8B9Z

Drosophila melanogaster complex I in the Active state (Dm1)

Functional Information from GO Data

Chain	GOid	namespace	contents
a	0003674	molecular_function	molecular_function
a	0005739	cellular_component	mitochondrion
a	0005743	cellular_component	mitochondrial inner membrane
a	0005747	cellular_component	obsolete mitochondrial respiratory chain complex I
a	0008150	biological_process	biological_process
a	0070469	cellular_component	respirasome
A	0005739	cellular_component	mitochondrion
A	0005747	cellular_component	obsolete mitochondrial respiratory chain complex I
A	0006120	biological_process	mitochondrial electron transport, NADH to ubiquinone
A	0008137	molecular_function	NADH dehydrogenase (ubiquinone) activity
A	0016020	cellular_component	membrane
A	0031966	cellular_component	mitochondrial membrane
A	0045271	cellular_component	respiratory chain complex I
A	0070469	cellular_component	respirasome
A	1902600	biological_process	proton transmembrane transport
B	0008137	molecular_function	NADH dehydrogenase (ubiquinone) activity
B	0048038	molecular_function	quinone binding
B	0051536	molecular_function	iron-sulfur cluster binding
B	0051539	molecular_function	4 iron, 4 sulfur cluster binding
C	0008137	molecular_function	NADH dehydrogenase (ubiquinone) activity
C	0016651	molecular_function	oxidoreductase activity, acting on NAD(P)H
d	0005739	cellular_component	mitochondrion
d	0005743	cellular_component	mitochondrial inner membrane
d	0005747	cellular_component	obsolete mitochondrial respiratory chain complex I
d	0006120	biological_process	mitochondrial electron transport, NADH to ubiquinone
d	0032981	biological_process	mitochondrial respiratory chain complex I assembly
d	0045271	cellular_component	respiratory chain complex I
d	0070469	cellular_component	respirasome
D	0003954	molecular_function	NADH dehydrogenase activity
D	0005739	cellular_component	mitochondrion
D	0005747	cellular_component	obsolete mitochondrial respiratory chain complex I
D	0006120	biological_process	mitochondrial electron transport, NADH to ubiquinone
D	0008137	molecular_function	NADH dehydrogenase (ubiquinone) activity
D	0016491	molecular_function	oxidoreductase activity
D	0016651	molecular_function	oxidoreductase activity, acting on NAD(P)H
D	0045271	cellular_component	respiratory chain complex I
D	0048038	molecular_function	quinone binding
D	0051287	molecular_function	NAD binding
D	1902600	biological_process	proton transmembrane transport
e	0005747	cellular_component	obsolete mitochondrial respiratory chain complex I
e	0006120	biological_process	mitochondrial electron transport, NADH to ubiquinone
e	0045271	cellular_component	respiratory chain complex I
E	0016491	molecular_function	oxidoreductase activity
f	0005739	cellular_component	mitochondrion
f	0005747	cellular_component	obsolete mitochondrial respiratory chain complex I
f	0006120	biological_process	mitochondrial electron transport, NADH to ubiquinone
f	0016491	molecular_function	oxidoreductase activity
f	0032981	biological_process	mitochondrial respiratory chain complex I assembly
f	0045271	cellular_component	respiratory chain complex I
F	0005739	cellular_component	mitochondrion
F	0005743	cellular_component	mitochondrial inner membrane
F	0005747	cellular_component	obsolete mitochondrial respiratory chain complex I
F	0006120	biological_process	mitochondrial electron transport, NADH to ubiquinone
F	0008137	molecular_function	NADH dehydrogenase (ubiquinone) activity
F	0010181	molecular_function	FMN binding
F	0045271	cellular_component	respiratory chain complex I
F	0046872	molecular_function	metal ion binding
F	0051287	molecular_function	NAD binding
F	0051539	molecular_function	4 iron, 4 sulfur cluster binding
F	0070469	cellular_component	respirasome
F	1902600	biological_process	proton transmembrane transport
G	0005739	cellular_component	mitochondrion
G	0005743	cellular_component	mitochondrial inner membrane
