7ZVD

K89 acetylated glucose-6-phosphate dehydrogenase (G6PD) in a complex with structural NADP+

Functional Information from GO Data

Chain	GOid	namespace	contents
N	0004345	molecular_function	glucose-6-phosphate dehydrogenase activity
N	0005515	molecular_function	protein binding
N	0005536	molecular_function	glucose binding
N	0005737	cellular_component	cytoplasm
N	0005829	cellular_component	cytosol
N	0006006	biological_process	glucose metabolic process
N	0006098	biological_process	pentose-phosphate shunt
N	0006629	biological_process	lipid metabolic process
N	0006695	biological_process	cholesterol biosynthetic process
N	0006739	biological_process	NADP metabolic process
N	0006740	biological_process	NADPH regeneration
N	0006749	biological_process	glutathione metabolic process
N	0009051	biological_process	pentose-phosphate shunt, oxidative branch
N	0009898	cellular_component	cytoplasmic side of plasma membrane
N	0010041	biological_process	response to iron(III) ion
N	0010734	biological_process	negative regulation of protein glutathionylation
N	0014070	biological_process	response to organic cyclic compound
N	0016020	cellular_component	membrane
N	0016491	molecular_function	oxidoreductase activity
N	0016614	molecular_function	oxidoreductase activity, acting on CH-OH group of donors
N	0019322	biological_process	pentose biosynthetic process
N	0021762	biological_process	substantia nigra development
N	0030246	molecular_function	carbohydrate binding
N	0032094	biological_process	response to food
N	0034451	cellular_component	centriolar satellite
N	0034599	biological_process	cellular response to oxidative stress
N	0042802	molecular_function	identical protein binding
N	0042803	molecular_function	protein homodimerization activity
N	0043231	cellular_component	intracellular membrane-bounded organelle
N	0043249	biological_process	erythrocyte maturation
N	0043523	biological_process	regulation of neuron apoptotic process
N	0045471	biological_process	response to ethanol
N	0046390	biological_process	ribose phosphate biosynthetic process
N	0050661	molecular_function	NADP binding
N	0051156	biological_process	glucose 6-phosphate metabolic process
N	0061052	biological_process	negative regulation of cell growth involved in cardiac muscle cell development
N	0070062	cellular_component	extracellular exosome
N	1904879	biological_process	positive regulation of calcium ion transmembrane transport via high voltage-gated calcium channel
N	2000378	biological_process	negative regulation of reactive oxygen species metabolic process

Functional Information from PROSITE/UniProt

site_id	PS00069
Number of Residues	7
Details	G6P_DEHYDROGENASE Glucose-6-phosphate dehydrogenase active site. DHYLGKE

Chain	Residue	Details
N	ASP200-GLU206

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	ACT_SITE: Proton acceptor => ECO:0000250|UniProtKB:P11411

Chain	Residue	Details
N	HIS263

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site_id	SWS_FT_FI2
Number of Residues	12
Details	BINDING: BINDING => ECO:0000269|PubMed:10745013, ECO:0000269|PubMed:15858258, ECO:0007744|PDB:1QKI, ECO:0007744|PDB:2BH9

Chain	Residue	Details
N	GLY38
N	ARG72
N	TYR147
N	ARG357
N	LYS366
N	ARG370
N	ARG393
N	TYR401
N	ASP421
N	ARG487
N	TYR503
N	TRP509

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site_id	SWS_FT_FI3
Number of Residues	4
Details	BINDING: BINDING => ECO:0000269|PubMed:15858258, ECO:0007744|PDB:2BH9

Chain	Residue	Details
N	LYS171
N	HIS201
N	GLU239
N	ASP258

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site_id	SWS_FT_FI4
Number of Residues	3
Details	BINDING: BINDING => ECO:0000269|PubMed:15858258, ECO:0007744|PDB:2BHL

Chain	Residue	Details
N	LYS360
N	ARG365
N	GLN395

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site_id	SWS_FT_FI5
Number of Residues	3
Details	MOD_RES: N6-acetyllysine => ECO:0007744|PubMed:19608861

Chain	Residue	Details
N	ALY89
N	LYS432
N	LYS497

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site_id	SWS_FT_FI6
Number of Residues	1
Details	MOD_RES: N6-acetyllysine; alternate => ECO:0007744|PubMed:19608861

Chain	Residue	Details
N	LYS171

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site_id	SWS_FT_FI7
Number of Residues	1
Details	MOD_RES: N6-acetyllysine => ECO:0000269|PubMed:24769394, ECO:0007744|PubMed:19608861

Chain	Residue	Details
N	LYS403

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site_id	SWS_FT_FI8
Number of Residues	1
Details	MOD_RES: Phosphotyrosine => ECO:0007744|PubMed:23186163

Chain	Residue	Details
N	TYR503

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