8ADL

Cryo-EM structure of the SEA complex

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000324	cellular_component	fungal-type vacuole
A	0005774	cellular_component	vacuolar membrane
A	0005829	cellular_component	cytosol
A	0008270	molecular_function	zinc ion binding
A	0015031	biological_process	protein transport
A	0016239	biological_process	positive regulation of macroautophagy
A	0032008	biological_process	positive regulation of TOR signaling
A	0035859	cellular_component	Seh1-associated complex
A	0046872	molecular_function	metal ion binding
A	0061700	cellular_component	GATOR2 complex
A	1903432	biological_process	regulation of TORC1 signaling
A	1904263	biological_process	positive regulation of TORC1 signaling
B	0005515	molecular_function	protein binding
B	0005737	cellular_component	cytoplasm
B	0005774	cellular_component	vacuolar membrane
B	0008270	molecular_function	zinc ion binding
B	0015031	biological_process	protein transport
B	0035859	cellular_component	Seh1-associated complex
B	1903432	biological_process	regulation of TORC1 signaling
B	1904263	biological_process	positive regulation of TORC1 signaling
C	0000329	cellular_component	fungal-type vacuole membrane
C	0005515	molecular_function	protein binding
C	0005774	cellular_component	vacuolar membrane
C	0008270	molecular_function	zinc ion binding
C	0015031	biological_process	protein transport
C	0034198	biological_process	cellular response to amino acid starvation
C	0035591	molecular_function	signaling adaptor activity
C	0035859	cellular_component	Seh1-associated complex
C	1903432	biological_process	regulation of TORC1 signaling
C	1904263	biological_process	positive regulation of TORC1 signaling
D	0005198	molecular_function	structural molecule activity
D	0005515	molecular_function	protein binding
D	0005635	cellular_component	nuclear envelope
D	0005643	cellular_component	nuclear pore
D	0005774	cellular_component	vacuolar membrane
D	0006913	biological_process	nucleocytoplasmic transport
D	0015031	biological_process	protein transport
D	0017056	molecular_function	structural constituent of nuclear pore
D	0031080	cellular_component	nuclear pore outer ring
D	0031965	cellular_component	nuclear membrane
D	0034198	biological_process	cellular response to amino acid starvation
D	0035859	cellular_component	Seh1-associated complex
D	0051028	biological_process	mRNA transport
D	1903432	biological_process	regulation of TORC1 signaling
D	1904263	biological_process	positive regulation of TORC1 signaling
E	0005198	molecular_function	structural molecule activity
E	0005515	molecular_function	protein binding
E	0005635	cellular_component	nuclear envelope
E	0005643	cellular_component	nuclear pore
E	0005774	cellular_component	vacuolar membrane
E	0006913	biological_process	nucleocytoplasmic transport
E	0015031	biological_process	protein transport
E	0017056	molecular_function	structural constituent of nuclear pore
E	0031080	cellular_component	nuclear pore outer ring
E	0031965	cellular_component	nuclear membrane
E	0034198	biological_process	cellular response to amino acid starvation
E	0035859	cellular_component	Seh1-associated complex
E	0051028	biological_process	mRNA transport
E	1903432	biological_process	regulation of TORC1 signaling
E	1904263	biological_process	positive regulation of TORC1 signaling
F	0005198	molecular_function	structural molecule activity
F	0005515	molecular_function	protein binding
F	0005635	cellular_component	nuclear envelope
F	0005643	cellular_component	nuclear pore
F	0005774	cellular_component	vacuolar membrane
F	0006913	biological_process	nucleocytoplasmic transport
F	0015031	biological_process	protein transport
F	0017056	molecular_function	structural constituent of nuclear pore
F	0031080	cellular_component	nuclear pore outer ring
F	0031965	cellular_component	nuclear membrane
F	0034198	biological_process	cellular response to amino acid starvation
F	0035859	cellular_component	Seh1-associated complex
F	0051028	biological_process	mRNA transport
F	1903432	biological_process	regulation of TORC1 signaling
F	1904263	biological_process	positive regulation of TORC1 signaling
G	0005515	molecular_function	protein binding
G	0005737	cellular_component	cytoplasm
G	0005774	cellular_component	vacuolar membrane
G	0008270	molecular_function	zinc ion binding
G	0015031	biological_process	protein transport
G	0035859	cellular_component	Seh1-associated complex
G	1903432	biological_process	regulation of TORC1 signaling
G	1904263	biological_process	positive regulation of TORC1 signaling
H	0005198	molecular_function	structural molecule activity
H	0005515	molecular_function	protein binding
H	0005635	cellular_component	nuclear envelope
H	0005643	cellular_component	nuclear pore
H	0005774	cellular_component	vacuolar membrane
H	0005783	cellular_component	endoplasmic reticulum
H	0005789	cellular_component	endoplasmic reticulum membrane
H	0006606	biological_process	protein import into nucleus
H	0006913	biological_process	nucleocytoplasmic transport
H	0012507	cellular_component	ER to Golgi transport vesicle membrane
H	0015031	biological_process	protein transport
H	0016192	biological_process	vesicle-mediated transport
H	0030127	cellular_component	COPII vesicle coat
H	0031080	cellular_component	nuclear pore outer ring
H	0031410	cellular_component	cytoplasmic vesicle
H	0032008	biological_process	positive regulation of TOR signaling
H	0032527	biological_process	protein exit from endoplasmic reticulum
