Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

7ZVE

K403 acetylated glucose-6-phosphate dehydrogenase (G6PD)

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004345	molecular_function	glucose-6-phosphate dehydrogenase activity
A	0005515	molecular_function	protein binding
A	0005536	molecular_function	glucose binding
A	0005737	cellular_component	cytoplasm
A	0005829	cellular_component	cytosol
A	0006006	biological_process	glucose metabolic process
A	0006098	biological_process	pentose-phosphate shunt
A	0006629	biological_process	lipid metabolic process
A	0006695	biological_process	cholesterol biosynthetic process
A	0006739	biological_process	NADP metabolic process
A	0006740	biological_process	NADPH regeneration
A	0006749	biological_process	glutathione metabolic process
A	0009051	biological_process	pentose-phosphate shunt, oxidative branch
A	0009898	cellular_component	cytoplasmic side of plasma membrane
A	0010041	biological_process	response to iron(III) ion
A	0010734	biological_process	negative regulation of protein glutathionylation
A	0014070	biological_process	response to organic cyclic compound
A	0016020	cellular_component	membrane
A	0016491	molecular_function	oxidoreductase activity
A	0016614	molecular_function	oxidoreductase activity, acting on CH-OH group of donors
A	0019322	biological_process	pentose biosynthetic process
A	0021762	biological_process	substantia nigra development
A	0030246	molecular_function	carbohydrate binding
A	0032094	biological_process	response to food
A	0034451	cellular_component	centriolar satellite
A	0034599	biological_process	cellular response to oxidative stress
A	0042802	molecular_function	identical protein binding
A	0042803	molecular_function	protein homodimerization activity
A	0043231	cellular_component	intracellular membrane-bounded organelle
A	0043249	biological_process	erythrocyte maturation
A	0043523	biological_process	regulation of neuron apoptotic process
A	0045471	biological_process	response to ethanol
A	0046390	biological_process	ribose phosphate biosynthetic process
A	0050661	molecular_function	NADP binding
A	0051156	biological_process	glucose 6-phosphate metabolic process
A	0061052	biological_process	negative regulation of cell growth involved in cardiac muscle cell development
A	0070062	cellular_component	extracellular exosome
A	1904879	biological_process	positive regulation of calcium ion transmembrane transport via high voltage-gated calcium channel
A	2000378	biological_process	negative regulation of reactive oxygen species metabolic process
B	0004345	molecular_function	glucose-6-phosphate dehydrogenase activity
B	0005515	molecular_function	protein binding
B	0005536	molecular_function	glucose binding
B	0005737	cellular_component	cytoplasm
B	0005829	cellular_component	cytosol
B	0006006	biological_process	glucose metabolic process
B	0006098	biological_process	pentose-phosphate shunt
B	0006629	biological_process	lipid metabolic process
B	0006695	biological_process	cholesterol biosynthetic process
B	0006739	biological_process	NADP metabolic process
B	0006740	biological_process	NADPH regeneration
B	0006749	biological_process	glutathione metabolic process
B	0009051	biological_process	pentose-phosphate shunt, oxidative branch
B	0009898	cellular_component	cytoplasmic side of plasma membrane
B	0010041	biological_process	response to iron(III) ion
B	0010734	biological_process	negative regulation of protein glutathionylation
B	0014070	biological_process	response to organic cyclic compound
B	0016020	cellular_component	membrane
B	0016491	molecular_function	oxidoreductase activity
B	0016614	molecular_function	oxidoreductase activity, acting on CH-OH group of donors
B	0019322	biological_process	pentose biosynthetic process
B	0021762	biological_process	substantia nigra development
B	0030246	molecular_function	carbohydrate binding
B	0032094	biological_process	response to food
B	0034451	cellular_component	centriolar satellite
B	0034599	biological_process	cellular response to oxidative stress
B	0042802	molecular_function	identical protein binding
B	0042803	molecular_function	protein homodimerization activity
B	0043231	cellular_component	intracellular membrane-bounded organelle
B	0043249	biological_process	erythrocyte maturation
B	0043523	biological_process	regulation of neuron apoptotic process
B	0045471	biological_process	response to ethanol
B	0046390	biological_process	ribose phosphate biosynthetic process
B	0050661	molecular_function	NADP binding
B	0051156	biological_process	glucose 6-phosphate metabolic process
B	0061052	biological_process	negative regulation of cell growth involved in cardiac muscle cell development
B	0070062	cellular_component	extracellular exosome
B	1904879	biological_process	positive regulation of calcium ion transmembrane transport via high voltage-gated calcium channel
