Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

8BNR

Escherichia coli anaerobic fatty acid beta oxidation trifunctional enzyme (anEcTFE) octameric complex

This is a non-PDB format compatible entry.

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003857	molecular_function	(3S)-3-hydroxyacyl-CoA dehydrogenase (NAD+) activity
A	0003985	molecular_function	acetyl-CoA C-acetyltransferase activity
A	0003988	molecular_function	acetyl-CoA C-acyltransferase activity
A	0004300	molecular_function	enoyl-CoA hydratase activity
A	0005737	cellular_component	cytoplasm
A	0005829	cellular_component	cytosol
A	0006629	biological_process	lipid metabolic process
A	0006631	biological_process	fatty acid metabolic process
A	0006635	biological_process	fatty acid beta-oxidation
A	0016042	biological_process	lipid catabolic process
A	0016740	molecular_function	transferase activity
A	0016746	molecular_function	acyltransferase activity
A	0016747	molecular_function	acyltransferase activity, transferring groups other than amino-acyl groups
A	0033542	biological_process	fatty acid beta-oxidation, unsaturated, even number
A	0044281	biological_process	small molecule metabolic process
B	0003857	molecular_function	(3S)-3-hydroxyacyl-CoA dehydrogenase (NAD+) activity
B	0003985	molecular_function	acetyl-CoA C-acetyltransferase activity
B	0003988	molecular_function	acetyl-CoA C-acyltransferase activity
B	0004300	molecular_function	enoyl-CoA hydratase activity
B	0005737	cellular_component	cytoplasm
B	0005829	cellular_component	cytosol
B	0006629	biological_process	lipid metabolic process
B	0006631	biological_process	fatty acid metabolic process
B	0006635	biological_process	fatty acid beta-oxidation
B	0016042	biological_process	lipid catabolic process
B	0016740	molecular_function	transferase activity
B	0016746	molecular_function	acyltransferase activity
B	0016747	molecular_function	acyltransferase activity, transferring groups other than amino-acyl groups
B	0033542	biological_process	fatty acid beta-oxidation, unsaturated, even number
B	0044281	biological_process	small molecule metabolic process
C	0003824	molecular_function	catalytic activity
C	0003857	molecular_function	(3S)-3-hydroxyacyl-CoA dehydrogenase (NAD+) activity
C	0004300	molecular_function	enoyl-CoA hydratase activity
C	0005515	molecular_function	protein binding
C	0005737	cellular_component	cytoplasm
C	0006629	biological_process	lipid metabolic process
C	0006631	biological_process	fatty acid metabolic process
C	0006635	biological_process	fatty acid beta-oxidation
C	0008692	molecular_function	3-hydroxybutyryl-CoA epimerase activity
C	0016042	biological_process	lipid catabolic process
C	0016491	molecular_function	oxidoreductase activity
C	0016509	molecular_function	long-chain (3S)-3-hydroxyacyl-CoA dehydrogenase (NAD+) activity
C	0016616	molecular_function	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
C	0016829	molecular_function	lyase activity
C	0016853	molecular_function	isomerase activity
C	0018812	molecular_function	3-hydroxyacyl-CoA dehydratase activity
C	0051287	molecular_function	NAD binding
C	0070403	molecular_function	NAD+ binding
D	0003824	molecular_function	catalytic activity
D	0003857	molecular_function	(3S)-3-hydroxyacyl-CoA dehydrogenase (NAD+) activity
D	0004300	molecular_function	enoyl-CoA hydratase activity
D	0005515	molecular_function	protein binding
D	0005737	cellular_component	cytoplasm
D	0006629	biological_process	lipid metabolic process
D	0006631	biological_process	fatty acid metabolic process
D	0006635	biological_process	fatty acid beta-oxidation
D	0008692	molecular_function	3-hydroxybutyryl-CoA epimerase activity
D	0016042	biological_process	lipid catabolic process
D	0016491	molecular_function	oxidoreductase activity
D	0016509	molecular_function	long-chain (3S)-3-hydroxyacyl-CoA dehydrogenase (NAD+) activity
D	0016616	molecular_function	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
D	0016829	molecular_function	lyase activity
D	0016853	molecular_function	isomerase activity
D	0018812	molecular_function	3-hydroxyacyl-CoA dehydratase activity
D	0051287	molecular_function	NAD binding
D	0070403	molecular_function	NAD+ binding
E	0003857	molecular_function	(3S)-3-hydroxyacyl-CoA dehydrogenase (NAD+) activity
E	0003985	molecular_function	acetyl-CoA C-acetyltransferase activity
E	0003988	molecular_function	acetyl-CoA C-acyltransferase activity
E	0004300	molecular_function	enoyl-CoA hydratase activity
E	0005737	cellular_component	cytoplasm
E	0005829	cellular_component	cytosol
E	0006629	biological_process	lipid metabolic process
E	0006631	biological_process	fatty acid metabolic process
E	0006635	biological_process	fatty acid beta-oxidation
E	0016042	biological_process	lipid catabolic process
E	0016740	molecular_function	transferase activity
E	0016746	molecular_function	acyltransferase activity
E	0016747	molecular_function	acyltransferase activity, transferring groups other than amino-acyl groups
E	0033542	biological_process	fatty acid beta-oxidation, unsaturated, even number
E	0044281	biological_process	small molecule metabolic process
F	0003857	molecular_function	(3S)-3-hydroxyacyl-CoA dehydrogenase (NAD+) activity
F	0003985	molecular_function	acetyl-CoA C-acetyltransferase activity
F	0003988	molecular_function	acetyl-CoA C-acyltransferase activity
F	0004300	molecular_function	enoyl-CoA hydratase activity
F	0005737	cellular_component	cytoplasm
F	0005829	cellular_component	cytosol
F	0006629	biological_process	lipid metabolic process
F	0006631	biological_process	fatty acid metabolic process
F	0006635	biological_process	fatty acid beta-oxidation
F	0016042	biological_process	lipid catabolic process
F	0016740	molecular_function	transferase activity
F	0016746	molecular_function	acyltransferase activity
F	0016747	molecular_function	acyltransferase activity, transferring groups other than amino-acyl groups
F	0033542	biological_process	fatty acid beta-oxidation, unsaturated, even number
F	0044281	biological_process	small molecule metabolic process
G	0003824	molecular_function	catalytic activity
G	0003857	molecular_function	(3S)-3-hydroxyacyl-CoA dehydrogenase (NAD+) activity
G	0004300	molecular_function	enoyl-CoA hydratase activity
G	0005515	molecular_function	protein binding
G	0005737	cellular_component	cytoplasm
G	0006629	biological_process	lipid metabolic process
G	0006631	biological_process	fatty acid metabolic process
G	0006635	biological_process	fatty acid beta-oxidation
G	0008692	molecular_function	3-hydroxybutyryl-CoA epimerase activity
G	0016042	biological_process	lipid catabolic process
G	0016491	molecular_function	oxidoreductase activity
G	0016509	molecular_function	long-chain (3S)-3-hydroxyacyl-CoA dehydrogenase (NAD+) activity
G	0016616	molecular_function	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
G	0016829	molecular_function	lyase activity
G	0016853	molecular_function	isomerase activity
G	0018812	molecular_function	3-hydroxyacyl-CoA dehydratase activity
G	0051287	molecular_function	NAD binding
G	0070403	molecular_function	NAD+ binding
H	0003824	molecular_function	catalytic activity
H	0003857	molecular_function	(3S)-3-hydroxyacyl-CoA dehydrogenase (NAD+) activity
H	0004300	molecular_function	enoyl-CoA hydratase activity
H	0005515	molecular_function	protein binding
H	0005737	cellular_component	cytoplasm
H	0006629	biological_process	lipid metabolic process
H	0006631	biological_process	fatty acid metabolic process
H	0006635	biological_process	fatty acid beta-oxidation
H	0008692	molecular_function	3-hydroxybutyryl-CoA epimerase activity
H	0016042	biological_process	lipid catabolic process
H	0016491	molecular_function	oxidoreductase activity
H	0016509	molecular_function	long-chain (3S)-3-hydroxyacyl-CoA dehydrogenase (NAD+) activity
H	0016616	molecular_function	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
H	0016829	molecular_function	lyase activity
H	0016853	molecular_function	isomerase activity
H	0018812	molecular_function	3-hydroxyacyl-CoA dehydratase activity
H	0051287	molecular_function	NAD binding
H	0070403	molecular_function	NAD+ binding

