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8B9I

Cryo-EM structure of MLE in complex with ADP:AlF4 and UUC RNA

Functional Information from GO Data
ChainGOidnamespacecontents
A0000228cellular_componentnuclear chromosome
A0000785cellular_componentchromatin
A0000805cellular_componentX chromosome
A0001069molecular_functionregulatory region RNA binding
A0003676molecular_functionnucleic acid binding
A0003678molecular_functionDNA helicase activity
A0003682molecular_functionchromatin binding
A0003689molecular_functionDNA clamp loader activity
A0003690molecular_functiondouble-stranded DNA binding
A0003723molecular_functionRNA binding
A0003724molecular_functionRNA helicase activity
A0003725molecular_functiondouble-stranded RNA binding
A0004386molecular_functionhelicase activity
A0005524molecular_functionATP binding
A0005634cellular_componentnucleus
A0005694cellular_componentchromosome
A0005730cellular_componentnucleolus
A0005829cellular_componentcytosol
A0007549biological_processsex-chromosome dosage compensation
A0008340biological_processdetermination of adult lifespan
A0009047biological_processdosage compensation by hyperactivation of X chromosome
A0010468biological_processregulation of gene expression
A0016456cellular_componentX chromosome located dosage compensation complex, transcription activating
A0016787molecular_functionhydrolase activity
A0016887molecular_functionATP hydrolysis activity
A0031453biological_processpositive regulation of heterochromatin formation
A0032508biological_processDNA duplex unwinding
A0033679molecular_function3'-5' DNA/RNA helicase activity
A0034458molecular_function3'-5' RNA helicase activity
A0042714biological_processdosage compensation complex assembly
A0043138molecular_function3'-5' DNA helicase activity
A0045433biological_processmale courtship behavior, veined wing generated song production
A0045944biological_processpositive regulation of transcription by RNA polymerase II
A0048675biological_processaxon extension
A0050684biological_processregulation of mRNA processing
A0061775molecular_functioncohesin loader activity
A0072487cellular_componentMSL complex
A0106222molecular_functionlncRNA binding
A0140584molecular_functionchromatin extrusion motor activity
A0140588biological_processchromatin looping
A0140665molecular_functionATP-dependent H3-H4 histone complex chaperone activity
A0140849molecular_functionATP-dependent H2AZ histone chaperone activity
A1990904cellular_componentribonucleoprotein complex
A2000373biological_processpositive regulation of DNA topoisomerase (ATP-hydrolyzing) activity
A2000765biological_processregulation of cytoplasmic translation
Functional Information from PROSITE/UniProt
site_idPS00690
Number of Residues10
DetailsDEAH_ATP_HELICASE DEAH-box subfamily ATP-dependent helicases signature. ShIIVDEIHE
ChainResidueDetails
ASER502-GLU511

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues8
DetailsBINDING: BINDING => ECO:0007744|PDB:5AOR
ChainResidueDetails
AGLY410
AGLY412
ALYS413
ATHR414
ATHR415
AASP507
AGLU508
AARG771

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PDB entries from 2024-11-06

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