B	2000378	biological_process	negative regulation of reactive oxygen species metabolic process
C	0004345	molecular_function	glucose-6-phosphate dehydrogenase activity
C	0005515	molecular_function	protein binding
C	0005536	molecular_function	glucose binding
C	0005737	cellular_component	cytoplasm
C	0005829	cellular_component	cytosol
C	0006006	biological_process	glucose metabolic process
C	0006098	biological_process	pentose-phosphate shunt
C	0006629	biological_process	lipid metabolic process
C	0006695	biological_process	cholesterol biosynthetic process
C	0006739	biological_process	NADP metabolic process
C	0006740	biological_process	NADPH regeneration
C	0006749	biological_process	glutathione metabolic process
C	0009051	biological_process	pentose-phosphate shunt, oxidative branch
C	0009898	cellular_component	cytoplasmic side of plasma membrane
C	0010041	biological_process	response to iron(III) ion
C	0010734	biological_process	negative regulation of protein glutathionylation
C	0014070	biological_process	response to organic cyclic compound
C	0016020	cellular_component	membrane
C	0016491	molecular_function	oxidoreductase activity
C	0016614	molecular_function	oxidoreductase activity, acting on CH-OH group of donors
C	0019322	biological_process	pentose biosynthetic process
C	0021762	biological_process	substantia nigra development
C	0030246	molecular_function	carbohydrate binding
C	0032094	biological_process	response to food
C	0034451	cellular_component	centriolar satellite
C	0034599	biological_process	cellular response to oxidative stress
C	0042802	molecular_function	identical protein binding
C	0042803	molecular_function	protein homodimerization activity
C	0043231	cellular_component	intracellular membrane-bounded organelle
C	0043249	biological_process	erythrocyte maturation
C	0043523	biological_process	regulation of neuron apoptotic process
C	0045471	biological_process	response to ethanol
C	0046390	biological_process	ribose phosphate biosynthetic process
C	0050661	molecular_function	NADP binding
C	0051156	biological_process	glucose 6-phosphate metabolic process
C	0061052	biological_process	negative regulation of cell growth involved in cardiac muscle cell development
C	0070062	cellular_component	extracellular exosome
C	1904879	biological_process	positive regulation of calcium ion transmembrane transport via high voltage-gated calcium channel
C	2000378	biological_process	negative regulation of reactive oxygen species metabolic process
D	0004345	molecular_function	glucose-6-phosphate dehydrogenase activity
D	0005515	molecular_function	protein binding
D	0005536	molecular_function	glucose binding
D	0005737	cellular_component	cytoplasm
D	0005829	cellular_component	cytosol
D	0006006	biological_process	glucose metabolic process
D	0006098	biological_process	pentose-phosphate shunt
D	0006629	biological_process	lipid metabolic process
D	0006695	biological_process	cholesterol biosynthetic process
D	0006739	biological_process	NADP metabolic process
D	0006740	biological_process	NADPH regeneration
D	0006749	biological_process	glutathione metabolic process
D	0009051	biological_process	pentose-phosphate shunt, oxidative branch
D	0009898	cellular_component	cytoplasmic side of plasma membrane
D	0010041	biological_process	response to iron(III) ion
D	0010734	biological_process	negative regulation of protein glutathionylation
D	0014070	biological_process	response to organic cyclic compound
D	0016020	cellular_component	membrane
D	0016491	molecular_function	oxidoreductase activity
D	0016614	molecular_function	oxidoreductase activity, acting on CH-OH group of donors
D	0019322	biological_process	pentose biosynthetic process
D	0021762	biological_process	substantia nigra development
D	0030246	molecular_function	carbohydrate binding
D	0032094	biological_process	response to food
D	0034451	cellular_component	centriolar satellite
D	0034599	biological_process	cellular response to oxidative stress
D	0042802	molecular_function	identical protein binding
D	0042803	molecular_function	protein homodimerization activity
D	0043231	cellular_component	intracellular membrane-bounded organelle
D	0043249	biological_process	erythrocyte maturation
D	0043523	biological_process	regulation of neuron apoptotic process
D	0045471	biological_process	response to ethanol
D	0046390	biological_process	ribose phosphate biosynthetic process
D	0050661	molecular_function	NADP binding
D	0051156	biological_process	glucose 6-phosphate metabolic process
D	0061052	biological_process	negative regulation of cell growth involved in cardiac muscle cell development
D	0070062	cellular_component	extracellular exosome
D	1904879	biological_process	positive regulation of calcium ion transmembrane transport via high voltage-gated calcium channel
