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8ADL

Cryo-EM structure of the SEA complex

Functional Information from GO Data
ChainGOidnamespacecontents
A0000324cellular_componentfungal-type vacuole
A0005773cellular_componentvacuole
A0005774cellular_componentvacuolar membrane
A0005829cellular_componentcytosol
A0008270molecular_functionzinc ion binding
A0015031biological_processprotein transport
A0016020cellular_componentmembrane
A0016239biological_processpositive regulation of macroautophagy
A0032008biological_processpositive regulation of TOR signaling
A0035859cellular_componentSeh1-associated complex
A0046872molecular_functionmetal ion binding
A0061700cellular_componentGATOR2 complex
A1903432biological_processregulation of TORC1 signaling
A1904263biological_processpositive regulation of TORC1 signaling
B0005515molecular_functionprotein binding
B0005737cellular_componentcytoplasm
B0005773cellular_componentvacuole
B0005774cellular_componentvacuolar membrane
B0008270molecular_functionzinc ion binding
B0015031biological_processprotein transport
B0016020cellular_componentmembrane
B0035859cellular_componentSeh1-associated complex
B1903432biological_processregulation of TORC1 signaling
B1904263biological_processpositive regulation of TORC1 signaling
C0000329cellular_componentfungal-type vacuole membrane
C0005515molecular_functionprotein binding
C0005773cellular_componentvacuole
C0005774cellular_componentvacuolar membrane
C0008270molecular_functionzinc ion binding
C0015031biological_processprotein transport
C0016020cellular_componentmembrane
C0034198biological_processcellular response to amino acid starvation
C0035591molecular_functionsignaling adaptor activity
C0035859cellular_componentSeh1-associated complex
C1903432biological_processregulation of TORC1 signaling
C1904263biological_processpositive regulation of TORC1 signaling
D0005198molecular_functionstructural molecule activity
D0005515molecular_functionprotein binding
D0005634cellular_componentnucleus
D0005635cellular_componentnuclear envelope
D0005643cellular_componentnuclear pore
D0005773cellular_componentvacuole
D0005774cellular_componentvacuolar membrane
D0006913biological_processnucleocytoplasmic transport
D0015031biological_processprotein transport
D0016020cellular_componentmembrane
D0017056molecular_functionstructural constituent of nuclear pore
D0031080cellular_componentnuclear pore outer ring
D0031965cellular_componentnuclear membrane
D0034198biological_processcellular response to amino acid starvation
D0035859cellular_componentSeh1-associated complex
D0051028biological_processmRNA transport
D1903432biological_processregulation of TORC1 signaling
D1904263biological_processpositive regulation of TORC1 signaling
E0005198molecular_functionstructural molecule activity
E0005515molecular_functionprotein binding
E0005634cellular_componentnucleus
E0005635cellular_componentnuclear envelope
E0005643cellular_componentnuclear pore
E0005773cellular_componentvacuole
E0005774cellular_componentvacuolar membrane
E0006913biological_processnucleocytoplasmic transport
E0015031biological_processprotein transport
E0016020cellular_componentmembrane
E0017056molecular_functionstructural constituent of nuclear pore
E0031080cellular_componentnuclear pore outer ring
E0031965cellular_componentnuclear membrane
E0034198biological_processcellular response to amino acid starvation
E0035859cellular_componentSeh1-associated complex
E0051028biological_processmRNA transport
E1903432biological_processregulation of TORC1 signaling
E1904263biological_processpositive regulation of TORC1 signaling
F0005198molecular_functionstructural molecule activity
F0005515molecular_functionprotein binding
F0005634cellular_componentnucleus
F0005635cellular_componentnuclear envelope
F0005643cellular_componentnuclear pore
F0005773cellular_componentvacuole
F0005774cellular_componentvacuolar membrane
F0006913biological_processnucleocytoplasmic transport
F0015031biological_processprotein transport
F0016020cellular_componentmembrane
F0017056molecular_functionstructural constituent of nuclear pore
F0031080cellular_componentnuclear pore outer ring
F0031965cellular_componentnuclear membrane
F0034198biological_processcellular response to amino acid starvation
F0035859cellular_componentSeh1-associated complex
F0051028biological_processmRNA transport
F1903432biological_processregulation of TORC1 signaling
F1904263biological_processpositive regulation of TORC1 signaling
G0005515molecular_functionprotein binding
