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7ZXT

cryo-EM structure of Connexin 32 W3S mutation hemi channel

Functional Information from GO Data
ChainGOidnamespacecontents
A0005243molecular_functiongap junction channel activity
A0005515molecular_functionprotein binding
A0005737cellular_componentcytoplasm
A0005789cellular_componentendoplasmic reticulum membrane
A0005886cellular_componentplasma membrane
A0005921cellular_componentgap junction
A0005922cellular_componentconnexin complex
A0007154biological_processcell communication
A0007267biological_processcell-cell signaling
A0007399biological_processnervous system development
A0016020cellular_componentmembrane
A0016264biological_processgap junction assembly
A0042802molecular_functionidentical protein binding
A0055085biological_processtransmembrane transport
A0070161cellular_componentanchoring junction
B0005243molecular_functiongap junction channel activity
B0005515molecular_functionprotein binding
B0005737cellular_componentcytoplasm
B0005789cellular_componentendoplasmic reticulum membrane
B0005886cellular_componentplasma membrane
B0005921cellular_componentgap junction
B0005922cellular_componentconnexin complex
B0007154biological_processcell communication
B0007267biological_processcell-cell signaling
B0007399biological_processnervous system development
B0016020cellular_componentmembrane
B0016264biological_processgap junction assembly
B0042802molecular_functionidentical protein binding
B0055085biological_processtransmembrane transport
B0070161cellular_componentanchoring junction
C0005243molecular_functiongap junction channel activity
C0005515molecular_functionprotein binding
C0005737cellular_componentcytoplasm
C0005789cellular_componentendoplasmic reticulum membrane
C0005886cellular_componentplasma membrane
C0005921cellular_componentgap junction
C0005922cellular_componentconnexin complex
C0007154biological_processcell communication
C0007267biological_processcell-cell signaling
C0007399biological_processnervous system development
C0016020cellular_componentmembrane
C0016264biological_processgap junction assembly
C0042802molecular_functionidentical protein binding
C0055085biological_processtransmembrane transport
C0070161cellular_componentanchoring junction
D0005243molecular_functiongap junction channel activity
D0005515molecular_functionprotein binding
D0005737cellular_componentcytoplasm
D0005789cellular_componentendoplasmic reticulum membrane
D0005886cellular_componentplasma membrane
D0005921cellular_componentgap junction
D0005922cellular_componentconnexin complex
D0007154biological_processcell communication
D0007267biological_processcell-cell signaling
D0007399biological_processnervous system development
D0016020cellular_componentmembrane
D0016264biological_processgap junction assembly
D0042802molecular_functionidentical protein binding
D0055085biological_processtransmembrane transport
D0070161cellular_componentanchoring junction
E0005243molecular_functiongap junction channel activity
E0005515molecular_functionprotein binding
E0005737cellular_componentcytoplasm
E0005789cellular_componentendoplasmic reticulum membrane
E0005886cellular_componentplasma membrane
E0005921cellular_componentgap junction
E0005922cellular_componentconnexin complex
E0007154biological_processcell communication
E0007267biological_processcell-cell signaling
E0007399biological_processnervous system development
E0016020cellular_componentmembrane
E0016264biological_processgap junction assembly
E0042802molecular_functionidentical protein binding
E0055085biological_processtransmembrane transport
E0070161cellular_componentanchoring junction
F0005243molecular_functiongap junction channel activity
F0005515molecular_functionprotein binding
F0005737cellular_componentcytoplasm
F0005789cellular_componentendoplasmic reticulum membrane
F0005886cellular_componentplasma membrane
F0005921cellular_componentgap junction
F0005922cellular_componentconnexin complex
F0007154biological_processcell communication
F0007267biological_processcell-cell signaling
F0007399biological_processnervous system development
F0016020cellular_componentmembrane
F0016264biological_processgap junction assembly
F0042802molecular_functionidentical protein binding
F0055085biological_processtransmembrane transport
F0070161cellular_componentanchoring junction
Functional Information from PROSITE/UniProt
site_idPS00407
Number of Residues14
DetailsCONNEXINS_1 Connexins signature 1. CNTlQPGCnsVCYD
ChainResidueDetails
ACYS53-ASP66

site_idPS00408
Number of Residues17
DetailsCONNEXINS_2 Connexins signature 2. Cdvy.PCpntVDCFVSRP
ChainResidueDetails
ACYS168-PRO184

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues126
DetailsTopological domain: {"description":"Cytoplasmic","evidences":[{"source":"PubMed","id":"2460334","evidenceCode":"ECO:0000305"}]}
ChainResidueDetails

site_idSWS_FT_FI2
Number of Residues510
DetailsTransmembrane: {"description":"Helical","evidences":[{"evidenceCode":"ECO:0000305"}]}
ChainResidueDetails

site_idSWS_FT_FI3
Number of Residues396
DetailsTopological domain: {"description":"Extracellular","evidences":[{"source":"PubMed","id":"2460334","evidenceCode":"ECO:0000305"}]}
ChainResidueDetails

239803

PDB entries from 2025-08-06

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