7ZG7

Structure of human Apoferritin obtained from ssDNA coated grid

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004322	molecular_function	ferroxidase activity
A	0005506	molecular_function	iron ion binding
A	0005515	molecular_function	protein binding
A	0005576	cellular_component	extracellular region
A	0005634	cellular_component	nucleus
A	0005737	cellular_component	cytoplasm
A	0005764	cellular_component	lysosome
A	0005776	cellular_component	autophagosome
A	0005829	cellular_component	cytosol
A	0006826	biological_process	iron ion transport
A	0006879	biological_process	intracellular iron ion homeostasis
A	0006955	biological_process	immune response
A	0008198	molecular_function	ferrous iron binding
A	0008199	molecular_function	ferric iron binding
A	0008285	biological_process	negative regulation of cell population proliferation
A	0016020	cellular_component	membrane
A	0016491	molecular_function	oxidoreductase activity
A	0031410	cellular_component	cytoplasmic vesicle
A	0042802	molecular_function	identical protein binding
A	0044754	cellular_component	autolysosome
A	0046872	molecular_function	metal ion binding
A	0048147	biological_process	negative regulation of fibroblast proliferation
A	0070062	cellular_component	extracellular exosome
A	0070288	cellular_component	ferritin complex
A	0110076	biological_process	negative regulation of ferroptosis
A	0140315	molecular_function	iron ion sequestering activity
A	1904724	cellular_component	tertiary granule lumen
A	1904813	cellular_component	ficolin-1-rich granule lumen
B	0004322	molecular_function	ferroxidase activity
B	0005506	molecular_function	iron ion binding
B	0005515	molecular_function	protein binding
B	0005576	cellular_component	extracellular region
B	0005634	cellular_component	nucleus
B	0005737	cellular_component	cytoplasm
B	0005764	cellular_component	lysosome
B	0005776	cellular_component	autophagosome
B	0005829	cellular_component	cytosol
B	0006826	biological_process	iron ion transport
B	0006879	biological_process	intracellular iron ion homeostasis
B	0006955	biological_process	immune response
B	0008198	molecular_function	ferrous iron binding
B	0008199	molecular_function	ferric iron binding
B	0008285	biological_process	negative regulation of cell population proliferation
B	0016020	cellular_component	membrane
B	0016491	molecular_function	oxidoreductase activity
B	0031410	cellular_component	cytoplasmic vesicle
B	0042802	molecular_function	identical protein binding
B	0044754	cellular_component	autolysosome
B	0046872	molecular_function	metal ion binding
B	0048147	biological_process	negative regulation of fibroblast proliferation
B	0070062	cellular_component	extracellular exosome
B	0070288	cellular_component	ferritin complex
B	0110076	biological_process	negative regulation of ferroptosis
B	0140315	molecular_function	iron ion sequestering activity
B	1904724	cellular_component	tertiary granule lumen
B	1904813	cellular_component	ficolin-1-rich granule lumen
C	0004322	molecular_function	ferroxidase activity
C	0005506	molecular_function	iron ion binding
C	0005515	molecular_function	protein binding
C	0005576	cellular_component	extracellular region
C	0005634	cellular_component	nucleus
C	0005737	cellular_component	cytoplasm
C	0005764	cellular_component	lysosome
C	0005776	cellular_component	autophagosome
C	0005829	cellular_component	cytosol
C	0006826	biological_process	iron ion transport
C	0006879	biological_process	intracellular iron ion homeostasis
C	0006955	biological_process	immune response
C	0008198	molecular_function	ferrous iron binding
C	0008199	molecular_function	ferric iron binding
C	0008285	biological_process	negative regulation of cell population proliferation
C	0016020	cellular_component	membrane
C	0016491	molecular_function	oxidoreductase activity
C	0031410	cellular_component	cytoplasmic vesicle
C	0042802	molecular_function	identical protein binding
C	0044754	cellular_component	autolysosome
C	0046872	molecular_function	metal ion binding
C	0048147	biological_process	negative regulation of fibroblast proliferation