G0005737cellular_componentcytoplasm
G0005773cellular_componentvacuole
G0005774cellular_componentvacuolar membrane
G0008270molecular_functionzinc ion binding
G0015031biological_processprotein transport
G0016020cellular_componentmembrane
G0035859cellular_componentSeh1-associated complex
G1903432biological_processregulation of TORC1 signaling
G1904263biological_processpositive regulation of TORC1 signaling
H0005198molecular_functionstructural molecule activity
H0005515molecular_functionprotein binding
H0005634cellular_componentnucleus
H0005635cellular_componentnuclear envelope
H0005643cellular_componentnuclear pore
H0005773cellular_componentvacuole
H0005774cellular_componentvacuolar membrane
H0005783cellular_componentendoplasmic reticulum
H0005789cellular_componentendoplasmic reticulum membrane
H0006606biological_processprotein import into nucleus
H0006913biological_processnucleocytoplasmic transport
H0012507cellular_componentER to Golgi transport vesicle membrane
H0015031biological_processprotein transport
H0016020cellular_componentmembrane
H0016192biological_processvesicle-mediated transport
H0030127cellular_componentCOPII vesicle coat
H0031080cellular_componentnuclear pore outer ring
H0031410cellular_componentcytoplasmic vesicle
H0032008biological_processpositive regulation of TOR signaling
H0032527biological_processprotein exit from endoplasmic reticulum
H0035859cellular_componentSeh1-associated complex
H0036503biological_processERAD pathway
H0045893biological_processpositive regulation of DNA-templated transcription
H0051028biological_processmRNA transport
H0051664biological_processnuclear pore localization
H0070863biological_processpositive regulation of protein exit from endoplasmic reticulum
H0071944cellular_componentcell periphery
H0090114biological_processCOPII-coated vesicle budding
H1902953biological_processpositive regulation of ER to Golgi vesicle-mediated transport
H1903432biological_processregulation of TORC1 signaling
H1904263biological_processpositive regulation of TORC1 signaling
I0000324cellular_componentfungal-type vacuole
I0005773cellular_componentvacuole
I0005774cellular_componentvacuolar membrane
I0005829cellular_componentcytosol
I0008270molecular_functionzinc ion binding
I0015031biological_processprotein transport
I0016020cellular_componentmembrane
I0016239biological_processpositive regulation of macroautophagy
I0032008biological_processpositive regulation of TOR signaling
I0035859cellular_componentSeh1-associated complex
I0046872molecular_functionmetal ion binding
I0061700cellular_componentGATOR2 complex
I1903432biological_processregulation of TORC1 signaling
I1904263biological_processpositive regulation of TORC1 signaling
J0005515molecular_functionprotein binding
J0005737cellular_componentcytoplasm
J0005773cellular_componentvacuole
J0005774cellular_componentvacuolar membrane
J0008270molecular_functionzinc ion binding
J0015031biological_processprotein transport
J0016020cellular_componentmembrane
J0035859cellular_componentSeh1-associated complex
J1903432biological_processregulation of TORC1 signaling
J1904263biological_processpositive regulation of TORC1 signaling
L0005198molecular_functionstructural molecule activity
L0005515molecular_functionprotein binding
L0005634cellular_componentnucleus
L0005635cellular_componentnuclear envelope
L0005643cellular_componentnuclear pore
L0005773cellular_componentvacuole
L0005774cellular_componentvacuolar membrane
L0006913biological_processnucleocytoplasmic transport
L0015031biological_processprotein transport
L0016020cellular_componentmembrane
L0017056molecular_functionstructural constituent of nuclear pore
L0031080cellular_componentnuclear pore outer ring
L0031965cellular_componentnuclear membrane
L0034198biological_processcellular response to amino acid starvation
L0035859cellular_componentSeh1-associated complex
L0051028biological_processmRNA transport
L1903432biological_processregulation of TORC1 signaling
L1904263biological_processpositive regulation of TORC1 signaling
M0005198molecular_functionstructural molecule activity
M0005515molecular_functionprotein binding
M0005634cellular_componentnucleus
M0005635cellular_componentnuclear envelope
M0005643cellular_componentnuclear pore
M0005773cellular_componentvacuole
M0005774cellular_componentvacuolar membrane
M0006913biological_processnucleocytoplasmic transport
M0015031biological_processprotein transport
M0016020cellular_componentmembrane
M0017056molecular_functionstructural constituent of nuclear pore
