7ZL8

NME1 in complex with succinyl-CoA

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000287	molecular_function	magnesium ion binding
A	0004536	molecular_function	DNA nuclease activity
A	0004550	molecular_function	nucleoside diphosphate kinase activity
A	0005524	molecular_function	ATP binding
A	0005525	molecular_function	GTP binding
A	0005634	cellular_component	nucleus
A	0005737	cellular_component	cytoplasm
A	0005739	cellular_component	mitochondrion
A	0005769	cellular_component	early endosome
A	0005829	cellular_component	cytosol
A	0006183	biological_process	GTP biosynthetic process
A	0006228	biological_process	UTP biosynthetic process
A	0006231	biological_process	dTMP biosynthetic process
A	0006241	biological_process	CTP biosynthetic process
A	0006259	biological_process	DNA metabolic process
A	0006897	biological_process	endocytosis
A	0007399	biological_process	nervous system development
A	0007595	biological_process	lactation
A	0008408	molecular_function	3'-5' exonuclease activity
A	0009117	biological_process	nucleotide metabolic process
A	0016301	molecular_function	kinase activity
A	0016310	biological_process	phosphorylation
A	0030154	biological_process	cell differentiation
A	0030879	biological_process	mammary gland development
A	0032587	cellular_component	ruffle membrane
A	0042802	molecular_function	identical protein binding
A	0043024	molecular_function	ribosomal small subunit binding
A	0043209	cellular_component	myelin sheath
A	0046872	molecular_function	metal ion binding
A	0050679	biological_process	positive regulation of epithelial cell proliferation
B	0000287	molecular_function	magnesium ion binding
B	0004536	molecular_function	DNA nuclease activity
B	0004550	molecular_function	nucleoside diphosphate kinase activity
B	0005524	molecular_function	ATP binding
B	0005525	molecular_function	GTP binding
B	0005634	cellular_component	nucleus
B	0005737	cellular_component	cytoplasm
B	0005739	cellular_component	mitochondrion
B	0005769	cellular_component	early endosome
B	0005829	cellular_component	cytosol
B	0006183	biological_process	GTP biosynthetic process
B	0006228	biological_process	UTP biosynthetic process
B	0006231	biological_process	dTMP biosynthetic process
B	0006241	biological_process	CTP biosynthetic process
B	0006259	biological_process	DNA metabolic process
B	0006897	biological_process	endocytosis
B	0007399	biological_process	nervous system development
B	0007595	biological_process	lactation
B	0008408	molecular_function	3'-5' exonuclease activity
B	0009117	biological_process	nucleotide metabolic process
B	0016301	molecular_function	kinase activity
B	0016310	biological_process	phosphorylation
B	0030154	biological_process	cell differentiation
B	0030879	biological_process	mammary gland development
B	0032587	cellular_component	ruffle membrane
B	0042802	molecular_function	identical protein binding
B	0043024	molecular_function	ribosomal small subunit binding
B	0043209	cellular_component	myelin sheath
B	0046872	molecular_function	metal ion binding
B	0050679	biological_process	positive regulation of epithelial cell proliferation
C	0000287	molecular_function	magnesium ion binding
C	0004536	molecular_function	DNA nuclease activity
C	0004550	molecular_function	nucleoside diphosphate kinase activity
C	0005524	molecular_function	ATP binding
C	0005525	molecular_function	GTP binding
C	0005634	cellular_component	nucleus
C	0005737	cellular_component	cytoplasm
C	0005739	cellular_component	mitochondrion
C	0005769	cellular_component	early endosome
C	0005829	cellular_component	cytosol
C	0006183	biological_process	GTP biosynthetic process
C	0006228	biological_process	UTP biosynthetic process
C	0006231	biological_process	dTMP biosynthetic process
C	0006241	biological_process	CTP biosynthetic process
C	0006259	biological_process	DNA metabolic process
C	0006897	biological_process	endocytosis
C	0007399	biological_process	nervous system development
C	0007595	biological_process	lactation
C	0008408	molecular_function	3'-5' exonuclease activity
C	0009117	biological_process	nucleotide metabolic process
C	0016301	molecular_function	kinase activity
C	0016310	biological_process	phosphorylation
C	0030154	biological_process	cell differentiation
C	0030879	biological_process	mammary gland development
C	0032587	cellular_component	ruffle membrane
C	0042802	molecular_function	identical protein binding
C	0043024	molecular_function	ribosomal small subunit binding
C	0043209	cellular_component	myelin sheath
C	0046872	molecular_function	metal ion binding
