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7ZXP

cryo-EM structure of Connexin 32 R22G mutation gap junction channel

Functional Information from GO Data
ChainGOidnamespacecontents
A0005243molecular_functiongap junction channel activity
A0005515molecular_functionprotein binding
A0005737cellular_componentcytoplasm
A0005789cellular_componentendoplasmic reticulum membrane
A0005886cellular_componentplasma membrane
A0005921cellular_componentgap junction
A0005922cellular_componentconnexin complex
A0007154biological_processcell communication
A0007267biological_processcell-cell signaling
A0007399biological_processnervous system development
A0015868biological_processpurine ribonucleotide transport
A0016264biological_processgap junction assembly
A0016328cellular_componentlateral plasma membrane
A0032991cellular_componentprotein-containing complex
A0042802molecular_functionidentical protein binding
A0055085biological_processtransmembrane transport
A1905867biological_processepididymis development
B0005243molecular_functiongap junction channel activity
B0005515molecular_functionprotein binding
B0005737cellular_componentcytoplasm
B0005789cellular_componentendoplasmic reticulum membrane
B0005886cellular_componentplasma membrane
B0005921cellular_componentgap junction
B0005922cellular_componentconnexin complex
B0007154biological_processcell communication
B0007267biological_processcell-cell signaling
B0007399biological_processnervous system development
B0015868biological_processpurine ribonucleotide transport
B0016264biological_processgap junction assembly
B0016328cellular_componentlateral plasma membrane
B0032991cellular_componentprotein-containing complex
B0042802molecular_functionidentical protein binding
B0055085biological_processtransmembrane transport
B1905867biological_processepididymis development
C0005243molecular_functiongap junction channel activity
C0005515molecular_functionprotein binding
C0005737cellular_componentcytoplasm
C0005789cellular_componentendoplasmic reticulum membrane
C0005886cellular_componentplasma membrane
C0005921cellular_componentgap junction
C0005922cellular_componentconnexin complex
C0007154biological_processcell communication
C0007267biological_processcell-cell signaling
C0007399biological_processnervous system development
C0015868biological_processpurine ribonucleotide transport
C0016264biological_processgap junction assembly
C0016328cellular_componentlateral plasma membrane
C0032991cellular_componentprotein-containing complex
C0042802molecular_functionidentical protein binding
C0055085biological_processtransmembrane transport
C1905867biological_processepididymis development
D0005243molecular_functiongap junction channel activity
D0005515molecular_functionprotein binding
D0005737cellular_componentcytoplasm
D0005789cellular_componentendoplasmic reticulum membrane
D0005886cellular_componentplasma membrane
D0005921cellular_componentgap junction
D0005922cellular_componentconnexin complex
D0007154biological_processcell communication
D0007267biological_processcell-cell signaling
D0007399biological_processnervous system development
D0015868biological_processpurine ribonucleotide transport
D0016264biological_processgap junction assembly
D0016328cellular_componentlateral plasma membrane
D0032991cellular_componentprotein-containing complex
D0042802molecular_functionidentical protein binding
D0055085biological_processtransmembrane transport
D1905867biological_processepididymis development
E0005243molecular_functiongap junction channel activity
E0005515molecular_functionprotein binding
E0005737cellular_componentcytoplasm
E0005789cellular_componentendoplasmic reticulum membrane
E0005886cellular_componentplasma membrane
E0005921cellular_componentgap junction
E0005922cellular_componentconnexin complex
E0007154biological_processcell communication
E0007267biological_processcell-cell signaling
E0007399biological_processnervous system development
E0015868biological_processpurine ribonucleotide transport
E0016264biological_processgap junction assembly
E0016328cellular_componentlateral plasma membrane
E0032991cellular_componentprotein-containing complex
E0042802molecular_functionidentical protein binding
E0055085biological_processtransmembrane transport
E1905867biological_processepididymis development
F0005243molecular_functiongap junction channel activity
F0005515molecular_functionprotein binding
F0005737cellular_componentcytoplasm
F0005789cellular_componentendoplasmic reticulum membrane
F0005886cellular_componentplasma membrane
F0005921cellular_componentgap junction
F0005922cellular_componentconnexin complex
F0007154biological_processcell communication
F0007267biological_processcell-cell signaling
F0007399biological_processnervous system development
F0015868biological_processpurine ribonucleotide transport
F0016264biological_processgap junction assembly
F0016328cellular_componentlateral plasma membrane
F0032991cellular_componentprotein-containing complex
F0042802molecular_functionidentical protein binding
F0055085biological_processtransmembrane transport
F1905867biological_processepididymis development
G0005243molecular_functiongap junction channel activity
