7ZXP

cryo-EM structure of Connexin 32 R22G mutation gap junction channel

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005243	molecular_function	gap junction channel activity
A	0005515	molecular_function	protein binding
A	0005737	cellular_component	cytoplasm
A	0005789	cellular_component	endoplasmic reticulum membrane
A	0005886	cellular_component	plasma membrane
A	0005921	cellular_component	gap junction
A	0005922	cellular_component	connexin complex
A	0007154	biological_process	cell communication
A	0007267	biological_process	cell-cell signaling
A	0007399	biological_process	nervous system development
A	0016264	biological_process	gap junction assembly
A	0042802	molecular_function	identical protein binding
A	0055085	biological_process	transmembrane transport
B	0005243	molecular_function	gap junction channel activity
B	0005515	molecular_function	protein binding
B	0005737	cellular_component	cytoplasm
B	0005789	cellular_component	endoplasmic reticulum membrane
B	0005886	cellular_component	plasma membrane
B	0005921	cellular_component	gap junction
B	0005922	cellular_component	connexin complex
B	0007154	biological_process	cell communication
B	0007267	biological_process	cell-cell signaling
B	0007399	biological_process	nervous system development
B	0016264	biological_process	gap junction assembly
B	0042802	molecular_function	identical protein binding
B	0055085	biological_process	transmembrane transport
C	0005243	molecular_function	gap junction channel activity
C	0005515	molecular_function	protein binding
C	0005737	cellular_component	cytoplasm
C	0005789	cellular_component	endoplasmic reticulum membrane
C	0005886	cellular_component	plasma membrane
C	0005921	cellular_component	gap junction
C	0005922	cellular_component	connexin complex
C	0007154	biological_process	cell communication
C	0007267	biological_process	cell-cell signaling
C	0007399	biological_process	nervous system development
C	0016264	biological_process	gap junction assembly
C	0042802	molecular_function	identical protein binding
C	0055085	biological_process	transmembrane transport
D	0005243	molecular_function	gap junction channel activity
D	0005515	molecular_function	protein binding
D	0005737	cellular_component	cytoplasm
D	0005789	cellular_component	endoplasmic reticulum membrane
D	0005886	cellular_component	plasma membrane
D	0005921	cellular_component	gap junction
D	0005922	cellular_component	connexin complex
D	0007154	biological_process	cell communication
D	0007267	biological_process	cell-cell signaling
D	0007399	biological_process	nervous system development
D	0016264	biological_process	gap junction assembly
D	0042802	molecular_function	identical protein binding
D	0055085	biological_process	transmembrane transport
E	0005243	molecular_function	gap junction channel activity
E	0005515	molecular_function	protein binding
E	0005737	cellular_component	cytoplasm
E	0005789	cellular_component	endoplasmic reticulum membrane
E	0005886	cellular_component	plasma membrane
E	0005921	cellular_component	gap junction
E	0005922	cellular_component	connexin complex
E	0007154	biological_process	cell communication
E	0007267	biological_process	cell-cell signaling
E	0007399	biological_process	nervous system development
E	0016264	biological_process	gap junction assembly
E	0042802	molecular_function	identical protein binding
E	0055085	biological_process	transmembrane transport
F	0005243	molecular_function	gap junction channel activity
F	0005515	molecular_function	protein binding
F	0005737	cellular_component	cytoplasm
F	0005789	cellular_component	endoplasmic reticulum membrane
F	0005886	cellular_component	plasma membrane
F	0005921	cellular_component	gap junction
F	0005922	cellular_component	connexin complex
F	0007154	biological_process	cell communication
F	0007267	biological_process	cell-cell signaling
F	0007399	biological_process	nervous system development
F	0016264	biological_process	gap junction assembly
F	0042802	molecular_function	identical protein binding
F	0055085	biological_process	transmembrane transport
G	0005243	molecular_function	gap junction channel activity
G	0005515	molecular_function	protein binding
G	0005737	cellular_component	cytoplasm
G	0005789	cellular_component	endoplasmic reticulum membrane
G	0005886	cellular_component	plasma membrane
G	0005921	cellular_component	gap junction
