8BHV

DNA-PK XLF mediated dimer bound to PAXX

This is a non-PDB format compatible entry.

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000166	molecular_function	nucleotide binding
A	0000460	biological_process	maturation of 5.8S rRNA
A	0000723	biological_process	telomere maintenance
A	0000781	cellular_component	chromosome, telomeric region
A	0000785	cellular_component	chromatin
A	0001933	biological_process	negative regulation of protein phosphorylation
A	0002218	biological_process	activation of innate immune response
A	0002376	biological_process	immune system process
A	0003677	molecular_function	DNA binding
A	0003690	molecular_function	double-stranded DNA binding
A	0003723	molecular_function	RNA binding
A	0004672	molecular_function	protein kinase activity
A	0004674	molecular_function	protein serine/threonine kinase activity
A	0004677	molecular_function	DNA-dependent protein kinase activity
A	0005515	molecular_function	protein binding
A	0005524	molecular_function	ATP binding
A	0005634	cellular_component	nucleus
A	0005654	cellular_component	nucleoplasm
A	0005667	cellular_component	transcription regulator complex
A	0005730	cellular_component	nucleolus
A	0005829	cellular_component	cytosol
A	0005958	cellular_component	DNA-dependent protein kinase-DNA ligase 4 complex
A	0006281	biological_process	DNA repair
A	0006302	biological_process	double-strand break repair
A	0006303	biological_process	double-strand break repair via nonhomologous end joining
A	0006310	biological_process	DNA recombination
A	0006338	biological_process	chromatin remodeling
A	0006468	biological_process	protein phosphorylation
A	0006974	biological_process	DNA damage response
A	0008630	biological_process	intrinsic apoptotic signaling pathway in response to DNA damage
A	0016020	cellular_component	membrane
A	0016233	biological_process	telomere capping
A	0016301	molecular_function	kinase activity
A	0016740	molecular_function	transferase activity
A	0018105	biological_process	peptidyl-serine phosphorylation
A	0018107	biological_process	peptidyl-threonine phosphorylation
A	0019899	molecular_function	enzyme binding
A	0019904	molecular_function	protein domain specific binding
A	0031571	biological_process	mitotic G1 DNA damage checkpoint signaling
A	0032040	cellular_component	small-subunit processome
A	0032869	biological_process	cellular response to insulin stimulus
A	0032991	cellular_component	protein-containing complex
A	0032993	cellular_component	protein-DNA complex
A	0033152	biological_process	immunoglobulin V(D)J recombination
A	0034462	biological_process	small-subunit processome assembly
A	0034511	molecular_function	U3 snoRNA binding
A	0035979	molecular_function	histone H2AXS139 kinase activity
A	0036211	biological_process	protein modification process
A	0042254	biological_process	ribosome biogenesis
A	0042752	biological_process	regulation of circadian rhythm
A	0043066	biological_process	negative regulation of apoptotic process
A	0045087	biological_process	innate immune response
A	0045621	biological_process	positive regulation of lymphocyte differentiation
A	0045648	biological_process	positive regulation of erythrocyte differentiation
A	0045727	biological_process	positive regulation of translation
A	0045944	biological_process	positive regulation of transcription by RNA polymerase II
A	0048511	biological_process	rhythmic process
A	0048660	biological_process	regulation of smooth muscle cell proliferation
A	0050678	biological_process	regulation of epithelial cell proliferation
A	0061629	molecular_function	RNA polymerase II-specific DNA-binding transcription factor binding
A	0070419	cellular_component	nonhomologous end joining complex
A	0080135	biological_process	regulation of cellular response to stress
A	0097681	biological_process	double-strand break repair via alternative nonhomologous end joining
A	0106310	molecular_function	protein serine kinase activity
A	0160049	biological_process	negative regulation of cGAS/STING signaling pathway
A	1902036	biological_process	regulation of hematopoietic stem cell differentiation
A	1905221	biological_process	positive regulation of platelet formation
A	2001034	biological_process	positive regulation of double-strand break repair via nonhomologous end joining
F	0000166	molecular_function	nucleotide binding
F	0000460	biological_process	maturation of 5.8S rRNA
F	0000723	biological_process	telomere maintenance
F	0000781	cellular_component	chromosome, telomeric region
F	0000785	cellular_component	chromatin
F	0001933	biological_process	negative regulation of protein phosphorylation
F	0002218	biological_process	activation of innate immune response
F	0002376	biological_process	immune system process
F	0003677	molecular_function	DNA binding
F	0003690	molecular_function	double-stranded DNA binding
F	0003723	molecular_function	RNA binding
F	0004672	molecular_function	protein kinase activity
F	0004674	molecular_function	protein serine/threonine kinase activity
F	0004677	molecular_function	DNA-dependent protein kinase activity
F	0005515	molecular_function	protein binding
F	0005524	molecular_function	ATP binding
F	0005634	cellular_component	nucleus
F	0005654	cellular_component	nucleoplasm
F	0005667	cellular_component	transcription regulator complex
F	0005730	cellular_component	nucleolus
F	0005829	cellular_component	cytosol
F	0005958	cellular_component	DNA-dependent protein kinase-DNA ligase 4 complex
F	0006281	biological_process	DNA repair
