8ARK

Crystal structure of DEAD-box protein Dbp2 in apo form

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000166	molecular_function	nucleotide binding
A	0000184	biological_process	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay
A	0000380	biological_process	alternative mRNA splicing, via spliceosome
A	0002151	molecular_function	G-quadruplex RNA binding
A	0003676	molecular_function	nucleic acid binding
A	0003723	molecular_function	RNA binding
A	0003724	molecular_function	RNA helicase activity
A	0003729	molecular_function	mRNA binding
A	0004386	molecular_function	helicase activity
A	0005515	molecular_function	protein binding
A	0005524	molecular_function	ATP binding
A	0005634	cellular_component	nucleus
A	0005737	cellular_component	cytoplasm
A	0005739	cellular_component	mitochondrion
A	0006364	biological_process	rRNA processing
A	0006369	biological_process	termination of RNA polymerase II transcription
A	0008186	molecular_function	ATP-dependent activity, acting on RNA
A	0010467	biological_process	gene expression
A	0016787	molecular_function	hydrolase activity
A	0016887	molecular_function	ATP hydrolysis activity
A	0030515	molecular_function	snoRNA binding
A	0042254	biological_process	ribosome biogenesis
A	0051880	molecular_function	G-quadruplex DNA binding
A	0071042	biological_process	nuclear polyadenylation-dependent mRNA catabolic process
A	0140098	molecular_function	catalytic activity, acting on RNA
A	1990904	cellular_component	ribonucleoprotein complex
B	0000166	molecular_function	nucleotide binding
B	0000184	biological_process	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay
B	0000380	biological_process	alternative mRNA splicing, via spliceosome
B	0002151	molecular_function	G-quadruplex RNA binding
B	0003676	molecular_function	nucleic acid binding
B	0003723	molecular_function	RNA binding
B	0003724	molecular_function	RNA helicase activity
B	0003729	molecular_function	mRNA binding
B	0004386	molecular_function	helicase activity
B	0005515	molecular_function	protein binding
B	0005524	molecular_function	ATP binding
B	0005634	cellular_component	nucleus
B	0005737	cellular_component	cytoplasm
B	0005739	cellular_component	mitochondrion
B	0006364	biological_process	rRNA processing
B	0006369	biological_process	termination of RNA polymerase II transcription
B	0008186	molecular_function	ATP-dependent activity, acting on RNA
B	0010467	biological_process	gene expression
B	0016787	molecular_function	hydrolase activity
B	0016887	molecular_function	ATP hydrolysis activity
B	0030515	molecular_function	snoRNA binding
B	0042254	biological_process	ribosome biogenesis
B	0051880	molecular_function	G-quadruplex DNA binding
B	0071042	biological_process	nuclear polyadenylation-dependent mRNA catabolic process
B	0140098	molecular_function	catalytic activity, acting on RNA
B	1990904	cellular_component	ribonucleoprotein complex
C	0000166	molecular_function	nucleotide binding
C	0000184	biological_process	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay
C	0000380	biological_process	alternative mRNA splicing, via spliceosome
C	0002151	molecular_function	G-quadruplex RNA binding
C	0003676	molecular_function	nucleic acid binding
C	0003723	molecular_function	RNA binding
C	0003724	molecular_function	RNA helicase activity
C	0003729	molecular_function	mRNA binding
C	0004386	molecular_function	helicase activity
C	0005515	molecular_function	protein binding
C	0005524	molecular_function	ATP binding
C	0005634	cellular_component	nucleus
C	0005737	cellular_component	cytoplasm
C	0005739	cellular_component	mitochondrion
C	0006364	biological_process	rRNA processing
C	0006369	biological_process	termination of RNA polymerase II transcription
C	0008186	molecular_function	ATP-dependent activity, acting on RNA
C	0010467	biological_process	gene expression
C	0016787	molecular_function	hydrolase activity
C	0016887	molecular_function	ATP hydrolysis activity
C	0030515	molecular_function	snoRNA binding
C	0042254	biological_process	ribosome biogenesis
C	0051880	molecular_function	G-quadruplex DNA binding
C	0071042	biological_process	nuclear polyadenylation-dependent mRNA catabolic process
C	0140098	molecular_function	catalytic activity, acting on RNA
C	1990904	cellular_component	ribonucleoprotein complex

Functional Information from PROSITE/UniProt

site_id	PS00039
Number of Residues	9
Details	DEAD_ATP_HELICASE DEAD-box subfamily ATP-dependent helicases signature. VLDEADRmL

Chain	Residue	Details
A	VAL265-LEU273

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	525
Details	Domain: {"description":"Helicase ATP-binding","evidences":[{"source":"PROSITE-ProRule","id":"PRU00541","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	294
Details	Domain: {"description":"Helicase C-terminal","evidences":[{"source":"PROSITE-ProRule","id":"PRU00542","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	84
Details	Motif: {"description":"Q motif"}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	9
Details	Motif: {"description":"DEAD box"}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	21
Details	Binding site: {}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	3
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"18407956","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"19779198","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	3
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"17330950","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"18407956","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"19779198","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI8
Number of Residues	4
Details	Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)","evidences":[{"source":"PubMed","id":"22106047","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---