C	0070062	cellular_component	extracellular exosome
C	0070288	cellular_component	ferritin complex
C	0110076	biological_process	negative regulation of ferroptosis
C	0140315	molecular_function	iron ion sequestering activity
C	1904724	cellular_component	tertiary granule lumen
C	1904813	cellular_component	ficolin-1-rich granule lumen
D	0004322	molecular_function	ferroxidase activity
D	0005506	molecular_function	iron ion binding
D	0005515	molecular_function	protein binding
D	0005576	cellular_component	extracellular region
D	0005634	cellular_component	nucleus
D	0005737	cellular_component	cytoplasm
D	0005764	cellular_component	lysosome
D	0005776	cellular_component	autophagosome
D	0005829	cellular_component	cytosol
D	0006826	biological_process	iron ion transport
D	0006879	biological_process	intracellular iron ion homeostasis
D	0006955	biological_process	immune response
D	0008198	molecular_function	ferrous iron binding
D	0008199	molecular_function	ferric iron binding
D	0008285	biological_process	negative regulation of cell population proliferation
D	0016020	cellular_component	membrane
D	0016491	molecular_function	oxidoreductase activity
D	0031410	cellular_component	cytoplasmic vesicle
D	0042802	molecular_function	identical protein binding
D	0044754	cellular_component	autolysosome
D	0046872	molecular_function	metal ion binding
D	0048147	biological_process	negative regulation of fibroblast proliferation
D	0070062	cellular_component	extracellular exosome
D	0070288	cellular_component	ferritin complex
D	0110076	biological_process	negative regulation of ferroptosis
D	0140315	molecular_function	iron ion sequestering activity
D	1904724	cellular_component	tertiary granule lumen
D	1904813	cellular_component	ficolin-1-rich granule lumen
E	0004322	molecular_function	ferroxidase activity
E	0005506	molecular_function	iron ion binding
E	0005515	molecular_function	protein binding
E	0005576	cellular_component	extracellular region
E	0005634	cellular_component	nucleus
E	0005737	cellular_component	cytoplasm
E	0005764	cellular_component	lysosome
E	0005776	cellular_component	autophagosome
E	0005829	cellular_component	cytosol
E	0006826	biological_process	iron ion transport
E	0006879	biological_process	intracellular iron ion homeostasis
E	0006955	biological_process	immune response
E	0008198	molecular_function	ferrous iron binding
E	0008199	molecular_function	ferric iron binding
E	0008285	biological_process	negative regulation of cell population proliferation
E	0016020	cellular_component	membrane
E	0016491	molecular_function	oxidoreductase activity
E	0031410	cellular_component	cytoplasmic vesicle
E	0042802	molecular_function	identical protein binding
E	0044754	cellular_component	autolysosome
E	0046872	molecular_function	metal ion binding
E	0048147	biological_process	negative regulation of fibroblast proliferation
E	0070062	cellular_component	extracellular exosome
E	0070288	cellular_component	ferritin complex
E	0110076	biological_process	negative regulation of ferroptosis
E	0140315	molecular_function	iron ion sequestering activity
E	1904724	cellular_component	tertiary granule lumen
E	1904813	cellular_component	ficolin-1-rich granule lumen
F	0004322	molecular_function	ferroxidase activity
F	0005506	molecular_function	iron ion binding
F	0005515	molecular_function	protein binding
F	0005576	cellular_component	extracellular region
F	0005634	cellular_component	nucleus
F	0005737	cellular_component	cytoplasm
F	0005764	cellular_component	lysosome
F	0005776	cellular_component	autophagosome
F	0005829	cellular_component	cytosol
F	0006826	biological_process	iron ion transport
F	0006879	biological_process	intracellular iron ion homeostasis
F	0006955	biological_process	immune response
F	0008198	molecular_function	ferrous iron binding
F	0008199	molecular_function	ferric iron binding
F	0008285	biological_process	negative regulation of cell population proliferation
F	0016020	cellular_component	membrane
F	0016491	molecular_function	oxidoreductase activity
F	0031410	cellular_component	cytoplasmic vesicle
F	0042802	molecular_function	identical protein binding