F	0006302	biological_process	double-strand break repair
F	0006303	biological_process	double-strand break repair via nonhomologous end joining
F	0006310	biological_process	DNA recombination
F	0006338	biological_process	chromatin remodeling
F	0006468	biological_process	protein phosphorylation
F	0006974	biological_process	DNA damage response
F	0008630	biological_process	intrinsic apoptotic signaling pathway in response to DNA damage
F	0016020	cellular_component	membrane
F	0016233	biological_process	telomere capping
F	0016301	molecular_function	kinase activity
F	0016740	molecular_function	transferase activity
F	0018105	biological_process	peptidyl-serine phosphorylation
F	0018107	biological_process	peptidyl-threonine phosphorylation
F	0019899	molecular_function	enzyme binding
F	0019904	molecular_function	protein domain specific binding
F	0031571	biological_process	mitotic G1 DNA damage checkpoint signaling
F	0032040	cellular_component	small-subunit processome
F	0032869	biological_process	cellular response to insulin stimulus
F	0032991	cellular_component	protein-containing complex
F	0032993	cellular_component	protein-DNA complex
F	0033152	biological_process	immunoglobulin V(D)J recombination
F	0034462	biological_process	small-subunit processome assembly
F	0034511	molecular_function	U3 snoRNA binding
F	0035979	molecular_function	histone H2AXS139 kinase activity
F	0036211	biological_process	protein modification process
F	0042254	biological_process	ribosome biogenesis
F	0042752	biological_process	regulation of circadian rhythm
F	0043066	biological_process	negative regulation of apoptotic process
F	0045087	biological_process	innate immune response
F	0045621	biological_process	positive regulation of lymphocyte differentiation
F	0045648	biological_process	positive regulation of erythrocyte differentiation
F	0045727	biological_process	positive regulation of translation
F	0045944	biological_process	positive regulation of transcription by RNA polymerase II
F	0048511	biological_process	rhythmic process
F	0048660	biological_process	regulation of smooth muscle cell proliferation
F	0050678	biological_process	regulation of epithelial cell proliferation
F	0061629	molecular_function	RNA polymerase II-specific DNA-binding transcription factor binding
F	0070419	cellular_component	nonhomologous end joining complex
F	0080135	biological_process	regulation of cellular response to stress
F	0097681	biological_process	double-strand break repair via alternative nonhomologous end joining
F	0106310	molecular_function	protein serine kinase activity
F	0160049	biological_process	negative regulation of cGAS/STING signaling pathway
F	1902036	biological_process	regulation of hematopoietic stem cell differentiation
F	1905221	biological_process	positive regulation of platelet formation
F	2001034	biological_process	positive regulation of double-strand break repair via nonhomologous end joining
K	0000793	cellular_component	condensed chromosome
K	0003677	molecular_function	DNA binding
K	0005515	molecular_function	protein binding
K	0005634	cellular_component	nucleus
K	0005654	cellular_component	nucleoplasm
K	0005694	cellular_component	chromosome
K	0005737	cellular_component	cytoplasm
K	0005829	cellular_component	cytosol
K	0005958	cellular_component	DNA-dependent protein kinase-DNA ligase 4 complex
K	0006281	biological_process	DNA repair
K	0006284	biological_process	base-excision repair
K	0006302	biological_process	double-strand break repair
K	0006303	biological_process	double-strand break repair via nonhomologous end joining
K	0006310	biological_process	DNA recombination
K	0006974	biological_process	DNA damage response
K	0010165	biological_process	response to X-ray
K	0016874	molecular_function	ligase activity
K	0019899	molecular_function	enzyme binding
K	0030674	molecular_function	protein-macromolecule adaptor activity
K	0032807	cellular_component	DNA ligase IV complex
K	0033152	biological_process	immunoglobulin V(D)J recombination
K	0035861	cellular_component	site of double-strand break
K	0042802	molecular_function	identical protein binding
K	0051351	biological_process	positive regulation of ligase activity
K	0070419	cellular_component	nonhomologous end joining complex
K	0070975	molecular_function	FHA domain binding
K	1990166	biological_process	protein localization to site of double-strand break
K	1990683	biological_process	DNA double-strand break attachment to nuclear envelope
L	0000793	cellular_component	condensed chromosome
L	0003677	molecular_function	DNA binding
L	0005515	molecular_function	protein binding
L	0005634	cellular_component	nucleus
L	0005654	cellular_component	nucleoplasm
L	0005694	cellular_component	chromosome
L	0005737	cellular_component	cytoplasm
L	0005829	cellular_component	cytosol
L	0005958	cellular_component	DNA-dependent protein kinase-DNA ligase 4 complex
L	0006281	biological_process	DNA repair
L	0006284	biological_process	base-excision repair
L	0006302	biological_process	double-strand break repair
L	0006303	biological_process	double-strand break repair via nonhomologous end joining
L	0006310	biological_process	DNA recombination
L	0006974	biological_process	DNA damage response
L	0010165	biological_process	response to X-ray
L	0016874	molecular_function	ligase activity
L	0019899	molecular_function	enzyme binding
L	0030674	molecular_function	protein-macromolecule adaptor activity
L	0032807	cellular_component	DNA ligase IV complex
L	0033152	biological_process	immunoglobulin V(D)J recombination
