8BJA
Structure of the human UBR5 Dimer.
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000209 | biological_process | protein polyubiquitination |
| A | 0000785 | cellular_component | chromatin |
| A | 0003723 | molecular_function | RNA binding |
| A | 0004842 | molecular_function | ubiquitin-protein transferase activity |
| A | 0005515 | molecular_function | protein binding |
| A | 0005634 | cellular_component | nucleus |
| A | 0005654 | cellular_component | nucleoplasm |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005829 | cellular_component | cytosol |
| A | 0006281 | biological_process | DNA repair |
| A | 0006974 | biological_process | DNA damage response |
| A | 0008270 | molecular_function | zinc ion binding |
| A | 0010628 | biological_process | positive regulation of gene expression |
| A | 0016020 | cellular_component | membrane |
| A | 0016567 | biological_process | protein ubiquitination |
| A | 0016740 | molecular_function | transferase activity |
| A | 0032991 | cellular_component | protein-containing complex |
| A | 0033696 | biological_process | heterochromatin boundary formation |
| A | 0034450 | molecular_function | ubiquitin-ubiquitin ligase activity |
| A | 0035519 | biological_process | protein K29-linked ubiquitination |
| A | 0042307 | biological_process | positive regulation of protein import into nucleus |
| A | 0043130 | molecular_function | ubiquitin binding |
| A | 0043161 | biological_process | proteasome-mediated ubiquitin-dependent protein catabolic process |
| A | 0045879 | biological_process | negative regulation of smoothened signaling pathway |
| A | 0046872 | molecular_function | metal ion binding |
| A | 0048471 | cellular_component | perinuclear region of cytoplasm |
| A | 0050847 | biological_process | progesterone receptor signaling pathway |
| A | 0061630 | molecular_function | ubiquitin protein ligase activity |
| A | 0070936 | biological_process | protein K48-linked ubiquitination |
| A | 0070979 | biological_process | protein K11-linked ubiquitination |
| A | 0071629 | biological_process | cytoplasm protein quality control by the ubiquitin-proteasome system |
| A | 0071630 | biological_process | nuclear protein quality control by the ubiquitin-proteasome system |
| A | 0090263 | biological_process | positive regulation of canonical Wnt signaling pathway |
| A | 0140455 | biological_process | cytoplasm protein quality control |
| A | 0140861 | biological_process | DNA repair-dependent chromatin remodeling |
| A | 0141198 | biological_process | protein branched polyubiquitination |
| B | 0000209 | biological_process | protein polyubiquitination |
| B | 0000785 | cellular_component | chromatin |
| B | 0003723 | molecular_function | RNA binding |
| B | 0004842 | molecular_function | ubiquitin-protein transferase activity |
| B | 0005515 | molecular_function | protein binding |
| B | 0005634 | cellular_component | nucleus |
| B | 0005654 | cellular_component | nucleoplasm |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0005829 | cellular_component | cytosol |
| B | 0006281 | biological_process | DNA repair |
| B | 0006974 | biological_process | DNA damage response |
| B | 0008270 | molecular_function | zinc ion binding |
| B | 0010628 | biological_process | positive regulation of gene expression |
| B | 0016020 | cellular_component | membrane |
| B | 0016567 | biological_process | protein ubiquitination |
| B | 0016740 | molecular_function | transferase activity |
| B | 0032991 | cellular_component | protein-containing complex |
| B | 0033696 | biological_process | heterochromatin boundary formation |
| B | 0034450 | molecular_function | ubiquitin-ubiquitin ligase activity |
| B | 0035519 | biological_process | protein K29-linked ubiquitination |
| B | 0042307 | biological_process | positive regulation of protein import into nucleus |
| B | 0043130 | molecular_function | ubiquitin binding |
| B | 0043161 | biological_process | proteasome-mediated ubiquitin-dependent protein catabolic process |
| B | 0045879 | biological_process | negative regulation of smoothened signaling pathway |
| B | 0046872 | molecular_function | metal ion binding |
| B | 0048471 | cellular_component | perinuclear region of cytoplasm |
| B | 0050847 | biological_process | progesterone receptor signaling pathway |
| B | 0061630 | molecular_function | ubiquitin protein ligase activity |
| B | 0070936 | biological_process | protein K48-linked ubiquitination |
| B | 0070979 | biological_process | protein K11-linked ubiquitination |
| B | 0071629 | biological_process | cytoplasm protein quality control by the ubiquitin-proteasome system |
| B | 0071630 | biological_process | nuclear protein quality control by the ubiquitin-proteasome system |
| B | 0090263 | biological_process | positive regulation of canonical Wnt signaling pathway |
| B | 0140455 | biological_process | cytoplasm protein quality control |