F	0044754	cellular_component	autolysosome
F	0046872	molecular_function	metal ion binding
F	0048147	biological_process	negative regulation of fibroblast proliferation
F	0070062	cellular_component	extracellular exosome
F	0070288	cellular_component	ferritin complex
F	0110076	biological_process	negative regulation of ferroptosis
F	0140315	molecular_function	iron ion sequestering activity
F	1904724	cellular_component	tertiary granule lumen
F	1904813	cellular_component	ficolin-1-rich granule lumen
G	0004322	molecular_function	ferroxidase activity
G	0005506	molecular_function	iron ion binding
G	0005515	molecular_function	protein binding
G	0005576	cellular_component	extracellular region
G	0005634	cellular_component	nucleus
G	0005737	cellular_component	cytoplasm
G	0005764	cellular_component	lysosome
G	0005776	cellular_component	autophagosome
G	0005829	cellular_component	cytosol
G	0006826	biological_process	iron ion transport
G	0006879	biological_process	intracellular iron ion homeostasis
G	0006955	biological_process	immune response
G	0008198	molecular_function	ferrous iron binding
G	0008199	molecular_function	ferric iron binding
G	0008285	biological_process	negative regulation of cell population proliferation
G	0016020	cellular_component	membrane
G	0016491	molecular_function	oxidoreductase activity
G	0031410	cellular_component	cytoplasmic vesicle
G	0042802	molecular_function	identical protein binding
G	0044754	cellular_component	autolysosome
G	0046872	molecular_function	metal ion binding
G	0048147	biological_process	negative regulation of fibroblast proliferation
G	0070062	cellular_component	extracellular exosome
G	0070288	cellular_component	ferritin complex
G	0110076	biological_process	negative regulation of ferroptosis
G	0140315	molecular_function	iron ion sequestering activity
G	1904724	cellular_component	tertiary granule lumen
G	1904813	cellular_component	ficolin-1-rich granule lumen
H	0004322	molecular_function	ferroxidase activity
H	0005506	molecular_function	iron ion binding
H	0005515	molecular_function	protein binding
H	0005576	cellular_component	extracellular region
H	0005634	cellular_component	nucleus
H	0005737	cellular_component	cytoplasm
H	0005764	cellular_component	lysosome
H	0005776	cellular_component	autophagosome
H	0005829	cellular_component	cytosol
H	0006826	biological_process	iron ion transport
H	0006879	biological_process	intracellular iron ion homeostasis
H	0006955	biological_process	immune response
H	0008198	molecular_function	ferrous iron binding
H	0008199	molecular_function	ferric iron binding
H	0008285	biological_process	negative regulation of cell population proliferation
H	0016020	cellular_component	membrane
H	0016491	molecular_function	oxidoreductase activity
H	0031410	cellular_component	cytoplasmic vesicle
H	0042802	molecular_function	identical protein binding
H	0044754	cellular_component	autolysosome
H	0046872	molecular_function	metal ion binding
H	0048147	biological_process	negative regulation of fibroblast proliferation
H	0070062	cellular_component	extracellular exosome
H	0070288	cellular_component	ferritin complex
H	0110076	biological_process	negative regulation of ferroptosis
H	0140315	molecular_function	iron ion sequestering activity
H	1904724	cellular_component	tertiary granule lumen
H	1904813	cellular_component	ficolin-1-rich granule lumen
I	0004322	molecular_function	ferroxidase activity
I	0005506	molecular_function	iron ion binding
I	0005515	molecular_function	protein binding
I	0005576	cellular_component	extracellular region
I	0005634	cellular_component	nucleus
I	0005737	cellular_component	cytoplasm
I	0005764	cellular_component	lysosome
I	0005776	cellular_component	autophagosome
I	0005829	cellular_component	cytosol
I	0006826	biological_process	iron ion transport
I	0006879	biological_process	intracellular iron ion homeostasis
I	0006955	biological_process	immune response
I	0008198	molecular_function	ferrous iron binding
I	0008199	molecular_function	ferric iron binding
I	0008285	biological_process	negative regulation of cell population proliferation