M0031080cellular_componentnuclear pore outer ring
M0031965cellular_componentnuclear membrane
M0034198biological_processcellular response to amino acid starvation
M0035859cellular_componentSeh1-associated complex
M0051028biological_processmRNA transport
M1903432biological_processregulation of TORC1 signaling
M1904263biological_processpositive regulation of TORC1 signaling
N0005198molecular_functionstructural molecule activity
N0005515molecular_functionprotein binding
N0005634cellular_componentnucleus
N0005635cellular_componentnuclear envelope
N0005643cellular_componentnuclear pore
N0005773cellular_componentvacuole
N0005774cellular_componentvacuolar membrane
N0006913biological_processnucleocytoplasmic transport
N0015031biological_processprotein transport
N0016020cellular_componentmembrane
N0017056molecular_functionstructural constituent of nuclear pore
N0031080cellular_componentnuclear pore outer ring
N0031965cellular_componentnuclear membrane
N0034198biological_processcellular response to amino acid starvation
N0035859cellular_componentSeh1-associated complex
N0051028biological_processmRNA transport
N1903432biological_processregulation of TORC1 signaling
N1904263biological_processpositive regulation of TORC1 signaling
O0005515molecular_functionprotein binding
O0005737cellular_componentcytoplasm
O0005773cellular_componentvacuole
O0005774cellular_componentvacuolar membrane
O0008270molecular_functionzinc ion binding
O0015031biological_processprotein transport
O0016020cellular_componentmembrane
O0035859cellular_componentSeh1-associated complex
O1903432biological_processregulation of TORC1 signaling
O1904263biological_processpositive regulation of TORC1 signaling
P0005198molecular_functionstructural molecule activity
P0005515molecular_functionprotein binding
P0005634cellular_componentnucleus
P0005635cellular_componentnuclear envelope
P0005643cellular_componentnuclear pore
P0005773cellular_componentvacuole
P0005774cellular_componentvacuolar membrane
P0005783cellular_componentendoplasmic reticulum
P0005789cellular_componentendoplasmic reticulum membrane
P0006606biological_processprotein import into nucleus
P0006913biological_processnucleocytoplasmic transport
P0012507cellular_componentER to Golgi transport vesicle membrane
P0015031biological_processprotein transport
P0016020cellular_componentmembrane
P0016192biological_processvesicle-mediated transport
P0030127cellular_componentCOPII vesicle coat
P0031080cellular_componentnuclear pore outer ring
P0031410cellular_componentcytoplasmic vesicle
P0032008biological_processpositive regulation of TOR signaling
P0032527biological_processprotein exit from endoplasmic reticulum
P0035859cellular_componentSeh1-associated complex
P0036503biological_processERAD pathway
P0045893biological_processpositive regulation of DNA-templated transcription
P0051028biological_processmRNA transport
P0051664biological_processnuclear pore localization
P0070863biological_processpositive regulation of protein exit from endoplasmic reticulum
P0071944cellular_componentcell periphery
P0090114biological_processCOPII-coated vesicle budding
P1902953biological_processpositive regulation of ER to Golgi vesicle-mediated transport
P1903432biological_processregulation of TORC1 signaling
P1904263biological_processpositive regulation of TORC1 signaling
Q0000329cellular_componentfungal-type vacuole membrane
Q0005515molecular_functionprotein binding
Q0005773cellular_componentvacuole
Q0005774cellular_componentvacuolar membrane
Q0008270molecular_functionzinc ion binding
Q0015031biological_processprotein transport
Q0016020cellular_componentmembrane
Q0034198biological_processcellular response to amino acid starvation
Q0035591molecular_functionsignaling adaptor activity
Q0035859cellular_componentSeh1-associated complex
Q1903432biological_processregulation of TORC1 signaling
Q1904263biological_processpositive regulation of TORC1 signaling
S0003674molecular_functionmolecular_function
S0005096molecular_functionGTPase activator activity
S0005515molecular_functionprotein binding
S0005773cellular_componentvacuole
S0005774cellular_componentvacuolar membrane
S0006995biological_processcellular response to nitrogen starvation
S0009410biological_processresponse to xenobiotic stimulus
S0010508biological_processpositive regulation of autophagy
S0015031biological_processprotein transport
S0015824biological_processproline transport
S0015840biological_processurea transport
S0016020cellular_componentmembrane
S0034198biological_processcellular response to amino acid starvation
