7ZI4

Cryo-EM structure of the human INO80 complex bound to a WT nucleosome

This is a non-PDB format compatible entry.

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000492	biological_process	box C/D snoRNP assembly
A	0000723	biological_process	telomere maintenance
A	0000786	cellular_component	nucleosome
A	0000812	cellular_component	Swr1 complex
A	0001094	molecular_function	TFIID-class transcription factor complex binding
A	0003678	molecular_function	DNA helicase activity
A	0003713	molecular_function	transcription coactivator activity
A	0004386	molecular_function	helicase activity
A	0005515	molecular_function	protein binding
A	0005524	molecular_function	ATP binding
A	0005634	cellular_component	nucleus
A	0005654	cellular_component	nucleoplasm
A	0005737	cellular_component	cytoplasm
A	0005813	cellular_component	centrosome
A	0005829	cellular_component	cytosol
A	0005856	cellular_component	cytoskeleton
A	0006275	biological_process	regulation of DNA replication
A	0006281	biological_process	DNA repair
A	0006282	biological_process	regulation of DNA repair
A	0006310	biological_process	DNA recombination
A	0006325	biological_process	chromatin organization
A	0006338	biological_process	chromatin remodeling
A	0006355	biological_process	regulation of DNA-templated transcription
A	0006357	biological_process	regulation of transcription by RNA polymerase II
A	0007283	biological_process	spermatogenesis
A	0008094	molecular_function	ATP-dependent activity, acting on DNA
A	0016020	cellular_component	membrane
A	0016363	cellular_component	nuclear matrix
A	0016787	molecular_function	hydrolase activity
A	0016887	molecular_function	ATP hydrolysis activity
A	0017025	molecular_function	TBP-class protein binding
A	0031011	cellular_component	Ino80 complex
A	0032508	biological_process	DNA duplex unwinding
A	0033044	biological_process	regulation of chromosome organization
A	0035267	cellular_component	NuA4 histone acetyltransferase complex
A	0042981	biological_process	regulation of apoptotic process
A	0043531	molecular_function	ADP binding
A	0045296	molecular_function	cadherin binding
A	0045739	biological_process	positive regulation of DNA repair
A	0045893	biological_process	positive regulation of DNA-templated transcription
A	0045995	biological_process	regulation of embryonic development
A	0050821	biological_process	protein stabilization
A	0051117	molecular_function	ATPase binding
A	0051276	biological_process	chromosome organization
A	0051301	biological_process	cell division
A	0051726	biological_process	regulation of cell cycle
A	0060382	biological_process	regulation of DNA strand elongation
A	0070062	cellular_component	extracellular exosome
A	0071339	cellular_component	MLL1 complex
A	0090263	biological_process	positive regulation of canonical Wnt signaling pathway
A	0097255	cellular_component	R2TP complex
A	0101031	cellular_component	protein folding chaperone complex
A	0120293	cellular_component	dynein axonemal particle
A	1904507	biological_process	positive regulation of telomere maintenance in response to DNA damage
A	1904874	biological_process	positive regulation of telomerase RNA localization to Cajal body
A	1905168	biological_process	positive regulation of double-strand break repair via homologous recombination
A	1990062	cellular_component	RPAP3/R2TP/prefoldin-like complex
A	1990904	cellular_component	ribonucleoprotein complex
A	2000779	biological_process	regulation of double-strand break repair
B	0000492	biological_process	box C/D snoRNP assembly
B	0000723	biological_process	telomere maintenance
B	0000786	cellular_component	nucleosome
B	0000791	cellular_component	euchromatin
B	0000812	cellular_component	Swr1 complex
B	0000978	molecular_function	RNA polymerase II cis-regulatory region sequence-specific DNA binding
B	0000979	molecular_function	RNA polymerase II core promoter sequence-specific DNA binding
B	0001094	molecular_function	TFIID-class transcription factor complex binding
B	0003678	molecular_function	DNA helicase activity
B	0003714	molecular_function	transcription corepressor activity
B	0004386	molecular_function	helicase activity
B	0005515	molecular_function	protein binding
B	0005524	molecular_function	ATP binding
B	0005634	cellular_component	nucleus
B	0005654	cellular_component	nucleoplasm
B	0005737	cellular_component	cytoplasm
B	0005813	cellular_component	centrosome
B	0005829	cellular_component	cytosol
B	0006275	biological_process	regulation of DNA replication
B	0006281	biological_process	DNA repair
B	0006282	biological_process	regulation of DNA repair
B	0006310	biological_process	DNA recombination
B	0006325	biological_process	chromatin organization
B	0006338	biological_process	chromatin remodeling
B	0006355	biological_process	regulation of DNA-templated transcription
B	0006357	biological_process	regulation of transcription by RNA polymerase II
B	0006457	biological_process	protein folding
B	0008013	molecular_function	beta-catenin binding
B	0008094	molecular_function	ATP-dependent activity, acting on DNA
B	0016020	cellular_component	membrane
B	0016363	cellular_component	nuclear matrix
B	0016787	molecular_function	hydrolase activity
B	0016887	molecular_function	ATP hydrolysis activity
B	0017025	molecular_function	TBP-class protein binding
B	0031011	cellular_component	Ino80 complex
B	0031490	molecular_function	chromatin DNA binding
B	0032508	biological_process	DNA duplex unwinding
B	0033044	biological_process	regulation of chromosome organization
B	0034644	biological_process	cellular response to UV
B	0035267	cellular_component	NuA4 histone acetyltransferase complex
B	0042802	molecular_function	identical protein binding
B	0042803	molecular_function	protein homodimerization activity
B	0042981	biological_process	regulation of apoptotic process
B	0043531	molecular_function	ADP binding
B	0045739	biological_process	positive regulation of DNA repair
B	0045892	biological_process	negative regulation of DNA-templated transcription
B	0045893	biological_process	positive regulation of DNA-templated transcription
B	0045944	biological_process	positive regulation of transcription by RNA polymerase II
