8AZU
Paired helical tau filaments from high-spin supernatants of aqueous extracts from Alzheimer's disease brains | PHF Tau
Functional Information from GO Data
Functional Information from PROSITE/UniProt
| site_id | PS00229 |
| Number of Residues | 13 |
| Details | TAU_MAP_1 Tau and MAP proteins tubulin-binding repeat signature. GSteNlkHqPGGG |
| Chain | Residue | Details |
| C | GLY261-GLY273 | |
| C | GLY292-GLY304 | |
| C | GLY323-GLY335 | |
| C | GLY355-GLY367 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 7 |
| Details | SITE: Not glycated => ECO:0000269|PubMed:9326300 |
| Chain | Residue | Details |
| C | LYS24 | |
| C | LYS44 | |
| C | LYS67 | |
| C | ASN381 | |
| C | GLU391 | |
| C | ILE392 | |
| C | TYR394 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 1 |
| Details | MOD_RES: N-acetylalanine => ECO:0000269|PubMed:1512244 |
| Chain | Residue | Details |
| C | ALA2 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphotyrosine; by FYN => ECO:0000269|PubMed:14999081 |
| Chain | Residue | Details |
| C | TYR18 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphotyrosine => ECO:0000250|UniProtKB:P10637 |
| Chain | Residue | Details |
| C | TYR29 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 2 |
| Details | MOD_RES: Phosphoserine => ECO:0000250|UniProtKB:P19332 |
| Chain | Residue | Details |
| C | SER46 | |
| C | SER61 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 2 |
| Details | MOD_RES: Phosphothreonine => ECO:0000250|UniProtKB:P10637 |
| Chain | Residue | Details |
| C | THR69 | |
| C | THR111 |
| site_id | SWS_FT_FI7 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphothreonine => ECO:0000250|UniProtKB:P19332 |
| Chain | Residue | Details |
| C | THR71 |
| site_id | SWS_FT_FI8 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphoserine; by SGK1 => ECO:0000269|PubMed:16982696 |
| Chain | Residue | Details |
| C | SER214 |
| site_id | SWS_FT_FI9 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphoserine; in PHF-tau => ECO:0000269|PubMed:1899488 |
| Chain | Residue | Details |
| C | SER396 |
| site_id | SWS_FT_FI10 |
| Number of Residues | 2 |
| Details | CARBOHYD: N-linked (Glc) (glycation) lysine; in PHF-tau; in vitro => ECO:0000269|PubMed:9326300 |
| Chain | Residue | Details |
| C | LYS87 | |
| C | LYS383 |
| site_id | SWS_FT_FI11 |
| Number of Residues | 2 |
| Details | CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000250|UniProtKB:P10637 |
| Chain | Residue | Details |
| C | LYS44 |