G	0006120	biological_process	mitochondrial electron transport, NADH to ubiquinone
G	0008137	molecular_function	NADH dehydrogenase (ubiquinone) activity
G	0016020	cellular_component	membrane
G	0016491	molecular_function	oxidoreductase activity
G	0016651	molecular_function	oxidoreductase activity, acting on NAD(P)H
G	0032981	biological_process	mitochondrial respiratory chain complex I assembly
G	0042773	biological_process	ATP synthesis coupled electron transport
G	0045271	cellular_component	respiratory chain complex I
G	0045333	biological_process	cellular respiration
G	0046872	molecular_function	metal ion binding
G	0051536	molecular_function	iron-sulfur cluster binding
G	0051537	molecular_function	2 iron, 2 sulfur cluster binding
G	0051539	molecular_function	4 iron, 4 sulfur cluster binding
G	0070469	cellular_component	respirasome
G	0072593	biological_process	reactive oxygen species metabolic process
G	1902600	biological_process	proton transmembrane transport
H	0003954	molecular_function	NADH dehydrogenase activity
H	0005739	cellular_component	mitochondrion
H	0005743	cellular_component	mitochondrial inner membrane
H	0005747	cellular_component	obsolete mitochondrial respiratory chain complex I
H	0006120	biological_process	mitochondrial electron transport, NADH to ubiquinone
H	0008137	molecular_function	NADH dehydrogenase (ubiquinone) activity
H	0009060	biological_process	aerobic respiration
H	0016020	cellular_component	membrane
H	0045271	cellular_component	respiratory chain complex I
H	0070469	cellular_component	respirasome
H	1902600	biological_process	proton transmembrane transport
i	0005747	cellular_component	obsolete mitochondrial respiratory chain complex I
i	0006120	biological_process	mitochondrial electron transport, NADH to ubiquinone
i	0045271	cellular_component	respiratory chain complex I
I	0016020	cellular_component	membrane
I	0016651	molecular_function	oxidoreductase activity, acting on NAD(P)H
I	0051539	molecular_function	4 iron, 4 sulfur cluster binding
j	0005743	cellular_component	mitochondrial inner membrane
j	0005747	cellular_component	obsolete mitochondrial respiratory chain complex I
J	0005739	cellular_component	mitochondrion
J	0006120	biological_process	mitochondrial electron transport, NADH to ubiquinone
J	0008137	molecular_function	NADH dehydrogenase (ubiquinone) activity
J	0016020	cellular_component	membrane
J	0031966	cellular_component	mitochondrial membrane
J	0045271	cellular_component	respiratory chain complex I
J	0070469	cellular_component	respirasome
J	1902600	biological_process	proton transmembrane transport
k	0005739	cellular_component	mitochondrion
k	0022900	biological_process	electron transport chain
K	0005739	cellular_component	mitochondrion
K	0005747	cellular_component	obsolete mitochondrial respiratory chain complex I
K	0006120	biological_process	mitochondrial electron transport, NADH to ubiquinone
K	0008137	molecular_function	NADH dehydrogenase (ubiquinone) activity
K	0016020	cellular_component	membrane
K	0016651	molecular_function	oxidoreductase activity, acting on NAD(P)H
K	0031966	cellular_component	mitochondrial membrane
K	0042773	biological_process	ATP synthesis coupled electron transport
K	0045271	cellular_component	respiratory chain complex I
K	0070469	cellular_component	respirasome
K	1902600	biological_process	proton transmembrane transport
l	0005739	cellular_component	mitochondrion
L	0003954	molecular_function	NADH dehydrogenase activity
L	0005739	cellular_component	mitochondrion
L	0005743	cellular_component	mitochondrial inner membrane
L	0005747	cellular_component	obsolete mitochondrial respiratory chain complex I
L	0006120	biological_process	mitochondrial electron transport, NADH to ubiquinone
L	0008137	molecular_function	NADH dehydrogenase (ubiquinone) activity
L	0015990	biological_process	electron transport coupled proton transport
L	0042773	biological_process	ATP synthesis coupled electron transport
L	0045271	cellular_component	respiratory chain complex I