B	0045995	biological_process	regulation of embryonic development
B	0050821	biological_process	protein stabilization
B	0051082	molecular_function	unfolded protein binding
B	0051117	molecular_function	ATPase binding
B	0051276	biological_process	chromosome organization
B	0051726	biological_process	regulation of cell cycle
B	0060382	biological_process	regulation of DNA strand elongation
B	0070062	cellular_component	extracellular exosome
B	0071169	biological_process	establishment of protein localization to chromatin
B	0071339	cellular_component	MLL1 complex
B	0071392	biological_process	cellular response to estradiol stimulus
B	0090090	biological_process	negative regulation of canonical Wnt signaling pathway
B	0097255	cellular_component	R2TP complex
B	0101031	cellular_component	protein folding chaperone complex
B	0120293	cellular_component	dynein axonemal particle
B	0140585	molecular_function	promoter-enhancer loop anchoring activity
B	1904507	biological_process	positive regulation of telomere maintenance in response to DNA damage
B	1904874	biological_process	positive regulation of telomerase RNA localization to Cajal body
B	1905168	biological_process	positive regulation of double-strand break repair via homologous recombination
B	1990062	cellular_component	RPAP3/R2TP/prefoldin-like complex
B	1990904	cellular_component	ribonucleoprotein complex
B	2000779	biological_process	regulation of double-strand break repair
C	0000492	biological_process	box C/D snoRNP assembly
C	0000723	biological_process	telomere maintenance
C	0000786	cellular_component	nucleosome
C	0000812	cellular_component	Swr1 complex
C	0001094	molecular_function	TFIID-class transcription factor complex binding
C	0003678	molecular_function	DNA helicase activity
C	0003713	molecular_function	transcription coactivator activity
C	0004386	molecular_function	helicase activity
C	0005515	molecular_function	protein binding
C	0005524	molecular_function	ATP binding
C	0005634	cellular_component	nucleus
C	0005654	cellular_component	nucleoplasm
C	0005737	cellular_component	cytoplasm
C	0005813	cellular_component	centrosome
C	0005829	cellular_component	cytosol
C	0005856	cellular_component	cytoskeleton
C	0006275	biological_process	regulation of DNA replication
C	0006281	biological_process	DNA repair
C	0006282	biological_process	regulation of DNA repair
C	0006310	biological_process	DNA recombination
C	0006325	biological_process	chromatin organization
C	0006338	biological_process	chromatin remodeling
C	0006355	biological_process	regulation of DNA-templated transcription
C	0006357	biological_process	regulation of transcription by RNA polymerase II
C	0007283	biological_process	spermatogenesis
C	0008094	molecular_function	ATP-dependent activity, acting on DNA
C	0016020	cellular_component	membrane
C	0016363	cellular_component	nuclear matrix
C	0016787	molecular_function	hydrolase activity
C	0016887	molecular_function	ATP hydrolysis activity
C	0017025	molecular_function	TBP-class protein binding
C	0031011	cellular_component	Ino80 complex
C	0032508	biological_process	DNA duplex unwinding
C	0033044	biological_process	regulation of chromosome organization
C	0035267	cellular_component	NuA4 histone acetyltransferase complex
C	0042981	biological_process	regulation of apoptotic process
C	0043531	molecular_function	ADP binding
C	0045296	molecular_function	cadherin binding
C	0045739	biological_process	positive regulation of DNA repair
C	0045893	biological_process	positive regulation of DNA-templated transcription
C	0045995	biological_process	regulation of embryonic development
C	0050821	biological_process	protein stabilization
C	0051117	molecular_function	ATPase binding
C	0051276	biological_process	chromosome organization
C	0051301	biological_process	cell division
C	0051726	biological_process	regulation of cell cycle
C	0060382	biological_process	regulation of DNA strand elongation
C	0070062	cellular_component	extracellular exosome
C	0071339	cellular_component	MLL1 complex
C	0090263	biological_process	positive regulation of canonical Wnt signaling pathway
C	0097255	cellular_component	R2TP complex
C	0101031	cellular_component	protein folding chaperone complex
C	0120293	cellular_component	dynein axonemal particle
C	1904507	biological_process	positive regulation of telomere maintenance in response to DNA damage
C	1904874	biological_process	positive regulation of telomerase RNA localization to Cajal body
C	1905168	biological_process	positive regulation of double-strand break repair via homologous recombination
C	1990062	cellular_component	RPAP3/R2TP/prefoldin-like complex
C	1990904	cellular_component	ribonucleoprotein complex
C	2000779	biological_process	regulation of double-strand break repair
D	0000492	biological_process	box C/D snoRNP assembly
D	0000723	biological_process	telomere maintenance
D	0000786	cellular_component	nucleosome
D	0000791	cellular_component	euchromatin
D	0000812	cellular_component	Swr1 complex
D	0000978	molecular_function	RNA polymerase II cis-regulatory region sequence-specific DNA binding
D	0000979	molecular_function	RNA polymerase II core promoter sequence-specific DNA binding
D	0001094	molecular_function	TFIID-class transcription factor complex binding
D	0003678	molecular_function	DNA helicase activity
D	0003714	molecular_function	transcription corepressor activity
D	0004386	molecular_function	helicase activity
D	0005515	molecular_function	protein binding
D	0005524	molecular_function	ATP binding
D	0005634	cellular_component	nucleus
D	0005654	cellular_component	nucleoplasm
D	0005737	cellular_component	cytoplasm
D	0005813	cellular_component	centrosome
D	0005829	cellular_component	cytosol
D	0006275	biological_process	regulation of DNA replication
D	0006281	biological_process	DNA repair
D	0006282	biological_process	regulation of DNA repair
D	0006310	biological_process	DNA recombination
D	0006325	biological_process	chromatin organization
D	0006338	biological_process	chromatin remodeling
D	0006355	biological_process	regulation of DNA-templated transcription
D	0006357	biological_process	regulation of transcription by RNA polymerase II
