7ZIA
Crystal structure of dCK C4S-S74E mutant in complex with UDP and the OR0634 inhibitor
Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0004136 | molecular_function | deoxyadenosine kinase activity |
A | 0004137 | molecular_function | deoxycytidine kinase activity |
A | 0004138 | molecular_function | deoxyguanosine kinase activity |
A | 0005524 | molecular_function | ATP binding |
A | 0005634 | cellular_component | nucleus |
A | 0005654 | cellular_component | nucleoplasm |
A | 0005737 | cellular_component | cytoplasm |
A | 0005739 | cellular_component | mitochondrion |
A | 0005829 | cellular_component | cytosol |
A | 0006139 | biological_process | nucleobase-containing compound metabolic process |
A | 0006220 | biological_process | pyrimidine nucleotide metabolic process |
A | 0008144 | molecular_function | obsolete drug binding |
A | 0009224 | biological_process | CMP biosynthetic process |
A | 0016301 | molecular_function | kinase activity |
A | 0019136 | molecular_function | deoxynucleoside kinase activity |
A | 0042803 | molecular_function | protein homodimerization activity |
A | 0043771 | molecular_function | cytidine kinase activity |
A | 0106383 | biological_process | dAMP salvage |
A | 1901135 | biological_process | carbohydrate derivative metabolic process |
A | 1901293 | biological_process | nucleoside phosphate biosynthetic process |
Functional Information from SwissProt/UniProt
site_id | SWS_FT_FI1 |
Number of Residues | 1 |
Details | ACT_SITE: Proton acceptor => ECO:0000255 |
Chain | Residue | Details |
A | GLU127 |
site_id | SWS_FT_FI2 |
Number of Residues | 9 |
Details | BINDING: |
Chain | Residue | Details |
A | GLY28 | |
A | GLU53 | |
A | TYR86 | |
A | GLN97 | |
A | ARG128 | |
A | ASP133 | |
A | ARG188 | |
A | GLU197 | |
A | GLU240 |
site_id | SWS_FT_FI3 |
Number of Residues | 2 |
Details | MOD_RES: Phosphoserine; by CK1 => ECO:0000305|PubMed:20637175 |
Chain | Residue | Details |
A | SER11 | |
A | SER15 |
site_id | SWS_FT_FI4 |
Number of Residues | 1 |
Details | MOD_RES: Phosphothreonine; by CK1 => ECO:0000305|PubMed:20637175 |
Chain | Residue | Details |
A | THR72 |
site_id | SWS_FT_FI5 |
Number of Residues | 1 |
Details | MOD_RES: Phosphoserine => ECO:0000269|PubMed:20637175, ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:23186163 |
Chain | Residue | Details |
A | GLU74 |