G0005515molecular_functionprotein binding
G0005737cellular_componentcytoplasm
G0005789cellular_componentendoplasmic reticulum membrane
G0005886cellular_componentplasma membrane
G0005921cellular_componentgap junction
G0005922cellular_componentconnexin complex
G0007154biological_processcell communication
G0007267biological_processcell-cell signaling
G0007399biological_processnervous system development
G0015868biological_processpurine ribonucleotide transport
G0016264biological_processgap junction assembly
G0016328cellular_componentlateral plasma membrane
G0032991cellular_componentprotein-containing complex
G0042802molecular_functionidentical protein binding
G0055085biological_processtransmembrane transport
G1905867biological_processepididymis development
H0005243molecular_functiongap junction channel activity
H0005515molecular_functionprotein binding
H0005737cellular_componentcytoplasm
H0005789cellular_componentendoplasmic reticulum membrane
H0005886cellular_componentplasma membrane
H0005921cellular_componentgap junction
H0005922cellular_componentconnexin complex
H0007154biological_processcell communication
H0007267biological_processcell-cell signaling
H0007399biological_processnervous system development
H0015868biological_processpurine ribonucleotide transport
H0016264biological_processgap junction assembly
H0016328cellular_componentlateral plasma membrane
H0032991cellular_componentprotein-containing complex
H0042802molecular_functionidentical protein binding
H0055085biological_processtransmembrane transport
H1905867biological_processepididymis development
I0005243molecular_functiongap junction channel activity
I0005515molecular_functionprotein binding
I0005737cellular_componentcytoplasm
I0005789cellular_componentendoplasmic reticulum membrane
I0005886cellular_componentplasma membrane
I0005921cellular_componentgap junction
I0005922cellular_componentconnexin complex
I0007154biological_processcell communication
I0007267biological_processcell-cell signaling
I0007399biological_processnervous system development
I0015868biological_processpurine ribonucleotide transport
I0016264biological_processgap junction assembly
I0016328cellular_componentlateral plasma membrane
I0032991cellular_componentprotein-containing complex
I0042802molecular_functionidentical protein binding
I0055085biological_processtransmembrane transport
I1905867biological_processepididymis development
J0005243molecular_functiongap junction channel activity
J0005515molecular_functionprotein binding
J0005737cellular_componentcytoplasm
J0005789cellular_componentendoplasmic reticulum membrane
J0005886cellular_componentplasma membrane
J0005921cellular_componentgap junction
J0005922cellular_componentconnexin complex
J0007154biological_processcell communication
J0007267biological_processcell-cell signaling
J0007399biological_processnervous system development
J0015868biological_processpurine ribonucleotide transport
J0016264biological_processgap junction assembly
J0016328cellular_componentlateral plasma membrane
J0032991cellular_componentprotein-containing complex
J0042802molecular_functionidentical protein binding
J0055085biological_processtransmembrane transport
J1905867biological_processepididymis development
K0005243molecular_functiongap junction channel activity
K0005515molecular_functionprotein binding
K0005737cellular_componentcytoplasm
K0005789cellular_componentendoplasmic reticulum membrane
K0005886cellular_componentplasma membrane
K0005921cellular_componentgap junction
K0005922cellular_componentconnexin complex
K0007154biological_processcell communication
K0007267biological_processcell-cell signaling
K0007399biological_processnervous system development
K0015868biological_processpurine ribonucleotide transport
K0016264biological_processgap junction assembly
K0016328cellular_componentlateral plasma membrane
K0032991cellular_componentprotein-containing complex
K0042802molecular_functionidentical protein binding
K0055085biological_processtransmembrane transport
K1905867biological_processepididymis development
L0005243molecular_functiongap junction channel activity
L0005515molecular_functionprotein binding
L0005737cellular_componentcytoplasm
L0005789cellular_componentendoplasmic reticulum membrane
L0005886cellular_componentplasma membrane
L0005921cellular_componentgap junction
L0005922cellular_componentconnexin complex
L0007154biological_processcell communication
L0007267biological_processcell-cell signaling
L0007399biological_processnervous system development
L0015868biological_processpurine ribonucleotide transport
L0016264biological_processgap junction assembly
L0016328cellular_componentlateral plasma membrane
L0032991cellular_componentprotein-containing complex
L0042802molecular_functionidentical protein binding
L0055085biological_processtransmembrane transport
L1905867biological_processepididymis development
Functional Information from PROSITE/UniProt
site_idPS00407
Number of Residues14
DetailsCONNEXINS_1 Connexins signature 1. CNTlQPGCnsVCYD
ChainResidueDetails
ACYS53-ASP66

site_idPS00408
Number of Residues17
DetailsCONNEXINS_2 Connexins signature 2. Cdvy.PCpntVDCFVSRP
ChainResidueDetails
ACYS168-PRO184