D	2000378	biological_process	negative regulation of reactive oxygen species metabolic process
E	0004345	molecular_function	glucose-6-phosphate dehydrogenase activity
E	0005515	molecular_function	protein binding
E	0005536	molecular_function	glucose binding
E	0005737	cellular_component	cytoplasm
E	0005829	cellular_component	cytosol
E	0006006	biological_process	glucose metabolic process
E	0006098	biological_process	pentose-phosphate shunt
E	0006629	biological_process	lipid metabolic process
E	0006695	biological_process	cholesterol biosynthetic process
E	0006739	biological_process	NADP metabolic process
E	0006740	biological_process	NADPH regeneration
E	0006749	biological_process	glutathione metabolic process
E	0009051	biological_process	pentose-phosphate shunt, oxidative branch
E	0009898	cellular_component	cytoplasmic side of plasma membrane
E	0010041	biological_process	response to iron(III) ion
E	0010734	biological_process	negative regulation of protein glutathionylation
E	0014070	biological_process	response to organic cyclic compound
E	0016020	cellular_component	membrane
E	0016491	molecular_function	oxidoreductase activity
E	0016614	molecular_function	oxidoreductase activity, acting on CH-OH group of donors
E	0019322	biological_process	pentose biosynthetic process
E	0021762	biological_process	substantia nigra development
E	0030246	molecular_function	carbohydrate binding
E	0032094	biological_process	response to food
E	0034451	cellular_component	centriolar satellite
E	0034599	biological_process	cellular response to oxidative stress
E	0042802	molecular_function	identical protein binding
E	0042803	molecular_function	protein homodimerization activity
E	0043231	cellular_component	intracellular membrane-bounded organelle
E	0043249	biological_process	erythrocyte maturation
E	0043523	biological_process	regulation of neuron apoptotic process
E	0045471	biological_process	response to ethanol
E	0046390	biological_process	ribose phosphate biosynthetic process
E	0050661	molecular_function	NADP binding
E	0051156	biological_process	glucose 6-phosphate metabolic process
E	0061052	biological_process	negative regulation of cell growth involved in cardiac muscle cell development
E	0070062	cellular_component	extracellular exosome
E	1904879	biological_process	positive regulation of calcium ion transmembrane transport via high voltage-gated calcium channel
E	2000378	biological_process	negative regulation of reactive oxygen species metabolic process
F	0004345	molecular_function	glucose-6-phosphate dehydrogenase activity
F	0005515	molecular_function	protein binding
F	0005536	molecular_function	glucose binding
F	0005737	cellular_component	cytoplasm
F	0005829	cellular_component	cytosol
F	0006006	biological_process	glucose metabolic process
F	0006098	biological_process	pentose-phosphate shunt
F	0006629	biological_process	lipid metabolic process
F	0006695	biological_process	cholesterol biosynthetic process
F	0006739	biological_process	NADP metabolic process
F	0006740	biological_process	NADPH regeneration
F	0006749	biological_process	glutathione metabolic process
F	0009051	biological_process	pentose-phosphate shunt, oxidative branch
F	0009898	cellular_component	cytoplasmic side of plasma membrane
F	0010041	biological_process	response to iron(III) ion
F	0010734	biological_process	negative regulation of protein glutathionylation
F	0014070	biological_process	response to organic cyclic compound
F	0016020	cellular_component	membrane
F	0016491	molecular_function	oxidoreductase activity
F	0016614	molecular_function	oxidoreductase activity, acting on CH-OH group of donors
F	0019322	biological_process	pentose biosynthetic process
F	0021762	biological_process	substantia nigra development
F	0030246	molecular_function	carbohydrate binding
F	0032094	biological_process	response to food
F	0034451	cellular_component	centriolar satellite
F	0034599	biological_process	cellular response to oxidative stress
F	0042802	molecular_function	identical protein binding
F	0042803	molecular_function	protein homodimerization activity
F	0043231	cellular_component	intracellular membrane-bounded organelle
F	0043249	biological_process	erythrocyte maturation
F	0043523	biological_process	regulation of neuron apoptotic process
F	0045471	biological_process	response to ethanol
F	0046390	biological_process	ribose phosphate biosynthetic process
F	0050661	molecular_function	NADP binding
F	0051156	biological_process	glucose 6-phosphate metabolic process
F	0061052	biological_process	negative regulation of cell growth involved in cardiac muscle cell development
F	0070062	cellular_component	extracellular exosome
F	1904879	biological_process	positive regulation of calcium ion transmembrane transport via high voltage-gated calcium channel
F	2000378	biological_process	negative regulation of reactive oxygen species metabolic process