L	0070469	cellular_component	respirasome
m	0005739	cellular_component	mitochondrion
m	0005747	cellular_component	obsolete mitochondrial respiratory chain complex I
m	0006120	biological_process	mitochondrial electron transport, NADH to ubiquinone
m	0016020	cellular_component	membrane
m	0016491	molecular_function	oxidoreductase activity
m	0032981	biological_process	mitochondrial respiratory chain complex I assembly
m	0045271	cellular_component	respiratory chain complex I
M	0003954	molecular_function	NADH dehydrogenase activity
M	0005739	cellular_component	mitochondrion
M	0005747	cellular_component	obsolete mitochondrial respiratory chain complex I
M	0006120	biological_process	mitochondrial electron transport, NADH to ubiquinone
M	0008137	molecular_function	NADH dehydrogenase (ubiquinone) activity
M	0009060	biological_process	aerobic respiration
M	0015990	biological_process	electron transport coupled proton transport
M	0016020	cellular_component	membrane
M	0031966	cellular_component	mitochondrial membrane
M	0042773	biological_process	ATP synthesis coupled electron transport
M	0045271	cellular_component	respiratory chain complex I
M	0048039	molecular_function	ubiquinone binding
M	0070469	cellular_component	respirasome
n	0005739	cellular_component	mitochondrion
n	0005743	cellular_component	mitochondrial inner membrane
n	0005747	cellular_component	obsolete mitochondrial respiratory chain complex I
n	0006120	biological_process	mitochondrial electron transport, NADH to ubiquinone
n	0032981	biological_process	mitochondrial respiratory chain complex I assembly
n	0045271	cellular_component	respiratory chain complex I
n	0070469	cellular_component	respirasome
N	0005739	cellular_component	mitochondrion
N	0005743	cellular_component	mitochondrial inner membrane
N	0005747	cellular_component	obsolete mitochondrial respiratory chain complex I
N	0006120	biological_process	mitochondrial electron transport, NADH to ubiquinone
N	0008137	molecular_function	NADH dehydrogenase (ubiquinone) activity
N	0045271	cellular_component	respiratory chain complex I
N	0070469	cellular_component	respirasome
N	1902600	biological_process	proton transmembrane transport
o	0005739	cellular_component	mitochondrion
o	0005743	cellular_component	mitochondrial inner membrane
o	0005747	cellular_component	obsolete mitochondrial respiratory chain complex I
o	0005758	cellular_component	mitochondrial intermembrane space
o	0006120	biological_process	mitochondrial electron transport, NADH to ubiquinone
o	0016020	cellular_component	membrane
o	0016491	molecular_function	oxidoreductase activity
o	0032981	biological_process	mitochondrial respiratory chain complex I assembly
o	0045271	cellular_component	respiratory chain complex I
O	0005515	molecular_function	protein binding
O	0005737	cellular_component	cytoplasm
O	0005739	cellular_component	mitochondrion
O	0005747	cellular_component	obsolete mitochondrial respiratory chain complex I
O	0005759	cellular_component	mitochondrial matrix
O	0006120	biological_process	mitochondrial electron transport, NADH to ubiquinone
O	0045271	cellular_component	respiratory chain complex I
O	0070469	cellular_component	respirasome
p	0005739	cellular_component	mitochondrion
p	0005743	cellular_component	mitochondrial inner membrane
p	0005747	cellular_component	obsolete mitochondrial respiratory chain complex I
p	0006120	biological_process	mitochondrial electron transport, NADH to ubiquinone
p	0032981	biological_process	mitochondrial respiratory chain complex I assembly
p	0045271	cellular_component	respiratory chain complex I
p	0070469	cellular_component	respirasome
P	0005739	cellular_component	mitochondrion
P	0006120	biological_process	mitochondrial electron transport, NADH to ubiquinone
P	0032981	biological_process	mitochondrial respiratory chain complex I assembly
P	0044877	molecular_function	protein-containing complex binding
P	0045271	cellular_component	respiratory chain complex I
