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8AS4

Crystal structure of human beta-arrestin-1

Functional Information from GO Data
ChainGOidnamespacecontents
A0000139cellular_componentGolgi membrane
A0000785cellular_componentchromatin
A0001664molecular_functionG protein-coupled receptor binding
A0001934biological_processpositive regulation of protein phosphorylation
A0002029biological_processdesensitization of G protein-coupled receptor signaling pathway
A0002031biological_processG protein-coupled receptor internalization
A0002092biological_processpositive regulation of receptor internalization
A0003713molecular_functiontranscription coactivator activity
A0004402molecular_functionhistone acetyltransferase activity
A0004857molecular_functionenzyme inhibitor activity
A0005096molecular_functionGTPase activator activity
A0005159molecular_functioninsulin-like growth factor receptor binding
A0005515molecular_functionprotein binding
A0005634cellular_componentnucleus
A0005654cellular_componentnucleoplasm
A0005737cellular_componentcytoplasm
A0005765cellular_componentlysosomal membrane
A0005829cellular_componentcytosol
A0005886cellular_componentplasma membrane
A0005905cellular_componentclathrin-coated pit
A0006357biological_processregulation of transcription by RNA polymerase II
A0006511biological_processubiquitin-dependent protein catabolic process
A0007165biological_processsignal transduction
A0007600biological_processsensory perception
A0009968biological_processnegative regulation of signal transduction
A0010613biological_processpositive regulation of cardiac muscle hypertrophy
A0015031biological_processprotein transport
A0016020cellular_componentmembrane
A0016567biological_processprotein ubiquitination
A0016604cellular_componentnuclear body
A0019899molecular_functionenzyme binding
A0030659cellular_componentcytoplasmic vesicle membrane
A0030666cellular_componentendocytic vesicle membrane
A0031143cellular_componentpseudopodium
A0031397biological_processnegative regulation of protein ubiquitination
A0031410cellular_componentcytoplasmic vesicle
A0031625molecular_functionubiquitin protein ligase binding
A0031701molecular_functionangiotensin receptor binding
A0032088biological_processnegative regulation of NF-kappaB transcription factor activity
A0032715biological_processnegative regulation of interleukin-6 production
A0032717biological_processnegative regulation of interleukin-8 production
A0035025biological_processpositive regulation of Rho protein signal transduction
A0042995cellular_componentcell projection
A0043149biological_processstress fiber assembly
A0043161biological_processproteasome-mediated ubiquitin-dependent protein catabolic process
A0045746biological_processnegative regulation of Notch signaling pathway
A0045944biological_processpositive regulation of transcription by RNA polymerase II
A0060090molecular_functionmolecular adaptor activity
A0070374biological_processpositive regulation of ERK1 and ERK2 cascade
A1902533biological_processpositive regulation of intracellular signal transduction
A1990763molecular_functionarrestin family protein binding
B0000139cellular_componentGolgi membrane
B0000785cellular_componentchromatin
B0001664molecular_functionG protein-coupled receptor binding
B0001934biological_processpositive regulation of protein phosphorylation
B0002029biological_processdesensitization of G protein-coupled receptor signaling pathway
B0002031biological_processG protein-coupled receptor internalization
B0002092biological_processpositive regulation of receptor internalization
B0003713molecular_functiontranscription coactivator activity
B0004402molecular_functionhistone acetyltransferase activity
B0004857molecular_functionenzyme inhibitor activity
B0005096molecular_functionGTPase activator activity
B0005159molecular_functioninsulin-like growth factor receptor binding
B0005515molecular_functionprotein binding
B0005634cellular_componentnucleus
B0005654cellular_componentnucleoplasm
B0005737cellular_componentcytoplasm
B0005765cellular_componentlysosomal membrane
B0005829cellular_componentcytosol
B0005886cellular_componentplasma membrane
B0005905cellular_componentclathrin-coated pit
B0006357biological_processregulation of transcription by RNA polymerase II
B0006511biological_processubiquitin-dependent protein catabolic process
B0007165biological_processsignal transduction
B0007600biological_processsensory perception
B0009968biological_processnegative regulation of signal transduction
B0010613biological_processpositive regulation of cardiac muscle hypertrophy
B0015031biological_processprotein transport
B0016020cellular_componentmembrane
B0016567biological_processprotein ubiquitination
B0016604cellular_componentnuclear body
B0019899molecular_functionenzyme binding
B0030659cellular_componentcytoplasmic vesicle membrane
B0030666cellular_componentendocytic vesicle membrane
B0031143cellular_componentpseudopodium
B0031397biological_processnegative regulation of protein ubiquitination
B0031410cellular_componentcytoplasmic vesicle
B0031625molecular_functionubiquitin protein ligase binding
B0031701molecular_functionangiotensin receptor binding
B0032088biological_processnegative regulation of NF-kappaB transcription factor activity
B0032715biological_processnegative regulation of interleukin-6 production
B0032717biological_processnegative regulation of interleukin-8 production
B0035025biological_processpositive regulation of Rho protein signal transduction
B0042995cellular_componentcell projection
B0043149biological_processstress fiber assembly
B0043161biological_processproteasome-mediated ubiquitin-dependent protein catabolic process
B0045746biological_processnegative regulation of Notch signaling pathway
B0045944biological_processpositive regulation of transcription by RNA polymerase II
B0060090molecular_functionmolecular adaptor activity
B0070374biological_processpositive regulation of ERK1 and ERK2 cascade
B1902533biological_processpositive regulation of intracellular signal transduction
B1990763molecular_functionarrestin family protein binding
Functional Information from PROSITE/UniProt
site_idPS00295
Number of Residues19
DetailsARRESTINS Arrestins signature. FRYGrEDlDVLGLtFrKDL
ChainResidueDetails
APHE61-LEU79

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues8
DetailsBinding site: {"evidences":[{"evidenceCode":"ECO:0000250"}]}
ChainResidueDetails

site_idSWS_FT_FI2
Number of Residues2
DetailsModified residue: {"description":"Phosphotyrosine","evidences":[{"source":"UniProtKB","id":"Q8BWG8","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails

site_idSWS_FT_FI3
Number of Residues41
DetailsRegion: {"description":"Interaction with CHRM2","evidences":[{"evidenceCode":"ECO:0000250"}]}
ChainResidueDetails

site_idSWS_FT_FI4
Number of Residues10
DetailsMotif: {"description":"[DE]-X(1,2)-F-X-X-[FL]-X-X-X-R motif"}
ChainResidueDetails

239492

PDB entries from 2025-07-30

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