| B | 0140861 | biological_process | DNA repair-dependent chromatin remodeling |
| B | 0141198 | biological_process | protein branched polyubiquitination |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 136 |
| Details | ZN_FING: UBR-type => ECO:0000255|PROSITE-ProRule:PRU00508 |
| Chain | Residue | Details |
| B | ASP1177-ALA1245 | |
| A | ASP1177-ALA1245 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 2 |
| Details | ACT_SITE: Glycyl thioester intermediate => ECO:0000255|PROSITE-ProRule:PRU00104, ECO:0000305|PubMed:11287654, ECO:0000305|PubMed:23027739, ECO:0000305|PubMed:28689657, ECO:0000305|PubMed:37040767, ECO:0000305|PubMed:37478862, ECO:0000305|PubMed:37620400 |
| Chain | Residue | Details |
| B | CYS2768 | |
| A | CYS2768 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 22 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:37040767, ECO:0000269|PubMed:37409633, ECO:0000269|PubMed:37478846, ECO:0000269|PubMed:37620400, ECO:0007744|PDB:8BJA, ECO:0007744|PDB:8C06, ECO:0007744|PDB:8D4X, ECO:0007744|PDB:8E0Q, ECO:0007744|PDB:8EWI, ECO:0007744|PDB:8P82 |
| Chain | Residue | Details |
| B | CYS1179 | |
| B | CYS1234 | |
| B | CYS1240 | |
| A | CYS1179 | |
| A | CYS1196 | |
| A | CYS1199 | |
| A | CYS1208 | |
| A | CYS1211 | |
| A | CYS1215 | |
| A | HIS1216 | |
| A | HIS1219 | |
| B | CYS1196 | |
| A | CYS1232 | |
| A | CYS1234 | |
| A | CYS1240 | |
| B | CYS1199 | |
| B | CYS1208 | |
| B | CYS1211 | |
| B | CYS1215 | |
| B | HIS1216 | |
| B | HIS1219 | |
| B | CYS1232 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 2 |
| Details | MOD_RES: N-acetylthreonine => ECO:0007744|PubMed:19413330 |
| Chain | Residue | Details |
| B | THR2 | |
| A | THR2 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 8 |
| Details | MOD_RES: Phosphoserine => ECO:0000269|PubMed:21924388, ECO:0007744|PubMed:23186163 |
| Chain | Residue | Details |
| B | SER110 | |
| B | SER578 | |
| B | SER612 | |
| B | SER808 | |
| A | SER110 | |
| A | SER578 | |
| A | SER612 | |
| A | SER808 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 2 |
| Details | MOD_RES: Phosphoserine => ECO:0000269|PubMed:21924388, ECO:0007744|PubMed:21406692, ECO:0007744|PubMed:23186163 |
| Chain | Residue | Details |
| B | SER327 | |
| A | SER327 |
| site_id | SWS_FT_FI7 |
| Number of Residues | 28 |
| Details | MOD_RES: Phosphoserine => ECO:0000269|PubMed:21924388 |
| Chain | Residue | Details |
| B | SER352 | |
| B | SER2026 | |
| B | SER2028 | |
| B | SER2076 | |
| B | SER2289 | |
| B | SER2484 | |
| A | SER352 | |
| A | SER928 | |
| A | SER1018 | |
| A | SER1227 | |
| A | SER1355 | |
| B | SER928 | |
| A | SER1375 | |
| A | SER1481 | |
| A | SER1741 | |
| A | SER1780 | |
| A | SER2026 | |
| A | SER2028 | |
| A | SER2076 | |
| A | SER2289 | |
| A | SER2484 | |
| B | SER1018 | |
| B | SER1227 | |
| B | SER1355 | |
| B | SER1375 | |
| B | SER1481 | |
| B | SER1741 | |
| B | SER1780 |
| site_id | SWS_FT_FI8 |
| Number of Residues | 12 |
| Details | MOD_RES: Phosphothreonine => ECO:0000269|PubMed:21924388 |
| Chain | Residue | Details |
| B | THR637 | |
| A | THR1736 | |
| A | THR2030 | |
| A | THR2213 | |
| B | THR1115 | |
| B | THR1135 | |
| B | THR1736 | |
| B | THR2030 | |
| B | THR2213 | |
| A | THR637 | |
| A | THR1115 | |
| A | THR1135 |
| site_id | SWS_FT_FI9 |
| Number of Residues | 2 |
| Details | MOD_RES: Phosphoserine => ECO:0000269|PubMed:21924388, ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:23186163 |
| Chain | Residue | Details |
| B | SER1308 | |
| A | SER1308 |
| site_id | SWS_FT_FI10 |
| Number of Residues | 2 |
| Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:21406692, ECO:0007744|PubMed:23186163, ECO:0007744|PubMed:24275569 |
| Chain | Residue | Details |
| B | SER1549 | |
| A | SER1549 |
| site_id | SWS_FT_FI11 |
| Number of Residues | 2 |
| Details | MOD_RES: Phosphotyrosine => ECO:0007744|PubMed:15592455 |
| Chain | Residue | Details |
| B | TYR1746 | |
| A | TYR1746 |
| site_id | SWS_FT_FI12 |
| Number of Residues | 2 |
| Details | MOD_RES: Phosphothreonine => ECO:0000269|PubMed:21924388, ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:18691976, ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:23186163 |
| Chain | Residue | Details |
| B | THR1969 | |
| A | THR1969 |
| site_id | SWS_FT_FI13 |
| Number of Residues | 2 |
| Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:24275569 |
| Chain | Residue | Details |
| B | SER1990 | |
| A | SER1990 |
| site_id | SWS_FT_FI14 |
| Number of Residues | 4 |
| Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:23186163 |
| Chain | Residue | Details |
| B | SER2241 | |
| B | SER2469 | |
| A | SER2241 | |
| A | SER2469 |
| site_id | SWS_FT_FI15 |
| Number of Residues | 2 |
| Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:19690332, ECO:0007744|PubMed:21406692, ECO:0007744|PubMed:23186163 |
| Chain | Residue | Details |
| B | SER2486 | |
| A | SER2486 |
