005739	cellular_component	mitochondrion
b	0046872	molecular_function	metal ion binding
c	0009055	molecular_function	electron transfer activity
c	0016020	cellular_component	membrane
c	0016491	molecular_function	oxidoreductase activity
c	0022904	biological_process	respiratory electron transport chain
c	0046872	molecular_function	metal ion binding
d	0005739	cellular_component	mitochondrion
d	0006122	biological_process	mitochondrial electron transport, ubiquinol to cytochrome c
d	0009055	molecular_function	electron transfer activity
d	0016020	cellular_component	membrane
d	0020037	molecular_function	heme binding
d	0046872	molecular_function	metal ion binding
e	0016020	cellular_component	membrane
e	0046872	molecular_function	metal ion binding
e	0051536	molecular_function	iron-sulfur cluster binding
e	0051537	molecular_function	2 iron, 2 sulfur cluster binding
f	0005743	cellular_component	mitochondrial inner membrane
f	0016020	cellular_component	membrane
f	0022904	biological_process	respiratory electron transport chain

Functional Information from PROSITE/UniProt

site_id	PS00012
Number of Residues	16
Details	PHOSPHOPANTETHEINE Phosphopantetheine attachment site. KLGLDSLDQTALLASI

Chain	Residue	Details
AV	LYS90-ILE105

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site_id	PS00022
Number of Residues	12
Details	EGF_1 EGF-like domain signature 1. CsCgiSqsGPwC

Chain	Residue	Details
EF	CYS99-CYS110

---

site_id	PS00077
Number of Residues	55
Details	COX1_CUB Heme-copper oxidase catalytic subunit, copper B binding region signature. WFFGHPeVyvliiptfgfinmivphnntrrvaskhhmiwaiyvmaymgylvwg..HH

Chain	Residue	Details
DA	TRP387-HIS441

---

site_id	PS00197
Number of Residues	9
Details	2FE2S_FER_1 2Fe-2S ferredoxin-type iron-sulfur binding region signature. CREGICGSC

Chain	Residue	Details
CB	CYS122-CYS130

---

site_id	PS00198
Number of Residues	12
Details	4FE4S_FER_1 4Fe-4S ferredoxin-type iron-sulfur binding region signature. CiACKlCQsACP

Chain	Residue	Details
AL	CYS136-PRO147
AL	CYS175-PRO186
CB	CYS215-PRO226

---

site_id	PS00213
Number of Residues	13
Details	LIPOCALIN Lipocalin signature. NWEy.QYDGQWWSM

Chain	Residue	Details
BT	ASN81-MET93

---

site_id	PS00504
Number of Residues	10
Details	FRD_SDH_FAD_BINDING Fumarate reductase / succinate dehydrogenase FAD-binding site. RSHTvaAqGG

Chain	Residue	Details
CA	ARG84-GLY93

---

site_id	PS00535
Number of Residues	12
Details	COMPLEX1_49K Respiratory chain NADH dehydrogenase 49 Kd subunit signature. LHRGsEKLiEdR

Chain	Residue	Details
AE	LEU62-ARG73

---

site_id	PS00542
Number of Residues	22
Details	COMPLEX1_30K Respiratory chain NADH dehydrogenase 30 Kd subunit signature. EREtsEMYginykwKidtRkLL

Chain	Residue	Details
AO	GLU136-LEU157

---

site_id	PS00641
Number of Residues	18
Details	COMPLEX1_75K_1 Respiratory-chain NADH dehydrogenase 75 Kd subunit signature 1. PrfCYherlsvaGnCRmC

Chain	Residue	Details
AB	PRO62-CYS79

---

site_id	PS00642
Number of Residues	13
Details	COMPLEX1_75K_2 Respiratory-chain NADH dehydrogenase 75 Kd subunit signature 2. CPiCDqGGeCdLQ

Chain	Residue	Details
AB	CYS129-GLN141

---

site_id	PS00643
Number of Residues	11
Details	COMPLEX1_75K_3 Respiratory-chain NADH dehydrogenase 75 Kd subunit signature 3. RCIhCtRCVrF

Chain	Residue	Details
AB	ARG176-PHE186

---

site_id	PS00645
Number of Residues	12
Details	COMPLEX1_51K_2 Respiratory-chain NADH dehydrogenase 51 Kd subunit signature 2. ESCGqCtPCReG

Chain	Residue	Details
AD	GLU378-GLY389

---

site_id	PS00667
Number of Residues	16
Details	COMPLEX1_ND1_1 Respiratory-chain NADH dehydrogenase subunit 1 signature 1. GRLQyIaDALKLFiKG

Chain	Residue	Details
AH	GLY63-GLY78

---

site_id	PS00668
Number of Residues	14
Details	COMPLEX1_ND1_2 Respiratory-chain NADH dehydrogenase subunit 1 signature 2. PFDLAEAEseLVt.G

Chain	Residue	Details
AH	PRO218-GLY231

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site_id	PS00848
Number of Residues	23
Details	COX5B_1 Cytochrome c oxidase subunit Vb, zinc binding region signature. LLFfllregslqrCmgCGqvFKL

Chain	Residue	Details
DD	LEU175-LEU197

---