7ZII

Crystal structure of human tryptophan hydroxylase 1 in complex with inhibitor KM-05-193

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004497	molecular_function	monooxygenase activity
A	0005506	molecular_function	iron ion binding
A	0009072	biological_process	aromatic amino acid metabolic process
A	0016714	molecular_function	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced pteridine as one donor, and incorporation of one atom of oxygen

Functional Information from PROSITE/UniProt

site_id	PS00367
Number of Residues	12
Details	BH4_AAA_HYDROXYL_1 Biopterin-dependent aromatic amino acid hydroxylases signature. PDtcHELLGHVP

Chain	Residue	Details
A	PRO268-PRO279

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	5
Details	BINDING: BINDING => ECO:0000250|UniProtKB:P70080

Chain	Residue	Details
A	TYR235
A	ARG257
A	THR265
A	SER336
A	ILE366

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site_id	SWS_FT_FI2
Number of Residues	3
Details	BINDING: BINDING => ECO:0000269|PubMed:12379098, ECO:0007744|PDB:1MLW

Chain	Residue	Details
A	HIS272
A	HIS277
A	GLU317

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