I	0016020	cellular_component	membrane
I	0016491	molecular_function	oxidoreductase activity
I	0031410	cellular_component	cytoplasmic vesicle
I	0042802	molecular_function	identical protein binding
I	0044754	cellular_component	autolysosome
I	0046872	molecular_function	metal ion binding
I	0048147	biological_process	negative regulation of fibroblast proliferation
I	0070062	cellular_component	extracellular exosome
I	0070288	cellular_component	ferritin complex
I	0110076	biological_process	negative regulation of ferroptosis
I	0140315	molecular_function	iron ion sequestering activity
I	1904724	cellular_component	tertiary granule lumen
I	1904813	cellular_component	ficolin-1-rich granule lumen
J	0004322	molecular_function	ferroxidase activity
J	0005506	molecular_function	iron ion binding
J	0005515	molecular_function	protein binding
J	0005576	cellular_component	extracellular region
J	0005634	cellular_component	nucleus
J	0005737	cellular_component	cytoplasm
J	0005764	cellular_component	lysosome
J	0005776	cellular_component	autophagosome
J	0005829	cellular_component	cytosol
J	0006826	biological_process	iron ion transport
J	0006879	biological_process	intracellular iron ion homeostasis
J	0006955	biological_process	immune response
J	0008198	molecular_function	ferrous iron binding
J	0008199	molecular_function	ferric iron binding
J	0008285	biological_process	negative regulation of cell population proliferation
J	0016020	cellular_component	membrane
J	0016491	molecular_function	oxidoreductase activity
J	0031410	cellular_component	cytoplasmic vesicle
J	0042802	molecular_function	identical protein binding
J	0044754	cellular_component	autolysosome
J	0046872	molecular_function	metal ion binding
J	0048147	biological_process	negative regulation of fibroblast proliferation
J	0070062	cellular_component	extracellular exosome
J	0070288	cellular_component	ferritin complex
J	0110076	biological_process	negative regulation of ferroptosis
J	0140315	molecular_function	iron ion sequestering activity
J	1904724	cellular_component	tertiary granule lumen
J	1904813	cellular_component	ficolin-1-rich granule lumen
K	0004322	molecular_function	ferroxidase activity
K	0005506	molecular_function	iron ion binding
K	0005515	molecular_function	protein binding
K	0005576	cellular_component	extracellular region
K	0005634	cellular_component	nucleus
K	0005737	cellular_component	cytoplasm
K	0005764	cellular_component	lysosome
K	0005776	cellular_component	autophagosome
K	0005829	cellular_component	cytosol
K	0006826	biological_process	iron ion transport
K	0006879	biological_process	intracellular iron ion homeostasis
K	0006955	biological_process	immune response
K	0008198	molecular_function	ferrous iron binding
K	0008199	molecular_function	ferric iron binding
K	0008285	biological_process	negative regulation of cell population proliferation
K	0016020	cellular_component	membrane
K	0016491	molecular_function	oxidoreductase activity
K	0031410	cellular_component	cytoplasmic vesicle
K	0042802	molecular_function	identical protein binding
K	0044754	cellular_component	autolysosome
K	0046872	molecular_function	metal ion binding
K	0048147	biological_process	negative regulation of fibroblast proliferation
K	0070062	cellular_component	extracellular exosome
K	0070288	cellular_component	ferritin complex
K	0110076	biological_process	negative regulation of ferroptosis
K	0140315	molecular_function	iron ion sequestering activity
K	1904724	cellular_component	tertiary granule lumen
K	1904813	cellular_component	ficolin-1-rich granule lumen
L	0004322	molecular_function	ferroxidase activity
L	0005506	molecular_function	iron ion binding
L	0005515	molecular_function	protein binding
L	0005576	cellular_component	extracellular region
L	0005634	cellular_component	nucleus
L	0005737	cellular_component	cytoplasm
L	0005764	cellular_component	lysosome
L	0005776	cellular_component	autophagosome
L	0005829	cellular_component	cytosol
L	0006826	biological_process	iron ion transport
L	0006879	biological_process	intracellular iron ion homeostasis