H	0035859	cellular_component	Seh1-associated complex
H	0036503	biological_process	ERAD pathway
H	0045893	biological_process	positive regulation of DNA-templated transcription
H	0051028	biological_process	mRNA transport
H	0051664	biological_process	nuclear pore localization
H	0070863	biological_process	positive regulation of protein exit from endoplasmic reticulum
H	0070971	cellular_component	endoplasmic reticulum exit site
H	0071944	cellular_component	cell periphery
H	0090114	biological_process	COPII-coated vesicle budding
H	1902953	biological_process	positive regulation of ER to Golgi vesicle-mediated transport
H	1903432	biological_process	regulation of TORC1 signaling
H	1904263	biological_process	positive regulation of TORC1 signaling
I	0000324	cellular_component	fungal-type vacuole
I	0005774	cellular_component	vacuolar membrane
I	0005829	cellular_component	cytosol
I	0008270	molecular_function	zinc ion binding
I	0015031	biological_process	protein transport
I	0016239	biological_process	positive regulation of macroautophagy
I	0032008	biological_process	positive regulation of TOR signaling
I	0035859	cellular_component	Seh1-associated complex
I	0046872	molecular_function	metal ion binding
I	0061700	cellular_component	GATOR2 complex
I	1903432	biological_process	regulation of TORC1 signaling
I	1904263	biological_process	positive regulation of TORC1 signaling
J	0005515	molecular_function	protein binding
J	0005737	cellular_component	cytoplasm
J	0005774	cellular_component	vacuolar membrane
J	0008270	molecular_function	zinc ion binding
J	0015031	biological_process	protein transport
J	0035859	cellular_component	Seh1-associated complex
J	1903432	biological_process	regulation of TORC1 signaling
J	1904263	biological_process	positive regulation of TORC1 signaling
L	0005198	molecular_function	structural molecule activity
L	0005515	molecular_function	protein binding
L	0005635	cellular_component	nuclear envelope
L	0005643	cellular_component	nuclear pore
L	0005774	cellular_component	vacuolar membrane
L	0006913	biological_process	nucleocytoplasmic transport
L	0015031	biological_process	protein transport
L	0017056	molecular_function	structural constituent of nuclear pore
L	0031080	cellular_component	nuclear pore outer ring
L	0031965	cellular_component	nuclear membrane
L	0034198	biological_process	cellular response to amino acid starvation
L	0035859	cellular_component	Seh1-associated complex
L	0051028	biological_process	mRNA transport
L	1903432	biological_process	regulation of TORC1 signaling
L	1904263	biological_process	positive regulation of TORC1 signaling
M	0005198	molecular_function	structural molecule activity
M	0005515	molecular_function	protein binding
M	0005635	cellular_component	nuclear envelope
M	0005643	cellular_component	nuclear pore
M	0005774	cellular_component	vacuolar membrane
M	0006913	biological_process	nucleocytoplasmic transport
M	0015031	biological_process	protein transport
M	0017056	molecular_function	structural constituent of nuclear pore
M	0031080	cellular_component	nuclear pore outer ring
M	0031965	cellular_component	nuclear membrane
M	0034198	biological_process	cellular response to amino acid starvation
M	0035859	cellular_component	Seh1-associated complex
M	0051028	biological_process	mRNA transport
M	1903432	biological_process	regulation of TORC1 signaling
M	1904263	biological_process	positive regulation of TORC1 signaling
N	0005198	molecular_function	structural molecule activity
N	0005515	molecular_function	protein binding
N	0005635	cellular_component	nuclear envelope
N	0005643	cellular_component	nuclear pore
N	0005774	cellular_component	vacuolar membrane
N	0006913	biological_process	nucleocytoplasmic transport
N	0015031	biological_process	protein transport
N	0017056	molecular_function	structural constituent of nuclear pore
N	0031080	cellular_component	nuclear pore outer ring
N	0031965	cellular_component	nuclear membrane
N	0034198	biological_process	cellular response to amino acid starvation
N	0035859	cellular_component	Seh1-associated complex
N	0051028	biological_process	mRNA transport
N	1903432	biological_process	regulation of TORC1 signaling
N	1904263	biological_process	positive regulation of TORC1 signaling
O	0005515	molecular_function	protein binding
O	0005737	cellular_component	cytoplasm
O	0005774	cellular_component	vacuolar membrane
O	0008270	molecular_function	zinc ion binding
O	0015031	biological_process	protein transport
O	0035859	cellular_component	Seh1-associated complex
O	1903432	biological_process	regulation of TORC1 signaling
O	1904263	biological_process	positive regulation of TORC1 signaling
P	0005198	molecular_function	structural molecule activity
P	0005515	molecular_function	protein binding
P	0005635	cellular_component	nuclear envelope
P	0005643	cellular_component	nuclear pore
P	0005774	cellular_component	vacuolar membrane
P	0005783	cellular_component	endoplasmic reticulum
P	0005789	cellular_component	endoplasmic reticulum membrane
P	0006606	biological_process	protein import into nucleus
P	0006913	biological_process	nucleocytoplasmic transport
P	0012507	cellular_component	ER to Golgi transport vesicle membrane
P	0015031	biological_process	protein transport
P	0016192	biological_process	vesicle-mediated transport
P	0030127	cellular_component	COPII vesicle coat
P	0031080	cellular_component	nuclear pore outer ring
P	0031410	cellular_component	cytoplasmic vesicle
P	0032008	biological_process	positive regulation of TOR signaling
