Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

8A3T

S. cerevisiae APC/C-Cdh1 complex

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005515	molecular_function	protein binding
A	0005634	cellular_component	nucleus
A	0005680	cellular_component	anaphase-promoting complex
A	0005737	cellular_component	cytoplasm
A	0005739	cellular_component	mitochondrion
A	0006325	biological_process	chromatin organization
A	0007346	biological_process	regulation of mitotic cell cycle
A	0016567	biological_process	protein ubiquitination
A	0030234	molecular_function	enzyme regulator activity
A	0031145	biological_process	anaphase-promoting complex-dependent catabolic process
A	0051301	biological_process	cell division
A	0051445	biological_process	regulation of meiotic cell cycle
A	0061630	molecular_function	ubiquitin protein ligase activity
A	0070979	biological_process	protein K11-linked ubiquitination
B	0005515	molecular_function	protein binding
B	0005634	cellular_component	nucleus
B	0005680	cellular_component	anaphase-promoting complex
B	0005737	cellular_component	cytoplasm
B	0010697	biological_process	negative regulation of mitotic spindle pole body separation
B	0010997	molecular_function	anaphase-promoting complex binding
B	0030332	molecular_function	cyclin binding
B	0031145	biological_process	anaphase-promoting complex-dependent catabolic process
B	0045732	biological_process	positive regulation of protein catabolic process
B	0045842	biological_process	positive regulation of mitotic metaphase/anaphase transition
B	0051301	biological_process	cell division
B	0097027	molecular_function	ubiquitin-protein transferase activator activity
B	1902426	biological_process	deactivation of mitotic spindle assembly checkpoint
B	1903473	biological_process	positive regulation of mitotic actomyosin contractile ring contraction
B	1904668	biological_process	positive regulation of ubiquitin protein ligase activity
B	1905786	biological_process	positive regulation of anaphase-promoting complex-dependent catabolic process
B	1990757	molecular_function	ubiquitin ligase activator activity
B	2000060	biological_process	positive regulation of ubiquitin-dependent protein catabolic process
C	0000922	cellular_component	spindle pole
C	0005515	molecular_function	protein binding
C	0005634	cellular_component	nucleus
C	0005680	cellular_component	anaphase-promoting complex
C	0005737	cellular_component	cytoplasm
C	0007091	biological_process	metaphase/anaphase transition of mitotic cell cycle
C	0007346	biological_process	regulation of mitotic cell cycle
C	0010458	biological_process	exit from mitosis
C	0016567	biological_process	protein ubiquitination
C	0031145	biological_process	anaphase-promoting complex-dependent catabolic process
C	0042802	molecular_function	identical protein binding
C	0051301	biological_process	cell division
C	0051445	biological_process	regulation of meiotic cell cycle
C	0060090	molecular_function	molecular adaptor activity
C	0061630	molecular_function	ubiquitin protein ligase activity
C	0070979	biological_process	protein K11-linked ubiquitination
D	0000776	cellular_component	kinetochore
D	0005515	molecular_function	protein binding
D	0005634	cellular_component	nucleus
D	0005680	cellular_component	anaphase-promoting complex
D	0007346	biological_process	regulation of mitotic cell cycle
D	0016567	biological_process	protein ubiquitination
D	0030332	molecular_function	cyclin binding
D	0031145	biological_process	anaphase-promoting complex-dependent catabolic process
D	0045842	biological_process	positive regulation of mitotic metaphase/anaphase transition
D	0051301	biological_process	cell division
D	0051445	biological_process	regulation of meiotic cell cycle
D	0061630	molecular_function	ubiquitin protein ligase activity
E	0005634	cellular_component	nucleus
E	0005680	cellular_component	anaphase-promoting complex
E	0005737	cellular_component	cytoplasm
E	0006325	biological_process	chromatin organization
E	0007346	biological_process	regulation of mitotic cell cycle
E	0016567	biological_process	protein ubiquitination
E	0031145	biological_process	anaphase-promoting complex-dependent catabolic process
E	0051301	biological_process	cell division
E	0051445	biological_process	regulation of meiotic cell cycle
E	0061630	molecular_function	ubiquitin protein ligase activity
F	0005515	molecular_function	protein binding
F	0005634	cellular_component	nucleus
F	0005680	cellular_component	anaphase-promoting complex
F	0005737	cellular_component	cytoplasm
F	0007091	biological_process	metaphase/anaphase transition of mitotic cell cycle
F	0007346	biological_process	regulation of mitotic cell cycle
F	0016567	biological_process	protein ubiquitination
F	0031145	biological_process	anaphase-promoting complex-dependent catabolic process
F	0034399	cellular_component	nuclear periphery
F	0051301	biological_process	cell division
F	0051445	biological_process	regulation of meiotic cell cycle
F	0061630	molecular_function	ubiquitin protein ligase activity
G	0005634	cellular_component	nucleus
