Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

8AOX

CryoEM structure of the Chikungunya virus nsP1 capping pores in complex with SAM

This is a non-PDB format compatible entry.

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003723	molecular_function	RNA binding
A	0006396	biological_process	RNA processing
A	0008174	molecular_function	mRNA methyltransferase activity
A	0016556	biological_process	mRNA modification
BA	0003723	molecular_function	RNA binding
BA	0006396	biological_process	RNA processing
BA	0008174	molecular_function	mRNA methyltransferase activity
BA	0016556	biological_process	mRNA modification
C	0003723	molecular_function	RNA binding
C	0006396	biological_process	RNA processing
C	0008174	molecular_function	mRNA methyltransferase activity
C	0016556	biological_process	mRNA modification
DA	0003723	molecular_function	RNA binding
DA	0006396	biological_process	RNA processing
DA	0008174	molecular_function	mRNA methyltransferase activity
DA	0016556	biological_process	mRNA modification
E	0003723	molecular_function	RNA binding
E	0006396	biological_process	RNA processing
E	0008174	molecular_function	mRNA methyltransferase activity
E	0016556	biological_process	mRNA modification
FA	0003723	molecular_function	RNA binding
FA	0006396	biological_process	RNA processing
FA	0008174	molecular_function	mRNA methyltransferase activity
FA	0016556	biological_process	mRNA modification
G	0003723	molecular_function	RNA binding
G	0006396	biological_process	RNA processing
G	0008174	molecular_function	mRNA methyltransferase activity
G	0016556	biological_process	mRNA modification
HA	0003723	molecular_function	RNA binding
HA	0006396	biological_process	RNA processing
HA	0008174	molecular_function	mRNA methyltransferase activity
HA	0016556	biological_process	mRNA modification
I	0003723	molecular_function	RNA binding
I	0006396	biological_process	RNA processing
I	0008174	molecular_function	mRNA methyltransferase activity
I	0016556	biological_process	mRNA modification
JA	0003723	molecular_function	RNA binding
JA	0006396	biological_process	RNA processing
JA	0008174	molecular_function	mRNA methyltransferase activity
JA	0016556	biological_process	mRNA modification
K	0003723	molecular_function	RNA binding
K	0006396	biological_process	RNA processing
K	0008174	molecular_function	mRNA methyltransferase activity
K	0016556	biological_process	mRNA modification
LA	0003723	molecular_function	RNA binding
LA	0006396	biological_process	RNA processing
LA	0008174	molecular_function	mRNA methyltransferase activity
LA	0016556	biological_process	mRNA modification
M	0003723	molecular_function	RNA binding
M	0006396	biological_process	RNA processing
M	0008174	molecular_function	mRNA methyltransferase activity
M	0016556	biological_process	mRNA modification
NA	0003723	molecular_function	RNA binding
NA	0006396	biological_process	RNA processing
NA	0008174	molecular_function	mRNA methyltransferase activity
NA	0016556	biological_process	mRNA modification
O	0003723	molecular_function	RNA binding
O	0006396	biological_process	RNA processing
O	0008174	molecular_function	mRNA methyltransferase activity
O	0016556	biological_process	mRNA modification
PA	0003723	molecular_function	RNA binding
PA	0006396	biological_process	RNA processing
PA	0008174	molecular_function	mRNA methyltransferase activity
PA	0016556	biological_process	mRNA modification
Q	0003723	molecular_function	RNA binding
Q	0006396	biological_process	RNA processing
Q	0008174	molecular_function	mRNA methyltransferase activity
Q	0016556	biological_process	mRNA modification
RA	0003723	molecular_function	RNA binding
RA	0006396	biological_process	RNA processing
RA	0008174	molecular_function	mRNA methyltransferase activity
RA	0016556	biological_process	mRNA modification
S	0003723	molecular_function	RNA binding
S	0006396	biological_process	RNA processing
S	0008174	molecular_function	mRNA methyltransferase activity
S	0016556	biological_process	mRNA modification
TA	0003723	molecular_function	RNA binding
TA	0006396	biological_process	RNA processing
TA	0008174	molecular_function	mRNA methyltransferase activity
TA	0016556	biological_process	mRNA modification
V	0003723	molecular_function	RNA binding
V	0006396	biological_process	RNA processing
V	0008174	molecular_function	mRNA methyltransferase activity
V	0016556	biological_process	mRNA modification
VA	0003723	molecular_function	RNA binding
VA	0006396	biological_process	RNA processing
VA	0008174	molecular_function	mRNA methyltransferase activity
VA	0016556	biological_process	mRNA modification
X	0003723	molecular_function	RNA binding
X	0006396	biological_process	RNA processing
X	0008174	molecular_function	mRNA methyltransferase activity
X	0016556	biological_process	mRNA modification
Z	0003723	molecular_function	RNA binding
Z	0006396	biological_process	RNA processing
Z	0008174	molecular_function	mRNA methyltransferase activity
Z	0016556	biological_process	mRNA modification