L	0035861	cellular_component	site of double-strand break
L	0042802	molecular_function	identical protein binding
L	0051351	biological_process	positive regulation of ligase activity
L	0070419	cellular_component	nonhomologous end joining complex
L	0070975	molecular_function	FHA domain binding
L	1990166	biological_process	protein localization to site of double-strand break
L	1990683	biological_process	DNA double-strand break attachment to nuclear envelope
M	0000012	biological_process	single strand break repair
M	0000166	molecular_function	nucleotide binding
M	0000287	molecular_function	magnesium ion binding
M	0000781	cellular_component	chromosome, telomeric region
M	0000793	cellular_component	condensed chromosome
M	0001701	biological_process	in utero embryonic development
M	0002328	biological_process	pro-B cell differentiation
M	0003677	molecular_function	DNA binding
M	0003909	molecular_function	DNA ligase activity
M	0003910	molecular_function	DNA ligase (ATP) activity
M	0005515	molecular_function	protein binding
M	0005524	molecular_function	ATP binding
M	0005634	cellular_component	nucleus
M	0005654	cellular_component	nucleoplasm
M	0005958	cellular_component	DNA-dependent protein kinase-DNA ligase 4 complex
M	0006281	biological_process	DNA repair
M	0006284	biological_process	base-excision repair
M	0006297	biological_process	nucleotide-excision repair, DNA gap filling
M	0006302	biological_process	double-strand break repair
M	0006303	biological_process	double-strand break repair via nonhomologous end joining
M	0006310	biological_process	DNA recombination
M	0006974	biological_process	DNA damage response
M	0007417	biological_process	central nervous system development
M	0008283	biological_process	cell population proliferation
M	0010165	biological_process	response to X-ray
M	0010212	biological_process	response to ionizing radiation
M	0010332	biological_process	response to gamma radiation
M	0016874	molecular_function	ligase activity
M	0032807	cellular_component	DNA ligase IV complex
M	0033077	biological_process	T cell differentiation in thymus
M	0033151	biological_process	V(D)J recombination
M	0033152	biological_process	immunoglobulin V(D)J recombination
M	0033153	biological_process	T cell receptor V(D)J recombination
M	0035019	biological_process	somatic stem cell population maintenance
M	0043524	biological_process	negative regulation of neuron apoptotic process
M	0045190	biological_process	isotype switching
M	0046872	molecular_function	metal ion binding
M	0048146	biological_process	positive regulation of fibroblast proliferation
M	0050769	biological_process	positive regulation of neurogenesis
M	0051276	biological_process	chromosome organization
M	0051301	biological_process	cell division
M	0051402	biological_process	neuron apoptotic process
M	0070419	cellular_component	nonhomologous end joining complex
M	0071479	biological_process	cellular response to ionizing radiation
M	0071897	biological_process	DNA biosynthetic process
M	0075713	biological_process	establishment of integrated proviral latency
M	0097680	biological_process	double-strand break repair via classical nonhomologous end joining
M	2001252	biological_process	positive regulation of chromosome organization
N	0000793	cellular_component	condensed chromosome
N	0003677	molecular_function	DNA binding
N	0005515	molecular_function	protein binding
N	0005634	cellular_component	nucleus
N	0005654	cellular_component	nucleoplasm
N	0005694	cellular_component	chromosome
N	0005737	cellular_component	cytoplasm
N	0005829	cellular_component	cytosol
N	0005958	cellular_component	DNA-dependent protein kinase-DNA ligase 4 complex
N	0006281	biological_process	DNA repair
N	0006284	biological_process	base-excision repair
N	0006302	biological_process	double-strand break repair
N	0006303	biological_process	double-strand break repair via nonhomologous end joining
N	0006310	biological_process	DNA recombination
N	0006974	biological_process	DNA damage response
N	0010165	biological_process	response to X-ray
N	0016874	molecular_function	ligase activity
N	0019899	molecular_function	enzyme binding
N	0030674	molecular_function	protein-macromolecule adaptor activity
N	0032807	cellular_component	DNA ligase IV complex
N	0033152	biological_process	immunoglobulin V(D)J recombination
N	0035861	cellular_component	site of double-strand break
N	0042802	molecular_function	identical protein binding
N	0051351	biological_process	positive regulation of ligase activity
N	0070419	cellular_component	nonhomologous end joining complex
N	0070975	molecular_function	FHA domain binding
N	1990166	biological_process	protein localization to site of double-strand break
N	1990683	biological_process	DNA double-strand break attachment to nuclear envelope
O	0000793	cellular_component	condensed chromosome
O	0003677	molecular_function	DNA binding
O	0005515	molecular_function	protein binding
O	0005634	cellular_component	nucleus
O	0005654	cellular_component	nucleoplasm
O	0005694	cellular_component	chromosome
O	0005737	cellular_component	cytoplasm
O	0005829	cellular_component	cytosol
O	0005958	cellular_component	DNA-dependent protein kinase-DNA ligase 4 complex
O	0006281	biological_process	DNA repair
O	0006284	biological_process	base-excision repair
O	0006302	biological_process	double-strand break repair
O	0006303	biological_process	double-strand break repair via nonhomologous end joining
O	0006310	biological_process	DNA recombination
