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8A3Y

Structure of mammalian Pol II-DSIF-SPT6-PAF1-TFIIS-hexasome elongation complex

This is a non-PDB format compatible entry.
Functional Information from GO Data
ChainGOidnamespacecontents
A0000428cellular_componentDNA-directed RNA polymerase complex
A0001172biological_processRNA-templated transcription
A0003676molecular_functionnucleic acid binding
A0003677molecular_functionDNA binding
A0003899molecular_functionDNA-directed RNA polymerase activity
A0003968molecular_functionRNA-directed RNA polymerase activity
A0005634cellular_componentnucleus
A0005654cellular_componentnucleoplasm
A0005694cellular_componentchromosome
A0005737cellular_componentcytoplasm
A0006351biological_processDNA-templated transcription
A0006366biological_processtranscription by RNA polymerase II
A0016740molecular_functiontransferase activity
A0016779molecular_functionnucleotidyltransferase activity
A0016787molecular_functionhydrolase activity
A0046872molecular_functionmetal ion binding
B0000428cellular_componentDNA-directed RNA polymerase complex
B0000781cellular_componentchromosome, telomeric region
B0001172biological_processRNA-templated transcription
B0003677molecular_functionDNA binding
B0003682molecular_functionchromatin binding
B0003899molecular_functionDNA-directed RNA polymerase activity
B0003968molecular_functionRNA-directed RNA polymerase activity
B0005634cellular_componentnucleus
B0005654cellular_componentnucleoplasm
B0005665cellular_componentRNA polymerase II, core complex
B0006351biological_processDNA-templated transcription
B0006366biological_processtranscription by RNA polymerase II
B0008270molecular_functionzinc ion binding
B0016740molecular_functiontransferase activity
B0016779molecular_functionnucleotidyltransferase activity
B0016787molecular_functionhydrolase activity
B0032549molecular_functionribonucleoside binding
B0034062molecular_function5'-3' RNA polymerase activity
B0046872molecular_functionmetal ion binding
C0000428cellular_componentDNA-directed RNA polymerase complex
C0003677molecular_functionDNA binding
C0003899molecular_functionDNA-directed RNA polymerase activity
C0005634cellular_componentnucleus
C0005654cellular_componentnucleoplasm
C0005665cellular_componentRNA polymerase II, core complex
C0005829cellular_componentcytosol
C0006351biological_processDNA-templated transcription
C0006366biological_processtranscription by RNA polymerase II
C0046983molecular_functionprotein dimerization activity
D0000166molecular_functionnucleotide binding
D0006352biological_processDNA-templated transcription initiation
D0030880cellular_componentRNA polymerase complex
E0000428cellular_componentDNA-directed RNA polymerase complex
E0003677molecular_functionDNA binding
E0003899molecular_functionDNA-directed RNA polymerase activity
E0005634cellular_componentnucleus
E0005654cellular_componentnucleoplasm
E0005665cellular_componentRNA polymerase II, core complex
E0005666cellular_componentRNA polymerase III complex
E0005736cellular_componentRNA polymerase I complex
E0006351biological_processDNA-templated transcription
E0006362biological_processtranscription elongation by RNA polymerase I
E0006366biological_processtranscription by RNA polymerase II
E0042797biological_processtRNA transcription by RNA polymerase III
F0000428cellular_componentDNA-directed RNA polymerase complex
F0001650cellular_componentfibrillar center
F0003677molecular_functionDNA binding
F0003899molecular_functionDNA-directed RNA polymerase activity
F0005634cellular_componentnucleus
F0005654cellular_componentnucleoplasm
F0005665cellular_componentRNA polymerase II, core complex
F0005666cellular_componentRNA polymerase III complex
F0005736cellular_componentRNA polymerase I complex
F0006351biological_processDNA-templated transcription
F0006360biological_processtranscription by RNA polymerase I
F0006366biological_processtranscription by RNA polymerase II
F0042797biological_processtRNA transcription by RNA polymerase III
G0000428cellular_componentDNA-directed RNA polymerase complex
G0003676molecular_functionnucleic acid binding
G0005634cellular_componentnucleus
G0006351biological_processDNA-templated transcription
G0006352biological_processDNA-templated transcription initiation
H0000428cellular_componentDNA-directed RNA polymerase complex
H0003899molecular_functionDNA-directed RNA polymerase activity
H0005634cellular_componentnucleus
H0005654cellular_componentnucleoplasm
