8B3I

CRL4CSA-E2-Ub (state 2)

Functional Information from GO Data

Chain	GOid	namespace	contents
a	0000012	biological_process	single strand break repair
a	0000109	cellular_component	nucleotide-excision repair complex
a	0000209	biological_process	protein polyubiquitination
a	0004842	molecular_function	ubiquitin-protein transferase activity
a	0005515	molecular_function	protein binding
a	0005634	cellular_component	nucleus
a	0005654	cellular_component	nucleoplasm
a	0006281	biological_process	DNA repair
a	0006283	biological_process	transcription-coupled nucleotide-excision repair
a	0006974	biological_process	DNA damage response
a	0006979	biological_process	response to oxidative stress
a	0009411	biological_process	response to UV
a	0010165	biological_process	response to X-ray
a	0016363	cellular_component	nuclear matrix
a	0016567	biological_process	protein ubiquitination
a	0031464	cellular_component	Cul4A-RING E3 ubiquitin ligase complex
a	0032991	cellular_component	protein-containing complex
a	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
a	0044877	molecular_function	protein-containing complex binding
a	0051865	biological_process	protein autoubiquitination
a	0080008	cellular_component	Cul4-RING E3 ubiquitin ligase complex
a	0090262	biological_process	regulation of transcription-coupled nucleotide-excision repair
a	0097680	biological_process	double-strand break repair via classical nonhomologous end joining
d	0000781	cellular_component	chromosome, telomeric region
d	0003676	molecular_function	nucleic acid binding
d	0003677	molecular_function	DNA binding
d	0003684	molecular_function	damaged DNA binding
d	0005515	molecular_function	protein binding
d	0005615	cellular_component	extracellular space
d	0005634	cellular_component	nucleus
d	0005654	cellular_component	nucleoplasm
d	0005730	cellular_component	nucleolus
d	0005737	cellular_component	cytoplasm
d	0006281	biological_process	DNA repair
d	0006289	biological_process	nucleotide-excision repair
d	0006511	biological_process	ubiquitin-dependent protein catabolic process
d	0006915	biological_process	apoptotic process
d	0006974	biological_process	DNA damage response
d	0007056	biological_process	spindle assembly involved in female meiosis
d	0010498	biological_process	proteasomal protein catabolic process
d	0016055	biological_process	Wnt signaling pathway
d	0016567	biological_process	protein ubiquitination
d	0019076	biological_process	viral release from host cell
d	0030674	molecular_function	protein-macromolecule adaptor activity
d	0031464	cellular_component	Cul4A-RING E3 ubiquitin ligase complex
d	0031465	cellular_component	Cul4B-RING E3 ubiquitin ligase complex
d	0032991	cellular_component	protein-containing complex
d	0034644	biological_process	cellular response to UV
d	0035234	biological_process	ectopic germ cell programmed cell death
d	0035861	cellular_component	site of double-strand break
d	0042752	biological_process	regulation of circadian rhythm
d	0043066	biological_process	negative regulation of apoptotic process
d	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
d	0044725	biological_process	epigenetic programming in the zygotic pronuclei
d	0044877	molecular_function	protein-containing complex binding
d	0045070	biological_process	positive regulation of viral genome replication
d	0045722	biological_process	positive regulation of gluconeogenesis
d	0045732	biological_process	positive regulation of protein catabolic process
d	0046726	biological_process	positive regulation by virus of viral protein levels in host cell
d	0048511	biological_process	rhythmic process
d	0051093	biological_process	negative regulation of developmental process
d	0051702	biological_process	biological process involved in interaction with symbiont
d	0070062	cellular_component	extracellular exosome
d	0070914	biological_process	UV-damage excision repair
d	0071987	molecular_function	WD40-repeat domain binding
d	0080008	cellular_component	Cul4-RING E3 ubiquitin ligase complex
d	0097602	molecular_function	cullin family protein binding
d	0160072	molecular_function	ubiquitin ligase complex scaffold activity
d	1901990	biological_process	regulation of mitotic cell cycle phase transition
d	2000242	biological_process	negative regulation of reproductive process
D	0000151	cellular_component	ubiquitin ligase complex
D	0000209	biological_process	protein polyubiquitination
D	0004842	molecular_function	ubiquitin-protein transferase activity
D	0005515	molecular_function	protein binding
D	0005524	molecular_function	ATP binding
D	0005634	cellular_component	nucleus
D	0005654	cellular_component	nucleoplasm
D	0005829	cellular_component	cytosol
D	0006511	biological_process	ubiquitin-dependent protein catabolic process
D	0016567	biological_process	protein ubiquitination
D	0016740	molecular_function	transferase activity
D	0019787	molecular_function	ubiquitin-like protein transferase activity
D	0031371	cellular_component	ubiquitin conjugating enzyme complex
D	0031625	molecular_function	ubiquitin protein ligase binding
D	0032991	cellular_component	protein-containing complex
D	0036211	biological_process	protein modification process
D	0051865	biological_process	protein autoubiquitination
D	0061630	molecular_function	ubiquitin protein ligase activity
D	0061631	molecular_function	ubiquitin conjugating enzyme activity
D	0070062	cellular_component	extracellular exosome
D	0070936	biological_process	protein K48-linked ubiquitination
e	0000082	biological_process	G1/S transition of mitotic cell cycle
e	0001701	biological_process	in utero embryonic development
e	0005515	molecular_function	protein binding
e	0005634	cellular_component	nucleus
e	0005654	cellular_component	nucleoplasm
e	0005737	cellular_component	cytoplasm
e	0006281	biological_process	DNA repair
e	0006511	biological_process	ubiquitin-dependent protein catabolic process
e	0006974	biological_process	DNA damage response