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues1476
DetailsTOPO_DOM: Cytoplasmic => ECO:0000305|PubMed:2460334
ChainResidueDetails
AMET1-GLY22
DMET1-GLY22
DALA96-THR130
DARG215-CYS283
EMET1-GLY22
EALA96-THR130
EARG215-CYS283
FMET1-GLY22
FALA96-THR130
FARG215-CYS283
GMET1-GLY22
AALA96-THR130
GALA96-THR130
GARG215-CYS283
HMET1-GLY22
HALA96-THR130
HARG215-CYS283
IMET1-GLY22
IALA96-THR130
IARG215-CYS283
JMET1-GLY22
JALA96-THR130
AARG215-CYS283
JARG215-CYS283
KMET1-GLY22
KALA96-THR130
KARG215-CYS283
LMET1-GLY22
LALA96-THR130
LARG215-CYS283
BMET1-GLY22
BALA96-THR130
BARG215-CYS283
CMET1-GLY22
CALA96-THR130
CARG215-CYS283

site_idSWS_FT_FI2
Number of Residues1020
DetailsTRANSMEM: Helical => ECO:0000305
ChainResidueDetails
AVAL23-GLY45
CLEU76-VAL95
CLEU131-PHE153
CVAL192-ILE214
DVAL23-GLY45
DLEU76-VAL95
DLEU131-PHE153
DVAL192-ILE214
EVAL23-GLY45
ELEU76-VAL95
ELEU131-PHE153
ALEU76-VAL95
EVAL192-ILE214
FVAL23-GLY45
FLEU76-VAL95
FLEU131-PHE153
FVAL192-ILE214
GVAL23-GLY45
GLEU76-VAL95
GLEU131-PHE153
GVAL192-ILE214
HVAL23-GLY45
ALEU131-PHE153
HLEU76-VAL95
HLEU131-PHE153
HVAL192-ILE214
IVAL23-GLY45
ILEU76-VAL95
ILEU131-PHE153
IVAL192-ILE214
JVAL23-GLY45
JLEU76-VAL95
JLEU131-PHE153
AVAL192-ILE214
JVAL192-ILE214
KVAL23-GLY45
KLEU76-VAL95
KLEU131-PHE153
KVAL192-ILE214
LVAL23-GLY45
LLEU76-VAL95
LLEU131-PHE153
LVAL192-ILE214
BVAL23-GLY45
BLEU76-VAL95
BLEU131-PHE153
BVAL192-ILE214
CVAL23-GLY45

site_idSWS_FT_FI3
Number of Residues792
DetailsTOPO_DOM: Extracellular => ECO:0000305|PubMed:2460334
ChainResidueDetails
AASP46-ARG75
ETYR154-THR191
FASP46-ARG75
FTYR154-THR191
GASP46-ARG75
GTYR154-THR191
HASP46-ARG75
HTYR154-THR191
IASP46-ARG75
ITYR154-THR191
JASP46-ARG75
ATYR154-THR191
JTYR154-THR191
KASP46-ARG75
KTYR154-THR191
LASP46-ARG75
LTYR154-THR191
BASP46-ARG75
BTYR154-THR191
CASP46-ARG75
CTYR154-THR191
DASP46-ARG75
DTYR154-THR191
EASP46-ARG75

site_idSWS_FT_FI4
Number of Residues12
DetailsMOD_RES: Phosphoserine => ECO:0000250|UniProtKB:P08033
ChainResidueDetails
ASER233
JSER233
KSER233
LSER233
BSER233
CSER233
DSER233
ESER233
FSER233
GSER233
HSER233
ISER233

site_idSWS_FT_FI5
Number of Residues36
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:24275569
ChainResidueDetails
ASER258
DSER258
DSER266
DSER277
ESER258
ESER266
ESER277
FSER258
FSER266
FSER277
GSER258
ASER266
GSER266
GSER277
HSER258
HSER266
HSER277
ISER258
ISER266
ISER277
JSER258
JSER266
ASER277
JSER277
KSER258
KSER266
KSER277
LSER258
LSER266
LSER277
BSER258
BSER266
BSER277
CSER258
CSER266
CSER277

222415

PDB entries from 2024-07-10

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