C	0050679	biological_process	positive regulation of epithelial cell proliferation
D	0000287	molecular_function	magnesium ion binding
D	0004536	molecular_function	DNA nuclease activity
D	0004550	molecular_function	nucleoside diphosphate kinase activity
D	0005524	molecular_function	ATP binding
D	0005525	molecular_function	GTP binding
D	0005634	cellular_component	nucleus
D	0005737	cellular_component	cytoplasm
D	0005739	cellular_component	mitochondrion
D	0005769	cellular_component	early endosome
D	0005829	cellular_component	cytosol
D	0006183	biological_process	GTP biosynthetic process
D	0006228	biological_process	UTP biosynthetic process
D	0006231	biological_process	dTMP biosynthetic process
D	0006241	biological_process	CTP biosynthetic process
D	0006259	biological_process	DNA metabolic process
D	0006897	biological_process	endocytosis
D	0007399	biological_process	nervous system development
D	0007595	biological_process	lactation
D	0008408	molecular_function	3'-5' exonuclease activity
D	0009117	biological_process	nucleotide metabolic process
D	0016301	molecular_function	kinase activity
D	0016310	biological_process	phosphorylation
D	0030154	biological_process	cell differentiation
D	0030879	biological_process	mammary gland development
D	0032587	cellular_component	ruffle membrane
D	0042802	molecular_function	identical protein binding
D	0043024	molecular_function	ribosomal small subunit binding
D	0043209	cellular_component	myelin sheath
D	0046872	molecular_function	metal ion binding
D	0050679	biological_process	positive regulation of epithelial cell proliferation
E	0000287	molecular_function	magnesium ion binding
E	0004536	molecular_function	DNA nuclease activity
E	0004550	molecular_function	nucleoside diphosphate kinase activity
E	0005524	molecular_function	ATP binding
E	0005525	molecular_function	GTP binding
E	0005634	cellular_component	nucleus
E	0005737	cellular_component	cytoplasm
E	0005739	cellular_component	mitochondrion
E	0005769	cellular_component	early endosome
E	0005829	cellular_component	cytosol
E	0006183	biological_process	GTP biosynthetic process
E	0006228	biological_process	UTP biosynthetic process
E	0006231	biological_process	dTMP biosynthetic process
E	0006241	biological_process	CTP biosynthetic process
E	0006259	biological_process	DNA metabolic process
E	0006897	biological_process	endocytosis
E	0007399	biological_process	nervous system development
E	0007595	biological_process	lactation
E	0008408	molecular_function	3'-5' exonuclease activity
E	0009117	biological_process	nucleotide metabolic process
E	0016301	molecular_function	kinase activity
E	0016310	biological_process	phosphorylation
E	0030154	biological_process	cell differentiation
E	0030879	biological_process	mammary gland development
E	0032587	cellular_component	ruffle membrane
E	0042802	molecular_function	identical protein binding
E	0043024	molecular_function	ribosomal small subunit binding
E	0043209	cellular_component	myelin sheath
E	0046872	molecular_function	metal ion binding
E	0050679	biological_process	positive regulation of epithelial cell proliferation
F	0000287	molecular_function	magnesium ion binding
F	0004536	molecular_function	DNA nuclease activity
F	0004550	molecular_function	nucleoside diphosphate kinase activity
F	0005524	molecular_function	ATP binding
F	0005525	molecular_function	GTP binding
F	0005634	cellular_component	nucleus
F	0005737	cellular_component	cytoplasm
F	0005739	cellular_component	mitochondrion
F	0005769	cellular_component	early endosome
F	0005829	cellular_component	cytosol
F	0006183	biological_process	GTP biosynthetic process
F	0006228	biological_process	UTP biosynthetic process
F	0006231	biological_process	dTMP biosynthetic process
F	0006241	biological_process	CTP biosynthetic process
F	0006259	biological_process	DNA metabolic process
F	0006897	biological_process	endocytosis
F	0007399	biological_process	nervous system development
F	0007595	biological_process	lactation
F	0008408	molecular_function	3'-5' exonuclease activity
F	0009117	biological_process	nucleotide metabolic process
F	0016301	molecular_function	kinase activity
F	0016310	biological_process	phosphorylation
F	0030154	biological_process	cell differentiation
F	0030879	biological_process	mammary gland development
F	0032587	cellular_component	ruffle membrane
F	0042802	molecular_function	identical protein binding
F	0043024	molecular_function	ribosomal small subunit binding
F	0043209	cellular_component	myelin sheath
F	0046872	molecular_function	metal ion binding