G	0004345	molecular_function	glucose-6-phosphate dehydrogenase activity
G	0005515	molecular_function	protein binding
G	0005536	molecular_function	glucose binding
G	0005737	cellular_component	cytoplasm
G	0005829	cellular_component	cytosol
G	0006006	biological_process	glucose metabolic process
G	0006098	biological_process	pentose-phosphate shunt
G	0006629	biological_process	lipid metabolic process
G	0006695	biological_process	cholesterol biosynthetic process
G	0006739	biological_process	NADP metabolic process
G	0006740	biological_process	NADPH regeneration
G	0006749	biological_process	glutathione metabolic process
G	0009051	biological_process	pentose-phosphate shunt, oxidative branch
G	0009898	cellular_component	cytoplasmic side of plasma membrane
G	0010041	biological_process	response to iron(III) ion
G	0010734	biological_process	negative regulation of protein glutathionylation
G	0014070	biological_process	response to organic cyclic compound
G	0016020	cellular_component	membrane
G	0016491	molecular_function	oxidoreductase activity
G	0016614	molecular_function	oxidoreductase activity, acting on CH-OH group of donors
G	0019322	biological_process	pentose biosynthetic process
G	0021762	biological_process	substantia nigra development
G	0030246	molecular_function	carbohydrate binding
G	0032094	biological_process	response to food
G	0034451	cellular_component	centriolar satellite
G	0034599	biological_process	cellular response to oxidative stress
G	0042802	molecular_function	identical protein binding
G	0042803	molecular_function	protein homodimerization activity
G	0043231	cellular_component	intracellular membrane-bounded organelle
G	0043249	biological_process	erythrocyte maturation
G	0043523	biological_process	regulation of neuron apoptotic process
G	0045471	biological_process	response to ethanol
G	0046390	biological_process	ribose phosphate biosynthetic process
G	0050661	molecular_function	NADP binding
G	0051156	biological_process	glucose 6-phosphate metabolic process
G	0061052	biological_process	negative regulation of cell growth involved in cardiac muscle cell development
G	0070062	cellular_component	extracellular exosome
G	1904879	biological_process	positive regulation of calcium ion transmembrane transport via high voltage-gated calcium channel
G	2000378	biological_process	negative regulation of reactive oxygen species metabolic process
H	0004345	molecular_function	glucose-6-phosphate dehydrogenase activity
H	0005515	molecular_function	protein binding
H	0005536	molecular_function	glucose binding
H	0005737	cellular_component	cytoplasm
H	0005829	cellular_component	cytosol
H	0006006	biological_process	glucose metabolic process
H	0006098	biological_process	pentose-phosphate shunt
H	0006629	biological_process	lipid metabolic process
H	0006695	biological_process	cholesterol biosynthetic process
H	0006739	biological_process	NADP metabolic process
H	0006740	biological_process	NADPH regeneration
H	0006749	biological_process	glutathione metabolic process
H	0009051	biological_process	pentose-phosphate shunt, oxidative branch
H	0009898	cellular_component	cytoplasmic side of plasma membrane
H	0010041	biological_process	response to iron(III) ion
H	0010734	biological_process	negative regulation of protein glutathionylation
H	0014070	biological_process	response to organic cyclic compound
H	0016020	cellular_component	membrane
H	0016491	molecular_function	oxidoreductase activity
H	0016614	molecular_function	oxidoreductase activity, acting on CH-OH group of donors
H	0019322	biological_process	pentose biosynthetic process
H	0021762	biological_process	substantia nigra development
H	0030246	molecular_function	carbohydrate binding
H	0032094	biological_process	response to food
H	0034451	cellular_component	centriolar satellite
H	0034599	biological_process	cellular response to oxidative stress
H	0042802	molecular_function	identical protein binding
H	0042803	molecular_function	protein homodimerization activity
H	0043231	cellular_component	intracellular membrane-bounded organelle
H	0043249	biological_process	erythrocyte maturation
H	0043523	biological_process	regulation of neuron apoptotic process
H	0045471	biological_process	response to ethanol
H	0046390	biological_process	ribose phosphate biosynthetic process
H	0050661	molecular_function	NADP binding
H	0051156	biological_process	glucose 6-phosphate metabolic process
H	0061052	biological_process	negative regulation of cell growth involved in cardiac muscle cell development
H	0070062	cellular_component	extracellular exosome
H	1904879	biological_process	positive regulation of calcium ion transmembrane transport via high voltage-gated calcium channel
H	2000378	biological_process	negative regulation of reactive oxygen species metabolic process

