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8AFZ

Architecture of the ESCPE-1 membrane coat

Functional Information from GO Data
ChainGOidnamespacecontents
A0005154molecular_functionepidermal growth factor receptor binding
A0005158molecular_functioninsulin receptor binding
A0005515molecular_functionprotein binding
A0005737cellular_componentcytoplasm
A0005764cellular_componentlysosome
A0005768cellular_componentendosome
A0005769cellular_componentearly endosome
A0005794cellular_componentGolgi apparatus
A0005829cellular_componentcytosol
A0006886biological_processintracellular protein transport
A0008289molecular_functionlipid binding
A0010008cellular_componentendosome membrane
A0015031biological_processprotein transport
A0016020cellular_componentmembrane
A0016197biological_processendosomal transport
A0030027cellular_componentlamellipodium
A0030904cellular_componentretromer complex
A0030905cellular_componentretromer, tubulation complex
A0031623biological_processreceptor internalization
A0031901cellular_componentearly endosome membrane
A0031982cellular_componentvesicle
A0032991cellular_componentprotein-containing complex
A0034498biological_processearly endosome to Golgi transport
A0035091molecular_functionphosphatidylinositol binding
A0042147biological_processretrograde transport, endosome to Golgi
A0042802molecular_functionidentical protein binding
A0042803molecular_functionprotein homodimerization activity
A0045296molecular_functioncadherin binding
A0045732biological_processpositive regulation of protein catabolic process
A0046982molecular_functionprotein heterodimerization activity
A0072673biological_processlamellipodium morphogenesis
A0097750biological_processendosome membrane tubulation
A1990459molecular_functiontransferrin receptor binding
A1990460molecular_functionleptin receptor binding
B0001726cellular_componentruffle
B0001891cellular_componentphagocytic cup
B0005515molecular_functionprotein binding
B0005737cellular_componentcytoplasm
B0005768cellular_componentendosome
B0005769cellular_componentearly endosome
B0005829cellular_componentcytosol
B0005886cellular_componentplasma membrane
B0005903cellular_componentbrush border
B0006886biological_processintracellular protein transport
B0006897biological_processendocytosis
B0006907biological_processpinocytosis
B0007174biological_processepidermal growth factor catabolic process
B0008289molecular_functionlipid binding
B0009898cellular_componentcytoplasmic side of plasma membrane
B0010008cellular_componentendosome membrane
B0010314molecular_functionphosphatidylinositol-5-phosphate binding
B0015031biological_processprotein transport
B0016241biological_processregulation of macroautophagy
B0030659cellular_componentcytoplasmic vesicle membrane
B0030904cellular_componentretromer complex
B0030905cellular_componentretromer, tubulation complex
B0031410cellular_componentcytoplasmic vesicle
B0031748molecular_functionD1 dopamine receptor binding
B0031901cellular_componentearly endosome membrane
B0034452molecular_functiondynactin binding
B0035091molecular_functionphosphatidylinositol binding
B0042147biological_processretrograde transport, endosome to Golgi
B0045296molecular_functioncadherin binding
B0045776biological_processnegative regulation of blood pressure
B0045893biological_processpositive regulation of DNA-templated transcription
B0046628biological_processpositive regulation of insulin receptor signaling pathway
B0048471cellular_componentperinuclear region of cytoplasm
B0070273molecular_functionphosphatidylinositol-4-phosphate binding
B0070685cellular_componentmacropinocytic cup
B0080025molecular_functionphosphatidylinositol-3,5-bisphosphate binding
B0097422cellular_componenttubular endosome
B0097750biological_processendosome membrane tubulation
B0098559cellular_componentcytoplasmic side of early endosome membrane
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues129
DetailsDomain: {"description":"PX","evidences":[{"source":"PROSITE-ProRule","id":"PRU00147","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails

site_idSWS_FT_FI2
Number of Residues422
DetailsDomain: {"description":"BAR"}
ChainResidueDetails

site_idSWS_FT_FI3
Number of Residues17
DetailsRegion: {"description":"Membrane-binding amphipathic helix","evidences":[{"source":"PubMed","id":"19816406","evidenceCode":"ECO:0000303"}]}
ChainResidueDetails

site_idSWS_FT_FI4
Number of Residues4
DetailsBinding site: {"evidences":[{"source":"UniProtKB","id":"Q96L94","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails

site_idSWS_FT_FI5
Number of Residues1
DetailsModified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"18669648","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"19690332","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"20068231","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"24275569","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails

site_idSWS_FT_FI6
Number of Residues3
DetailsModified residue: {"description":"N6-acetyllysine","evidences":[{"source":"PubMed","id":"19608861","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails

site_idSWS_FT_FI7
Number of Residues1
DetailsModified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"24275569","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails

site_idSWS_FT_FI8
Number of Residues92
DetailsRegion: {"description":"Interaction with DOCK1","evidences":[{"source":"PubMed","id":"18596235","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails

site_idSWS_FT_FI9
Number of Residues17
DetailsRegion: {"description":"Membrane-binding amphipathic helix","evidences":[{"source":"PubMed","id":"23085988","evidenceCode":"ECO:0000303"}]}
ChainResidueDetails

site_idSWS_FT_FI10
Number of Residues15
DetailsBinding site: {"evidences":[{"source":"UniProtKB","id":"B1H267","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails

site_idSWS_FT_FI11
Number of Residues1
DetailsModified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails

246704

PDB entries from 2025-12-24

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