Functional Information from PROSITE/UniProt

site_id	PS00067
Number of Residues	25
Details	3HCDH 3-hydroxyacyl-CoA dehydrogenase signature. DkaGFYvNRilaPYIneair.MLtqG

Chain	Residue	Details
C	ASP489-GLY513

site_id	PS00098
Number of Residues	19
Details	THIOLASE_1 Thiolases acyl-enzyme intermediate signature. VSRaCATSFqAVanvaesL

Chain	Residue	Details
A	VAL95-LEU113

site_id	PS00099
Number of Residues	14
Details	THIOLASE_3 Thiolases active site. GLVTACAAgGlGaA

Chain	Residue	Details
A	GLY417-ALA430

site_id	PS00737
Number of Residues	17
Details	THIOLASE_2 Thiolases signature 2. NvlGGsIAyGHPfAaTG

Chain	Residue	Details
A	ASN382-GLY398

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	4
Details	Active site: {"description":"Acyl-thioester intermediate","evidences":[{"evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI2
Number of Residues	8
Details	Active site: {"description":"Proton acceptor","evidences":[{"evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI3
Number of Residues	756
Details	Region: {"description":"Enoyl-CoA hydratase"}

Chain

Residue

Details

site_id	SWS_FT_FI4
Number of Residues	8
Details	Site: {"description":"Important for catalytic activity","evidences":[{"evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		Validation report (PDF)