D	0006457	biological_process	protein folding
D	0008013	molecular_function	beta-catenin binding
D	0008094	molecular_function	ATP-dependent activity, acting on DNA
D	0016020	cellular_component	membrane
D	0016363	cellular_component	nuclear matrix
D	0016787	molecular_function	hydrolase activity
D	0016887	molecular_function	ATP hydrolysis activity
D	0017025	molecular_function	TBP-class protein binding
D	0031011	cellular_component	Ino80 complex
D	0031490	molecular_function	chromatin DNA binding
D	0032508	biological_process	DNA duplex unwinding
D	0033044	biological_process	regulation of chromosome organization
D	0034644	biological_process	cellular response to UV
D	0035267	cellular_component	NuA4 histone acetyltransferase complex
D	0042802	molecular_function	identical protein binding
D	0042803	molecular_function	protein homodimerization activity
D	0042981	biological_process	regulation of apoptotic process
D	0043531	molecular_function	ADP binding
D	0045739	biological_process	positive regulation of DNA repair
D	0045892	biological_process	negative regulation of DNA-templated transcription
D	0045893	biological_process	positive regulation of DNA-templated transcription
D	0045944	biological_process	positive regulation of transcription by RNA polymerase II
D	0045995	biological_process	regulation of embryonic development
D	0050821	biological_process	protein stabilization
D	0051082	molecular_function	unfolded protein binding
D	0051117	molecular_function	ATPase binding
D	0051276	biological_process	chromosome organization
D	0051726	biological_process	regulation of cell cycle
D	0060382	biological_process	regulation of DNA strand elongation
D	0070062	cellular_component	extracellular exosome
D	0071169	biological_process	establishment of protein localization to chromatin
D	0071339	cellular_component	MLL1 complex
D	0071392	biological_process	cellular response to estradiol stimulus
D	0090090	biological_process	negative regulation of canonical Wnt signaling pathway
D	0097255	cellular_component	R2TP complex
D	0101031	cellular_component	protein folding chaperone complex
D	0120293	cellular_component	dynein axonemal particle
D	0140585	molecular_function	promoter-enhancer loop anchoring activity
D	1904507	biological_process	positive regulation of telomere maintenance in response to DNA damage
D	1904874	biological_process	positive regulation of telomerase RNA localization to Cajal body
D	1905168	biological_process	positive regulation of double-strand break repair via homologous recombination
D	1990062	cellular_component	RPAP3/R2TP/prefoldin-like complex
D	1990904	cellular_component	ribonucleoprotein complex
D	2000779	biological_process	regulation of double-strand break repair
E	0000492	biological_process	box C/D snoRNP assembly
E	0000723	biological_process	telomere maintenance
E	0000786	cellular_component	nucleosome
E	0000812	cellular_component	Swr1 complex
E	0001094	molecular_function	TFIID-class transcription factor complex binding
E	0003678	molecular_function	DNA helicase activity
E	0003713	molecular_function	transcription coactivator activity
E	0004386	molecular_function	helicase activity
E	0005515	molecular_function	protein binding
E	0005524	molecular_function	ATP binding
E	0005634	cellular_component	nucleus
E	0005654	cellular_component	nucleoplasm
E	0005737	cellular_component	cytoplasm
E	0005813	cellular_component	centrosome
E	0005829	cellular_component	cytosol
E	0005856	cellular_component	cytoskeleton
E	0006275	biological_process	regulation of DNA replication
E	0006281	biological_process	DNA repair
E	0006282	biological_process	regulation of DNA repair
E	0006310	biological_process	DNA recombination
E	0006325	biological_process	chromatin organization
E	0006338	biological_process	chromatin remodeling
E	0006355	biological_process	regulation of DNA-templated transcription
E	0006357	biological_process	regulation of transcription by RNA polymerase II
E	0007283	biological_process	spermatogenesis
E	0008094	molecular_function	ATP-dependent activity, acting on DNA
E	0016020	cellular_component	membrane
E	0016363	cellular_component	nuclear matrix
E	0016787	molecular_function	hydrolase activity
E	0016887	molecular_function	ATP hydrolysis activity
E	0017025	molecular_function	TBP-class protein binding
E	0031011	cellular_component	Ino80 complex
E	0032508	biological_process	DNA duplex unwinding
E	0033044	biological_process	regulation of chromosome organization
E	0035267	cellular_component	NuA4 histone acetyltransferase complex
E	0042981	biological_process	regulation of apoptotic process
E	0043531	molecular_function	ADP binding
E	0045296	molecular_function	cadherin binding
E	0045739	biological_process	positive regulation of DNA repair
E	0045893	biological_process	positive regulation of DNA-templated transcription
E	0045995	biological_process	regulation of embryonic development
E	0050821	biological_process	protein stabilization
E	0051117	molecular_function	ATPase binding
E	0051276	biological_process	chromosome organization
E	0051301	biological_process	cell division
E	0051726	biological_process	regulation of cell cycle
E	0060382	biological_process	regulation of DNA strand elongation
E	0070062	cellular_component	extracellular exosome
E	0071339	cellular_component	MLL1 complex
E	0090263	biological_process	positive regulation of canonical Wnt signaling pathway
E	0097255	cellular_component	R2TP complex
E	0101031	cellular_component	protein folding chaperone complex
E	0120293	cellular_component	dynein axonemal particle
E	1904507	biological_process	positive regulation of telomere maintenance in response to DNA damage
E	1904874	biological_process	positive regulation of telomerase RNA localization to Cajal body
E	1905168	biological_process	positive regulation of double-strand break repair via homologous recombination
E	1990062	cellular_component	RPAP3/R2TP/prefoldin-like complex
E	1990904	cellular_component	ribonucleoprotein complex
E	2000779	biological_process	regulation of double-strand break repair
F	0000492	biological_process	box C/D snoRNP assembly
F	0000723	biological_process	telomere maintenance
F	0000786	cellular_component	nucleosome