e	0007283	biological_process	spermatogenesis
e	0008283	biological_process	cell population proliferation
e	0008284	biological_process	positive regulation of cell population proliferation
e	0016567	biological_process	protein ubiquitination
e	0030097	biological_process	hemopoiesis
e	0030853	biological_process	negative regulation of granulocyte differentiation
e	0031461	cellular_component	cullin-RING ubiquitin ligase complex
e	0031464	cellular_component	Cul4A-RING E3 ubiquitin ligase complex
e	0031625	molecular_function	ubiquitin protein ligase binding
e	0034644	biological_process	cellular response to UV
e	0035019	biological_process	somatic stem cell population maintenance
e	0042110	biological_process	T cell activation
e	0042254	biological_process	ribosome biogenesis
e	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
e	0045732	biological_process	positive regulation of protein catabolic process
e	0048511	biological_process	rhythmic process
e	0051246	biological_process	regulation of protein metabolic process
e	0061630	molecular_function	ubiquitin protein ligase activity
e	0080008	cellular_component	Cul4-RING E3 ubiquitin ligase complex
e	0097193	biological_process	intrinsic apoptotic signaling pathway
e	0140627	biological_process	ubiquitin-dependent protein catabolic process via the C-end degron rule pathway
e	0160072	molecular_function	ubiquitin ligase complex scaffold activity
e	1900087	biological_process	positive regulation of G1/S transition of mitotic cell cycle
e	2000001	biological_process	regulation of DNA damage checkpoint
e	2000819	biological_process	regulation of nucleotide-excision repair
N	0005515	molecular_function	protein binding
N	0005634	cellular_component	nucleus
N	0005654	cellular_component	nucleoplasm
N	0005829	cellular_component	cytosol
N	0006357	biological_process	regulation of transcription by RNA polymerase II
N	0006508	biological_process	proteolysis
N	0006511	biological_process	ubiquitin-dependent protein catabolic process
N	0008104	biological_process	protein localization
N	0009653	biological_process	anatomical structure morphogenesis
N	0016567	biological_process	protein ubiquitination
N	0019941	biological_process	modification-dependent protein catabolic process
N	0030162	biological_process	regulation of proteolysis
N	0031386	molecular_function	protein tag activity
N	0031625	molecular_function	ubiquitin protein ligase binding
N	0036211	biological_process	protein modification process
N	0045116	biological_process	protein neddylation
N	0070062	cellular_component	extracellular exosome
R	0000165	biological_process	MAPK cascade
R	0000209	biological_process	protein polyubiquitination
R	0004842	molecular_function	ubiquitin-protein transferase activity
R	0005515	molecular_function	protein binding
R	0005634	cellular_component	nucleus
R	0005654	cellular_component	nucleoplasm
R	0005737	cellular_component	cytoplasm
R	0005829	cellular_component	cytosol
R	0006281	biological_process	DNA repair
R	0006511	biological_process	ubiquitin-dependent protein catabolic process
R	0006513	biological_process	protein monoubiquitination
R	0006974	biological_process	DNA damage response
R	0007283	biological_process	spermatogenesis
R	0008270	molecular_function	zinc ion binding
R	0016567	biological_process	protein ubiquitination
R	0016740	molecular_function	transferase activity
R	0019005	cellular_component	SCF ubiquitin ligase complex
R	0019788	molecular_function	NEDD8 transferase activity
R	0030163	biological_process	protein catabolic process
R	0031146	biological_process	SCF-dependent proteasomal ubiquitin-dependent protein catabolic process
R	0031461	cellular_component	cullin-RING ubiquitin ligase complex
R	0031462	cellular_component	Cul2-RING ubiquitin ligase complex
R	0031463	cellular_component	Cul3-RING ubiquitin ligase complex
R	0031464	cellular_component	Cul4A-RING E3 ubiquitin ligase complex
R	0031465	cellular_component	Cul4B-RING E3 ubiquitin ligase complex
R	0031466	cellular_component	Cul5-RING ubiquitin ligase complex
R	0031467	cellular_component	Cul7-RING ubiquitin ligase complex
R	0031625	molecular_function	ubiquitin protein ligase binding
R	0032436	biological_process	positive regulation of proteasomal ubiquitin-dependent protein catabolic process
R	0032480	biological_process	negative regulation of type I interferon production
R	0034450	molecular_function	ubiquitin-ubiquitin ligase activity
R	0034644	biological_process	cellular response to UV
R	0042110	biological_process	T cell activation
R	0043123	biological_process	positive regulation of canonical NF-kappaB signal transduction
R	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
R	0043687	biological_process	post-translational protein modification
R	0045116	biological_process	protein neddylation
R	0045732	biological_process	positive regulation of protein catabolic process
R	0046872	molecular_function	metal ion binding
R	0060090	molecular_function	molecular adaptor activity
R	0061629	molecular_function	RNA polymerase II-specific DNA-binding transcription factor binding
R	0061630	molecular_function	ubiquitin protein ligase activity
R	0061663	molecular_function	NEDD8 ligase activity
R	0062197	biological_process	cellular response to chemical stress
R	0070936	biological_process	protein K48-linked ubiquitination
R	0071230	biological_process	cellular response to amino acid stimulus
R	0090090	biological_process	negative regulation of canonical Wnt signaling pathway
R	0097602	molecular_function	cullin family protein binding
R	0140627	biological_process	ubiquitin-dependent protein catabolic process via the C-end degron rule pathway
R	1900076	biological_process	regulation of cellular response to insulin stimulus
R	1902499	biological_process	positive regulation of protein autoubiquitination
R	1902883	biological_process	negative regulation of response to oxidative stress
R	1904263	biological_process	positive regulation of TORC1 signaling

