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8AS4

Crystal structure of human beta-arrestin-1

Functional Information from GO Data
ChainGOidnamespacecontents
A0000139cellular_componentGolgi membrane
A0000785cellular_componentchromatin
A0001664molecular_functionG protein-coupled receptor binding
A0001934biological_processpositive regulation of protein phosphorylation
A0002031biological_processG protein-coupled receptor internalization
A0002092biological_processpositive regulation of receptor internalization
A0003713molecular_functiontranscription coactivator activity
A0004402molecular_functionhistone acetyltransferase activity
A0004857molecular_functionenzyme inhibitor activity
A0005096molecular_functionGTPase activator activity
A0005159molecular_functioninsulin-like growth factor receptor binding
A0005515molecular_functionprotein binding
A0005634cellular_componentnucleus
A0005654cellular_componentnucleoplasm
A0005737cellular_componentcytoplasm
A0005765cellular_componentlysosomal membrane
A0005829cellular_componentcytosol
A0005886cellular_componentplasma membrane
A0005905cellular_componentclathrin-coated pit
A0006357biological_processregulation of transcription by RNA polymerase II
A0006511biological_processubiquitin-dependent protein catabolic process
A0007165biological_processsignal transduction
A0007601biological_processvisual perception
A0009968biological_processnegative regulation of signal transduction
A0015031biological_processprotein transport
A0016567biological_processprotein ubiquitination
A0016604cellular_componentnuclear body
A0030659cellular_componentcytoplasmic vesicle membrane
A0030666cellular_componentendocytic vesicle membrane
A0031143cellular_componentpseudopodium
A0031397biological_processnegative regulation of protein ubiquitination
A0031410cellular_componentcytoplasmic vesicle
A0031625molecular_functionubiquitin protein ligase binding
A0031701molecular_functionangiotensin receptor binding
A0032088biological_processnegative regulation of NF-kappaB transcription factor activity
A0032715biological_processnegative regulation of interleukin-6 production
A0032717biological_processnegative regulation of interleukin-8 production
A0035025biological_processpositive regulation of Rho protein signal transduction
A0042995cellular_componentcell projection
A0043149biological_processstress fiber assembly
A0043161biological_processproteasome-mediated ubiquitin-dependent protein catabolic process
A0045746biological_processnegative regulation of Notch signaling pathway
A0045944biological_processpositive regulation of transcription by RNA polymerase II
A0070374biological_processpositive regulation of ERK1 and ERK2 cascade
A1990763molecular_functionarrestin family protein binding
B0000139cellular_componentGolgi membrane
B0000785cellular_componentchromatin
B0001664molecular_functionG protein-coupled receptor binding
B0001934biological_processpositive regulation of protein phosphorylation
B0002031biological_processG protein-coupled receptor internalization
B0002092biological_processpositive regulation of receptor internalization
B0003713molecular_functiontranscription coactivator activity
B0004402molecular_functionhistone acetyltransferase activity
B0004857molecular_functionenzyme inhibitor activity
B0005096molecular_functionGTPase activator activity
B0005159molecular_functioninsulin-like growth factor receptor binding
B0005515molecular_functionprotein binding
B0005634cellular_componentnucleus
B0005654cellular_componentnucleoplasm
B0005737cellular_componentcytoplasm
B0005765cellular_componentlysosomal membrane
B0005829cellular_componentcytosol
B0005886cellular_componentplasma membrane
B0005905cellular_componentclathrin-coated pit
B0006357biological_processregulation of transcription by RNA polymerase II
B0006511biological_processubiquitin-dependent protein catabolic process
B0007165biological_processsignal transduction
B0007601biological_processvisual perception
B0009968biological_processnegative regulation of signal transduction
B0015031biological_processprotein transport
B0016567biological_processprotein ubiquitination
B0016604cellular_componentnuclear body
B0030659cellular_componentcytoplasmic vesicle membrane
B0030666cellular_componentendocytic vesicle membrane
B0031143cellular_componentpseudopodium
B0031397biological_processnegative regulation of protein ubiquitination
B0031410cellular_componentcytoplasmic vesicle
B0031625molecular_functionubiquitin protein ligase binding
B0031701molecular_functionangiotensin receptor binding
B0032088biological_processnegative regulation of NF-kappaB transcription factor activity
B0032715biological_processnegative regulation of interleukin-6 production
B0032717biological_processnegative regulation of interleukin-8 production
B0035025biological_processpositive regulation of Rho protein signal transduction
B0042995cellular_componentcell projection
B0043149biological_processstress fiber assembly
B0043161biological_processproteasome-mediated ubiquitin-dependent protein catabolic process
B0045746biological_processnegative regulation of Notch signaling pathway
B0045944biological_processpositive regulation of transcription by RNA polymerase II
B0070374biological_processpositive regulation of ERK1 and ERK2 cascade
B1990763molecular_functionarrestin family protein binding
Functional Information from PROSITE/UniProt
site_idPS00295
Number of Residues19
DetailsARRESTINS Arrestins signature. FRYGrEDlDVLGLtFrKDL
ChainResidueDetails
APHE61-LEU79

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues8
DetailsBINDING: BINDING => ECO:0000250
ChainResidueDetails
ALYS250
AMET255
ALYS324
ALYS326
BLYS250
BMET255
BLYS324
BLYS326

site_idSWS_FT_FI2
Number of Residues2
DetailsMOD_RES: Phosphotyrosine => ECO:0000250|UniProtKB:Q8BWG8
ChainResidueDetails
ATYR47
BTYR47

site_idSWS_FT_FI3
Number of Residues2
DetailsMOD_RES: Phosphoserine; by GRK5 => ECO:0000269|PubMed:19661922, ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:21406692, ECO:0007744|PubMed:23186163, ECO:0007744|PubMed:24275569
ChainResidueDetails
ASER412
BSER412

226707

PDB entries from 2024-10-30

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