8A2H
human STING in complex with 2',3'-cyclic-GMP-7-deazaphenyl-AMP
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0002218 | biological_process | activation of innate immune response |
| A | 0032481 | biological_process | positive regulation of type I interferon production |
| B | 0002218 | biological_process | activation of innate immune response |
| B | 0032481 | biological_process | positive regulation of type I interferon production |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 2 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:22728660, ECO:0007744|PDB:4F5Y |
| Chain | Residue | Details |
| A | SER162 | |
| B | SER162 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 2 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:22579474, ECO:0000269|PubMed:22705373, ECO:0000269|PubMed:22728658, ECO:0000269|PubMed:22728659, ECO:0000269|PubMed:22728660, ECO:0007744|PDB:4EF4, ECO:0007744|PDB:4EMT, ECO:0007744|PDB:4F5D, ECO:0007744|PDB:4F5Y, ECO:0007744|PDB:4F9G |
| Chain | Residue | Details |
| A | TYR167 | |
| B | TYR167 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 2 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:37379839, ECO:0007744|PDB:8GJX |
| Chain | Residue | Details |
| A | ARG238 | |
| B | ARG238 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 2 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:22579474, ECO:0000269|PubMed:22705373, ECO:0000269|PubMed:22728658, ECO:0000269|PubMed:22728660, ECO:0007744|PDB:4EF4, ECO:0007744|PDB:4EMT, ECO:0007744|PDB:4F5Y, ECO:0007744|PDB:4F9G |
| Chain | Residue | Details |
| A | THR263 | |
| B | THR263 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 6 |
| Details | MOD_RES: Phosphothreonine => ECO:0000269|PubMed:37832545 |
| Chain | Residue | Details |
| A | THR229 | |
| A | THR354 | |
| A | THR356 | |
| B | THR229 | |
| B | THR354 | |
| B | THR356 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 2 |
| Details | MOD_RES: Phosphoserine => ECO:0000269|PubMed:37832545 |
| Chain | Residue | Details |
| A | SER241 | |
| B | SER241 |
| site_id | SWS_FT_FI7 |
| Number of Residues | 2 |
| Details | MOD_RES: Phosphoserine; by MAP3K7 => ECO:0000269|PubMed:37832545 |
| Chain | Residue | Details |
| A | SER355 | |
| B | SER355 |
| site_id | SWS_FT_FI8 |
| Number of Residues | 2 |
| Details | MOD_RES: Phosphoserine; by TBK1 => ECO:0000269|PubMed:18818105, ECO:0000269|PubMed:25636800 |
| Chain | Residue | Details |
| A | SER358 | |
| B | SER358 |
| site_id | SWS_FT_FI9 |
| Number of Residues | 2 |
| Details | MOD_RES: Phosphoserine; by TBK1 => ECO:0000269|PubMed:25636800, ECO:0000269|PubMed:27302953, ECO:0000269|PubMed:32753499 |
| Chain | Residue | Details |
| A | SER366 | |
| B | SER366 |
| site_id | SWS_FT_FI10 |
| Number of Residues | 2 |
| Details | CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:19285439, ECO:0000269|PubMed:21074459 |
| Chain | Residue | Details |
| A | LYS150 | |
| B | LYS150 |
| site_id | SWS_FT_FI11 |
| Number of Residues | 4 |
| Details | CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO) => ECO:0000250|UniProtKB:Q3TBT3 |
| Chain | Residue | Details |
| A | LYS338 | |
| B | LYS338 |
| site_id | SWS_FT_FI12 |
| Number of Residues | 2 |
| Details | CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:31968013 |
| Chain | Residue | Details |
| A | LYS236 | |
| B | LYS236 |