H0005665cellular_componentRNA polymerase II, core complex
H0005666cellular_componentRNA polymerase III complex
H0005736cellular_componentRNA polymerase I complex
H0006351biological_processDNA-templated transcription
I0000428cellular_componentDNA-directed RNA polymerase complex
I0001193biological_processmaintenance of transcriptional fidelity during transcription elongation by RNA polymerase II
I0003676molecular_functionnucleic acid binding
I0003899molecular_functionDNA-directed RNA polymerase activity
I0005634cellular_componentnucleus
I0005654cellular_componentnucleoplasm
I0005665cellular_componentRNA polymerase II, core complex
I0005730cellular_componentnucleolus
I0006283biological_processtranscription-coupled nucleotide-excision repair
I0006351biological_processDNA-templated transcription
I0006366biological_processtranscription by RNA polymerase II
I0006367biological_processtranscription initiation at RNA polymerase II promoter
I0008270molecular_functionzinc ion binding
I0046872molecular_functionmetal ion binding
J0000428cellular_componentDNA-directed RNA polymerase complex
J0003677molecular_functionDNA binding
J0003899molecular_functionDNA-directed RNA polymerase activity
J0005634cellular_componentnucleus
J0005665cellular_componentRNA polymerase II, core complex
J0006351biological_processDNA-templated transcription
J0008270molecular_functionzinc ion binding
J0046872molecular_functionmetal ion binding
K0000428cellular_componentDNA-directed RNA polymerase complex
K0003677molecular_functionDNA binding
K0003899molecular_functionDNA-directed RNA polymerase activity
K0005634cellular_componentnucleus
K0005665cellular_componentRNA polymerase II, core complex
K0006351biological_processDNA-templated transcription
K0006366biological_processtranscription by RNA polymerase II
K0046983molecular_functionprotein dimerization activity
L0000428cellular_componentDNA-directed RNA polymerase complex
L0003677molecular_functionDNA binding
L0003899molecular_functionDNA-directed RNA polymerase activity
L0005634cellular_componentnucleus
L0005654cellular_componentnucleoplasm
L0005665cellular_componentRNA polymerase II, core complex
L0005666cellular_componentRNA polymerase III complex
L0005730cellular_componentnucleolus
L0005736cellular_componentRNA polymerase I complex
L0006351biological_processDNA-templated transcription
L0006366biological_processtranscription by RNA polymerase II
L0008270molecular_functionzinc ion binding
L0046872molecular_functionmetal ion binding
M0003676molecular_functionnucleic acid binding
M0003677molecular_functionDNA binding
M0006139biological_processnucleobase-containing compound metabolic process
M0140673biological_processtranscription elongation-coupled chromatin remodeling
Q0000122biological_processnegative regulation of transcription by RNA polymerase II
Q0000791cellular_componenteuchromatin
Q0000993molecular_functionRNA polymerase II complex binding
Q0001650cellular_componentfibrillar center
Q0001711biological_processendodermal cell fate commitment
Q0001826biological_processinner cell mass cell differentiation
Q0001829biological_processtrophectodermal cell differentiation
Q0001832biological_processblastocyst growth
Q0001835biological_processblastocyst hatching
Q0005515molecular_functionprotein binding
Q0005634cellular_componentnucleus
Q0005654cellular_componentnucleoplasm
Q0005813cellular_componentcentrosome
Q0006325biological_processchromatin organization
Q0006355biological_processregulation of DNA-templated transcription
Q0006357biological_processregulation of transcription by RNA polymerase II
Q0006368biological_processtranscription elongation by RNA polymerase II
Q0007259biological_processcell surface receptor signaling pathway via JAK-STAT
Q0016055biological_processWnt signaling pathway
Q0016593cellular_componentCdc73/Paf1 complex
Q0016607cellular_componentnuclear speck
Q0019827biological_processstem cell population maintenance
Q0031124biological_processmRNA 3'-end processing
Q0032968biological_processpositive regulation of transcription elongation by RNA polymerase II
Q0042169molecular_functionSH2 domain binding
Q0045638biological_processnegative regulation of myeloid cell differentiation
Q0045814biological_processnegative regulation of gene expression, epigenetic
Q0045944biological_processpositive regulation of transcription by RNA polymerase II
Q0070102biological_processinterleukin-6-mediated signaling pathway
Q0071222biological_processcellular response to lipopolysaccharide