F	0050679	biological_process	positive regulation of epithelial cell proliferation
G	0000287	molecular_function	magnesium ion binding
G	0004536	molecular_function	DNA nuclease activity
G	0004550	molecular_function	nucleoside diphosphate kinase activity
G	0005524	molecular_function	ATP binding
G	0005525	molecular_function	GTP binding
G	0005634	cellular_component	nucleus
G	0005737	cellular_component	cytoplasm
G	0005739	cellular_component	mitochondrion
G	0005769	cellular_component	early endosome
G	0005829	cellular_component	cytosol
G	0006183	biological_process	GTP biosynthetic process
G	0006228	biological_process	UTP biosynthetic process
G	0006231	biological_process	dTMP biosynthetic process
G	0006241	biological_process	CTP biosynthetic process
G	0006259	biological_process	DNA metabolic process
G	0006897	biological_process	endocytosis
G	0007399	biological_process	nervous system development
G	0007595	biological_process	lactation
G	0008408	molecular_function	3'-5' exonuclease activity
G	0009117	biological_process	nucleotide metabolic process
G	0016301	molecular_function	kinase activity
G	0016310	biological_process	phosphorylation
G	0030154	biological_process	cell differentiation
G	0030879	biological_process	mammary gland development
G	0032587	cellular_component	ruffle membrane
G	0042802	molecular_function	identical protein binding
G	0043024	molecular_function	ribosomal small subunit binding
G	0043209	cellular_component	myelin sheath
G	0046872	molecular_function	metal ion binding
G	0050679	biological_process	positive regulation of epithelial cell proliferation
H	0000287	molecular_function	magnesium ion binding
H	0004536	molecular_function	DNA nuclease activity
H	0004550	molecular_function	nucleoside diphosphate kinase activity
H	0005524	molecular_function	ATP binding
H	0005525	molecular_function	GTP binding
H	0005634	cellular_component	nucleus
H	0005737	cellular_component	cytoplasm
H	0005739	cellular_component	mitochondrion
H	0005769	cellular_component	early endosome
H	0005829	cellular_component	cytosol
H	0006183	biological_process	GTP biosynthetic process
H	0006228	biological_process	UTP biosynthetic process
H	0006231	biological_process	dTMP biosynthetic process
H	0006241	biological_process	CTP biosynthetic process
H	0006259	biological_process	DNA metabolic process
H	0006897	biological_process	endocytosis
H	0007399	biological_process	nervous system development
H	0007595	biological_process	lactation
H	0008408	molecular_function	3'-5' exonuclease activity
H	0009117	biological_process	nucleotide metabolic process
H	0016301	molecular_function	kinase activity
H	0016310	biological_process	phosphorylation
H	0030154	biological_process	cell differentiation
H	0030879	biological_process	mammary gland development
H	0032587	cellular_component	ruffle membrane
H	0042802	molecular_function	identical protein binding
H	0043024	molecular_function	ribosomal small subunit binding
H	0043209	cellular_component	myelin sheath
H	0046872	molecular_function	metal ion binding
H	0050679	biological_process	positive regulation of epithelial cell proliferation
I	0000287	molecular_function	magnesium ion binding
I	0004536	molecular_function	DNA nuclease activity
I	0004550	molecular_function	nucleoside diphosphate kinase activity
I	0005524	molecular_function	ATP binding
I	0005525	molecular_function	GTP binding
I	0005634	cellular_component	nucleus
I	0005737	cellular_component	cytoplasm
I	0005739	cellular_component	mitochondrion
I	0005769	cellular_component	early endosome
I	0005829	cellular_component	cytosol
I	0006183	biological_process	GTP biosynthetic process
I	0006228	biological_process	UTP biosynthetic process
I	0006231	biological_process	dTMP biosynthetic process
I	0006241	biological_process	CTP biosynthetic process
I	0006259	biological_process	DNA metabolic process
I	0006897	biological_process	endocytosis
I	0007399	biological_process	nervous system development
I	0007595	biological_process	lactation
I	0008408	molecular_function	3'-5' exonuclease activity
I	0009117	biological_process	nucleotide metabolic process
I	0016301	molecular_function	kinase activity
I	0016310	biological_process	phosphorylation
I	0030154	biological_process	cell differentiation
I	0030879	biological_process	mammary gland development
I	0032587	cellular_component	ruffle membrane
I	0042802	molecular_function	identical protein binding
I	0043024	molecular_function	ribosomal small subunit binding
I	0043209	cellular_component	myelin sheath
I	0046872	molecular_function	metal ion binding
I	0050679	biological_process	positive regulation of epithelial cell proliferation
