8BIQ

Crystal structure of acyl-COA synthetase from Metallosphaera sedula in complex with acetyl-AMP

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003987	molecular_function	acetate-CoA ligase activity
A	0004321	molecular_function	fatty-acyl-CoA synthase activity
A	0005524	molecular_function	ATP binding
A	0006631	biological_process	fatty acid metabolic process
A	0006633	biological_process	fatty acid biosynthetic process
A	0006637	biological_process	acyl-CoA metabolic process
A	0015645	molecular_function	fatty acid ligase activity
A	0016020	cellular_component	membrane
A	0016405	molecular_function	CoA-ligase activity
A	0016874	molecular_function	ligase activity
A	0016878	molecular_function	acid-thiol ligase activity
A	0031956	molecular_function	medium-chain fatty acid-CoA ligase activity
A	0047760	molecular_function	obsolete butyrate-CoA ligase activity
A	0050218	molecular_function	propionate-CoA ligase activity
B	0003987	molecular_function	acetate-CoA ligase activity
B	0004321	molecular_function	fatty-acyl-CoA synthase activity
B	0005524	molecular_function	ATP binding
B	0006631	biological_process	fatty acid metabolic process
B	0006633	biological_process	fatty acid biosynthetic process
B	0006637	biological_process	acyl-CoA metabolic process
B	0015645	molecular_function	fatty acid ligase activity
B	0016020	cellular_component	membrane
B	0016405	molecular_function	CoA-ligase activity
B	0016874	molecular_function	ligase activity
B	0016878	molecular_function	acid-thiol ligase activity
B	0031956	molecular_function	medium-chain fatty acid-CoA ligase activity
B	0047760	molecular_function	obsolete butyrate-CoA ligase activity
B	0050218	molecular_function	propionate-CoA ligase activity
C	0003987	molecular_function	acetate-CoA ligase activity
C	0004321	molecular_function	fatty-acyl-CoA synthase activity
C	0005524	molecular_function	ATP binding
C	0006631	biological_process	fatty acid metabolic process
C	0006633	biological_process	fatty acid biosynthetic process
C	0006637	biological_process	acyl-CoA metabolic process
C	0015645	molecular_function	fatty acid ligase activity
C	0016020	cellular_component	membrane
C	0016405	molecular_function	CoA-ligase activity
C	0016874	molecular_function	ligase activity
C	0016878	molecular_function	acid-thiol ligase activity
C	0031956	molecular_function	medium-chain fatty acid-CoA ligase activity
C	0047760	molecular_function	obsolete butyrate-CoA ligase activity
C	0050218	molecular_function	propionate-CoA ligase activity
D	0003987	molecular_function	acetate-CoA ligase activity
D	0004321	molecular_function	fatty-acyl-CoA synthase activity
D	0005524	molecular_function	ATP binding
D	0006631	biological_process	fatty acid metabolic process
D	0006633	biological_process	fatty acid biosynthetic process
D	0006637	biological_process	acyl-CoA metabolic process
D	0015645	molecular_function	fatty acid ligase activity
D	0016020	cellular_component	membrane
D	0016405	molecular_function	CoA-ligase activity
D	0016874	molecular_function	ligase activity
D	0016878	molecular_function	acid-thiol ligase activity
D	0031956	molecular_function	medium-chain fatty acid-CoA ligase activity
D	0047760	molecular_function	obsolete butyrate-CoA ligase activity
D	0050218	molecular_function	propionate-CoA ligase activity

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	80
Details	TRANSMEM: Helical => ECO:0000255

Chain	Residue	Details
B	VAL111-PRO131
C	VAL111-PRO131
D	VAL111-PRO131
A	VAL111-PRO131

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site_id	SWS_FT_FI2
Number of Residues	44
Details	BINDING: BINDING => ECO:0000250|UniProtKB:Q08AH3

Chain	Residue	Details
B	THR210
B	ASP349
B	THR354
B	ASP435
B	ARG450
B	SER458
B	ARG461
B	ARG490
B	LYS519
B	VAL527
B	LYS544
C	THR210
C	ASP349
C	THR354
C	ASP435
C	ARG450
C	SER458
C	ARG461
C	ARG490
C	LYS519
C	VAL527
C	LYS544
D	THR210
D	VAL527
D	LYS544
A	THR210
A	ASP349
A	THR354
A	ASP435
A	ARG450
A	SER458
A	ARG461
A	ARG490
D	ASP349
A	LYS519
A	VAL527
A	LYS544
D	THR354
D	ASP435
D	ARG450
D	SER458
D	ARG461
D	ARG490
D	LYS519

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