F	0000791	cellular_component	euchromatin
F	0000812	cellular_component	Swr1 complex
F	0000978	molecular_function	RNA polymerase II cis-regulatory region sequence-specific DNA binding
F	0000979	molecular_function	RNA polymerase II core promoter sequence-specific DNA binding
F	0001094	molecular_function	TFIID-class transcription factor complex binding
F	0003678	molecular_function	DNA helicase activity
F	0003714	molecular_function	transcription corepressor activity
F	0004386	molecular_function	helicase activity
F	0005515	molecular_function	protein binding
F	0005524	molecular_function	ATP binding
F	0005634	cellular_component	nucleus
F	0005654	cellular_component	nucleoplasm
F	0005737	cellular_component	cytoplasm
F	0005813	cellular_component	centrosome
F	0005829	cellular_component	cytosol
F	0006275	biological_process	regulation of DNA replication
F	0006281	biological_process	DNA repair
F	0006282	biological_process	regulation of DNA repair
F	0006310	biological_process	DNA recombination
F	0006325	biological_process	chromatin organization
F	0006338	biological_process	chromatin remodeling
F	0006355	biological_process	regulation of DNA-templated transcription
F	0006357	biological_process	regulation of transcription by RNA polymerase II
F	0006457	biological_process	protein folding
F	0008013	molecular_function	beta-catenin binding
F	0008094	molecular_function	ATP-dependent activity, acting on DNA
F	0016020	cellular_component	membrane
F	0016363	cellular_component	nuclear matrix
F	0016787	molecular_function	hydrolase activity
F	0016887	molecular_function	ATP hydrolysis activity
F	0017025	molecular_function	TBP-class protein binding
F	0031011	cellular_component	Ino80 complex
F	0031490	molecular_function	chromatin DNA binding
F	0032508	biological_process	DNA duplex unwinding
F	0033044	biological_process	regulation of chromosome organization
F	0034644	biological_process	cellular response to UV
F	0035267	cellular_component	NuA4 histone acetyltransferase complex
F	0042802	molecular_function	identical protein binding
F	0042803	molecular_function	protein homodimerization activity
F	0042981	biological_process	regulation of apoptotic process
F	0043531	molecular_function	ADP binding
F	0045739	biological_process	positive regulation of DNA repair
F	0045892	biological_process	negative regulation of DNA-templated transcription
F	0045893	biological_process	positive regulation of DNA-templated transcription
F	0045944	biological_process	positive regulation of transcription by RNA polymerase II
F	0045995	biological_process	regulation of embryonic development
F	0050821	biological_process	protein stabilization
F	0051082	molecular_function	unfolded protein binding
F	0051117	molecular_function	ATPase binding
F	0051276	biological_process	chromosome organization
F	0051726	biological_process	regulation of cell cycle
F	0060382	biological_process	regulation of DNA strand elongation
F	0070062	cellular_component	extracellular exosome
F	0071169	biological_process	establishment of protein localization to chromatin
F	0071339	cellular_component	MLL1 complex
F	0071392	biological_process	cellular response to estradiol stimulus
F	0090090	biological_process	negative regulation of canonical Wnt signaling pathway
F	0097255	cellular_component	R2TP complex
F	0101031	cellular_component	protein folding chaperone complex
F	0120293	cellular_component	dynein axonemal particle
F	0140585	molecular_function	promoter-enhancer loop anchoring activity
F	1904507	biological_process	positive regulation of telomere maintenance in response to DNA damage
F	1904874	biological_process	positive regulation of telomerase RNA localization to Cajal body
F	1905168	biological_process	positive regulation of double-strand break repair via homologous recombination
F	1990062	cellular_component	RPAP3/R2TP/prefoldin-like complex
F	1990904	cellular_component	ribonucleoprotein complex
F	2000779	biological_process	regulation of double-strand break repair
G	0000070	biological_process	mitotic sister chromatid segregation
G	0000723	biological_process	telomere maintenance
G	0000724	biological_process	double-strand break repair via homologous recombination
G	0003677	molecular_function	DNA binding
G	0003779	molecular_function	actin binding
G	0005515	molecular_function	protein binding
G	0005524	molecular_function	ATP binding
G	0005634	cellular_component	nucleus
G	0005654	cellular_component	nucleoplasm
G	0005694	cellular_component	chromosome
G	0005737	cellular_component	cytoplasm
G	0005819	cellular_component	spindle
G	0005829	cellular_component	cytosol
G	0005856	cellular_component	cytoskeleton
G	0005874	cellular_component	microtubule
G	0006275	biological_process	regulation of DNA replication
G	0006281	biological_process	DNA repair
G	0006282	biological_process	regulation of DNA repair
G	0006302	biological_process	double-strand break repair
G	0006310	biological_process	DNA recombination
G	0006338	biological_process	chromatin remodeling
G	0006351	biological_process	DNA-templated transcription
G	0008094	molecular_function	ATP-dependent activity, acting on DNA
G	0010571	biological_process	positive regulation of nuclear cell cycle DNA replication
G	0016604	cellular_component	nuclear body
G	0016787	molecular_function	hydrolase activity
G	0016887	molecular_function	ATP hydrolysis activity
G	0030307	biological_process	positive regulation of cell growth
G	0031011	cellular_component	Ino80 complex
G	0033044	biological_process	regulation of chromosome organization
G	0034644	biological_process	cellular response to UV
G	0042393	molecular_function	histone binding
G	0043014	molecular_function	alpha-tubulin binding
G	0045739	biological_process	positive regulation of DNA repair
G	0045893	biological_process	positive regulation of DNA-templated transcription
G	0045944	biological_process	positive regulation of transcription by RNA polymerase II
G	0045995	biological_process	regulation of embryonic development
G	0051225	biological_process	spindle assembly
G	0051301	biological_process	cell division
G	0051726	biological_process	regulation of cell cycle