S0035859cellular_componentSeh1-associated complex
S1903432biological_processregulation of TORC1 signaling
S1904262biological_processnegative regulation of TORC1 signaling
S1990130cellular_componentGATOR1 complex
S2000785biological_processregulation of autophagosome assembly
T0003674molecular_functionmolecular_function
T0005096molecular_functionGTPase activator activity
T0005515molecular_functionprotein binding
T0005773cellular_componentvacuole
T0005774cellular_componentvacuolar membrane
T0006995biological_processcellular response to nitrogen starvation
T0009410biological_processresponse to xenobiotic stimulus
T0010508biological_processpositive regulation of autophagy
T0015031biological_processprotein transport
T0015824biological_processproline transport
T0015840biological_processurea transport
T0016020cellular_componentmembrane
T0034198biological_processcellular response to amino acid starvation
T0035859cellular_componentSeh1-associated complex
T1903432biological_processregulation of TORC1 signaling
T1904262biological_processnegative regulation of TORC1 signaling
T1990130cellular_componentGATOR1 complex
T2000785biological_processregulation of autophagosome assembly
U0032007biological_processnegative regulation of TOR signaling
V0032007biological_processnegative regulation of TOR signaling
W0000329cellular_componentfungal-type vacuole membrane
W0005096molecular_functionGTPase activator activity
W0005773cellular_componentvacuole
W0005774cellular_componentvacuolar membrane
W0006995biological_processcellular response to nitrogen starvation
W0010508biological_processpositive regulation of autophagy
W0015031biological_processprotein transport
W0016020cellular_componentmembrane
W0030695molecular_functionGTPase regulator activity
W0032007biological_processnegative regulation of TOR signaling
W0034599biological_processcellular response to oxidative stress
W0035556biological_processintracellular signal transduction
W0035859cellular_componentSeh1-associated complex
W0051058biological_processnegative regulation of small GTPase mediated signal transduction
W1903432biological_processregulation of TORC1 signaling
W1904262biological_processnegative regulation of TORC1 signaling
W1990130cellular_componentGATOR1 complex
W2000785biological_processregulation of autophagosome assembly
X0000329cellular_componentfungal-type vacuole membrane
X0005096molecular_functionGTPase activator activity
X0005773cellular_componentvacuole
X0005774cellular_componentvacuolar membrane
X0006995biological_processcellular response to nitrogen starvation
X0010508biological_processpositive regulation of autophagy
X0015031biological_processprotein transport
X0016020cellular_componentmembrane
X0030695molecular_functionGTPase regulator activity
X0032007biological_processnegative regulation of TOR signaling
X0034599biological_processcellular response to oxidative stress
X0035556biological_processintracellular signal transduction
X0035859cellular_componentSeh1-associated complex
X0051058biological_processnegative regulation of small GTPase mediated signal transduction
X1903432biological_processregulation of TORC1 signaling
X1904262biological_processnegative regulation of TORC1 signaling
X1990130cellular_componentGATOR1 complex
X2000785biological_processregulation of autophagosome assembly
Functional Information from PROSITE/UniProt
site_idPS00092
Number of Residues7
DetailsN6_MTASE N-6 Adenine-specific DNA methylases signature. IIADPPW
ChainResidueDetails
AILE1153-TRP1159

site_idPS00678
Number of Residues15
DetailsWD_REPEATS_1 Trp-Asp (WD) repeats signature. IISGgqDsCVKIWDL
ChainResidueDetails
AILE274-LEU288
CLEU130-MET144

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues2
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:18407956, ECO:0007744|PubMed:19779198
ChainResidueDetails
SSER362
TSER362
BSER123
BSER136
OSER123
OSER136
JSER123
JSER136

site_idSWS_FT_FI2
Number of Residues2
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:18407956
ChainResidueDetails
WSER737
XSER737
ISER1036
ISER1123

site_idSWS_FT_FI3
Number of Residues2
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:17287358
ChainResidueDetails
USER987
VSER987
ISER1080
ISER1089

site_idSWS_FT_FI4
Number of Residues4
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:18407956
ChainResidueDetails
ASER1087
ASER1133
ISER1087
ISER1133

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PDB entries from 2024-07-24

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