Q1990269molecular_functionRNA polymerase II C-terminal domain phosphoserine binding
R0003677molecular_functionDNA binding
U0000122biological_processnegative regulation of transcription by RNA polymerase II
U0000791cellular_componenteuchromatin
U0000993molecular_functionRNA polymerase II complex binding
U0001650cellular_componentfibrillar center
U0001711biological_processendodermal cell fate commitment
U0001826biological_processinner cell mass cell differentiation
U0001829biological_processtrophectodermal cell differentiation
U0001832biological_processblastocyst growth
U0001835biological_processblastocyst hatching
U0005515molecular_functionprotein binding
U0005634cellular_componentnucleus
U0005654cellular_componentnucleoplasm
U0005813cellular_componentcentrosome
U0006325biological_processchromatin organization
U0006355biological_processregulation of DNA-templated transcription
U0006357biological_processregulation of transcription by RNA polymerase II
U0006368biological_processtranscription elongation by RNA polymerase II
U0007259biological_processcell surface receptor signaling pathway via JAK-STAT
U0016055biological_processWnt signaling pathway
U0016593cellular_componentCdc73/Paf1 complex
U0016607cellular_componentnuclear speck
U0019827biological_processstem cell population maintenance
U0031124biological_processmRNA 3'-end processing
U0032968biological_processpositive regulation of transcription elongation by RNA polymerase II
U0042169molecular_functionSH2 domain binding
U0045638biological_processnegative regulation of myeloid cell differentiation
U0045814biological_processnegative regulation of gene expression, epigenetic
U0045944biological_processpositive regulation of transcription by RNA polymerase II
U0070102biological_processinterleukin-6-mediated signaling pathway
U0071222biological_processcellular response to lipopolysaccharide
U1990269molecular_functionRNA polymerase II C-terminal domain phosphoserine binding
V0006368biological_processtranscription elongation by RNA polymerase II
V0016593cellular_componentCdc73/Paf1 complex
W0000791cellular_componenteuchromatin
W0005515molecular_functionprotein binding
W0005634cellular_componentnucleus
W0005654cellular_componentnucleoplasm
W0005737cellular_componentcytoplasm
W0005829cellular_componentcytosol
W0006368biological_processtranscription elongation by RNA polymerase II
W0016055biological_processWnt signaling pathway
W0016593cellular_componentCdc73/Paf1 complex
W0045638biological_processnegative regulation of myeloid cell differentiation
W0055087cellular_componentSki complex
W0070478biological_processnuclear-transcribed mRNA catabolic process, 3'-5' exonucleolytic nonsense-mediated decay
W0072344biological_processrescue of stalled ribosome
X0000122biological_processnegative regulation of transcription by RNA polymerase II
X0000781cellular_componentchromosome, telomeric region
X0000993molecular_functionRNA polymerase II complex binding
X0001558biological_processregulation of cell growth
X0001711biological_processendodermal cell fate commitment
X0005515molecular_functionprotein binding
X0005634cellular_componentnucleus
X0005654cellular_componentnucleoplasm
X0005829cellular_componentcytosol
X0006357biological_processregulation of transcription by RNA polymerase II
X0006368biological_processtranscription elongation by RNA polymerase II
X0008285biological_processnegative regulation of cell population proliferation
X0016055biological_processWnt signaling pathway
X0016593cellular_componentCdc73/Paf1 complex
X0019827biological_processstem cell population maintenance
X0030177biological_processpositive regulation of Wnt signaling pathway
X0031124biological_processmRNA 3'-end processing
X0031442biological_processpositive regulation of mRNA 3'-end processing
X0031648biological_processprotein destabilization
X0032968biological_processpositive regulation of transcription elongation by RNA polymerase II
X0043066biological_processnegative regulation of apoptotic process
X0045638biological_processnegative regulation of myeloid cell differentiation
X0045944biological_processpositive regulation of transcription by RNA polymerase II
X0048147biological_processnegative regulation of fibroblast proliferation
X0050680biological_processnegative regulation of epithelial cell proliferation
X0071222biological_processcellular response to lipopolysaccharide
X1902808biological_processpositive regulation of cell cycle G1/S phase transition