G	0005680	cellular_component	anaphase-promoting complex
G	0005829	cellular_component	cytosol
G	0006325	biological_process	chromatin organization
G	0007346	biological_process	regulation of mitotic cell cycle
G	0016567	biological_process	protein ubiquitination
G	0031145	biological_process	anaphase-promoting complex-dependent catabolic process
G	0051301	biological_process	cell division
G	0051445	biological_process	regulation of meiotic cell cycle
G	0061630	molecular_function	ubiquitin protein ligase activity
H	0005515	molecular_function	protein binding
H	0005634	cellular_component	nucleus
H	0005680	cellular_component	anaphase-promoting complex
H	0005737	cellular_component	cytoplasm
H	0007091	biological_process	metaphase/anaphase transition of mitotic cell cycle
H	0007346	biological_process	regulation of mitotic cell cycle
H	0016567	biological_process	protein ubiquitination
H	0031145	biological_process	anaphase-promoting complex-dependent catabolic process
H	0034399	cellular_component	nuclear periphery
H	0051301	biological_process	cell division
H	0051445	biological_process	regulation of meiotic cell cycle
H	0061630	molecular_function	ubiquitin protein ligase activity
I	0005515	molecular_function	protein binding
I	0005634	cellular_component	nucleus
I	0005680	cellular_component	anaphase-promoting complex
I	0007346	biological_process	regulation of mitotic cell cycle
I	0016567	biological_process	protein ubiquitination
I	0030071	biological_process	regulation of mitotic metaphase/anaphase transition
I	0030476	biological_process	ascospore wall assembly
I	0031145	biological_process	anaphase-promoting complex-dependent catabolic process
I	0051301	biological_process	cell division
I	0051321	biological_process	meiotic cell cycle
I	0051445	biological_process	regulation of meiotic cell cycle
I	0061630	molecular_function	ubiquitin protein ligase activity
I	1904824	biological_process	anaphase-promoting complex assembly
J	0005515	molecular_function	protein binding
J	0005634	cellular_component	nucleus
J	0005680	cellular_component	anaphase-promoting complex
J	0005737	cellular_component	cytoplasm
J	0005829	cellular_component	cytosol
J	0007346	biological_process	regulation of mitotic cell cycle
J	0016567	biological_process	protein ubiquitination
J	0031145	biological_process	anaphase-promoting complex-dependent catabolic process
J	0032297	biological_process	negative regulation of DNA-templated DNA replication initiation
J	0045842	biological_process	positive regulation of mitotic metaphase/anaphase transition
J	0051301	biological_process	cell division
J	0051445	biological_process	regulation of meiotic cell cycle
J	0061630	molecular_function	ubiquitin protein ligase activity
K	0005515	molecular_function	protein binding
K	0005634	cellular_component	nucleus
K	0005680	cellular_component	anaphase-promoting complex
K	0005737	cellular_component	cytoplasm
K	0005829	cellular_component	cytosol
K	0007346	biological_process	regulation of mitotic cell cycle
K	0016567	biological_process	protein ubiquitination
K	0031145	biological_process	anaphase-promoting complex-dependent catabolic process
K	0032297	biological_process	negative regulation of DNA-templated DNA replication initiation
K	0045842	biological_process	positive regulation of mitotic metaphase/anaphase transition
K	0051301	biological_process	cell division
K	0051445	biological_process	regulation of meiotic cell cycle
K	0061630	molecular_function	ubiquitin protein ligase activity
N	0000070	biological_process	mitotic sister chromatid segregation
N	0005515	molecular_function	protein binding
N	0005634	cellular_component	nucleus
N	0005680	cellular_component	anaphase-promoting complex
N	0007131	biological_process	reciprocal meiotic recombination
N	0007346	biological_process	regulation of mitotic cell cycle
N	0016567	biological_process	protein ubiquitination
N	0030071	biological_process	regulation of mitotic metaphase/anaphase transition
N	0031145	biological_process	anaphase-promoting complex-dependent catabolic process
N	0051301	biological_process	cell division
N	0051445	biological_process	regulation of meiotic cell cycle
N	1902426	biological_process	deactivation of mitotic spindle assembly checkpoint
N	1902499	biological_process	positive regulation of protein autoubiquitination
N	1905785	biological_process	negative regulation of anaphase-promoting complex-dependent catabolic process
N	1990948	molecular_function	ubiquitin ligase inhibitor activity
O	0005515	molecular_function	protein binding
O	0005634	cellular_component	nucleus
O	0005680	cellular_component	anaphase-promoting complex
O	0006325	biological_process	chromatin organization
O	0007346	biological_process	regulation of mitotic cell cycle
O	0016567	biological_process	protein ubiquitination
O	0031145	biological_process	anaphase-promoting complex-dependent catabolic process
O	0045842	biological_process	positive regulation of mitotic metaphase/anaphase transition
O	0051301	biological_process	cell division
O	0051445	biological_process	regulation of meiotic cell cycle