L	0006955	biological_process	immune response
L	0008198	molecular_function	ferrous iron binding
L	0008199	molecular_function	ferric iron binding
L	0008285	biological_process	negative regulation of cell population proliferation
L	0016020	cellular_component	membrane
L	0016491	molecular_function	oxidoreductase activity
L	0031410	cellular_component	cytoplasmic vesicle
L	0042802	molecular_function	identical protein binding
L	0044754	cellular_component	autolysosome
L	0046872	molecular_function	metal ion binding
L	0048147	biological_process	negative regulation of fibroblast proliferation
L	0070062	cellular_component	extracellular exosome
L	0070288	cellular_component	ferritin complex
L	0110076	biological_process	negative regulation of ferroptosis
L	0140315	molecular_function	iron ion sequestering activity
L	1904724	cellular_component	tertiary granule lumen
L	1904813	cellular_component	ficolin-1-rich granule lumen
M	0004322	molecular_function	ferroxidase activity
M	0005506	molecular_function	iron ion binding
M	0005515	molecular_function	protein binding
M	0005576	cellular_component	extracellular region
M	0005634	cellular_component	nucleus
M	0005737	cellular_component	cytoplasm
M	0005764	cellular_component	lysosome
M	0005776	cellular_component	autophagosome
M	0005829	cellular_component	cytosol
M	0006826	biological_process	iron ion transport
M	0006879	biological_process	intracellular iron ion homeostasis
M	0006955	biological_process	immune response
M	0008198	molecular_function	ferrous iron binding
M	0008199	molecular_function	ferric iron binding
M	0008285	biological_process	negative regulation of cell population proliferation
M	0016020	cellular_component	membrane
M	0016491	molecular_function	oxidoreductase activity
M	0031410	cellular_component	cytoplasmic vesicle
M	0042802	molecular_function	identical protein binding
M	0044754	cellular_component	autolysosome
M	0046872	molecular_function	metal ion binding
M	0048147	biological_process	negative regulation of fibroblast proliferation
M	0070062	cellular_component	extracellular exosome
M	0070288	cellular_component	ferritin complex
M	0110076	biological_process	negative regulation of ferroptosis
M	0140315	molecular_function	iron ion sequestering activity
M	1904724	cellular_component	tertiary granule lumen
M	1904813	cellular_component	ficolin-1-rich granule lumen
N	0004322	molecular_function	ferroxidase activity
N	0005506	molecular_function	iron ion binding
N	0005515	molecular_function	protein binding
N	0005576	cellular_component	extracellular region
N	0005634	cellular_component	nucleus
N	0005737	cellular_component	cytoplasm
N	0005764	cellular_component	lysosome
N	0005776	cellular_component	autophagosome
N	0005829	cellular_component	cytosol
N	0006826	biological_process	iron ion transport
N	0006879	biological_process	intracellular iron ion homeostasis
N	0006955	biological_process	immune response
N	0008198	molecular_function	ferrous iron binding
N	0008199	molecular_function	ferric iron binding
N	0008285	biological_process	negative regulation of cell population proliferation
N	0016020	cellular_component	membrane
N	0016491	molecular_function	oxidoreductase activity
N	0031410	cellular_component	cytoplasmic vesicle
N	0042802	molecular_function	identical protein binding
N	0044754	cellular_component	autolysosome
N	0046872	molecular_function	metal ion binding
N	0048147	biological_process	negative regulation of fibroblast proliferation
N	0070062	cellular_component	extracellular exosome
N	0070288	cellular_component	ferritin complex
N	0110076	biological_process	negative regulation of ferroptosis
N	0140315	molecular_function	iron ion sequestering activity
N	1904724	cellular_component	tertiary granule lumen
N	1904813	cellular_component	ficolin-1-rich granule lumen
O	0004322	molecular_function	ferroxidase activity
O	0005506	molecular_function	iron ion binding
O	0005515	molecular_function	protein binding
O	0005576	cellular_component	extracellular region
O	0005634	cellular_component	nucleus
O	0005737	cellular_component	cytoplasm
O	0005764	cellular_component	lysosome