X2000134biological_processnegative regulation of G1/S transition of mitotic cell cycle
Y0000122biological_processnegative regulation of transcription by RNA polymerase II
Y0000993molecular_functionRNA polymerase II complex binding
Y0005634cellular_componentnucleus
Y0005654cellular_componentnucleoplasm
Y0006355biological_processregulation of DNA-templated transcription
Y0006368biological_processtranscription elongation by RNA polymerase II
Y0008270molecular_functionzinc ion binding
Y0032044cellular_componentDSIF complex
Y0032785biological_processnegative regulation of DNA-templated transcription, elongation
Y0032786biological_processpositive regulation of DNA-templated transcription, elongation
Y0034243biological_processregulation of transcription elongation by RNA polymerase II
Y0034244biological_processnegative regulation of transcription elongation by RNA polymerase II
Y0045944biological_processpositive regulation of transcription by RNA polymerase II
Y0046872molecular_functionmetal ion binding
Y0046982molecular_functionprotein heterodimerization activity
Y0140673biological_processtranscription elongation-coupled chromatin remodeling
Z0000122biological_processnegative regulation of transcription by RNA polymerase II
Z0003682molecular_functionchromatin binding
Z0003723molecular_functionRNA binding
Z0003729molecular_functionmRNA binding
Z0005515molecular_functionprotein binding
Z0005634cellular_componentnucleus
Z0005654cellular_componentnucleoplasm
Z0006354biological_processDNA-templated transcription elongation
Z0006357biological_processregulation of transcription by RNA polymerase II
Z0006368biological_processtranscription elongation by RNA polymerase II
Z0016239biological_processpositive regulation of macroautophagy
Z0019899molecular_functionenzyme binding
Z0032044cellular_componentDSIF complex
Z0032784biological_processregulation of DNA-templated transcription elongation
Z0032785biological_processnegative regulation of DNA-templated transcription, elongation
Z0032786biological_processpositive regulation of DNA-templated transcription, elongation
Z0032968biological_processpositive regulation of transcription elongation by RNA polymerase II
Z0034243biological_processregulation of transcription elongation by RNA polymerase II
Z0045944biological_processpositive regulation of transcription by RNA polymerase II
Z0046982molecular_functionprotein heterodimerization activity
Z0140870molecular_functionRNA polymerase inhibitor activity
a0000786cellular_componentnucleosome
a0003677molecular_functionDNA binding
a0005515molecular_functionprotein binding
a0005634cellular_componentnucleus
a0005654cellular_componentnucleoplasm
a0005694cellular_componentchromosome
a0030527molecular_functionstructural constituent of chromatin
a0046982molecular_functionprotein heterodimerization activity
b0000786cellular_componentnucleosome
b0003677molecular_functionDNA binding
b0005515molecular_functionprotein binding
b0005634cellular_componentnucleus
b0005694cellular_componentchromosome
b0006334biological_processnucleosome assembly
b0030527molecular_functionstructural constituent of chromatin
b0046982molecular_functionprotein heterodimerization activity
c0000786cellular_componentnucleosome
c0003677molecular_functionDNA binding
c0030527molecular_functionstructural constituent of chromatin
c0046982molecular_functionprotein heterodimerization activity
d0000786cellular_componentnucleosome
d0003677molecular_functionDNA binding
d0030527molecular_functionstructural constituent of chromatin
d0046982molecular_functionprotein heterodimerization activity
e0000786cellular_componentnucleosome
e0003677molecular_functionDNA binding
e0005515molecular_functionprotein binding
e0005634cellular_componentnucleus
e0005654cellular_componentnucleoplasm
e0005694cellular_componentchromosome
e0030527molecular_functionstructural constituent of chromatin
e0046982molecular_functionprotein heterodimerization activity
f0000786cellular_componentnucleosome
f0003677molecular_functionDNA binding
f0005515molecular_functionprotein binding
f0005634cellular_componentnucleus
f0005694cellular_componentchromosome
f0006334biological_processnucleosome assembly
f0030527molecular_functionstructural constituent of chromatin
f0046982molecular_functionprotein heterodimerization activity
Functional Information from PROSITE/UniProt
site_idPS00018
Number of Residues13
DetailsEF_HAND_1 EF-hand calcium-binding domain. DNDPSDYVEqdDI
ChainResidueDetails
CASP136-ILE148