O	0061630	molecular_function	ubiquitin protein ligase activity
O	0070979	biological_process	protein K11-linked ubiquitination
P	0000776	cellular_component	kinetochore
P	0005515	molecular_function	protein binding
P	0005634	cellular_component	nucleus
P	0005680	cellular_component	anaphase-promoting complex
P	0007346	biological_process	regulation of mitotic cell cycle
P	0016567	biological_process	protein ubiquitination
P	0030332	molecular_function	cyclin binding
P	0031145	biological_process	anaphase-promoting complex-dependent catabolic process
P	0045842	biological_process	positive regulation of mitotic metaphase/anaphase transition
P	0051301	biological_process	cell division
P	0051445	biological_process	regulation of meiotic cell cycle
P	0061630	molecular_function	ubiquitin protein ligase activity
Q	0005515	molecular_function	protein binding
Q	0005634	cellular_component	nucleus
Q	0005680	cellular_component	anaphase-promoting complex
Q	0005737	cellular_component	cytoplasm
Q	0007346	biological_process	regulation of mitotic cell cycle
Q	0016567	biological_process	protein ubiquitination
Q	0031145	biological_process	anaphase-promoting complex-dependent catabolic process
Q	0034399	cellular_component	nuclear periphery
Q	0051301	biological_process	cell division
Q	0051445	biological_process	regulation of meiotic cell cycle
Q	0061630	molecular_function	ubiquitin protein ligase activity
Q	0070979	biological_process	protein K11-linked ubiquitination
S	0000086	biological_process	G2/M transition of mitotic cell cycle
S	0000144	cellular_component	cellular bud neck septin ring
S	0000166	molecular_function	nucleotide binding
S	0000399	cellular_component	cellular bud neck septin structure
S	0004672	molecular_function	protein kinase activity
S	0004674	molecular_function	protein serine/threonine kinase activity
S	0005515	molecular_function	protein binding
S	0005524	molecular_function	ATP binding
S	0005634	cellular_component	nucleus
S	0005737	cellular_component	cytoplasm
S	0005935	cellular_component	cellular bud neck
S	0005940	cellular_component	septin ring
S	0006468	biological_process	protein phosphorylation
S	0016301	molecular_function	kinase activity
S	0016740	molecular_function	transferase activity
S	0030163	biological_process	protein catabolic process
S	0032161	cellular_component	cleavage apparatus septin structure
S	0044879	biological_process	mitotic morphogenesis checkpoint signaling
S	0051726	biological_process	regulation of cell cycle
S	0106310	molecular_function	protein serine kinase activity
S	1900481	biological_process	negative regulation of diacylglycerol biosynthetic process
S	1902935	biological_process	protein localization to septin ring
T	0005515	molecular_function	protein binding
T	0005634	cellular_component	nucleus
T	0005680	cellular_component	anaphase-promoting complex
T	0005737	cellular_component	cytoplasm
T	0006511	biological_process	ubiquitin-dependent protein catabolic process
T	0007091	biological_process	metaphase/anaphase transition of mitotic cell cycle
T	0007346	biological_process	regulation of mitotic cell cycle
T	0010458	biological_process	exit from mitosis
T	0016567	biological_process	protein ubiquitination
T	0031145	biological_process	anaphase-promoting complex-dependent catabolic process
T	0031625	molecular_function	ubiquitin protein ligase binding
T	0051301	biological_process	cell division
T	0051445	biological_process	regulation of meiotic cell cycle
T	0061630	molecular_function	ubiquitin protein ligase activity
T	0070979	biological_process	protein K11-linked ubiquitination
T	1903473	biological_process	positive regulation of mitotic actomyosin contractile ring contraction
U	0005634	cellular_component	nucleus
U	0005680	cellular_component	anaphase-promoting complex
U	0006511	biological_process	ubiquitin-dependent protein catabolic process
U	0007346	biological_process	regulation of mitotic cell cycle
U	0008270	molecular_function	zinc ion binding
U	0016567	biological_process	protein ubiquitination
U	0016874	molecular_function	ligase activity
U	0031145	biological_process	anaphase-promoting complex-dependent catabolic process
U	0045842	biological_process	positive regulation of mitotic metaphase/anaphase transition
U	0046872	molecular_function	metal ion binding
U	0051301	biological_process	cell division
U	0051445	biological_process	regulation of meiotic cell cycle
U	0061630	molecular_function	ubiquitin protein ligase activity
U	0097602	molecular_function	cullin family protein binding
W	0005634	cellular_component	nucleus
W	0005680	cellular_component	anaphase-promoting complex
W	0005829	cellular_component	cytosol
W	0006325	biological_process	chromatin organization
W	0007346	biological_process	regulation of mitotic cell cycle
W	0016567	biological_process	protein ubiquitination
W	0031145	biological_process	anaphase-promoting complex-dependent catabolic process
W	0051301	biological_process	cell division
W	0051445	biological_process	regulation of meiotic cell cycle
W	0061630	molecular_function	ubiquitin protein ligase activity