G	0060382	biological_process	regulation of DNA strand elongation
G	0070914	biological_process	UV-damage excision repair
G	0071479	biological_process	cellular response to ionizing radiation
G	0140658	molecular_function	ATP-dependent chromatin remodeler activity
G	1904507	biological_process	positive regulation of telomere maintenance in response to DNA damage
G	2000045	biological_process	regulation of G1/S transition of mitotic cell cycle
H	0000723	biological_process	telomere maintenance
H	0005515	molecular_function	protein binding
H	0005634	cellular_component	nucleus
H	0005654	cellular_component	nucleoplasm
H	0005737	cellular_component	cytoplasm
H	0006275	biological_process	regulation of DNA replication
H	0006281	biological_process	DNA repair
H	0006282	biological_process	regulation of DNA repair
H	0006302	biological_process	double-strand break repair
H	0006310	biological_process	DNA recombination
H	0006338	biological_process	chromatin remodeling
H	0006355	biological_process	regulation of DNA-templated transcription
H	0031011	cellular_component	Ino80 complex
H	0033044	biological_process	regulation of chromosome organization
H	0045739	biological_process	positive regulation of DNA repair
H	0045893	biological_process	positive regulation of DNA-templated transcription
H	0045995	biological_process	regulation of embryonic development
H	0051726	biological_process	regulation of cell cycle
H	0060382	biological_process	regulation of DNA strand elongation
H	0070914	biological_process	UV-damage excision repair
H	1904507	biological_process	positive regulation of telomere maintenance in response to DNA damage
I	0000786	cellular_component	nucleosome
I	0003677	molecular_function	DNA binding
I	0005515	molecular_function	protein binding
I	0005576	cellular_component	extracellular region
I	0005634	cellular_component	nucleus
I	0005654	cellular_component	nucleoplasm
I	0005694	cellular_component	chromosome
I	0006325	biological_process	chromatin organization
I	0006334	biological_process	nucleosome assembly
I	0010467	biological_process	gene expression
I	0016020	cellular_component	membrane
I	0030527	molecular_function	structural constituent of chromatin
I	0032200	biological_process	telomere organization
I	0032991	cellular_component	protein-containing complex
I	0040029	biological_process	epigenetic regulation of gene expression
I	0043229	cellular_component	intracellular organelle
I	0045296	molecular_function	cadherin binding
I	0046982	molecular_function	protein heterodimerization activity
I	0070062	cellular_component	extracellular exosome
J	0000781	cellular_component	chromosome, telomeric region
J	0000786	cellular_component	nucleosome
J	0003677	molecular_function	DNA binding
J	0003723	molecular_function	RNA binding
J	0005515	molecular_function	protein binding
J	0005576	cellular_component	extracellular region
J	0005634	cellular_component	nucleus
J	0005654	cellular_component	nucleoplasm
J	0005694	cellular_component	chromosome
J	0006325	biological_process	chromatin organization
J	0006334	biological_process	nucleosome assembly
J	0016020	cellular_component	membrane
J	0030527	molecular_function	structural constituent of chromatin
J	0032200	biological_process	telomere organization
J	0032991	cellular_component	protein-containing complex
J	0043505	cellular_component	CENP-A containing nucleosome
J	0045653	biological_process	negative regulation of megakaryocyte differentiation
J	0046982	molecular_function	protein heterodimerization activity
J	0061644	biological_process	protein localization to CENP-A containing chromatin
J	0070062	cellular_component	extracellular exosome
K	0000786	cellular_component	nucleosome
K	0003677	molecular_function	DNA binding
K	0005515	molecular_function	protein binding
K	0005634	cellular_component	nucleus
K	0005694	cellular_component	chromosome
K	0006325	biological_process	chromatin organization
K	0008285	biological_process	negative regulation of cell population proliferation
K	0030527	molecular_function	structural constituent of chromatin
K	0031492	molecular_function	nucleosomal DNA binding
K	0031507	biological_process	heterochromatin formation
K	0043229	cellular_component	intracellular organelle
K	0043505	cellular_component	CENP-A containing nucleosome
K	0046982	molecular_function	protein heterodimerization activity
K	0061644	biological_process	protein localization to CENP-A containing chromatin
K	0070062	cellular_component	extracellular exosome
L	0000786	cellular_component	nucleosome
L	0001530	molecular_function	lipopolysaccharide binding
L	0002227	biological_process	innate immune response in mucosa
L	0003677	molecular_function	DNA binding
L	0005515	molecular_function	protein binding
L	0005615	cellular_component	extracellular space
L	0005634	cellular_component	nucleus
L	0005654	cellular_component	nucleoplasm
L	0005694	cellular_component	chromosome
L	0005829	cellular_component	cytosol
L	0005886	cellular_component	plasma membrane
L	0006325	biological_process	chromatin organization
L	0006334	biological_process	nucleosome assembly
L	0010804	biological_process	negative regulation of tumor necrosis factor-mediated signaling pathway
L	0019731	biological_process	antibacterial humoral response
L	0030527	molecular_function	structural constituent of chromatin
L	0031640	biological_process	killing of cells of another organism
L	0042742	biological_process	defense response to bacterium
L	0043229	cellular_component	intracellular organelle
L	0043505	cellular_component	CENP-A containing nucleosome
L	0046982	molecular_function	protein heterodimerization activity
L	0050829	biological_process	defense response to Gram-negative bacterium
L	0050830	biological_process	defense response to Gram-positive bacterium
L	0061644	biological_process	protein localization to CENP-A containing chromatin
L	0061844	biological_process	antimicrobial humoral immune response mediated by antimicrobial peptide
M	0000786	cellular_component	nucleosome
M	0003677	molecular_function	DNA binding
M	0005515	molecular_function	protein binding
M	0005576	cellular_component	extracellular region
M	0005634	cellular_component	nucleus
M	0005654	cellular_component	nucleoplasm