site_idPS00046
Number of Residues7
DetailsHISTONE_H2A Histone H2A signature. AGLqFPV
ChainResidueDetails
cALA21-VAL27

site_idPS00047
Number of Residues5
DetailsHISTONE_H4 Histone H4 signature. GAKRH
ChainResidueDetails
fGLY14-HIS18

site_idPS00115
Number of Residues7
DetailsRNA_POL_II_REPEAT Eukaryotic RNA polymerase II heptapeptide repeat. YSPTSPA
ChainResidueDetails
ATYR1593-ALA1599
ATYR1671-SER1677
ATYR1678-SER1684
ATYR1685-SER1691
ATYR1692-SER1698
ATYR1699-SER1705
ATYR1706-SER1712
ATYR1713-SER1719
ATYR1720-SER1726
ATYR1727-SER1733
ATYR1734-SER1740
ATYR1615-SER1621
ATYR1741-SER1747
ATYR1748-SER1754
ATYR1755-ASN1761
ATYR1762-ASN1768
ATYR1769-SER1775
ATYR1776-SER1782
ATYR1783-ASN1789
ATYR1790-ASN1796
ATYR1797-SER1803
ATYR1804-SER1810
ATYR1622-SER1628
ATYR1811-SER1817
ATYR1832-SER1838
ATYR1839-SER1845
ATYR1846-LYS1852
ATYR1853-SER1859
ATYR1867-LYS1873
ATYR1874-LYS1880
ATYR1881-LYS1887
ATYR1888-THR1894
ATYR1902-THR1908
ATYR1629-ASN1635
ATYR1916-LYS1922
ATYR1923-THR1929
ATYR1930-LYS1936
ATYR1937-THR1943
ATYR1944-LYS1950
ATYR1961-THR1967
ATYR1636-SER1642
ATYR1643-SER1649
ATYR1650-SER1656
ATYR1657-SER1663
ATYR1664-SER1670

site_idPS00290
Number of Residues7
DetailsIG_MHC Immunoglobulins and major histocompatibility complex proteins signature. YVCTAPH
ChainResidueDetails
ITYR112-HIS118

site_idPS00322
Number of Residues7
DetailsHISTONE_H3_1 Histone H3 signature 1. KAPRKQL
ChainResidueDetails
eLYS14-LEU20

site_idPS00357
Number of Residues23
DetailsHISTONE_H2B Histone H2B signature. REIQTavRlLLpGELaKHAVSEG
ChainResidueDetails
dARG89-GLY111

