8B6Z
CryoEM Structure of Extended eEF1A bound to the Ribosome in the Classical Pre State
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0003746 | molecular_function | translation elongation factor activity |
| A | 0003924 | molecular_function | GTPase activity |
| A | 0005515 | molecular_function | protein binding |
| A | 0005525 | molecular_function | GTP binding |
| A | 0005634 | cellular_component | nucleus |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005853 | cellular_component | eukaryotic translation elongation factor 1 complex |
| A | 0006412 | biological_process | translation |
| A | 0006414 | biological_process | translational elongation |
| A | 0008135 | molecular_function | translation factor activity, RNA binding |
| A | 0019901 | molecular_function | protein kinase binding |
| A | 0043065 | biological_process | positive regulation of apoptotic process |
| A | 0045202 | cellular_component | synapse |
| A | 0090218 | biological_process | positive regulation of lipid kinase activity |
| A | 0098574 | cellular_component | cytoplasmic side of lysosomal membrane |
| A | 1904714 | biological_process | regulation of chaperone-mediated autophagy |
Functional Information from PROSITE/UniProt
| site_id | PS00301 |
| Number of Residues | 16 |
| Details | G_TR_1 Translational (tr)-type guanine nucleotide-binding (G) domain signature. DKlkaEReRGITIdiS |
| Chain | Residue | Details |
| A | ASP61-SER76 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 3 |
| Details | BINDING: BINDING => ECO:0000250 |
| Chain | Residue | Details |
| A | GLY14 | |
| A | ASP91 | |
| A | ASN153 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 1 |
| Details | MOD_RES: N,N,N-trimethylglycine => ECO:0000250|UniProtKB:P68104 |
| Chain | Residue | Details |
| A | GLY2 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 1 |
| Details | MOD_RES: N6-methyllysine; alternate; by EEF1AKMT4 => ECO:0000269|PubMed:28520920 |
| Chain | Residue | Details |
| A | LYS36 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 1 |
| Details | MOD_RES: N6,N6-dimethyllysine => ECO:0000269|PubMed:30143613, ECO:0000269|PubMed:30612740 |
| Chain | Residue | Details |
| A | LYS55 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 1 |
| Details | MOD_RES: N6,N6,N6-trimethyllysine => ECO:0007744|PubMed:24129315 |
| Chain | Residue | Details |
| A | LYS79 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 1 |
| Details | MOD_RES: N6-methyllysine; alternate => ECO:0007744|PubMed:24129315 |
| Chain | Residue | Details |
| A | LYS165 |
| site_id | SWS_FT_FI7 |
| Number of Residues | 2 |
| Details | MOD_RES: N6-acetyllysine => ECO:0007744|PubMed:19608861 |
| Chain | Residue | Details |
| A | LYS179 | |
| A | LYS439 |
| site_id | SWS_FT_FI8 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphoserine => ECO:0000250|UniProtKB:P62632 |
| Chain | Residue | Details |
| A | SER224 |
| site_id | SWS_FT_FI9 |
| Number of Residues | 2 |
| Details | MOD_RES: 5-glutamyl glycerylphosphorylethanolamine => ECO:0000250|UniProtKB:Q71V39 |
| Chain | Residue | Details |
| A | GLU301 | |
| A | GLU374 |
