8BG6
SARS-CoV-2 S protein in complex with pT1644 Fab
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| E | 0005515 | molecular_function | protein binding |
| E | 0005886 | cellular_component | plasma membrane |
| E | 0007165 | biological_process | signal transduction |
| E | 0016020 | cellular_component | membrane |
| E | 0019031 | cellular_component | viral envelope |
| E | 0019062 | biological_process | virion attachment to host cell |
| E | 0019064 | biological_process | fusion of virus membrane with host plasma membrane |
| E | 0019065 | biological_process | receptor-mediated endocytosis of virus by host cell |
| E | 0019081 | biological_process | viral translation |
| E | 0020002 | cellular_component | host cell plasma membrane |
| E | 0039587 | biological_process | suppression by virus of host tetherin activity |
| E | 0039654 | biological_process | fusion of virus membrane with host endosome membrane |
| E | 0039660 | molecular_function | structural constituent of virion |
| E | 0042802 | molecular_function | identical protein binding |
| E | 0043655 | cellular_component | host extracellular space |
| E | 0044173 | cellular_component | host cell endoplasmic reticulum-Golgi intermediate compartment membrane |
| E | 0044228 | cellular_component | host cell surface |
| E | 0046598 | biological_process | positive regulation of viral entry into host cell |
| E | 0046718 | biological_process | symbiont entry into host cell |
| E | 0046789 | molecular_function | host cell surface receptor binding |
| E | 0046813 | biological_process | receptor-mediated virion attachment to host cell |
| E | 0048018 | molecular_function | receptor ligand activity |
| E | 0052170 | biological_process | symbiont-mediated suppression of host innate immune response |
| E | 0055036 | cellular_component | virion membrane |
| E | 0061025 | biological_process | membrane fusion |
| E | 0075509 | biological_process | endocytosis involved in viral entry into host cell |
| E | 0098670 | biological_process | entry receptor-mediated virion attachment to host cell |
Functional Information from PROSITE/UniProt
| site_id | PS00290 |
| Number of Residues | 7 |
| Details | IG_MHC Immunoglobulins and major histocompatibility complex proteins signature. YICNVNH |
| Chain | Residue | Details |
| A | TYR195-HIS201 | |
| B | TYR192-HIS198 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 1 |
| Details | SITE: Cleavage; by host furin => ECO:0000255|HAMAP-Rule:MF_04099, ECO:0000269|PubMed:32142651, ECO:0000269|PubMed:32362314, ECO:0000269|PubMed:32703818, ECO:0000269|PubMed:34159616 |
| Chain | Residue | Details |
| E | SER685 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 1 |
| Details | SITE: Cleavage; by host TMPRSS2 or CTSL => ECO:0000255|HAMAP-Rule:MF_04099, ECO:0000269|PubMed:32703818, ECO:0000269|PubMed:34159616 |
| Chain | Residue | Details |
| E | ARG815 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 3 |
| Details | CARBOHYD: N-linked (GlcNAc...) (complex) asparagine; by host => ECO:0000255|HAMAP-Rule:MF_04099, ECO:0000269|PubMed:32366695, ECO:0000269|PubMed:32979942 |
| Chain | Residue | Details |
| E | ASN17 | |
| E | ASN1158 | |
| E | ASN1173 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 5 |
| Details | CARBOHYD: N-linked (GlcNAc...) (hybrid) asparagine; by host => ECO:0000255|HAMAP-Rule:MF_04099, ECO:0000269|PubMed:32155444, ECO:0000269|PubMed:32363391, ECO:0000269|PubMed:32366695, ECO:0000269|PubMed:32979942 |
| Chain | Residue | Details |
| E | ASN61 | |
| E | ASN122 | |
| E | ASN717 | |
| E | ASN801 | |
| E | ASN1074 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 3 |
| Details | CARBOHYD: N-linked (GlcNAc...) (complex) asparagine; by host => ECO:0000255|HAMAP-Rule:MF_04099, ECO:0000269|PubMed:32363391, ECO:0000269|PubMed:32366695, ECO:0000269|PubMed:32979942 |
| Chain | Residue | Details |
| E | ASN74 | |
| E | ASN149 | |
| E | ASN1194 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 7 |
| Details | CARBOHYD: N-linked (GlcNAc...) (complex) asparagine; by host => ECO:0000255|HAMAP-Rule:MF_04099, ECO:0000269|PubMed:32155444, ECO:0000269|PubMed:32363391, ECO:0000269|PubMed:32366695, ECO:0000269|PubMed:32979942 |
| Chain | Residue | Details |
| E | ASN165 | |
| E | ASN282 | |
| E | ASN331 | |
| E | ASN343 | |
| E | ASN616 | |
| E | ASN657 | |
| E | ASN1098 |
| site_id | SWS_FT_FI7 |
| Number of Residues | 2 |
| Details | CARBOHYD: N-linked (GlcNAc...) (high mannose) asparagine; by host => ECO:0000255|HAMAP-Rule:MF_04099, ECO:0000269|PubMed:32155444, ECO:0000269|PubMed:32363391, ECO:0000269|PubMed:32366695, ECO:0000269|PubMed:32979942 |
| Chain | Residue | Details |
| E | ASN234 | |
| E | ASN709 |
| site_id | SWS_FT_FI8 |
| Number of Residues | 1 |
| Details | CARBOHYD: O-linked (GalNAc) threonine; by host => ECO:0000269|PubMed:32363391 |
| Chain | Residue | Details |
| E | THR323 |
| site_id | SWS_FT_FI9 |
| Number of Residues | 1 |
| Details | CARBOHYD: O-linked (HexNAc...) serine; by host => ECO:0000269|PubMed:32363391 |
| Chain | Residue | Details |
| E | SER325 |
| site_id | SWS_FT_FI10 |
| Number of Residues | 1 |
| Details | CARBOHYD: N-linked (GlcNAc...) (hybrid) asparagine; by host => ECO:0000255|HAMAP-Rule:MF_04099, ECO:0000269|PubMed:32155444, ECO:0000269|PubMed:32366695, ECO:0000269|PubMed:32979942 |
| Chain | Residue | Details |
| E | ASN603 |
| site_id | SWS_FT_FI11 |
| Number of Residues | 2 |
| Details | CARBOHYD: O-linked (GlcNAc...) threonine; by host GALNT1 => ECO:0000269|PubMed:34732583 |
| Chain | Residue | Details |
| E | THR676 | |
| E | THR678 |
| site_id | SWS_FT_FI12 |
| Number of Residues | 1 |
| Details | CARBOHYD: N-linked (GlcNAc...) (complex) asparagine; by host => ECO:0000255|HAMAP-Rule:MF_04099, ECO:0000269|PubMed:32155444, ECO:0000269|PubMed:32366695, ECO:0000269|PubMed:32979942 |
| Chain | Residue | Details |
| E | ASN1134 |