site_idPS00446
Number of Residues41
DetailsRNA_POL_D_30KD RNA polymerases D / 30 to 40 Kd subunits signature. NSIRRvfiaevpiiAidwVqidaNsSvlhDEfIAhRLGLIP
ChainResidueDetails
CASN32-PRO72

site_idPS00466
Number of Residues38
DetailsZF_TFIIS_1 Zinc finger TFIIS-type signature. CqkCghkeavffqSHSARaEDAmrlyyvCtaph.CghrW
ChainResidueDetails
ICYS86-TRP123

site_idPS00678
Number of Residues15
DetailsWD_REPEATS_1 Trp-Asp (WD) repeats signature. AASSslDaHIRLWDL
ChainResidueDetails
WALA79-LEU93

site_idPS00959
Number of Residues9
DetailsHISTONE_H3_2 Histone H3 signature 2. PFqRLVREI
ChainResidueDetails
ePRO66-ILE74

site_idPS01030
Number of Residues27
DetailsRNA_POL_M_15KD RNA polymerases M / 15 Kd subunits signature. FCQECNNMLypkedkenrillyaCrnC
ChainResidueDetails
IPHE16-CYS42

site_idPS01110
Number of Residues14
DetailsRNA_POL_H_23KD RNA polymerases H / 23 Kd subunits signature. HELVPEHvvMtkEE
ChainResidueDetails
EHIS142-GLU155

site_idPS01111
Number of Residues15
DetailsRNA_POL_K_14KD RNA polymerases K / 14 to 18 Kd subunits signature. TkYErARvLGtRAlQ
ChainResidueDetails
FTHR58-GLN72

site_idPS01112
Number of Residues10
DetailsRNA_POL_N_8KD RNA polymerases N / 8 Kd subunits signature. IIPVrCFTCG
ChainResidueDetails
JILE2-GLY11

site_idPS01154
Number of Residues32
DetailsRNA_POL_L_13KD RNA polymerases L / 13 to 16 Kd subunits signature. InkEdHTLgNiIksqLlkdpqVlfagYkvpHP
ChainResidueDetails
KILE35-PRO66

site_idPS01166
Number of Residues13
DetailsRNA_POL_BETA RNA polymerases beta chain signature. GdKFASrHGQKGT
ChainResidueDetails
BGLY932-THR944

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI11
Number of Residues45
DetailsZinc finger: {"description":"C4-type","evidences":[{"evidenceCode":"ECO:0000255"}]}
ChainResidueDetails

site_idSWS_FT_FI12
Number of Residues42
DetailsZinc finger: {"description":"TFIIS-type","evidences":[{"source":"PROSITE-ProRule","id":"PRU00472","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails

site_idSWS_FT_FI13
Number of Residues4
DetailsBinding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU10145","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails

site_idSWS_FT_FI14
Number of Residues4
DetailsBinding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00472","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails

site_idSWS_FT_FI16
Number of Residues1
DetailsModified residue: {"description":"N6-acetyllysine","evidences":[{"source":"PubMed","id":"19608861","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails

site_idSWS_FT_FI17
Number of Residues1
DetailsModified residue: {"description":"Phosphotyrosine","evidences":[{"source":"PubMed","id":"24275569","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails

site_idSWS_FT_FI18
Number of Residues34
DetailsRepeat: {"description":"TPR 1"}
ChainResidueDetails

site_idSWS_FT_FI19
Number of Residues33
DetailsRepeat: {"description":"TPR 2"}
ChainResidueDetails

site_idSWS_FT_FI20
Number of Residues33
DetailsRepeat: {"description":"TPR 3"}
ChainResidueDetails

site_idSWS_FT_FI21
Number of Residues33
DetailsRepeat: {"description":"TPR 4"}
ChainResidueDetails

site_idSWS_FT_FI22
Number of Residues33
DetailsRepeat: {"description":"TPR 5"}
ChainResidueDetails

site_idSWS_FT_FI23
Number of Residues33
DetailsRepeat: {"description":"TPR 6"}
ChainResidueDetails

