8BHK

GABA-A receptor a5 homomer - a5V3 - Diazepam

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004888	molecular_function	transmembrane signaling receptor activity
A	0004890	molecular_function	GABA-A receptor activity
A	0005216	molecular_function	monoatomic ion channel activity
A	0005230	molecular_function	extracellular ligand-gated monoatomic ion channel activity
A	0006811	biological_process	monoatomic ion transport
A	0016020	cellular_component	membrane
A	0034220	biological_process	monoatomic ion transmembrane transport
B	0004888	molecular_function	transmembrane signaling receptor activity
B	0004890	molecular_function	GABA-A receptor activity
B	0005216	molecular_function	monoatomic ion channel activity
B	0005230	molecular_function	extracellular ligand-gated monoatomic ion channel activity
B	0006811	biological_process	monoatomic ion transport
B	0016020	cellular_component	membrane
B	0034220	biological_process	monoatomic ion transmembrane transport
C	0004888	molecular_function	transmembrane signaling receptor activity
C	0004890	molecular_function	GABA-A receptor activity
C	0005216	molecular_function	monoatomic ion channel activity
C	0005230	molecular_function	extracellular ligand-gated monoatomic ion channel activity
C	0006811	biological_process	monoatomic ion transport
C	0016020	cellular_component	membrane
C	0034220	biological_process	monoatomic ion transmembrane transport
D	0004888	molecular_function	transmembrane signaling receptor activity
D	0004890	molecular_function	GABA-A receptor activity
D	0005216	molecular_function	monoatomic ion channel activity
D	0005230	molecular_function	extracellular ligand-gated monoatomic ion channel activity
D	0006811	biological_process	monoatomic ion transport
D	0016020	cellular_component	membrane
D	0034220	biological_process	monoatomic ion transmembrane transport
E	0004888	molecular_function	transmembrane signaling receptor activity
E	0004890	molecular_function	GABA-A receptor activity
E	0005216	molecular_function	monoatomic ion channel activity
E	0005230	molecular_function	extracellular ligand-gated monoatomic ion channel activity
E	0006811	biological_process	monoatomic ion transport
E	0016020	cellular_component	membrane
E	0034220	biological_process	monoatomic ion transmembrane transport

Functional Information from PROSITE/UniProt

site_id	PS00236
Number of Residues	15
Details	NEUROTR_ION_CHANNEL Neurotransmitter-gated ion-channels signature. CpMdLedFPmDeqnC

Chain	Residue	Details
A	CYS142-CYS156

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1140
Details	TOPO_DOM: Extracellular => ECO:0000255

Chain	Residue	Details
A	GLN1-PHE229
B	GLN1-PHE229
C	GLN1-PHE229
D	GLN1-PHE229
E	GLN1-PHE229

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site_id	SWS_FT_FI2
Number of Residues	305
Details	TRANSMEM: Helical => ECO:0000269|PubMed:30140029, ECO:0007744|PDB:6A96

Chain	Residue	Details
A	VAL230-LEU250
D	VAL230-LEU250
D	ALA256-ARG277
D	MET397-TYR417
E	VAL230-LEU250
E	ALA256-ARG277
E	MET397-TYR417
A	ALA256-ARG277
A	MET397-TYR417
B	VAL230-LEU250
B	ALA256-ARG277
B	MET397-TYR417
C	VAL230-LEU250
C	ALA256-ARG277
C	MET397-TYR417

---

site_id	SWS_FT_FI3
Number of Residues	20
Details	TOPO_DOM: Cytoplasmic => ECO:0000305

Chain	Residue	Details
A	ASN251-VAL255
B	ASN251-VAL255
C	ASN251-VAL255
D	ASN251-VAL255
E	ASN251-VAL255

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site_id	SWS_FT_FI4
Number of Residues	5
Details	BINDING: BINDING => ECO:0000269|PubMed:30140029, ECO:0007744|PDB:6A96

Chain	Residue	Details
A	ALA70
B	ALA70
C	ALA70
D	ALA70
E	ALA70

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site_id	SWS_FT_FI5
Number of Residues	5
Details	BINDING: BINDING => ECO:0000250|UniProtKB:P62813

Chain	Residue	Details
A	THR133
B	THR133
C	THR133
D	THR133
E	THR133

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site_id	SWS_FT_FI6
Number of Residues	10
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255

Chain	Residue	Details
A	ASN14
E	ASN176
A	ASN176
B	ASN14
B	ASN176
C	ASN14
C	ASN176
D	ASN14
D	ASN176
E	ASN14

---

site_id	SWS_FT_FI7
Number of Residues	10
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:30140029, ECO:0007744|PDB:6A96

Chain	Residue	Details
A	TRP114
E	ASN205
A	ASN205
B	TRP114
B	ASN205
C	TRP114
C	ASN205
D	TRP114
D	ASN205
E	TRP114

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