O	0006974	biological_process	DNA damage response
O	0010165	biological_process	response to X-ray
O	0016874	molecular_function	ligase activity
O	0019899	molecular_function	enzyme binding
O	0030674	molecular_function	protein-macromolecule adaptor activity
O	0032807	cellular_component	DNA ligase IV complex
O	0033152	biological_process	immunoglobulin V(D)J recombination
O	0035861	cellular_component	site of double-strand break
O	0042802	molecular_function	identical protein binding
O	0051351	biological_process	positive regulation of ligase activity
O	0070419	cellular_component	nonhomologous end joining complex
O	0070975	molecular_function	FHA domain binding
O	1990166	biological_process	protein localization to site of double-strand break
O	1990683	biological_process	DNA double-strand break attachment to nuclear envelope
P	0000012	biological_process	single strand break repair
P	0000166	molecular_function	nucleotide binding
P	0000287	molecular_function	magnesium ion binding
P	0000781	cellular_component	chromosome, telomeric region
P	0000793	cellular_component	condensed chromosome
P	0001701	biological_process	in utero embryonic development
P	0002328	biological_process	pro-B cell differentiation
P	0003677	molecular_function	DNA binding
P	0003909	molecular_function	DNA ligase activity
P	0003910	molecular_function	DNA ligase (ATP) activity
P	0005515	molecular_function	protein binding
P	0005524	molecular_function	ATP binding
P	0005634	cellular_component	nucleus
P	0005654	cellular_component	nucleoplasm
P	0005958	cellular_component	DNA-dependent protein kinase-DNA ligase 4 complex
P	0006281	biological_process	DNA repair
P	0006284	biological_process	base-excision repair
P	0006297	biological_process	nucleotide-excision repair, DNA gap filling
P	0006302	biological_process	double-strand break repair
P	0006303	biological_process	double-strand break repair via nonhomologous end joining
P	0006310	biological_process	DNA recombination
P	0006974	biological_process	DNA damage response
P	0007417	biological_process	central nervous system development
P	0008283	biological_process	cell population proliferation
P	0010165	biological_process	response to X-ray
P	0010212	biological_process	response to ionizing radiation
P	0010332	biological_process	response to gamma radiation
P	0016874	molecular_function	ligase activity
P	0032807	cellular_component	DNA ligase IV complex
P	0033077	biological_process	T cell differentiation in thymus
P	0033151	biological_process	V(D)J recombination
P	0033152	biological_process	immunoglobulin V(D)J recombination
P	0033153	biological_process	T cell receptor V(D)J recombination
P	0035019	biological_process	somatic stem cell population maintenance
P	0043524	biological_process	negative regulation of neuron apoptotic process
P	0045190	biological_process	isotype switching
P	0046872	molecular_function	metal ion binding
P	0048146	biological_process	positive regulation of fibroblast proliferation
P	0050769	biological_process	positive regulation of neurogenesis
P	0051276	biological_process	chromosome organization
P	0051301	biological_process	cell division
P	0051402	biological_process	neuron apoptotic process
P	0070419	cellular_component	nonhomologous end joining complex
P	0071479	biological_process	cellular response to ionizing radiation
P	0071897	biological_process	DNA biosynthetic process
P	0075713	biological_process	establishment of integrated proviral latency
P	0097680	biological_process	double-strand break repair via classical nonhomologous end joining
P	2001252	biological_process	positive regulation of chromosome organization
Q	0000723	biological_process	telomere maintenance
Q	0001650	cellular_component	fibrillar center
Q	0003677	molecular_function	DNA binding
Q	0005515	molecular_function	protein binding
Q	0005634	cellular_component	nucleus
Q	0005654	cellular_component	nucleoplasm
Q	0005694	cellular_component	chromosome
Q	0005958	cellular_component	DNA-dependent protein kinase-DNA ligase 4 complex
Q	0006281	biological_process	DNA repair
Q	0006302	biological_process	double-strand break repair
Q	0006303	biological_process	double-strand break repair via nonhomologous end joining
Q	0006974	biological_process	DNA damage response
Q	0007417	biological_process	central nervous system development
Q	0010212	biological_process	response to ionizing radiation
Q	0030183	biological_process	B cell differentiation
Q	0030217	biological_process	T cell differentiation
Q	0032807	cellular_component	DNA ligase IV complex
Q	0033152	biological_process	immunoglobulin V(D)J recombination
Q	0035861	cellular_component	site of double-strand break
Q	0045027	molecular_function	DNA end binding
Q	0051351	biological_process	positive regulation of ligase activity
Q	0070182	molecular_function	DNA polymerase binding
Q	0070419	cellular_component	nonhomologous end joining complex
R	0000723	biological_process	telomere maintenance
R	0001650	cellular_component	fibrillar center
R	0003677	molecular_function	DNA binding
R	0005515	molecular_function	protein binding
R	0005634	cellular_component	nucleus
R	0005654	cellular_component	nucleoplasm
R	0005694	cellular_component	chromosome
R	0005958	cellular_component	DNA-dependent protein kinase-DNA ligase 4 complex
R	0006281	biological_process	DNA repair
R	0006302	biological_process	double-strand break repair
R	0006303	biological_process	double-strand break repair via nonhomologous end joining
R	0006974	biological_process	DNA damage response