site_idSWS_FT_FI24
Number of Residues33
DetailsRepeat: {"description":"TPR 7"}
ChainResidueDetails

site_idSWS_FT_FI25
Number of Residues32
DetailsRepeat: {"description":"TPR 8"}
ChainResidueDetails

site_idSWS_FT_FI26
Number of Residues33
DetailsRepeat: {"description":"TPR 9"}
ChainResidueDetails

site_idSWS_FT_FI27
Number of Residues33
DetailsRepeat: {"description":"TPR 10"}
ChainResidueDetails

site_idSWS_FT_FI28
Number of Residues33
DetailsRepeat: {"description":"TPR 11"}
ChainResidueDetails

site_idSWS_FT_FI29
Number of Residues32
DetailsRepeat: {"description":"TPR 12"}
ChainResidueDetails

site_idSWS_FT_FI30
Number of Residues33
DetailsRepeat: {"description":"TPR 13"}
ChainResidueDetails

site_idSWS_FT_FI31
Number of Residues33
DetailsRepeat: {"description":"TPR 14"}
ChainResidueDetails

site_idSWS_FT_FI32
Number of Residues33
DetailsRepeat: {"description":"TPR 15"}
ChainResidueDetails

site_idSWS_FT_FI33
Number of Residues33
DetailsRepeat: {"description":"TPR 16"}
ChainResidueDetails

site_idSWS_FT_FI34
Number of Residues34
DetailsCoiled coil: {"evidences":[{"evidenceCode":"ECO:0000255"}]}
ChainResidueDetails

site_idSWS_FT_FI35
Number of Residues2
DetailsCross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)","evidences":[{"source":"PubMed","id":"28112733","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails

site_idSWS_FT_FI36
Number of Residues43
DetailsRepeat: {"description":"WD 1"}
ChainResidueDetails

site_idSWS_FT_FI37
Number of Residues39
DetailsRepeat: {"description":"WD 2"}
ChainResidueDetails

site_idSWS_FT_FI38
Number of Residues39
DetailsRepeat: {"description":"WD 3"}
ChainResidueDetails

site_idSWS_FT_FI39
Number of Residues41
DetailsRepeat: {"description":"WD 4"}
ChainResidueDetails

site_idSWS_FT_FI40
Number of Residues39
DetailsRepeat: {"description":"WD 5"}
ChainResidueDetails

site_idSWS_FT_FI41
Number of Residues39
DetailsRepeat: {"description":"WD 6"}
ChainResidueDetails

site_idSWS_FT_FI42
Number of Residues38
DetailsRegion: {"description":"Interaction with SUPT5H","evidences":[{"evidenceCode":"ECO:0000250"}]}
ChainResidueDetails

site_idSWS_FT_FI43
Number of Residues4
DetailsBinding site: {"evidences":[{"source":"UniProtKB","id":"P63272","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails

site_idSWS_FT_FI44
Number of Residues1
DetailsModified residue: {"description":"N-acetylalanine","evidences":[{"source":"UniProtKB","id":"P63272","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails

site_idSWS_FT_FI45
Number of Residues33
DetailsDomain: {"description":"KOW 1"}
ChainResidueDetails

site_idSWS_FT_FI46
Number of Residues31
DetailsDomain: {"description":"KOW 2"}
ChainResidueDetails

site_idSWS_FT_FI47
Number of Residues31
DetailsDomain: {"description":"KOW 3"}
ChainResidueDetails

site_idSWS_FT_FI48
Number of Residues33
DetailsDomain: {"description":"KOW 4"}
ChainResidueDetails

site_idSWS_FT_FI49
Number of Residues33
DetailsDomain: {"description":"KOW 5"}
ChainResidueDetails

site_idSWS_FT_FI50
Number of Residues5
DetailsRepeat: {"description":"CTR1-1; approximate"}
ChainResidueDetails

site_idSWS_FT_FI51
Number of Residues5
DetailsRepeat: {"description":"CTR1-2"}
ChainResidueDetails

