8AVD
Cryo-EM structure for a 3:3 complex between mouse leptin and the mouse LEP-R ectodomain (local refinement)
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0005179 | molecular_function | hormone activity |
| A | 0005576 | cellular_component | extracellular region |
| A | 0007165 | biological_process | signal transduction |
| B | 0003700 | molecular_function | DNA-binding transcription factor activity |
| B | 0004896 | molecular_function | cytokine receptor activity |
| B | 0006355 | biological_process | regulation of DNA-templated transcription |
| B | 0016020 | cellular_component | membrane |
| C | 0005179 | molecular_function | hormone activity |
| C | 0005576 | cellular_component | extracellular region |
| C | 0007165 | biological_process | signal transduction |
| D | 0003700 | molecular_function | DNA-binding transcription factor activity |
| D | 0004896 | molecular_function | cytokine receptor activity |
| D | 0006355 | biological_process | regulation of DNA-templated transcription |
| D | 0016020 | cellular_component | membrane |
| E | 0005179 | molecular_function | hormone activity |
| E | 0005576 | cellular_component | extracellular region |
| E | 0007165 | biological_process | signal transduction |
| F | 0003700 | molecular_function | DNA-binding transcription factor activity |
| F | 0004896 | molecular_function | cytokine receptor activity |
| F | 0006355 | biological_process | regulation of DNA-templated transcription |
| F | 0016020 | cellular_component | membrane |
Functional Information from PROSITE/UniProt
| site_id | PS01353 |
| Number of Residues | 57 |
| Details | HEMATOPO_REC_L_F2 Long hematopoietin receptor, gp130 family signature. NslgaSlvnfnltfswpmskvsaveslsayplssscvi...LsWtlsPddysll...YlvIeW |
| Chain | Residue | Details |
| B | ASN716-TRP772 |
| site_id | PS01355 |
| Number of Residues | 31 |
| Details | HEMATOPO_REC_S_F1 Short hematopoietin receptor family 1 signature. VlpgssyevqVRskrldgsgv...........WSdWSspqvF |
| Chain | Residue | Details |
| B | VAL296-PHE326 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 279 |
| Details | Domain: {"description":"Fibronectin type-III 1","evidences":[{"source":"PROSITE-ProRule","id":"PRU00316","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 294 |
| Details | Domain: {"description":"Ig-like"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 285 |
| Details | Domain: {"description":"Fibronectin type-III 2","evidences":[{"source":"PROSITE-ProRule","id":"PRU00316","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 51 |
| Details | Region: {"description":"Leptin-binding","evidences":[{"source":"UniProtKB","id":"P48357","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 12 |
| Details | Motif: {"description":"WSXWS motif"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 15 |
| Details | Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
