8BM3

H207A mutant of E. coli PgpB, a PAP2 type phosphatidyl glycerol phosphate and C55-PP phosphatase, in complex with farnesyl pyrophosphate

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000810	molecular_function	diacylglycerol diphosphate phosphatase activity
A	0005886	cellular_component	plasma membrane
A	0006629	biological_process	lipid metabolic process
A	0006655	biological_process	phosphatidylglycerol biosynthetic process
A	0008195	molecular_function	phosphatidate phosphatase activity
A	0008962	molecular_function	phosphatidylglycerophosphatase activity
A	0009252	biological_process	peptidoglycan biosynthetic process
A	0009279	cellular_component	cell outer membrane
A	0009395	biological_process	phospholipid catabolic process
A	0016042	biological_process	lipid catabolic process
A	0016787	molecular_function	hydrolase activity
A	0046474	biological_process	glycerophospholipid biosynthetic process
A	0050380	molecular_function	undecaprenyl-diphosphatase activity
B	0000810	molecular_function	diacylglycerol diphosphate phosphatase activity
B	0005886	cellular_component	plasma membrane
B	0006629	biological_process	lipid metabolic process
B	0006655	biological_process	phosphatidylglycerol biosynthetic process
B	0008195	molecular_function	phosphatidate phosphatase activity
B	0008962	molecular_function	phosphatidylglycerophosphatase activity
B	0009252	biological_process	peptidoglycan biosynthetic process
B	0009279	cellular_component	cell outer membrane
B	0009395	biological_process	phospholipid catabolic process
B	0016042	biological_process	lipid catabolic process
B	0016787	molecular_function	hydrolase activity
B	0046474	biological_process	glycerophospholipid biosynthetic process
B	0050380	molecular_function	undecaprenyl-diphosphatase activity
C	0000810	molecular_function	diacylglycerol diphosphate phosphatase activity
C	0005886	cellular_component	plasma membrane
C	0006629	biological_process	lipid metabolic process
C	0006655	biological_process	phosphatidylglycerol biosynthetic process
C	0008195	molecular_function	phosphatidate phosphatase activity
C	0008962	molecular_function	phosphatidylglycerophosphatase activity
C	0009252	biological_process	peptidoglycan biosynthetic process
C	0009279	cellular_component	cell outer membrane
C	0009395	biological_process	phospholipid catabolic process
C	0016042	biological_process	lipid catabolic process
C	0016787	molecular_function	hydrolase activity
C	0046474	biological_process	glycerophospholipid biosynthetic process
C	0050380	molecular_function	undecaprenyl-diphosphatase activity
D	0000810	molecular_function	diacylglycerol diphosphate phosphatase activity
D	0005886	cellular_component	plasma membrane
D	0006629	biological_process	lipid metabolic process
D	0006655	biological_process	phosphatidylglycerol biosynthetic process
D	0008195	molecular_function	phosphatidate phosphatase activity
D	0008962	molecular_function	phosphatidylglycerophosphatase activity
D	0009252	biological_process	peptidoglycan biosynthetic process
D	0009279	cellular_component	cell outer membrane
D	0009395	biological_process	phospholipid catabolic process
D	0016042	biological_process	lipid catabolic process
D	0016787	molecular_function	hydrolase activity
D	0046474	biological_process	glycerophospholipid biosynthetic process
D	0050380	molecular_function	undecaprenyl-diphosphatase activity

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	444
Details	Transmembrane: {"description":"Helical","evidences":[{"source":"PubMed","id":"24821770","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	400
Details	Topological domain: {"description":"Periplasmic","evidences":[{"source":"PubMed","id":"24821770","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI3
Number of Residues	36
Details	Topological domain: {"description":"Cytoplasmic","evidences":[{"source":"PubMed","id":"24821770","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	32
Details	Region: {"description":"Phosphatase sequence motif I","evidences":[{"evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	12
Details	Region: {"description":"Phosphatase sequence motif II","evidences":[{"evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	44
Details	Region: {"description":"Phosphatase sequence motif III","evidences":[{"evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	4
Details	Active site: {"description":"Proton donor; for a subset of substrates","evidences":[{"source":"PubMed","id":"27405756","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI8
Number of Residues	4
Details	Active site: {"description":"Nucleophile","evidences":[{"source":"PubMed","id":"27405756","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI9
Number of Residues	4
Details	Site: {"description":"Stabilizes the active site histidine for nucleophilic attack","evidences":[{"source":"PubMed","id":"27405756","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

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