R	0007417	biological_process	central nervous system development
R	0010212	biological_process	response to ionizing radiation
R	0030183	biological_process	B cell differentiation
R	0030217	biological_process	T cell differentiation
R	0032807	cellular_component	DNA ligase IV complex
R	0033152	biological_process	immunoglobulin V(D)J recombination
R	0035861	cellular_component	site of double-strand break
R	0045027	molecular_function	DNA end binding
R	0051351	biological_process	positive regulation of ligase activity
R	0070182	molecular_function	DNA polymerase binding
R	0070419	cellular_component	nonhomologous end joining complex
a	0000166	molecular_function	nucleotide binding
a	0000723	biological_process	telomere maintenance
a	0000725	biological_process	recombinational repair
a	0000781	cellular_component	chromosome, telomeric region
a	0000783	cellular_component	nuclear telomere cap complex
a	0000976	molecular_function	transcription cis-regulatory region binding
a	0002218	biological_process	activation of innate immune response
a	0002376	biological_process	immune system process
a	0002684	biological_process	positive regulation of immune system process
a	0003677	molecular_function	DNA binding
a	0003678	molecular_function	DNA helicase activity
a	0003684	molecular_function	damaged DNA binding
a	0003690	molecular_function	double-stranded DNA binding
a	0003691	molecular_function	double-stranded telomeric DNA binding
a	0003723	molecular_function	RNA binding
a	0003824	molecular_function	catalytic activity
a	0004386	molecular_function	helicase activity
a	0005515	molecular_function	protein binding
a	0005524	molecular_function	ATP binding
a	0005576	cellular_component	extracellular region
a	0005634	cellular_component	nucleus
a	0005654	cellular_component	nucleoplasm
a	0005667	cellular_component	transcription regulator complex
a	0005694	cellular_component	chromosome
a	0005730	cellular_component	nucleolus
a	0005737	cellular_component	cytoplasm
a	0005829	cellular_component	cytosol
a	0005958	cellular_component	DNA-dependent protein kinase-DNA ligase 4 complex
a	0006281	biological_process	DNA repair
a	0006303	biological_process	double-strand break repair via nonhomologous end joining
a	0006310	biological_process	DNA recombination
a	0006351	biological_process	DNA-templated transcription
a	0006974	biological_process	DNA damage response
a	0008094	molecular_function	ATP-dependent activity, acting on DNA
a	0010212	biological_process	response to ionizing radiation
a	0016020	cellular_component	membrane
a	0016787	molecular_function	hydrolase activity
a	0016829	molecular_function	lyase activity
a	0016853	molecular_function	isomerase activity
a	0016887	molecular_function	ATP hydrolysis activity
a	0030332	molecular_function	cyclin binding
a	0032991	cellular_component	protein-containing complex
a	0032993	cellular_component	protein-DNA complex
a	0034774	cellular_component	secretory granule lumen
a	0042162	molecular_function	telomeric DNA binding
a	0043138	molecular_function	3'-5' DNA helicase activity
a	0043564	cellular_component	Ku70:Ku80 complex
a	0044877	molecular_function	protein-containing complex binding
a	0045027	molecular_function	DNA end binding
a	0045087	biological_process	innate immune response
a	0045621	biological_process	positive regulation of lymphocyte differentiation
a	0045892	biological_process	negative regulation of DNA-templated transcription
a	0045893	biological_process	positive regulation of DNA-templated transcription
a	0045944	biological_process	positive regulation of transcription by RNA polymerase II
a	0048660	biological_process	regulation of smooth muscle cell proliferation
a	0051575	molecular_function	5'-deoxyribose-5-phosphate lyase activity
a	0070419	cellular_component	nonhomologous end joining complex
a	0071475	biological_process	cellular hyperosmotic salinity response
a	0071480	biological_process	cellular response to gamma radiation
a	0071481	biological_process	cellular response to X-ray
a	0097110	molecular_function	scaffold protein binding
a	0097680	biological_process	double-strand break repair via classical nonhomologous end joining
a	0140078	molecular_function	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
a	1904813	cellular_component	ficolin-1-rich granule lumen
b	0000166	molecular_function	nucleotide binding
b	0000723	biological_process	telomere maintenance
b	0000725	biological_process	recombinational repair
b	0000781	cellular_component	chromosome, telomeric region
b	0000783	cellular_component	nuclear telomere cap complex
b	0000976	molecular_function	transcription cis-regulatory region binding
b	0002218	biological_process	activation of innate immune response
b	0002376	biological_process	immune system process
b	0003677	molecular_function	DNA binding
b	0003678	molecular_function	DNA helicase activity
b	0003684	molecular_function	damaged DNA binding
b	0003690	molecular_function	double-stranded DNA binding
b	0003691	molecular_function	double-stranded telomeric DNA binding
b	0003723	molecular_function	RNA binding
b	0004386	molecular_function	helicase activity
b	0005515	molecular_function	protein binding
b	0005524	molecular_function	ATP binding
b	0005576	cellular_component	extracellular region
b	0005634	cellular_component	nucleus
b	0005654	cellular_component	nucleoplasm
b	0005694	cellular_component	chromosome
b	0005730	cellular_component	nucleolus
b	0005737	cellular_component	cytoplasm
b	0005829	cellular_component	cytosol
