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8B6L

Subtomogram average of the human Sec61-TRAP-OSTA-translocon

Functional Information from GO Data
ChainGOidnamespacecontents
A0005048molecular_functionsignal sequence binding
A0005262molecular_functioncalcium channel activity
A0005515molecular_functionprotein binding
A0005783cellular_componentendoplasmic reticulum
A0005784cellular_componentSec61 translocon complex
A0005789cellular_componentendoplasmic reticulum membrane
A0006613biological_processcotranslational protein targeting to membrane
A0006614biological_processSRP-dependent cotranslational protein targeting to membrane
A0006616biological_processSRP-dependent cotranslational protein targeting to membrane, translocation
A0006620biological_processpost-translational protein targeting to endoplasmic reticulum membrane
A0007029biological_processendoplasmic reticulum organization
A0008320molecular_functionprotein transmembrane transporter activity
A0015031biological_processprotein transport
A0016020cellular_componentmembrane
A0031204biological_processpost-translational protein targeting to membrane, translocation
A0039019biological_processpronephric nephron development
A0043022molecular_functionribosome binding
A0045047biological_processprotein targeting to ER
A0045048biological_processprotein insertion into ER membrane
A0070588biological_processcalcium ion transmembrane transport
B0003723molecular_functionRNA binding
B0005085molecular_functionguanyl-nucleotide exchange factor activity
B0005515molecular_functionprotein binding
B0005783cellular_componentendoplasmic reticulum
B0005784cellular_componentSec61 translocon complex
B0005789cellular_componentendoplasmic reticulum membrane
B0005829cellular_componentcytosol
B0006616biological_processSRP-dependent cotranslational protein targeting to membrane, translocation
B0006886biological_processintracellular protein transport
B0015031biological_processprotein transport
B0016020cellular_componentmembrane
B0030970biological_processretrograde protein transport, ER to cytosol
B0031204biological_processpost-translational protein targeting to membrane, translocation
B0031205cellular_componentendoplasmic reticulum Sec complex
B0036503biological_processERAD pathway
B0043022molecular_functionribosome binding
B0044322cellular_componentendoplasmic reticulum quality control compartment
B0048408molecular_functionepidermal growth factor binding
C0005515molecular_functionprotein binding
C0005783cellular_componentendoplasmic reticulum
C0005789cellular_componentendoplasmic reticulum membrane
C0005829cellular_componentcytosol
C0006605biological_processprotein targeting
C0006886biological_processintracellular protein transport
C0008320molecular_functionprotein transmembrane transporter activity
C0015031biological_processprotein transport
C0016020cellular_componentmembrane
C0031204biological_processpost-translational protein targeting to membrane, translocation
C0043022molecular_functionribosome binding
C0045047biological_processprotein targeting to ER
C0071261cellular_componentSsh1 translocon complex
E0005789cellular_componentendoplasmic reticulum membrane
F0005783cellular_componentendoplasmic reticulum
F0016020cellular_componentmembrane
G0005515molecular_functionprotein binding
G0005783cellular_componentendoplasmic reticulum
G0005789cellular_componentendoplasmic reticulum membrane
G0006614biological_processSRP-dependent cotranslational protein targeting to membrane
G0016020cellular_componentmembrane
H0005783cellular_componentendoplasmic reticulum
H0016020cellular_componentmembrane
I0004576molecular_functionoligosaccharyl transferase activity
I0004579molecular_functiondolichyl-diphosphooligosaccharide-protein glycotransferase activity
I0005515molecular_functionprotein binding
I0005783cellular_componentendoplasmic reticulum
I0005789cellular_componentendoplasmic reticulum membrane
I0006486biological_processprotein glycosylation
I0006487biological_processprotein N-linked glycosylation
I0008250cellular_componentoligosaccharyltransferase complex
I0016020cellular_componentmembrane
I0016757molecular_functionglycosyltransferase activity
I0018279biological_processprotein N-linked glycosylation via asparagine
I0035000cellular_componentoligosaccharyltransferase III complex
I0043686biological_processco-translational protein modification
I0043687biological_processpost-translational protein modification
I0046872molecular_functionmetal ion binding
J0004579molecular_functiondolichyl-diphosphooligosaccharide-protein glycotransferase activity
J0005515molecular_functionprotein binding
J0005783cellular_componentendoplasmic reticulum
J0005789cellular_componentendoplasmic reticulum membrane
J0006486biological_processprotein glycosylation
J0006487biological_processprotein N-linked glycosylation
J0008250cellular_componentoligosaccharyltransferase complex
J0016020cellular_componentmembrane
J0018279biological_processprotein N-linked glycosylation via asparagine
K0005515molecular_functionprotein binding
K0005783cellular_componentendoplasmic reticulum
K0005789cellular_componentendoplasmic reticulum membrane
K0006486biological_processprotein glycosylation
K0006487biological_processprotein N-linked glycosylation
K0008250cellular_componentoligosaccharyltransferase complex
K0016020cellular_componentmembrane
K0018279biological_processprotein N-linked glycosylation via asparagine
L0005515molecular_functionprotein binding
L0005737cellular_componentcytoplasm
L0005783cellular_componentendoplasmic reticulum
L0005789cellular_componentendoplasmic reticulum membrane
L0006486biological_processprotein glycosylation
L0006487biological_processprotein N-linked glycosylation
L0006954biological_processinflammatory response
L0008250cellular_componentoligosaccharyltransferase complex
L0016020cellular_componentmembrane
L0032991cellular_componentprotein-containing complex
L0034976biological_processresponse to endoplasmic reticulum stress
L0034998cellular_componentoligosaccharyltransferase I complex
L0062062molecular_functionoligosaccharyltransferase complex binding
L1904019biological_processepithelial cell apoptotic process
M0001824biological_processblastocyst development
M0005783cellular_componentendoplasmic reticulum
M0005789cellular_componentendoplasmic reticulum membrane
M0006486biological_processprotein glycosylation
M0006487biological_processprotein N-linked glycosylation
M0006915biological_processapoptotic process
M0008047molecular_functionenzyme activator activity
M0008250cellular_componentoligosaccharyltransferase complex
M0016020cellular_componentmembrane
M0018279biological_processprotein N-linked glycosylation via asparagine
M0031647biological_processregulation of protein stability
M0043066biological_processnegative regulation of apoptotic process
N0005789cellular_componentendoplasmic reticulum membrane
N0018279biological_processprotein N-linked glycosylation via asparagine
O0006486biological_processprotein glycosylation
O0016020cellular_componentmembrane
P0006487biological_processprotein N-linked glycosylation
P0008250cellular_componentoligosaccharyltransferase complex
P0016020cellular_componentmembrane
Functional Information from PROSITE/UniProt
site_idPS00755
Number of Residues20
DetailsSECY_1 Protein secY signature 1. TLMeLGIsPIVtSGLIMQLL
ChainResidueDetails
ATHR75-LEU94