site_idSWS_FT_FI52
Number of Residues2
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"28892040","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5OIK","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails

site_idSWS_FT_FI53
Number of Residues1
DetailsModified residue: {"description":"N6-acetyllysine","evidences":[{"source":"UniProtKB","id":"O55201","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails

site_idSWS_FT_FI54
Number of Residues1
DetailsModified residue: {"description":"Phosphothreonine; by CDK9","evidences":[{"source":"PubMed","id":"10757782","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16427012","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails

site_idSWS_FT_FI55
Number of Residues2
DetailsModified residue: {"description":"Phosphotyrosine","evidences":[{"source":"UniProtKB","id":"Q71DI3","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails

site_idSWS_FT_FI56
Number of Residues4
DetailsModified residue: {"description":"N6-succinyllysine; alternate","evidences":[{"source":"UniProtKB","id":"P84228","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails

site_idSWS_FT_FI57
Number of Residues2
DetailsModified residue: {"description":"Phosphoserine","evidences":[{"source":"UniProtKB","id":"Q71DI3","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails

site_idSWS_FT_FI58
Number of Residues2
DetailsModified residue: {"description":"N6-methyllysine; alternate","evidences":[{"source":"UniProtKB","id":"Q71DI3","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails

site_idSWS_FT_FI59
Number of Residues4
DetailsModified residue: {"description":"Phosphothreonine","evidences":[{"source":"UniProtKB","id":"Q71DI3","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails

site_idSWS_FT_FI60
Number of Residues2
DetailsModified residue: {"description":"Phosphoserine","evidences":[{"source":"UniProtKB","id":"P84243","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails

site_idSWS_FT_FI61
Number of Residues2
DetailsModified residue: {"description":"N6-glutaryllysine; alternate","evidences":[{"source":"UniProtKB","id":"Q71DI3","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails

site_idSWS_FT_FI62
Number of Residues2
DetailsModified residue: {"description":"N6-succinyllysine; alternate","evidences":[{"source":"UniProtKB","id":"Q71DI3","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails

site_idSWS_FT_FI63
Number of Residues2
DetailsLipidation: {"description":"S-palmitoyl cysteine","evidences":[{"source":"UniProtKB","id":"Q71DI3","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails

site_idSWS_FT_FI64
Number of Residues4
DetailsModified residue: {"description":"N6-succinyllysine; alternate","evidences":[{"source":"UniProtKB","id":"P62805","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails

site_idSWS_FT_FI65
Number of Residues4
DetailsModified residue: {"description":"N6-propionyllysine; alternate","evidences":[{"source":"UniProtKB","id":"P62805","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails

site_idSWS_FT_FI66
Number of Residues2
DetailsModified residue: {"description":"Phosphoserine; by PAK2","evidences":[{"source":"UniProtKB","id":"P62805","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails

site_idSWS_FT_FI67
Number of Residues4
DetailsModified residue: {"description":"Phosphotyrosine","evidences":[{"source":"UniProtKB","id":"P62805","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails

site_idSWS_FT_FI68
Number of Residues2
DetailsModified residue: {"description":"N6-glutaryllysine; alternate","evidences":[{"source":"UniProtKB","id":"P62805","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails

site_idSWS_FT_FI69
Number of Residues2
DetailsModified residue: {"description":"N6-succinyllysine","evidences":[{"source":"UniProtKB","id":"P62805","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails

site_idSWS_FT_FI70
Number of Residues2
DetailsCross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in UFM1); alternate","evidences":[{"source":"UniProtKB","id":"P62805","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails

site_idSWS_FT_FI71
Number of Residues4
DetailsCross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin); alternate","evidences":[{"source":"UniProtKB","id":"P62805","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails

site_idSWS_FT_FI72
Number of Residues1
DetailsModified residue: {"description":"N6-methyllysine; alternate","evidences":[{"source":"UniProtKB","id":"P62805","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails

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PDB entries from 2025-10-15

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