b	0005958	cellular_component	DNA-dependent protein kinase-DNA ligase 4 complex
b	0006281	biological_process	DNA repair
b	0006302	biological_process	double-strand break repair
b	0006303	biological_process	double-strand break repair via nonhomologous end joining
b	0006310	biological_process	DNA recombination
b	0006351	biological_process	DNA-templated transcription
b	0006974	biological_process	DNA damage response
b	0007004	biological_process	telomere maintenance via telomerase
b	0008047	molecular_function	enzyme activator activity
b	0008094	molecular_function	ATP-dependent activity, acting on DNA
b	0016020	cellular_component	membrane
b	0016787	molecular_function	hydrolase activity
b	0016829	molecular_function	lyase activity
b	0016853	molecular_function	isomerase activity
b	0016887	molecular_function	ATP hydrolysis activity
b	0031625	molecular_function	ubiquitin protein ligase binding
b	0032040	cellular_component	small-subunit processome
b	0032204	biological_process	regulation of telomere maintenance
b	0032991	cellular_component	protein-containing complex
b	0032993	cellular_component	protein-DNA complex
b	0034462	biological_process	small-subunit processome assembly
b	0034511	molecular_function	U3 snoRNA binding
b	0034774	cellular_component	secretory granule lumen
b	0042162	molecular_function	telomeric DNA binding
b	0042254	biological_process	ribosome biogenesis
b	0043138	molecular_function	3'-5' DNA helicase activity
b	0043564	cellular_component	Ku70:Ku80 complex
b	0044877	molecular_function	protein-containing complex binding
b	0045027	molecular_function	DNA end binding
b	0045087	biological_process	innate immune response
b	0045892	biological_process	negative regulation of DNA-templated transcription
b	0048660	biological_process	regulation of smooth muscle cell proliferation
b	0051575	molecular_function	5'-deoxyribose-5-phosphate lyase activity
b	0070198	biological_process	protein localization to chromosome, telomeric region
b	0070419	cellular_component	nonhomologous end joining complex
b	0071480	biological_process	cellular response to gamma radiation
b	0090734	cellular_component	site of DNA damage
b	0140078	molecular_function	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
b	1904430	biological_process	negative regulation of t-circle formation
b	1990904	cellular_component	ribonucleoprotein complex
c	0005515	molecular_function	protein binding
c	0005634	cellular_component	nucleus
c	0005654	cellular_component	nucleoplasm
c	0005694	cellular_component	chromosome
c	0005737	cellular_component	cytoplasm
c	0006281	biological_process	DNA repair
c	0006303	biological_process	double-strand break repair via nonhomologous end joining
c	0006974	biological_process	DNA damage response
c	0035861	cellular_component	site of double-strand break
c	0042803	molecular_function	protein homodimerization activity
c	0043564	cellular_component	Ku70:Ku80 complex
c	0060090	molecular_function	molecular adaptor activity
c	0070182	molecular_function	DNA polymerase binding
c	0070419	cellular_component	nonhomologous end joining complex
h	0000166	molecular_function	nucleotide binding
h	0000723	biological_process	telomere maintenance
h	0000725	biological_process	recombinational repair
h	0000781	cellular_component	chromosome, telomeric region
h	0000783	cellular_component	nuclear telomere cap complex
h	0000976	molecular_function	transcription cis-regulatory region binding
h	0002218	biological_process	activation of innate immune response
h	0002376	biological_process	immune system process
h	0002684	biological_process	positive regulation of immune system process
h	0003677	molecular_function	DNA binding
h	0003678	molecular_function	DNA helicase activity
h	0003684	molecular_function	damaged DNA binding
h	0003690	molecular_function	double-stranded DNA binding
h	0003691	molecular_function	double-stranded telomeric DNA binding
h	0003723	molecular_function	RNA binding
h	0003824	molecular_function	catalytic activity
h	0004386	molecular_function	helicase activity
h	0005515	molecular_function	protein binding
h	0005524	molecular_function	ATP binding
h	0005576	cellular_component	extracellular region
h	0005634	cellular_component	nucleus
h	0005654	cellular_component	nucleoplasm
h	0005667	cellular_component	transcription regulator complex
h	0005694	cellular_component	chromosome
h	0005730	cellular_component	nucleolus
h	0005737	cellular_component	cytoplasm
h	0005829	cellular_component	cytosol
h	0005958	cellular_component	DNA-dependent protein kinase-DNA ligase 4 complex
h	0006281	biological_process	DNA repair
h	0006303	biological_process	double-strand break repair via nonhomologous end joining
h	0006310	biological_process	DNA recombination
h	0006351	biological_process	DNA-templated transcription
h	0006974	biological_process	DNA damage response
h	0008094	molecular_function	ATP-dependent activity, acting on DNA
h	0010212	biological_process	response to ionizing radiation
h	0016020	cellular_component	membrane
h	0016787	molecular_function	hydrolase activity
h	0016829	molecular_function	lyase activity
h	0016853	molecular_function	isomerase activity
h	0016887	molecular_function	ATP hydrolysis activity
h	0030332	molecular_function	cyclin binding
h	0032991	cellular_component	protein-containing complex
h	0032993	cellular_component	protein-DNA complex
h	0034774	cellular_component	secretory granule lumen
h	0042162	molecular_function	telomeric DNA binding
h	0043138	molecular_function	3'-5' DNA helicase activity