Functional Information from PROSITE/UniProt

site_id	PS00069
Number of Residues	7
Details	G6P_DEHYDROGENASE Glucose-6-phosphate dehydrogenase active site. DHYLGKE

Chain	Residue	Details
F	ASP200-GLU206
C	ASP200-GLU206
D	ASP200-GLU206
B	ASP200-GLU206
A	ASP200-GLU206
G	ASP200-GLU206
E	ASP200-GLU206

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	ACT_SITE: Proton acceptor => ECO:0000250\|UniProtKB:P11411

Chain	Residue	Details
G	HIS263
H	HIS263

site_id	SWS_FT_FI2
Number of Residues	11
Details	BINDING: BINDING => ECO:0000269\|PubMed:10745013, ECO:0000269\|PubMed:15858258, ECO:0007744\|PDB:1QKI, ECO:0007744\|PDB:2BH9

Chain	Residue	Details
G	GLY38
G	ARG72
G	TYR147
G	ARG357
G	LYS366
G	ARG370
G	ARG393
G	TYR401
G	ASP421
G	ARG487
G	TYR503
H	GLY38
H	ARG72
H	TYR147
H	ARG357
H	LYS366
H	ARG370
H	ARG393
H	TYR401
H	ASP421
H	ARG487
H	TYR503

site_id	SWS_FT_FI3
Number of Residues	4
Details	BINDING: BINDING => ECO:0000269\|PubMed:15858258, ECO:0007744\|PDB:2BH9

Chain	Residue	Details
G	LYS171
G	HIS201
G	GLU239
G	ASP258
H	LYS171
H	HIS201
H	GLU239
H	ASP258

site_id	SWS_FT_FI4
Number of Residues	3
Details	BINDING: BINDING => ECO:0000269\|PubMed:15858258, ECO:0007744\|PDB:2BHL

Chain	Residue	Details
G	LYS360
G	ARG365
G	GLN395
H	LYS360
H	ARG365
H	GLN395

site_id	SWS_FT_FI5
Number of Residues	1
Details	MOD_RES: Phosphoserine => ECO:0007744\|PubMed:23186163

Chain	Residue	Details
G	SER8
H	SER8

site_id	SWS_FT_FI6
Number of Residues	1
Details	MOD_RES: Phosphothreonine => ECO:0007744\|PubMed:23186163

Chain	Residue	Details
G	THR10
H	THR10

site_id	SWS_FT_FI7
Number of Residues	3
Details	MOD_RES: N6-acetyllysine => ECO:0007744\|PubMed:19608861

Chain	Residue	Details
G	LYS89
G	LYS432
G	LYS497
H	LYS89
H	LYS432
H	LYS497

site_id	SWS_FT_FI8
Number of Residues	1
Details	MOD_RES: N6-acetyllysine; alternate => ECO:0007744\|PubMed:19608861

Chain	Residue	Details
G	LYS171
H	LYS171

site_id	SWS_FT_FI9
Number of Residues	1
Details	MOD_RES: N6-acetyllysine => ECO:0000269\|PubMed:24769394, ECO:0007744\|PubMed:19608861

Chain	Residue	Details
G	ALY403
H	ALY403

site_id	SWS_FT_FI10
Number of Residues	1
Details	MOD_RES: Phosphotyrosine => ECO:0007744\|PubMed:23186163

Chain	Residue	Details
G	TYR503
H	TYR503

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)