J	0000287	molecular_function	magnesium ion binding
J	0004536	molecular_function	DNA nuclease activity
J	0004550	molecular_function	nucleoside diphosphate kinase activity
J	0005524	molecular_function	ATP binding
J	0005525	molecular_function	GTP binding
J	0005634	cellular_component	nucleus
J	0005737	cellular_component	cytoplasm
J	0005739	cellular_component	mitochondrion
J	0005769	cellular_component	early endosome
J	0005829	cellular_component	cytosol
J	0006183	biological_process	GTP biosynthetic process
J	0006228	biological_process	UTP biosynthetic process
J	0006231	biological_process	dTMP biosynthetic process
J	0006241	biological_process	CTP biosynthetic process
J	0006259	biological_process	DNA metabolic process
J	0006897	biological_process	endocytosis
J	0007399	biological_process	nervous system development
J	0007595	biological_process	lactation
J	0008408	molecular_function	3'-5' exonuclease activity
J	0009117	biological_process	nucleotide metabolic process
J	0016301	molecular_function	kinase activity
J	0016310	biological_process	phosphorylation
J	0030154	biological_process	cell differentiation
J	0030879	biological_process	mammary gland development
J	0032587	cellular_component	ruffle membrane
J	0042802	molecular_function	identical protein binding
J	0043024	molecular_function	ribosomal small subunit binding
J	0043209	cellular_component	myelin sheath
J	0046872	molecular_function	metal ion binding
J	0050679	biological_process	positive regulation of epithelial cell proliferation
K	0000287	molecular_function	magnesium ion binding
K	0004536	molecular_function	DNA nuclease activity
K	0004550	molecular_function	nucleoside diphosphate kinase activity
K	0005524	molecular_function	ATP binding
K	0005525	molecular_function	GTP binding
K	0005634	cellular_component	nucleus
K	0005737	cellular_component	cytoplasm
K	0005739	cellular_component	mitochondrion
K	0005769	cellular_component	early endosome
K	0005829	cellular_component	cytosol
K	0006183	biological_process	GTP biosynthetic process
K	0006228	biological_process	UTP biosynthetic process
K	0006231	biological_process	dTMP biosynthetic process
K	0006241	biological_process	CTP biosynthetic process
K	0006259	biological_process	DNA metabolic process
K	0006897	biological_process	endocytosis
K	0007399	biological_process	nervous system development
K	0007595	biological_process	lactation
K	0008408	molecular_function	3'-5' exonuclease activity
K	0009117	biological_process	nucleotide metabolic process
K	0016301	molecular_function	kinase activity
K	0016310	biological_process	phosphorylation
K	0030154	biological_process	cell differentiation
K	0030879	biological_process	mammary gland development
K	0032587	cellular_component	ruffle membrane
K	0042802	molecular_function	identical protein binding
K	0043024	molecular_function	ribosomal small subunit binding
K	0043209	cellular_component	myelin sheath
K	0046872	molecular_function	metal ion binding
K	0050679	biological_process	positive regulation of epithelial cell proliferation
L	0000287	molecular_function	magnesium ion binding
L	0004536	molecular_function	DNA nuclease activity
L	0004550	molecular_function	nucleoside diphosphate kinase activity
L	0005524	molecular_function	ATP binding
L	0005525	molecular_function	GTP binding
L	0005634	cellular_component	nucleus
L	0005737	cellular_component	cytoplasm
L	0005739	cellular_component	mitochondrion
L	0005769	cellular_component	early endosome
L	0005829	cellular_component	cytosol
L	0006183	biological_process	GTP biosynthetic process
L	0006228	biological_process	UTP biosynthetic process
L	0006231	biological_process	dTMP biosynthetic process
L	0006241	biological_process	CTP biosynthetic process
L	0006259	biological_process	DNA metabolic process
L	0006897	biological_process	endocytosis
L	0007399	biological_process	nervous system development
L	0007595	biological_process	lactation
L	0008408	molecular_function	3'-5' exonuclease activity
L	0009117	biological_process	nucleotide metabolic process
L	0016301	molecular_function	kinase activity
L	0016310	biological_process	phosphorylation
L	0030154	biological_process	cell differentiation
L	0030879	biological_process	mammary gland development
L	0032587	cellular_component	ruffle membrane
L	0042802	molecular_function	identical protein binding
L	0043024	molecular_function	ribosomal small subunit binding
L	0043209	cellular_component	myelin sheath
L	0046872	molecular_function	metal ion binding
L	0050679	biological_process	positive regulation of epithelial cell proliferation

