8B51
Usutu virus methyltransferase domain in complex with sinefungin
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004482 | molecular_function | mRNA 5'-cap (guanine-N7-)-methyltransferase activity |
| A | 0004483 | molecular_function | mRNA (nucleoside-2'-O-)-methyltransferase activity |
| A | 0008168 | molecular_function | methyltransferase activity |
| A | 0032259 | biological_process | methylation |
| B | 0004482 | molecular_function | mRNA 5'-cap (guanine-N7-)-methyltransferase activity |
| B | 0004483 | molecular_function | mRNA (nucleoside-2'-O-)-methyltransferase activity |
| B | 0008168 | molecular_function | methyltransferase activity |
| B | 0032259 | biological_process | methylation |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 8 |
| Details | ACT_SITE: For 2'-O-MTase activity => ECO:0000250|UniProtKB:Q6YMS4 |
| Chain | Residue | Details |
| A | LYS62 | |
| A | ASP147 | |
| A | LYS183 | |
| A | GLU219 | |
| B | LYS62 | |
| B | ASP147 | |
| B | LYS183 | |
| B | GLU219 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 18 |
| Details | BINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU00924 |
| Chain | Residue | Details |
| A | SER57 | |
| A | GLY87 | |
| A | TRP88 | |
| A | THR105 | |
| A | LYS106 | |
| A | ASP132 | |
| A | VAL133 | |
| A | ILE148 | |
| A | TYR221 | |
| B | SER57 | |
| B | GLY87 | |
| B | TRP88 | |
| B | THR105 | |
| B | LYS106 | |
| B | ASP132 | |
| B | VAL133 | |
| B | ILE148 | |
| B | TYR221 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 14 |
| Details | SITE: mRNA cap binding => ECO:0000255|PROSITE-ProRule:PRU00924 |
| Chain | Residue | Details |
| A | LYS14 | |
| A | ASN18 | |
| A | PHE25 | |
| A | ARG29 | |
| A | SER151 | |
| A | ARG214 | |
| A | SER216 | |
| B | LYS14 | |
| B | ASN18 | |
| B | PHE25 | |
| B | ARG29 | |
| B | SER151 | |
| B | ARG214 | |
| B | SER216 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 4 |
| Details | SITE: mRNA cap binding; via carbonyl oxygen => ECO:0000255|PROSITE-ProRule:PRU00924 |
| Chain | Residue | Details |
| A | LEU17 | |
| A | LEU20 | |
| B | LEU17 | |
| B | LEU20 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 6 |
| Details | SITE: Essential for 2'-O-methyltransferase activity => ECO:0000255|PROSITE-ProRule:PRU00924 |
| Chain | Residue | Details |
| A | LYS62 | |
| A | LYS183 | |
| A | GLU219 | |
| B | LYS62 | |
| B | LYS183 | |
| B | GLU219 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 2 |
| Details | SITE: Essential for 2'-O-methyltransferase and N-7 methyltransferase activity => ECO:0000255|PROSITE-ProRule:PRU00924 |
| Chain | Residue | Details |
| A | ASP147 | |
| B | ASP147 |
| site_id | SWS_FT_FI7 |
| Number of Residues | 2 |
| Details | MOD_RES: Phosphoserine => ECO:0000250|UniProtKB:P03314 |
| Chain | Residue | Details |
| A | SER57 | |
| B | SER57 |