P	1901006	biological_process	ubiquinone-6 biosynthetic process
q	0005739	cellular_component	mitochondrion
q	0005743	cellular_component	mitochondrial inner membrane
q	0005747	cellular_component	obsolete mitochondrial respiratory chain complex I
q	0006120	biological_process	mitochondrial electron transport, NADH to ubiquinone
q	0006979	biological_process	response to oxidative stress
q	0016020	cellular_component	membrane
q	0032981	biological_process	mitochondrial respiratory chain complex I assembly
q	0042775	biological_process	mitochondrial ATP synthesis coupled electron transport
q	0045271	cellular_component	respiratory chain complex I
q	0070469	cellular_component	respirasome
Q	0022900	biological_process	electron transport chain
r	0005743	cellular_component	mitochondrial inner membrane
r	0005747	cellular_component	obsolete mitochondrial respiratory chain complex I
r	0006120	biological_process	mitochondrial electron transport, NADH to ubiquinone
r	0016020	cellular_component	membrane
r	0016491	molecular_function	oxidoreductase activity
r	0042773	biological_process	ATP synthesis coupled electron transport
r	0045271	cellular_component	respiratory chain complex I
R	0005747	cellular_component	obsolete mitochondrial respiratory chain complex I
R	0006120	biological_process	mitochondrial electron transport, NADH to ubiquinone
s	0005739	cellular_component	mitochondrion
s	0005747	cellular_component	obsolete mitochondrial respiratory chain complex I
T	0006633	biological_process	fatty acid biosynthetic process
U	0006633	biological_process	fatty acid biosynthetic process
V	0005739	cellular_component	mitochondrion
V	0005743	cellular_component	mitochondrial inner membrane
V	0005747	cellular_component	obsolete mitochondrial respiratory chain complex I
V	0006120	biological_process	mitochondrial electron transport, NADH to ubiquinone
V	0022904	biological_process	respiratory electron transport chain
V	0045271	cellular_component	respiratory chain complex I
W	0005739	cellular_component	mitochondrion
W	0005743	cellular_component	mitochondrial inner membrane
W	0005747	cellular_component	obsolete mitochondrial respiratory chain complex I
W	0006120	biological_process	mitochondrial electron transport, NADH to ubiquinone
W	0006979	biological_process	response to oxidative stress
W	0016491	molecular_function	oxidoreductase activity
W	0032981	biological_process	mitochondrial respiratory chain complex I assembly
W	0045271	cellular_component	respiratory chain complex I
W	0070469	cellular_component	respirasome
X	0005739	cellular_component	mitochondrion
X	0005743	cellular_component	mitochondrial inner membrane
X	0005747	cellular_component	obsolete mitochondrial respiratory chain complex I
X	0006120	biological_process	mitochondrial electron transport, NADH to ubiquinone
X	0016491	molecular_function	oxidoreductase activity
X	0032981	biological_process	mitochondrial respiratory chain complex I assembly
X	0045271	cellular_component	respiratory chain complex I
X	0070469	cellular_component	respirasome
Y	0003674	molecular_function	molecular_function
Y	0005739	cellular_component	mitochondrion
Y	0005743	cellular_component	mitochondrial inner membrane
Y	0005747	cellular_component	obsolete mitochondrial respiratory chain complex I
Y	0006120	biological_process	mitochondrial electron transport, NADH to ubiquinone
Y	0032981	biological_process	mitochondrial respiratory chain complex I assembly
Y	0045271	cellular_component	respiratory chain complex I
Z	0005739	cellular_component	mitochondrion
Z	0005743	cellular_component	mitochondrial inner membrane
Z	0005747	cellular_component	obsolete mitochondrial respiratory chain complex I
Z	0006120	biological_process	mitochondrial electron transport, NADH to ubiquinone
Z	0016020	cellular_component	membrane
Z	0032981	biological_process	mitochondrial respiratory chain complex I assembly
Z	0045271	cellular_component	respiratory chain complex I
Z	0070469	cellular_component	respirasome