G	0005922	cellular_component	connexin complex
G	0007154	biological_process	cell communication
G	0007267	biological_process	cell-cell signaling
G	0007399	biological_process	nervous system development
G	0016264	biological_process	gap junction assembly
G	0042802	molecular_function	identical protein binding
G	0055085	biological_process	transmembrane transport
H	0005243	molecular_function	gap junction channel activity
H	0005515	molecular_function	protein binding
H	0005737	cellular_component	cytoplasm
H	0005789	cellular_component	endoplasmic reticulum membrane
H	0005886	cellular_component	plasma membrane
H	0005921	cellular_component	gap junction
H	0005922	cellular_component	connexin complex
H	0007154	biological_process	cell communication
H	0007267	biological_process	cell-cell signaling
H	0007399	biological_process	nervous system development
H	0016264	biological_process	gap junction assembly
H	0042802	molecular_function	identical protein binding
H	0055085	biological_process	transmembrane transport
I	0005243	molecular_function	gap junction channel activity
I	0005515	molecular_function	protein binding
I	0005737	cellular_component	cytoplasm
I	0005789	cellular_component	endoplasmic reticulum membrane
I	0005886	cellular_component	plasma membrane
I	0005921	cellular_component	gap junction
I	0005922	cellular_component	connexin complex
I	0007154	biological_process	cell communication
I	0007267	biological_process	cell-cell signaling
I	0007399	biological_process	nervous system development
I	0016264	biological_process	gap junction assembly
I	0042802	molecular_function	identical protein binding
I	0055085	biological_process	transmembrane transport
J	0005243	molecular_function	gap junction channel activity
J	0005515	molecular_function	protein binding
J	0005737	cellular_component	cytoplasm
J	0005789	cellular_component	endoplasmic reticulum membrane
J	0005886	cellular_component	plasma membrane
J	0005921	cellular_component	gap junction
J	0005922	cellular_component	connexin complex
J	0007154	biological_process	cell communication
J	0007267	biological_process	cell-cell signaling
J	0007399	biological_process	nervous system development
J	0016264	biological_process	gap junction assembly
J	0042802	molecular_function	identical protein binding
J	0055085	biological_process	transmembrane transport
K	0005243	molecular_function	gap junction channel activity
K	0005515	molecular_function	protein binding
K	0005737	cellular_component	cytoplasm
K	0005789	cellular_component	endoplasmic reticulum membrane
K	0005886	cellular_component	plasma membrane
K	0005921	cellular_component	gap junction
K	0005922	cellular_component	connexin complex
K	0007154	biological_process	cell communication
K	0007267	biological_process	cell-cell signaling
K	0007399	biological_process	nervous system development
K	0016264	biological_process	gap junction assembly
K	0042802	molecular_function	identical protein binding
K	0055085	biological_process	transmembrane transport
L	0005243	molecular_function	gap junction channel activity
L	0005515	molecular_function	protein binding
L	0005737	cellular_component	cytoplasm
L	0005789	cellular_component	endoplasmic reticulum membrane
L	0005886	cellular_component	plasma membrane
L	0005921	cellular_component	gap junction
L	0005922	cellular_component	connexin complex
L	0007154	biological_process	cell communication
L	0007267	biological_process	cell-cell signaling
L	0007399	biological_process	nervous system development
L	0016264	biological_process	gap junction assembly
L	0042802	molecular_function	identical protein binding
L	0055085	biological_process	transmembrane transport

Functional Information from PROSITE/UniProt

site_id	PS00407
Number of Residues	14
Details	CONNEXINS_1 Connexins signature 1. CNTlQPGCnsVCYD

Chain	Residue	Details
A	CYS53-ASP66

---

site_id	PS00408
Number of Residues	17
Details	CONNEXINS_2 Connexins signature 2. Cdvy.PCpntVDCFVSRP

Chain	Residue	Details
A	CYS168-PRO184

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1020
Details	Transmembrane: {"description":"Helical","evidences":[{"evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	792
Details	Topological domain: {"description":"Extracellular","evidences":[{"source":"PubMed","id":"2460334","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---