P	0032527	biological_process	protein exit from endoplasmic reticulum
P	0035859	cellular_component	Seh1-associated complex
P	0036503	biological_process	ERAD pathway
P	0045893	biological_process	positive regulation of DNA-templated transcription
P	0051028	biological_process	mRNA transport
P	0051664	biological_process	nuclear pore localization
P	0070863	biological_process	positive regulation of protein exit from endoplasmic reticulum
P	0070971	cellular_component	endoplasmic reticulum exit site
P	0071944	cellular_component	cell periphery
P	0090114	biological_process	COPII-coated vesicle budding
P	1902953	biological_process	positive regulation of ER to Golgi vesicle-mediated transport
P	1903432	biological_process	regulation of TORC1 signaling
P	1904263	biological_process	positive regulation of TORC1 signaling
Q	0000329	cellular_component	fungal-type vacuole membrane
Q	0005515	molecular_function	protein binding
Q	0005774	cellular_component	vacuolar membrane
Q	0008270	molecular_function	zinc ion binding
Q	0015031	biological_process	protein transport
Q	0034198	biological_process	cellular response to amino acid starvation
Q	0035591	molecular_function	signaling adaptor activity
Q	0035859	cellular_component	Seh1-associated complex
Q	1903432	biological_process	regulation of TORC1 signaling
Q	1904263	biological_process	positive regulation of TORC1 signaling
S	0003674	molecular_function	molecular_function
S	0005096	molecular_function	GTPase activator activity
S	0005515	molecular_function	protein binding
S	0005774	cellular_component	vacuolar membrane
S	0006351	biological_process	DNA-templated transcription
S	0006995	biological_process	cellular response to nitrogen starvation
S	0009410	biological_process	response to xenobiotic stimulus
S	0010508	biological_process	positive regulation of autophagy
S	0015031	biological_process	protein transport
S	0015824	biological_process	proline transport
S	0015840	biological_process	urea transport
S	0034198	biological_process	cellular response to amino acid starvation
S	0035859	cellular_component	Seh1-associated complex
S	1903432	biological_process	regulation of TORC1 signaling
S	1904262	biological_process	negative regulation of TORC1 signaling
S	1990130	cellular_component	GATOR1 complex
S	2000785	biological_process	regulation of autophagosome assembly
T	0003674	molecular_function	molecular_function
T	0005096	molecular_function	GTPase activator activity
T	0005515	molecular_function	protein binding
T	0005774	cellular_component	vacuolar membrane
T	0006351	biological_process	DNA-templated transcription
T	0006995	biological_process	cellular response to nitrogen starvation
T	0009410	biological_process	response to xenobiotic stimulus
T	0010508	biological_process	positive regulation of autophagy
T	0015031	biological_process	protein transport
T	0015824	biological_process	proline transport
T	0015840	biological_process	urea transport
T	0034198	biological_process	cellular response to amino acid starvation
T	0035859	cellular_component	Seh1-associated complex
T	1903432	biological_process	regulation of TORC1 signaling
T	1904262	biological_process	negative regulation of TORC1 signaling
T	1990130	cellular_component	GATOR1 complex
T	2000785	biological_process	regulation of autophagosome assembly
U	0032007	biological_process	negative regulation of TOR signaling
V	0032007	biological_process	negative regulation of TOR signaling
W	0000329	cellular_component	fungal-type vacuole membrane
W	0005096	molecular_function	GTPase activator activity
W	0005515	molecular_function	protein binding
W	0005774	cellular_component	vacuolar membrane
W	0006995	biological_process	cellular response to nitrogen starvation
W	0010508	biological_process	positive regulation of autophagy
W	0015031	biological_process	protein transport
W	0030695	molecular_function	GTPase regulator activity
W	0032007	biological_process	negative regulation of TOR signaling
W	0034599	biological_process	cellular response to oxidative stress
W	0035556	biological_process	intracellular signal transduction
W	0035859	cellular_component	Seh1-associated complex
W	0051058	biological_process	negative regulation of small GTPase mediated signal transduction
W	1903432	biological_process	regulation of TORC1 signaling
W	1904262	biological_process	negative regulation of TORC1 signaling
W	1990130	cellular_component	GATOR1 complex
W	2000785	biological_process	regulation of autophagosome assembly
X	0000329	cellular_component	fungal-type vacuole membrane
X	0005096	molecular_function	GTPase activator activity
X	0005515	molecular_function	protein binding
X	0005774	cellular_component	vacuolar membrane
X	0006995	biological_process	cellular response to nitrogen starvation
X	0010508	biological_process	positive regulation of autophagy
X	0015031	biological_process	protein transport
X	0030695	molecular_function	GTPase regulator activity
X	0032007	biological_process	negative regulation of TOR signaling
X	0034599	biological_process	cellular response to oxidative stress
X	0035556	biological_process	intracellular signal transduction
X	0035859	cellular_component	Seh1-associated complex
X	0051058	biological_process	negative regulation of small GTPase mediated signal transduction
X	1903432	biological_process	regulation of TORC1 signaling
X	1904262	biological_process	negative regulation of TORC1 signaling
X	1990130	cellular_component	GATOR1 complex
X	2000785	biological_process	regulation of autophagosome assembly