Functional Information from PROSITE/UniProt

site_id	PS00469
Number of Residues	9
Details	NDPK Nucleoside diphosphate kinase (NDPK) active site signature. NiiHGSDSV

Chain	Residue	Details
A	ASN115-VAL123

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	12
Details	ACT_SITE: Pros-phosphohistidine intermediate

Chain	Residue	Details
A	HIS118
J	HIS118
K	HIS118
L	HIS118
B	HIS118
C	HIS118
D	HIS118
E	HIS118
F	HIS118
G	HIS118
H	HIS118
I	HIS118

---

site_id	SWS_FT_FI2
Number of Residues	72
Details	BINDING: BINDING => ECO:0000250

Chain	Residue	Details
A	LYS12
B	THR94
B	ARG105
B	ASN115
C	LYS12
C	PHE60
C	ARG88
C	THR94
C	ARG105
C	ASN115
D	LYS12
A	PHE60
D	PHE60
D	ARG88
D	THR94
D	ARG105
D	ASN115
E	LYS12
E	PHE60
E	ARG88
E	THR94
E	ARG105
A	ARG88
E	ASN115
F	LYS12
F	PHE60
F	ARG88
F	THR94
F	ARG105
F	ASN115
G	LYS12
G	PHE60
G	ARG88
A	THR94
G	THR94
G	ARG105
G	ASN115
H	LYS12
H	PHE60
H	ARG88
H	THR94
H	ARG105
H	ASN115
I	LYS12
A	ARG105
I	PHE60
I	ARG88
I	THR94
I	ARG105
I	ASN115
J	LYS12
J	PHE60
J	ARG88
J	THR94
J	ARG105
A	ASN115
J	ASN115
K	LYS12
K	PHE60
K	ARG88
K	THR94
K	ARG105
K	ASN115
L	LYS12
L	PHE60
L	ARG88
B	LYS12
L	THR94
L	ARG105
L	ASN115
B	PHE60
B	ARG88

---

site_id	SWS_FT_FI3
Number of Residues	36
Details	MOD_RES: Phosphoserine => ECO:0000250|UniProtKB:P15531

Chain	Residue	Details
A	SER120
D	SER120
D	SER122
D	SER125
E	SER120
E	SER122
E	SER125
F	SER120
F	SER122
F	SER125
G	SER120
A	SER122
G	SER122
G	SER125
H	SER120
H	SER122
H	SER125
I	SER120
I	SER122
I	SER125
J	SER120
J	SER122
A	SER125
J	SER125
K	SER120
K	SER122
K	SER125
L	SER120
L	SER122
L	SER125
B	SER120
B	SER122
B	SER125
C	SER120
C	SER122
C	SER125

---

site_id	SWS_FT_FI4
Number of Residues	12
Details	MOD_RES: N6-acetyllysine => ECO:0007744|PubMed:23806337

Chain	Residue	Details
A	LYS124
J	LYS124
K	LYS124
L	LYS124
B	LYS124
C	LYS124
D	LYS124
E	LYS124
F	LYS124
G	LYS124
H	LYS124
I	LYS124

---

site_id	SWS_FT_FI5
Number of Residues	24
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000250|UniProtKB:P15531

Chain	Residue	Details
A	LYS100
F	LYS100
G	LYS100
H	LYS100
I	LYS100
J	LYS100
K	LYS100
L	LYS100
B	LYS100
C	LYS100
D	LYS100
E	LYS100

---