Functional Information from PROSITE/UniProt

site_id	PS00198
Number of Residues	12
Details	4FE4S_FER_1 4Fe-4S ferredoxin-type iron-sulfur binding region signature. CiACKlCEaICP

Chain	Residue	Details
I	CYS118-PRO129
I	CYS157-PRO168

---

site_id	PS00535
Number of Residues	12
Details	COMPLEX1_49K Respiratory chain NADH dehydrogenase 49 Kd subunit signature. LHRGtEKLiEyK

Chain	Residue	Details
D	LEU121-LYS132

---

site_id	PS00542
Number of Residues	22
Details	COMPLEX1_30K Respiratory chain NADH dehydrogenase 30 Kd subunit signature. EREiwDMYgvffanHpdlRrIL

Chain	Residue	Details
C	GLU169-LEU190

---

site_id	PS00599
Number of Residues	10
Details	AA_TRANSFER_CLASS_2 Aminotransferases class-II pyridoxal-phosphate attachment site. TISKSIGGGA

Chain	Residue	Details
G	THR676-ALA685

---

site_id	PS00641
Number of Residues	18
Details	COMPLEX1_75K_1 Respiratory-chain NADH dehydrogenase 75 Kd subunit signature 1. PrfCYherlavaGnCRmC

Chain	Residue	Details
G	PRO71-CYS88

---

site_id	PS00642
Number of Residues	13
Details	COMPLEX1_75K_2 Respiratory-chain NADH dehydrogenase 75 Kd subunit signature 2. CPiCDqGGeCdLQ

Chain	Residue	Details
G	CYS138-GLN150

---

site_id	PS00643
Number of Residues	11
Details	COMPLEX1_75K_3 Respiratory-chain NADH dehydrogenase 75 Kd subunit signature 3. RCIhCtRCVrF

Chain	Residue	Details
G	ARG189-PHE199

---

site_id	PS00644
Number of Residues	16
Details	COMPLEX1_51K_1 Respiratory-chain NADH dehydrogenase 51 Kd subunit signature 1. GAGAYICGEETALIES

Chain	Residue	Details
F	GLY215-SER230

---

site_id	PS00645
Number of Residues	12
Details	COMPLEX1_51K_2 Respiratory-chain NADH dehydrogenase 51 Kd subunit signature 2. ESCGqCtPCReG

Chain	Residue	Details
F	GLU392-GLY403

---

site_id	PS00667
Number of Residues	16
Details	COMPLEX1_ND1_1 Respiratory-chain NADH dehydrogenase subunit 1 signature 1. GIPQpFcDAIKLFtKE

Chain	Residue	Details
H	GLY51-GLU66

---

site_id	PS00668
Number of Residues	14
Details	COMPLEX1_ND1_2 Respiratory-chain NADH dehydrogenase subunit 1 signature 2. PFDFAEGEseLVs.G

Chain	Residue	Details
H	PRO204-GLY217

---

site_id	PS01099
Number of Residues	19
Details	COMPLEX1_24K Respiratory-chain NADH dehydrogenase 24 Kd subunit signature. DrkFTiseveCLGaCvnAP

Chain	Residue	Details
E	ASP159-PRO177

---

site_id	PS01150
Number of Residues	17
Details	COMPLEX1_20K Respiratory-chain NADH dehydrogenase 20 Kd subunit signature. GcDRIIPVDIYvPgCPP

Chain	Residue	Details
B	GLY177-PRO193

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	322
Details	TRANSMEM: Helical => ECO:0000255

Chain	Residue	Details
L	ILE9-LEU29
L	PHE299-ILE319
L	SER342-TYR362
L	ASN377-VAL399
L	MET427-PHE447
L	LEU462-PHE482
L	PHE495-LEU515
L	LEU557-LEU577
L	ILE49-ILE69
L	ILE91-ILE111
L	SER112-GLN132
L	VAL152-TYR172
L	ILE175-THR195
L	SER222-THR242
L	TRP244-ALA264
L	ILE273-PHE293

---

site_id	SWS_FT_FI2
Number of Residues	4
Details	BINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU01184

Chain	Residue	Details
G	HIS134
G	CYS138
G	CYS141
G	CYS147

---