Functional Information from PROSITE/UniProt

site_id	PS00092
Number of Residues	7
Details	N6_MTASE N-6 Adenine-specific DNA methylases signature. IIADPPW

Chain	Residue	Details
A	ILE1153-TRP1159

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site_id	PS00678
Number of Residues	15
Details	WD_REPEATS_1 Trp-Asp (WD) repeats signature. LATCsvDtYVHAWDM

Chain	Residue	Details
C	LEU130-MET144
A	ILE274-LEU288

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	398
Details	Repeat: {"description":"WD 1"}

Chain

Residue

Details

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site_id	SWS_FT_FI2
Number of Residues	576
Details	Repeat: {"description":"WD 2"}

Chain

Residue

Details

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site_id	SWS_FT_FI3
Number of Residues	406
Details	Repeat: {"description":"WD 3"}

Chain

Residue

Details

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site_id	SWS_FT_FI4
Number of Residues	314
Details	Repeat: {"description":"WD 4"}

Chain

Residue

Details

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site_id	SWS_FT_FI5
Number of Residues	276
Details	Repeat: {"description":"WD 5"}

Chain

Residue

Details

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site_id	SWS_FT_FI6
Number of Residues	388
Details	Repeat: {"description":"WD 6"}

Chain

Residue

Details

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site_id	SWS_FT_FI7
Number of Residues	80
Details	Repeat: {"description":"WD 7"}

Chain

Residue

Details

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site_id	SWS_FT_FI8
Number of Residues	78
Details	Repeat: {"description":"WD 9"}

Chain

Residue

Details

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site_id	SWS_FT_FI9
Number of Residues	84
Details	Zinc finger: {"description":"RING-type; degenerate","evidences":[{"source":"PROSITE-ProRule","id":"PRU00175","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

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