Functional Information from PROSITE/UniProt

site_id	PS00107
Number of Residues	29
Details	PROTEIN_KINASE_ATP Protein kinases ATP-binding region signature. LGKGSSGRVRlAknmetgqlaaiki.....VPKK

Chain	Residue	Details
S	LEU87-LYS115

site_id	PS00108
Number of Residues	13
Details	PROTEIN_KINASE_ST Serine/Threonine protein kinases active-site signature. IcHrDLKpeNLLL

Chain	Residue	Details
S	ILE235-LEU247

site_id	PS00678
Number of Residues	15
Details	WD_REPEATS_1 Trp-Asp (WD) repeats signature. TGGGtaDrRLKIWNV

Chain	Residue	Details
B	THR445-VAL459

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	194
Details	Repeat: {"description":"TPR 1"}

Chain

Residue

Details

site_id	SWS_FT_FI2
Number of Residues	182
Details	Repeat: {"description":"TPR 2"}

Chain

Residue

Details

site_id	SWS_FT_FI3
Number of Residues	178
Details	Repeat: {"description":"TPR 3"}

Chain

Residue

Details

site_id	SWS_FT_FI4
Number of Residues	194
Details	Repeat: {"description":"TPR 4"}

Chain

Residue

Details

site_id	SWS_FT_FI5
Number of Residues	178
Details	Repeat: {"description":"TPR 5"}

Chain

Residue

Details

site_id	SWS_FT_FI6
Number of Residues	188
Details	Repeat: {"description":"TPR 6"}

Chain

Residue

Details

site_id	SWS_FT_FI7
Number of Residues	188
Details	Repeat: {"description":"TPR 7"}

Chain

Residue

Details

site_id	SWS_FT_FI8
Number of Residues	186
Details	Repeat: {"description":"TPR 8"}

Chain

Residue

Details

site_id	SWS_FT_FI9
Number of Residues	124
Details	Repeat: {"description":"TPR 9"}

Chain

Residue

Details

site_id	SWS_FT_FI10
Number of Residues	56
Details	Repeat: {"description":"TPR 10"}

Chain

Residue

Details

site_id	SWS_FT_FI11
Number of Residues	56
Details	Repeat: {"description":"TPR 11"}

Chain

Residue

Details

site_id	SWS_FT_FI12
Number of Residues	64
Details	Repeat: {"description":"TPR 12"}

Chain

Residue

Details

site_id	SWS_FT_FI13
Number of Residues	64
Details	Repeat: {"description":"TPR 13"}

Chain

Residue

Details

site_id	SWS_FT_FI14
Number of Residues	58
Details	Repeat: {"description":"TPR 14"}

Chain

Residue

Details

site_id	SWS_FT_FI15
Number of Residues	3
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"19779198","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI16
Number of Residues	40
Details	Repeat: {"description":"WD 1"}

Chain

Residue

Details

site_id	SWS_FT_FI17
Number of Residues	39
Details	Repeat: {"description":"WD 2"}

Chain

Residue

Details

site_id	SWS_FT_FI18
Number of Residues	37
Details	Repeat: {"description":"WD 3"}

Chain

Residue

Details

site_id	SWS_FT_FI19
Number of Residues	39
Details	Repeat: {"description":"WD 4"}

Chain

Residue

Details

site_id	SWS_FT_FI20
Number of Residues	42
Details	Repeat: {"description":"WD 5"}

Chain

Residue

Details

site_id	SWS_FT_FI21
Number of Residues	41
Details	Repeat: {"description":"WD 6"}

Chain

Residue

Details

site_id	SWS_FT_FI22
Number of Residues	6
Details	Motif: {"description":"C-box"}

Chain

Residue

Details

site_id	SWS_FT_FI23
Number of Residues	43
Details	Zinc finger: {"description":"RING-type; atypical","evidences":[{"source":"PROSITE-ProRule","id":"PRU00175","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)