h	0043564	cellular_component	Ku70:Ku80 complex
h	0044877	molecular_function	protein-containing complex binding
h	0045027	molecular_function	DNA end binding
h	0045087	biological_process	innate immune response
h	0045621	biological_process	positive regulation of lymphocyte differentiation
h	0045892	biological_process	negative regulation of DNA-templated transcription
h	0045893	biological_process	positive regulation of DNA-templated transcription
h	0045944	biological_process	positive regulation of transcription by RNA polymerase II
h	0048660	biological_process	regulation of smooth muscle cell proliferation
h	0051575	molecular_function	5'-deoxyribose-5-phosphate lyase activity
h	0070419	cellular_component	nonhomologous end joining complex
h	0071475	biological_process	cellular hyperosmotic salinity response
h	0071480	biological_process	cellular response to gamma radiation
h	0071481	biological_process	cellular response to X-ray
h	0097110	molecular_function	scaffold protein binding
h	0097680	biological_process	double-strand break repair via classical nonhomologous end joining
h	0140078	molecular_function	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
h	1904813	cellular_component	ficolin-1-rich granule lumen
i	0005515	molecular_function	protein binding
i	0005634	cellular_component	nucleus
i	0005654	cellular_component	nucleoplasm
i	0005694	cellular_component	chromosome
i	0005737	cellular_component	cytoplasm
i	0006281	biological_process	DNA repair
i	0006303	biological_process	double-strand break repair via nonhomologous end joining
i	0006974	biological_process	DNA damage response
i	0035861	cellular_component	site of double-strand break
i	0042803	molecular_function	protein homodimerization activity
i	0043564	cellular_component	Ku70:Ku80 complex
i	0060090	molecular_function	molecular adaptor activity
i	0070182	molecular_function	DNA polymerase binding
i	0070419	cellular_component	nonhomologous end joining complex
j	0000166	molecular_function	nucleotide binding
j	0000723	biological_process	telomere maintenance
j	0000725	biological_process	recombinational repair
j	0000781	cellular_component	chromosome, telomeric region
j	0000783	cellular_component	nuclear telomere cap complex
j	0000976	molecular_function	transcription cis-regulatory region binding
j	0002218	biological_process	activation of innate immune response
j	0002376	biological_process	immune system process
j	0003677	molecular_function	DNA binding
j	0003678	molecular_function	DNA helicase activity
j	0003684	molecular_function	damaged DNA binding
j	0003690	molecular_function	double-stranded DNA binding
j	0003691	molecular_function	double-stranded telomeric DNA binding
j	0003723	molecular_function	RNA binding
j	0004386	molecular_function	helicase activity
j	0005515	molecular_function	protein binding
j	0005524	molecular_function	ATP binding
j	0005576	cellular_component	extracellular region
j	0005634	cellular_component	nucleus
j	0005654	cellular_component	nucleoplasm
j	0005694	cellular_component	chromosome
j	0005730	cellular_component	nucleolus
j	0005737	cellular_component	cytoplasm
j	0005829	cellular_component	cytosol
j	0005958	cellular_component	DNA-dependent protein kinase-DNA ligase 4 complex
j	0006281	biological_process	DNA repair
j	0006302	biological_process	double-strand break repair
j	0006303	biological_process	double-strand break repair via nonhomologous end joining
j	0006310	biological_process	DNA recombination
j	0006351	biological_process	DNA-templated transcription
j	0006974	biological_process	DNA damage response
j	0007004	biological_process	telomere maintenance via telomerase
j	0008047	molecular_function	enzyme activator activity
j	0008094	molecular_function	ATP-dependent activity, acting on DNA
j	0016020	cellular_component	membrane
j	0016787	molecular_function	hydrolase activity
j	0016829	molecular_function	lyase activity
j	0016853	molecular_function	isomerase activity
j	0016887	molecular_function	ATP hydrolysis activity
j	0031625	molecular_function	ubiquitin protein ligase binding
j	0032040	cellular_component	small-subunit processome
j	0032204	biological_process	regulation of telomere maintenance
j	0032991	cellular_component	protein-containing complex
j	0032993	cellular_component	protein-DNA complex
j	0034462	biological_process	small-subunit processome assembly
j	0034511	molecular_function	U3 snoRNA binding
j	0034774	cellular_component	secretory granule lumen
j	0042162	molecular_function	telomeric DNA binding
j	0042254	biological_process	ribosome biogenesis
j	0043138	molecular_function	3'-5' DNA helicase activity
j	0043564	cellular_component	Ku70:Ku80 complex
j	0044877	molecular_function	protein-containing complex binding
j	0045027	molecular_function	DNA end binding
j	0045087	biological_process	innate immune response
j	0045892	biological_process	negative regulation of DNA-templated transcription
j	0048660	biological_process	regulation of smooth muscle cell proliferation
j	0051575	molecular_function	5'-deoxyribose-5-phosphate lyase activity
j	0070198	biological_process	protein localization to chromosome, telomeric region
j	0070419	cellular_component	nonhomologous end joining complex
j	0071480	biological_process	cellular response to gamma radiation
j	0090734	cellular_component	site of DNA damage
j	0140078	molecular_function	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
j	1904430	biological_process	negative regulation of t-circle formation
j	1990904	cellular_component	ribonucleoprotein complex