M	0005694	cellular_component	chromosome
M	0006325	biological_process	chromatin organization
M	0006334	biological_process	nucleosome assembly
M	0010467	biological_process	gene expression
M	0016020	cellular_component	membrane
M	0030527	molecular_function	structural constituent of chromatin
M	0032200	biological_process	telomere organization
M	0032991	cellular_component	protein-containing complex
M	0040029	biological_process	epigenetic regulation of gene expression
M	0043229	cellular_component	intracellular organelle
M	0045296	molecular_function	cadherin binding
M	0046982	molecular_function	protein heterodimerization activity
M	0070062	cellular_component	extracellular exosome
N	0000781	cellular_component	chromosome, telomeric region
N	0000786	cellular_component	nucleosome
N	0003677	molecular_function	DNA binding
N	0003723	molecular_function	RNA binding
N	0005515	molecular_function	protein binding
N	0005576	cellular_component	extracellular region
N	0005634	cellular_component	nucleus
N	0005654	cellular_component	nucleoplasm
N	0005694	cellular_component	chromosome
N	0006325	biological_process	chromatin organization
N	0006334	biological_process	nucleosome assembly
N	0016020	cellular_component	membrane
N	0030527	molecular_function	structural constituent of chromatin
N	0032200	biological_process	telomere organization
N	0032991	cellular_component	protein-containing complex
N	0043505	cellular_component	CENP-A containing nucleosome
N	0045653	biological_process	negative regulation of megakaryocyte differentiation
N	0046982	molecular_function	protein heterodimerization activity
N	0061644	biological_process	protein localization to CENP-A containing chromatin
N	0070062	cellular_component	extracellular exosome
O	0000786	cellular_component	nucleosome
O	0003677	molecular_function	DNA binding
O	0005515	molecular_function	protein binding
O	0005634	cellular_component	nucleus
O	0005694	cellular_component	chromosome
O	0006325	biological_process	chromatin organization
O	0008285	biological_process	negative regulation of cell population proliferation
O	0030527	molecular_function	structural constituent of chromatin
O	0031492	molecular_function	nucleosomal DNA binding
O	0031507	biological_process	heterochromatin formation
O	0043229	cellular_component	intracellular organelle
O	0043505	cellular_component	CENP-A containing nucleosome
O	0046982	molecular_function	protein heterodimerization activity
O	0061644	biological_process	protein localization to CENP-A containing chromatin
O	0070062	cellular_component	extracellular exosome
P	0000786	cellular_component	nucleosome
P	0001530	molecular_function	lipopolysaccharide binding
P	0002227	biological_process	innate immune response in mucosa
P	0003677	molecular_function	DNA binding
P	0005515	molecular_function	protein binding
P	0005615	cellular_component	extracellular space
P	0005634	cellular_component	nucleus
P	0005654	cellular_component	nucleoplasm
P	0005694	cellular_component	chromosome
P	0005829	cellular_component	cytosol
P	0005886	cellular_component	plasma membrane
P	0006325	biological_process	chromatin organization
P	0006334	biological_process	nucleosome assembly
P	0010804	biological_process	negative regulation of tumor necrosis factor-mediated signaling pathway
P	0019731	biological_process	antibacterial humoral response
P	0030527	molecular_function	structural constituent of chromatin
P	0031640	biological_process	killing of cells of another organism
P	0042742	biological_process	defense response to bacterium
P	0043229	cellular_component	intracellular organelle
P	0043505	cellular_component	CENP-A containing nucleosome
P	0046982	molecular_function	protein heterodimerization activity
P	0050829	biological_process	defense response to Gram-negative bacterium
P	0050830	biological_process	defense response to Gram-positive bacterium
P	0061644	biological_process	protein localization to CENP-A containing chromatin
P	0061844	biological_process	antimicrobial humoral immune response mediated by antimicrobial peptide
Q	0000723	biological_process	telomere maintenance
Q	0005515	molecular_function	protein binding
Q	0005634	cellular_component	nucleus
Q	0005654	cellular_component	nucleoplasm
Q	0006275	biological_process	regulation of DNA replication
Q	0006281	biological_process	DNA repair
Q	0006282	biological_process	regulation of DNA repair
Q	0006310	biological_process	DNA recombination
Q	0006338	biological_process	chromatin remodeling
Q	0031011	cellular_component	Ino80 complex
Q	0033044	biological_process	regulation of chromosome organization
Q	0045739	biological_process	positive regulation of DNA repair
Q	0045893	biological_process	positive regulation of DNA-templated transcription
Q	0045995	biological_process	regulation of embryonic development
Q	0051726	biological_process	regulation of cell cycle
Q	0060382	biological_process	regulation of DNA strand elongation
Q	0071339	cellular_component	MLL1 complex
Q	1904507	biological_process	positive regulation of telomere maintenance in response to DNA damage
R	0000723	biological_process	telomere maintenance
R	0005515	molecular_function	protein binding
R	0005634	cellular_component	nucleus
R	0005654	cellular_component	nucleoplasm
R	0005730	cellular_component	nucleolus
R	0006275	biological_process	regulation of DNA replication
R	0006281	biological_process	DNA repair
R	0006282	biological_process	regulation of DNA repair
R	0006310	biological_process	DNA recombination
R	0006338	biological_process	chromatin remodeling
R	0016604	cellular_component	nuclear body
R	0031011	cellular_component	Ino80 complex
R	0033044	biological_process	regulation of chromosome organization
R	0045739	biological_process	positive regulation of DNA repair
R	0045893	biological_process	positive regulation of DNA-templated transcription
R	0045995	biological_process	regulation of embryonic development
R	0046872	molecular_function	metal ion binding
R	0051726	biological_process	regulation of cell cycle
R	0060382	biological_process	regulation of DNA strand elongation
R	1904507	biological_process	positive regulation of telomere maintenance in response to DNA damage