Functional Information from PROSITE/UniProt

site_id	PS00183
Number of Residues	16
Details	UBC_1 Ubiquitin-conjugating (UBC) active site signature. YHPNInsn.GsICLdiL

Chain	Residue	Details
D	TYR74-LEU89

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site_id	PS00299
Number of Residues	26
Details	UBIQUITIN_1 Ubiquitin domain signature. KakIqDkegIPpdqQrLIFaGkqleD

Chain	Residue	Details
U	LYS27-ASP52
N	LYS27-ASP52

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site_id	PS00678
Number of Residues	15
Details	WD_REPEATS_1 Trp-Asp (WD) repeats signature. LATAsaDsRVKLWDV

Chain	Residue	Details
a	LEU202-VAL216
a	LEU260-SER274

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site_id	PS01256
Number of Residues	28
Details	CULLIN_1 Cullin family signature. LKkrIesLIDRdYMeRdkdnpnqYhYvA

Chain	Residue	Details
e	LEU732-ALA759

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:23186163, ECO:0007744|PubMed:24275569

Chain	Residue	Details
e	SER10
a	SER391
a	SER392

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site_id	SWS_FT_FI2
Number of Residues	1
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) => ECO:0007744|PubMed:28112733

Chain	Residue	Details
e	LYS8
R	CYS94
R	ASP97
R	CYS45
R	CYS53
R	CYS56
R	CYS68
R	CYS75
R	HIS77
R	HIS80
R	HIS82

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site_id	SWS_FT_FI3
Number of Residues	2
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in NEDD8) => ECO:0000250|UniProtKB:Q13616

Chain	Residue	Details
d	THR1125
e	LYS705

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site_id	SWS_FT_FI4
Number of Residues	1
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)

Chain	Residue	Details
e	LYS33

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site_id	SWS_FT_FI5
Number of Residues	1
Details	MOD_RES: ADP-ribosylglycine => ECO:0000269|PubMed:28525742

Chain	Residue	Details
U	GLY76

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site_id	SWS_FT_FI6
Number of Residues	1
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:16443603

Chain	Residue	Details
U	LYS6

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site_id	SWS_FT_FI7
Number of Residues	2
Details	CROSSLNK: Glycyl lysine isopeptide (Gly-Lys) (interchain with K-? in acceptor proteins)

Chain	Residue	Details
U	GLY76

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site_id	SWS_FT_FI8
Number of Residues	2
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:16443603, ECO:0000269|PubMed:16543144

Chain	Residue	Details
U	LYS11
U	LYS48

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site_id	SWS_FT_FI9
Number of Residues	1
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000305|PubMed:15466860

Chain	Residue	Details
U	LYS27

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site_id	SWS_FT_FI10
Number of Residues	1
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:16543144, ECO:0000269|PubMed:25752573, ECO:0000269|PubMed:25752577, ECO:0000269|PubMed:34239127

Chain	Residue	Details
U	LYS29

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site_id	SWS_FT_FI11
Number of Residues	1
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:25752577

Chain	Residue	Details
U	LYS33

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site_id	SWS_FT_FI12
Number of Residues	1
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:16543144, ECO:0000269|PubMed:18719106

Chain	Residue	Details
U	LYS63

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