8AVD

Cryo-EM structure for a 3:3 complex between mouse leptin and the mouse LEP-R ectodomain (local refinement)

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005179	molecular_function	hormone activity
A	0005576	cellular_component	extracellular region
A	0007165	biological_process	signal transduction
B	0003700	molecular_function	DNA-binding transcription factor activity
B	0004896	molecular_function	cytokine receptor activity
B	0006355	biological_process	regulation of DNA-templated transcription
B	0016020	cellular_component	membrane
C	0005179	molecular_function	hormone activity
C	0005576	cellular_component	extracellular region
C	0007165	biological_process	signal transduction
D	0003700	molecular_function	DNA-binding transcription factor activity
D	0004896	molecular_function	cytokine receptor activity
D	0006355	biological_process	regulation of DNA-templated transcription
D	0016020	cellular_component	membrane
E	0005179	molecular_function	hormone activity
E	0005576	cellular_component	extracellular region
E	0007165	biological_process	signal transduction
F	0003700	molecular_function	DNA-binding transcription factor activity
F	0004896	molecular_function	cytokine receptor activity
F	0006355	biological_process	regulation of DNA-templated transcription
F	0016020	cellular_component	membrane

Functional Information from PROSITE/UniProt

site_id	PS01353
Number of Residues	57
Details	HEMATOPO_REC_L_F2 Long hematopoietin receptor, gp130 family signature. NslgaSlvnfnltfswpmskvsaveslsayplssscvi...LsWtlsPddysll...YlvIeW

Chain	Residue	Details
B	ASN716-TRP772

site_id	PS01355
Number of Residues	31
Details	HEMATOPO_REC_S_F1 Short hematopoietin receptor family 1 signature. VlpgssyevqVRskrldgsgv...........WSdWSspqvF

Chain	Residue	Details
B	VAL296-PHE326

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI2
Number of Residues	48
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255