site_idPS00756
Number of Residues19
DetailsSECY_2 Protein secY signature 2. LLdElLQkgyGLGSGiSLF
ChainResidueDetails
ALEU164-PHE182

site_idPS01067
Number of Residues29
DetailsSECE_SEC61G Protein secE/sec61-gamma signature. FvKDsIrlVkRctKPdrkEfqkiaMATAI
ChainResidueDetails
CPHE14-ILE42

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues520
DetailsTOPO_DOM: Lumenal => ECO:0000255
ChainResidueDetails
PLEU23-VAL540
PTYR593-GLN596
IGLY190-SER191
ITHR229-SER233
ISER288-ARG300
ISER380-ALA385
ITYR429-LYS453

site_idSWS_FT_FI2
Number of Residues60
DetailsTRANSMEM: Helical => ECO:0000255
ChainResidueDetails
PVAL541-ILE561
AGLY423-VAL439
PPHE572-VAL592
PLEU597-GLY617
GVAL164-SER184
ATYR173-TRP193
AASN241-PHE261
AILE283-SER303
ALEU332-PHE352
AALA398-ILE418

site_idSWS_FT_FI3
Number of Residues22
DetailsTOPO_DOM: Cytoplasmic => ECO:0000255
ChainResidueDetails
PARG562-THR571
PASN618-HIS631
ISER207-GLY211
IGLN260-HIS267
ILYS322-THR356
IMET403-LEU406
IHIS474-THR705

site_idSWS_FT_FI4
Number of Residues1
DetailsCARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:19159218
ChainResidueDetails
PASN106
IMET407-THR428
IASN454-PHE473
IALA141-ILE158
IGLY170-THR189
IILE192-VAL206
ITYR212-LEU228
IHIS234-PHE259
IMET268-ARG287
ITRP357-PHE379
IARG386-VAL402

site_idSWS_FT_FI5
Number of Residues2
DetailsCROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)
ChainResidueDetails
PLYS154
IASP167
IGLU169
IARG405
ITYR530

site_idSWS_FT_FI6
Number of Residues1
DetailsCARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:19159218
ChainResidueDetails
OASN299
IGLU351
ILYS595

site_idSWS_FT_FI7
Number of Residues2
DetailsCROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternate => ECO:0007744|PubMed:25114211
ChainResidueDetails
OLYS538

site_idSWS_FT_FI8
Number of Residues2
DetailsCARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:19159218
ChainResidueDetails
IASN537
IASN544

site_idSWS_FT_FI9
Number of Residues1
DetailsCARBOHYD: N-linked (GlcNAc...) (high mannose) asparagine => ECO:0000269|PubMed:19159218
ChainResidueDetails
IASN548

site_idSWS_FT_FI10
Number of Residues1
DetailsLIPID: S-palmitoyl cysteine => ECO:0000305|PubMed:21044946
ChainResidueDetails
BCYS39

224572

PDB entries from 2024-09-04

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