8BG6

SARS-CoV-2 S protein in complex with pT1644 Fab

Functional Information from GO Data

Chain	GOid	namespace	contents
E	0005515	molecular_function	protein binding
E	0005886	cellular_component	plasma membrane
E	0007165	biological_process	signal transduction
E	0016020	cellular_component	membrane
E	0019031	cellular_component	viral envelope
E	0019062	biological_process	virion attachment to host cell
E	0019064	biological_process	fusion of virus membrane with host plasma membrane
E	0020002	cellular_component	host cell plasma membrane
E	0039587	biological_process	symbiont-mediated-mediated suppression of host tetherin activity
E	0039654	biological_process	fusion of virus membrane with host endosome membrane
E	0039660	molecular_function	structural constituent of virion
E	0039663	biological_process	membrane fusion involved in viral entry into host cell
E	0042802	molecular_function	identical protein binding
E	0043655	cellular_component	host extracellular space
E	0044173	cellular_component	host cell endoplasmic reticulum-Golgi intermediate compartment membrane
E	0044228	cellular_component	host cell surface
E	0044423	cellular_component	virion component
E	0046598	biological_process	positive regulation of viral entry into host cell
E	0046718	biological_process	symbiont entry into host cell
E	0046789	molecular_function	host cell surface receptor binding
E	0046813	biological_process	receptor-mediated virion attachment to host cell
E	0048018	molecular_function	receptor ligand activity
E	0052031	biological_process	symbiont-mediated perturbation of host defense response
E	0052170	biological_process	symbiont-mediated suppression of host innate immune response
E	0055036	cellular_component	virion membrane
E	0061025	biological_process	membrane fusion
E	0075509	biological_process	endocytosis involved in viral entry into host cell
E	0098670	biological_process	entry receptor-mediated virion attachment to host cell
E	0141146	biological_process	symbiont-mediated disruption of host tissue

Functional Information from PROSITE/UniProt

site_id	PS00290
Number of Residues	7
Details	IG_MHC Immunoglobulins and major histocompatibility complex proteins signature. YICNVNH

Chain	Residue	Details
A	TYR195-HIS201
B	TYR192-HIS198

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	2
Details	Region: {"description":"Integrin-binding motif;","evidences":[{"source":"PubMed","id":"33102950","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI2
Number of Residues	71
Details	Region: {"description":"Receptor-binding motif; binding to human ACE2","evidences":[{"source":"UniProtKB","id":"P59594","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI3
Number of Residues	8
Details	Region: {"description":"Immunodominant HLA epitope recognized by the CD8+; called NF9 peptide","evidences":[{"source":"PubMed","id":"34171266","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI4
Number of Residues	35
Details	Region: {"description":"Disordered","evidences":[{"source":"PubMed","id":"35108439","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI5
Number of Residues	1
Details	Glycosylation: {"description":"N-linked (GlcNAc...) (complex) asparagine; by host","evidences":[{"source":"HAMAP-Rule","id":"MF_04099","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"32155444","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"32363391","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"32366695","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"32979942","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

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