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7ZXT

cryo-EM structure of Connexin 32 W3S mutation hemi channel

Functional Information from GO Data
ChainGOidnamespacecontents
A0005243molecular_functiongap junction channel activity
A0005515molecular_functionprotein binding
A0005737cellular_componentcytoplasm
A0005789cellular_componentendoplasmic reticulum membrane
A0005886cellular_componentplasma membrane
A0005921cellular_componentgap junction
A0005922cellular_componentconnexin complex
A0007154biological_processcell communication
A0007267biological_processcell-cell signaling
A0007399biological_processnervous system development
A0015868biological_processpurine ribonucleotide transport
A0016264biological_processgap junction assembly
A0016328cellular_componentlateral plasma membrane
A0032991cellular_componentprotein-containing complex
A0042802molecular_functionidentical protein binding
A0055085biological_processtransmembrane transport
A1905867biological_processepididymis development
B0005243molecular_functiongap junction channel activity
B0005515molecular_functionprotein binding
B0005737cellular_componentcytoplasm
B0005789cellular_componentendoplasmic reticulum membrane
B0005886cellular_componentplasma membrane
B0005921cellular_componentgap junction
B0005922cellular_componentconnexin complex
B0007154biological_processcell communication
B0007267biological_processcell-cell signaling
B0007399biological_processnervous system development
B0015868biological_processpurine ribonucleotide transport
B0016264biological_processgap junction assembly
B0016328cellular_componentlateral plasma membrane
B0032991cellular_componentprotein-containing complex
B0042802molecular_functionidentical protein binding
B0055085biological_processtransmembrane transport
B1905867biological_processepididymis development
C0005243molecular_functiongap junction channel activity
C0005515molecular_functionprotein binding
C0005737cellular_componentcytoplasm
C0005789cellular_componentendoplasmic reticulum membrane
C0005886cellular_componentplasma membrane
C0005921cellular_componentgap junction
C0005922cellular_componentconnexin complex
C0007154biological_processcell communication
C0007267biological_processcell-cell signaling
C0007399biological_processnervous system development
C0015868biological_processpurine ribonucleotide transport
C0016264biological_processgap junction assembly
C0016328cellular_componentlateral plasma membrane
C0032991cellular_componentprotein-containing complex
C0042802molecular_functionidentical protein binding
C0055085biological_processtransmembrane transport
C1905867biological_processepididymis development
D0005243molecular_functiongap junction channel activity
D0005515molecular_functionprotein binding
D0005737cellular_componentcytoplasm
D0005789cellular_componentendoplasmic reticulum membrane
D0005886cellular_componentplasma membrane
D0005921cellular_componentgap junction
D0005922cellular_componentconnexin complex
D0007154biological_processcell communication
D0007267biological_processcell-cell signaling
D0007399biological_processnervous system development
D0015868biological_processpurine ribonucleotide transport
D0016264biological_processgap junction assembly
D0016328cellular_componentlateral plasma membrane
D0032991cellular_componentprotein-containing complex
D0042802molecular_functionidentical protein binding
D0055085biological_processtransmembrane transport
D1905867biological_processepididymis development
E0005243molecular_functiongap junction channel activity
E0005515molecular_functionprotein binding
E0005737cellular_componentcytoplasm
E0005789cellular_componentendoplasmic reticulum membrane
E0005886cellular_componentplasma membrane
E0005921cellular_componentgap junction
E0005922cellular_componentconnexin complex
E0007154biological_processcell communication
E0007267biological_processcell-cell signaling
E0007399biological_processnervous system development
E0015868biological_processpurine ribonucleotide transport
E0016264biological_processgap junction assembly
E0016328cellular_componentlateral plasma membrane
E0032991cellular_componentprotein-containing complex
E0042802molecular_functionidentical protein binding
E0055085biological_processtransmembrane transport
E1905867biological_processepididymis development
F0005243molecular_functiongap junction channel activity
F0005515molecular_functionprotein binding
F0005737cellular_componentcytoplasm
F0005789cellular_componentendoplasmic reticulum membrane
F0005886cellular_componentplasma membrane
F0005921cellular_componentgap junction
F0005922cellular_componentconnexin complex
F0007154biological_processcell communication
F0007267biological_processcell-cell signaling
F0007399biological_processnervous system development
F0015868biological_processpurine ribonucleotide transport
F0016264biological_processgap junction assembly
F0016328cellular_componentlateral plasma membrane
F0032991cellular_componentprotein-containing complex
F0042802molecular_functionidentical protein binding
F0055085biological_processtransmembrane transport
F1905867biological_processepididymis development
Functional Information from PROSITE/UniProt
site_idPS00407
Number of Residues14
DetailsCONNEXINS_1 Connexins signature 1. CNTlQPGCnsVCYD
ChainResidueDetails
ACYS53-ASP66

site_idPS00408
Number of Residues17
DetailsCONNEXINS_2 Connexins signature 2. Cdvy.PCpntVDCFVSRP
ChainResidueDetails
ACYS168-PRO184

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues738
DetailsTOPO_DOM: Cytoplasmic => ECO:0000305|PubMed:2460334
ChainResidueDetails
AMET1-ARG22
DMET1-ARG22
DALA96-THR130
DARG215-CYS283
EMET1-ARG22
EALA96-THR130
EARG215-CYS283
FMET1-ARG22
FALA96-THR130
FARG215-CYS283
AALA96-THR130
AARG215-CYS283
BMET1-ARG22
BALA96-THR130
BARG215-CYS283
CMET1-ARG22
CALA96-THR130
CARG215-CYS283

site_idSWS_FT_FI2
Number of Residues510
DetailsTRANSMEM: Helical => ECO:0000305
ChainResidueDetails
AVAL23-GLY45
CLEU76-VAL95
CLEU131-PHE153
CVAL192-ILE214
DVAL23-GLY45
DLEU76-VAL95
DLEU131-PHE153
DVAL192-ILE214
EVAL23-GLY45
ELEU76-VAL95
ELEU131-PHE153
ALEU76-VAL95
EVAL192-ILE214
FVAL23-GLY45
FLEU76-VAL95
FLEU131-PHE153
FVAL192-ILE214
ALEU131-PHE153
AVAL192-ILE214
BVAL23-GLY45
BLEU76-VAL95
BLEU131-PHE153
BVAL192-ILE214
CVAL23-GLY45

site_idSWS_FT_FI3
Number of Residues396
DetailsTOPO_DOM: Extracellular => ECO:0000305|PubMed:2460334
ChainResidueDetails
AASP46-ARG75
ETYR154-THR191
FASP46-ARG75
FTYR154-THR191
ATYR154-THR191
BASP46-ARG75
BTYR154-THR191
CASP46-ARG75
CTYR154-THR191
DASP46-ARG75
DTYR154-THR191
EASP46-ARG75

site_idSWS_FT_FI4
Number of Residues6
DetailsMOD_RES: Phosphoserine => ECO:0000250|UniProtKB:P08033
ChainResidueDetails
ASER233
BSER233
CSER233
DSER233
ESER233
FSER233

site_idSWS_FT_FI5
Number of Residues18
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:24275569
ChainResidueDetails
ASER258
DSER258
DSER266
DSER277
ESER258
ESER266
ESER277
FSER258
FSER266
FSER277
ASER266
ASER277
BSER258
BSER266
BSER277
CSER258
CSER266
CSER277

227344

PDB entries from 2024-11-13

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