Functional Information from PROSITE/UniProt

site_id	PS00046
Number of Residues	7
Details	HISTONE_H2A Histone H2A signature. AGLqFPV

Chain	Residue	Details
K	ALA21-VAL27

---

site_id	PS00047
Number of Residues	5
Details	HISTONE_H4 Histone H4 signature. GAKRH

Chain	Residue	Details
N	GLY14-HIS18

---

site_id	PS00322
Number of Residues	7
Details	HISTONE_H3_1 Histone H3 signature 1. KAPRKQL

Chain	Residue	Details
I	LYS14-LEU20

---

site_id	PS00357
Number of Residues	23
Details	HISTONE_H2B Histone H2B signature. REIQTavRlLLpGELaKHAVSEG

Chain	Residue	Details
L	ARG92-GLY114

---

site_id	PS00432
Number of Residues	9
Details	ACTINS_2 Actins signature 2. WITRkEYEE

Chain	Residue	Details
H	TRP551-GLU559

---

site_id	PS00959
Number of Residues	9
Details	HISTONE_H3_2 Histone H3 signature 2. PFqRLVREI

Chain	Residue	Details
I	PRO66-ILE74

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	2
Details	MOD_RES: Phosphoserine; by RPS6KA5 => ECO:0000269|PubMed:11709551, ECO:0000269|PubMed:15010469

Chain	Residue	Details
K	SER1
O	SER1
F	GLY77

---

site_id	SWS_FT_FI2
Number of Residues	2
Details	MOD_RES: Symmetric dimethylarginine; by PRMT5; alternate => ECO:0000250|UniProtKB:C0HKE1

Chain	Residue	Details
K	ARG3
O	ARG3
R	SER-80
R	SER-77
R	SER-75

---

site_id	SWS_FT_FI3
Number of Residues	2
Details	MOD_RES: N6-acetyllysine; alternate => ECO:0000250|UniProtKB:C0HKE1

Chain	Residue	Details
K	LYS5
P	LYS11
P	LYS15
P	LYS16
P	LYS20
P	LYS23
P	LYS43
P	LYS85
O	LYS5
F	SER437
L	LYS16
L	LYS20
L	LYS23
L	LYS43
L	LYS85
P	LYS5

---

site_id	SWS_FT_FI4
Number of Residues	4
Details	MOD_RES: N6-succinyllysine; alternate => ECO:0000269|PubMed:22389435

Chain	Residue	Details
K	LYS9
F	LYS444
F	LYS456
K	LYS95
O	LYS9
O	LYS95
D	LYS9
E	LYS445
D	LYS444
D	LYS456
F	LYS9

---

site_id	SWS_FT_FI5
Number of Residues	2
Details	MOD_RES: N6-(beta-hydroxybutyryl)lysine; alternate => ECO:0000269|PubMed:27105115

Chain	Residue	Details
K	LYS13
O	LYS13
N	LYS44
J	LYS8
J	LYS16
J	LYS44

---

site_id	SWS_FT_FI6
Number of Residues	2
Details	MOD_RES: N6-crotonyllysine; alternate => ECO:0000269|PubMed:21925322

Chain	Residue	Details
K	LYS36
O	LYS36
N	LYS77
N	LYS91
J	LYS12
J	LYS31
J	LYS77
J	LYS91

---

site_id	SWS_FT_FI7
Number of Residues	4
Details	MOD_RES: N6-(2-hydroxyisobutyryl)lysine => ECO:0000269|PubMed:24681537