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	24
Details	ACT_SITE: For mRNA-capping enzyme nsP1 activity => ECO:0000269\|PubMed:33730549

Chain	Residue	Details
JA	HIS37
Q	HIS37
S	HIS37
V	HIS37
X	HIS37
Z	HIS37
BA	HIS37
DA	HIS37
FA	HIS37
HA	HIS37
LA	HIS37
A	HIS37
NA	HIS37
PA	HIS37
RA	HIS37
TA	HIS37
VA	HIS37
C	HIS37
E	HIS37
G	HIS37
I	HIS37
K	HIS37
M	HIS37
O	HIS37

site_id	SWS_FT_FI2
Number of Residues	96
Details	BINDING: BINDING => ECO:0000269\|PubMed:33730549

Chain	Residue	Details
JA	HIS79
C	GLU129
C	CYS134
C	CYS141
E	HIS79
E	GLU129
E	CYS134
E	CYS141
G	HIS79
G	GLU129
G	CYS134
JA	GLU129
G	CYS141
I	HIS79
I	GLU129
I	CYS134
I	CYS141
K	HIS79
K	GLU129
K	CYS134
K	CYS141
M	HIS79
JA	CYS134
M	GLU129
M	CYS134
M	CYS141
O	HIS79
O	GLU129
O	CYS134
O	CYS141
Q	HIS79
Q	GLU129
Q	CYS134
JA	CYS141
Q	CYS141
S	HIS79
S	GLU129
S	CYS134
S	CYS141
V	HIS79
V	GLU129
V	CYS134
V	CYS141
X	HIS79
A	HIS79
X	GLU129
X	CYS134
X	CYS141
Z	HIS79
Z	GLU129
Z	CYS134
Z	CYS141
BA	HIS79
BA	GLU129
BA	CYS134
A	GLU129
BA	CYS141
DA	HIS79
DA	GLU129
DA	CYS134
DA	CYS141
FA	HIS79
FA	GLU129
FA	CYS134
FA	CYS141
HA	HIS79
A	CYS134
HA	GLU129
HA	CYS134
HA	CYS141
LA	HIS79
LA	GLU129
LA	CYS134
LA	CYS141
NA	HIS79
NA	GLU129
NA	CYS134
A	CYS141
NA	CYS141
PA	HIS79
PA	GLU129
PA	CYS134
PA	CYS141
RA	HIS79
RA	GLU129
RA	CYS134
RA	CYS141
TA	HIS79
C	HIS79
TA	GLU129
TA	CYS134
TA	CYS141
VA	HIS79
VA	GLU129
VA	CYS134
VA	CYS141

site_id	SWS_FT_FI3
Number of Residues	24
Details	SITE: Involved in the phosphoramide link with 7-methyl-GMP => ECO:0000250\|UniProtKB:P27282

Chain	Residue	Details
JA	HIS37
Q	HIS37
S	HIS37
V	HIS37
X	HIS37
Z	HIS37
BA	HIS37
DA	HIS37
FA	HIS37
HA	HIS37
LA	HIS37
A	HIS37
NA	HIS37
PA	HIS37
RA	HIS37
TA	HIS37
VA	HIS37
C	HIS37
E	HIS37
G	HIS37
I	HIS37
K	HIS37
M	HIS37
O	HIS37

site_id	SWS_FT_FI4
Number of Residues	24
Details	SITE: Cleavage; by protease nsP2 => ECO:0000250\|UniProtKB:P03317

Chain	Residue	Details
JA	ALA535
Q	ALA535
S	ALA535
V	ALA535
X	ALA535
Z	ALA535
BA	ALA535
DA	ALA535
FA	ALA535
HA	ALA535
LA	ALA535
A	ALA535
NA	ALA535
PA	ALA535
RA	ALA535
TA	ALA535
VA	ALA535
C	ALA535
E	ALA535
G	ALA535
I	ALA535
K	ALA535
M	ALA535
O	ALA535

site_id	SWS_FT_FI5
Number of Residues	48
Details	LIPID: S-palmitoyl cysteine; by host => ECO:0000305\|PubMed:30404808

Chain	Residue	Details
JA	CYS417
G	CYS419
I	CYS417
I	CYS419
K	CYS417
K	CYS419
M	CYS417
M	CYS419
O	CYS417
O	CYS419
Q	CYS417
JA	CYS419
Q	CYS419
S	CYS417
S	CYS419
V	CYS417
V	CYS419
X	CYS417
X	CYS419
Z	CYS417
Z	CYS419
BA	CYS417
A	CYS417
BA	CYS419
DA	CYS417
DA	CYS419
FA	CYS417
FA	CYS419
HA	CYS417
HA	CYS419
LA	CYS417
LA	CYS419
NA	CYS417
A	CYS419
NA	CYS419
PA	CYS417
PA	CYS419
RA	CYS417
RA	CYS419
TA	CYS417
TA	CYS419
VA	CYS417
VA	CYS419
C	CYS417
C	CYS419
E	CYS417
E	CYS419
G	CYS417

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		Validation report (PDF)