Functional Information from PROSITE/UniProt

site_id	PS00333
Number of Residues	25
Details	DNA_LIGASE_A2 ATP-dependent DNA ligase signature 2. EGIMVKqplsi...YKpdk...RgegwlKIK

Chain	Residue	Details
M	GLU427-LYS451

---

site_id	PS00697
Number of Residues	9
Details	DNA_LIGASE_A1 ATP-dependent DNA ligase AMP-binding site. ETKLDGERM

Chain	Residue	Details
M	GLU271-MET279

---

site_id	PS00915
Number of Residues	15
Details	PI3_4_KINASE_1 Phosphatidylinositol 3- and 4-kinases signature 1. VKgg.EDLRQDqrveQ

Chain	Residue	Details
A	VAL3752-GLN3766

---

site_id	PS00916
Number of Residues	21
Details	PI3_4_KINASE_2 Phosphatidylinositol 3- and 4-kinases signature 2. ShAlicIshWILgIgDRHlnN

Chain	Residue	Details
A	SER3907-ASN3927

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	70
Details	Repeat: {"description":"HEAT 1"}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	72
Details	Repeat: {"description":"HEAT 2"}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	66
Details	Repeat: {"description":"TPR 1"}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	56
Details	Repeat: {"description":"TPR 2"}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	66
Details	Repeat: {"description":"TPR 3"}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	64
Details	Domain: {"description":"FATC","evidences":[{"source":"PROSITE-ProRule","id":"PRU00534","evidenceCode":"ECO:0000255"},{"source":"PROSITE-ProRule","id":"PRU00535","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	56
Details	Region: {"description":"May split the end of the DNA molecule, with the two strands separating around the region","evidences":[{"source":"PubMed","id":"34352203","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI8
Number of Residues	12
Details	Region: {"description":"G-loop","evidences":[{"source":"PROSITE-ProRule","id":"PRU00269","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI9
Number of Residues	16
Details	Region: {"description":"Catalytic loop","evidences":[{"source":"PROSITE-ProRule","id":"PRU00269","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI10
Number of Residues	50
Details	Region: {"description":"Activation loop","evidences":[{"source":"PROSITE-ProRule","id":"PRU00269","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI11
Number of Residues	30
Details	Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"PubMed","id":"19608861","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI12
Number of Residues	17
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI13
Number of Residues	2
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"19369195","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI14
Number of Residues	4
Details	Modified residue: {"description":"Phosphothreonine","evidences":[{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI15
Number of Residues	136
Details	Coiled coil: {"evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI16
Number of Residues	4
Details	Modified residue: {"description":"Phosphoserine; by PRKDC","evidences":[{"source":"PubMed","id":"14599745","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI17
Number of Residues	4
Details	Modified residue: {"description":"Phosphoserine; by PRKDC","evidences":[{"source":"PubMed","id":"14599745","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"22228831","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"28500754","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI18
Number of Residues	178
Details	Domain: {"description":"BRCT 1","evidences":[{"source":"PROSITE-ProRule","id":"PRU00033","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI19
Number of Residues	103
Details	Domain: {"description":"BRCT 2","evidences":[{"source":"PROSITE-ProRule","id":"PRU00033","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI20
Number of Residues	84
Details	Coiled coil: {"evidences":[{"source":"PubMed","id":"18046455","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI21
Number of Residues	2
Details	Site: {"description":"Leu-lock","evidences":[{"source":"PubMed","id":"21775435","evidenceCode":"ECO:0000303"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI22
Number of Residues	3
Details	Modified residue: {"description":"Phosphoserine; by PRKDC","evidences":[{"source":"PubMed","id":"18644470","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"22228831","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"28500754","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI23
Number of Residues	414
Details	Domain: {"description":"Ku"}

Chain

Residue

Details

---

site_id	SWS_FT_FI24
Number of Residues	128
Details	Region: {"description":"DNA-binding","evidences":[{"source":"PubMed","id":"15023334","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI25
Number of Residues	218
Details	Region: {"description":"Interaction with XRCC5","evidences":[{"source":"PubMed","id":"15023334","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI26
Number of Residues	2
Details	Modified residue: {"description":"Phosphoserine; by PRKDC","evidences":[{"source":"PubMed","id":"9362500","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI27
Number of Residues	2
Details	Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"PubMed","id":"15023334","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI28
Number of Residues	4
Details	Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"PubMed","id":"15023334","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19608861","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI29
Number of Residues	2
Details	Modified residue: {"description":"Phosphothreonine","evidences":[{"source":"PubMed","id":"20068231","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"21406692","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI30
Number of Residues	2
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"18669648","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI31
Number of Residues	2
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"19690332","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI32
Number of Residues	18
Details	Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)","evidences":[{"source":"PubMed","id":"28112733","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI33
Number of Residues	54
Details	Region: {"description":"Leucine-zipper"}

Chain

Residue

Details

---

site_id	SWS_FT_FI34
Number of Residues	2
Details	Modified residue: {"description":"Phosphoserine; by PRKDC","evidences":[{"source":"PubMed","id":"10026262","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"24275569","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI35
Number of Residues	1
Details	Modified residue: {"description":"Phosphoserine; by PRKDC","evidences":[{"source":"PubMed","id":"10026262","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI36
Number of Residues	1
Details	Modified residue: {"description":"Phosphoserine; by PRKDC","evidences":[{"source":"PubMed","id":"10026262","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI37
Number of Residues	2
Details	Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)","evidences":[{"source":"PubMed","id":"25114211","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"28112733","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---