Chain	Residue	Details
K	LYS74
K	LYS75
O	LYS74
O	LYS75

---

site_id	SWS_FT_FI8
Number of Residues	2
Details	MOD_RES: N5-methylglutamine => ECO:0000269|PubMed:24352239

Chain	Residue	Details
K	GLN104
O	GLN104
L	LYS120
P	LYS34
P	LYS116
P	LYS120

---

site_id	SWS_FT_FI9
Number of Residues	6
Details	MOD_RES: N6-glutaryllysine; alternate => ECO:0000269|PubMed:31542297

Chain	Residue	Details
K	LYS118
K	LYS119
K	LYS125
O	LYS118
O	LYS119
O	LYS125

---

site_id	SWS_FT_FI10
Number of Residues	2
Details	MOD_RES: Phosphothreonine; by DCAF1 => ECO:0000269|PubMed:15078818, ECO:0000269|PubMed:24140421

Chain	Residue	Details
K	THR120
O	THR120
M	LYS14
M	LYS56

---

site_id	SWS_FT_FI11
Number of Residues	2
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin); alternate => ECO:0000269|PubMed:22713238, ECO:0000269|PubMed:22980979

Chain	Residue	Details
K	LYS13
O	LYS13
P	LYS46
P	LYS108

---

site_id	SWS_FT_FI12
Number of Residues	4
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin); alternate => ECO:0000269|PubMed:15386022, ECO:0000269|PubMed:16359901, ECO:0000269|PubMed:16702407, ECO:0000269|PubMed:25470042

Chain	Residue	Details
I	LYS18
K	LYS119
M	LYS18
O	LYS119

---

site_id	SWS_FT_FI13
Number of Residues	2
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:22713238, ECO:0000269|PubMed:22980979

Chain	Residue	Details
K	LYS15
O	LYS15

---

site_id	SWS_FT_FI14
Number of Residues	2
Details	MOD_RES: Citrulline => ECO:0000269|PubMed:16567635

Chain	Residue	Details
I	ARG26
M	ARG26
P	ARG86
P	ARG92

---

site_id	SWS_FT_FI15
Number of Residues	2
Details	MOD_RES: N6-methyllysine; alternate => ECO:0000269|PubMed:16185088, ECO:0000269|PubMed:16267050, ECO:0000269|PubMed:16627869, ECO:0000269|PubMed:17194708

Chain	Residue	Details
I	LYS27
M	LYS27
J	LYS91

---

site_id	SWS_FT_FI16
Number of Residues	2
Details	MOD_RES: Phosphoserine; alternate; by AURKB, AURKC and RPS6KA5 => ECO:0000269|PubMed:10464286, ECO:0000269|PubMed:11856369, ECO:0000269|PubMed:15681610, ECO:0000269|PubMed:15684425, ECO:0000269|PubMed:16185088, ECO:0000269|PubMed:16457588

Chain	Residue	Details
I	SER28
M	SER28
N	LYS79
J	LYS20
J	LYS59
J	LYS79

---

site_id	SWS_FT_FI17
Number of Residues	2
Details	MOD_RES: N6-methyllysine; alternate => ECO:0000269|PubMed:15983376, ECO:0000269|PubMed:16185088, ECO:0000269|PubMed:16267050, ECO:0000269|PubMed:16627869, ECO:0000269|PubMed:17194708

Chain	Residue	Details
I	LYS36
M	LYS36

---

site_id	SWS_FT_FI18
Number of Residues	2
Details	MOD_RES: N6-methyllysine => ECO:0000269|PubMed:15983376

Chain	Residue	Details
I	LYS37
M	LYS37
P	LYS120

---

site_id	SWS_FT_FI19
Number of Residues	2
Details	MOD_RES: Phosphotyrosine => ECO:0000269|PubMed:19783980

Chain	Residue	Details
I	TYR41
M	TYR41

---

site_id	SWS_FT_FI20
Number of Residues	2
Details	MOD_RES: Phosphoserine => ECO:0000269|PubMed:20850016

Chain	Residue	Details
I	SER57
M	SER57

---

site_id	SWS_FT_FI21
Number of Residues	2
Details	MOD_RES: N6-succinyllysine; alternate => ECO:0000269|PubMed:22389435, ECO:0000269|PubMed:29211711

Chain	Residue	Details
I	LYS79
M	LYS79

---

site_id	SWS_FT_FI22
Number of Residues	2
Details	MOD_RES: Phosphothreonine => ECO:0000269|PubMed:20850016

Chain	Residue	Details
I	THR80
M	THR80

---

site_id	SWS_FT_FI23
Number of Residues	2
Details	MOD_RES: Phosphoserine => ECO:0000250|UniProtKB:P84243

Chain	Residue	Details
I	SER86
M	SER86

---

site_id	SWS_FT_FI24
Number of Residues	2
Details	MOD_RES: Phosphothreonine => ECO:0000250|UniProtKB:Q71DI3

Chain	Residue	Details
I	THR107
M	THR107

---

site_id	SWS_FT_FI25
Number of Residues	2
Details	MOD_RES: N6-glutaryllysine; alternate => ECO:0000269|PubMed:31542297

Chain	Residue	Details
I	LYS115
M	LYS115

---

site_id	SWS_FT_FI26
Number of Residues	2
Details	MOD_RES: N6-succinyllysine; alternate => ECO:0000269|PubMed:22389435, ECO:0000269|PubMed:27436229

Chain	Residue	Details
I	LYS122
M	LYS122

---

site_id	SWS_FT_FI27
Number of Residues	2
Details	LIPID: N6-decanoyllysine => ECO:0000269|PubMed:35939806

Chain	Residue	Details
I	LYS18
M	LYS18

---