O	0005776	cellular_component	autophagosome
O	0005829	cellular_component	cytosol
O	0006826	biological_process	iron ion transport
O	0006879	biological_process	intracellular iron ion homeostasis
O	0006955	biological_process	immune response
O	0008198	molecular_function	ferrous iron binding
O	0008199	molecular_function	ferric iron binding
O	0008285	biological_process	negative regulation of cell population proliferation
O	0016020	cellular_component	membrane
O	0016491	molecular_function	oxidoreductase activity
O	0031410	cellular_component	cytoplasmic vesicle
O	0042802	molecular_function	identical protein binding
O	0044754	cellular_component	autolysosome
O	0046872	molecular_function	metal ion binding
O	0048147	biological_process	negative regulation of fibroblast proliferation
O	0070062	cellular_component	extracellular exosome
O	0070288	cellular_component	ferritin complex
O	0110076	biological_process	negative regulation of ferroptosis
O	0140315	molecular_function	iron ion sequestering activity
O	1904724	cellular_component	tertiary granule lumen
O	1904813	cellular_component	ficolin-1-rich granule lumen
P	0004322	molecular_function	ferroxidase activity
P	0005506	molecular_function	iron ion binding
P	0005515	molecular_function	protein binding
P	0005576	cellular_component	extracellular region
P	0005634	cellular_component	nucleus
P	0005737	cellular_component	cytoplasm
P	0005764	cellular_component	lysosome
P	0005776	cellular_component	autophagosome
P	0005829	cellular_component	cytosol
P	0006826	biological_process	iron ion transport
P	0006879	biological_process	intracellular iron ion homeostasis
P	0006955	biological_process	immune response
P	0008198	molecular_function	ferrous iron binding
P	0008199	molecular_function	ferric iron binding
P	0008285	biological_process	negative regulation of cell population proliferation
P	0016020	cellular_component	membrane
P	0016491	molecular_function	oxidoreductase activity
P	0031410	cellular_component	cytoplasmic vesicle
P	0042802	molecular_function	identical protein binding
P	0044754	cellular_component	autolysosome
P	0046872	molecular_function	metal ion binding
P	0048147	biological_process	negative regulation of fibroblast proliferation
P	0070062	cellular_component	extracellular exosome
P	0070288	cellular_component	ferritin complex
P	0110076	biological_process	negative regulation of ferroptosis
P	0140315	molecular_function	iron ion sequestering activity
P	1904724	cellular_component	tertiary granule lumen
P	1904813	cellular_component	ficolin-1-rich granule lumen
Q	0004322	molecular_function	ferroxidase activity
Q	0005506	molecular_function	iron ion binding
Q	0005515	molecular_function	protein binding
Q	0005576	cellular_component	extracellular region
Q	0005634	cellular_component	nucleus
Q	0005737	cellular_component	cytoplasm
Q	0005764	cellular_component	lysosome
Q	0005776	cellular_component	autophagosome
Q	0005829	cellular_component	cytosol
Q	0006826	biological_process	iron ion transport
Q	0006879	biological_process	intracellular iron ion homeostasis
Q	0006955	biological_process	immune response
Q	0008198	molecular_function	ferrous iron binding
Q	0008199	molecular_function	ferric iron binding
Q	0008285	biological_process	negative regulation of cell population proliferation
Q	0016020	cellular_component	membrane
Q	0016491	molecular_function	oxidoreductase activity
Q	0031410	cellular_component	cytoplasmic vesicle
Q	0042802	molecular_function	identical protein binding
Q	0044754	cellular_component	autolysosome
Q	0046872	molecular_function	metal ion binding
Q	0048147	biological_process	negative regulation of fibroblast proliferation
Q	0070062	cellular_component	extracellular exosome
Q	0070288	cellular_component	ferritin complex
Q	0110076	biological_process	negative regulation of ferroptosis
Q	0140315	molecular_function	iron ion sequestering activity
Q	1904724	cellular_component	tertiary granule lumen
Q	1904813	cellular_component	ficolin-1-rich granule lumen
R	0004322	molecular_function	ferroxidase activity
R	0005506	molecular_function	iron ion binding
R	0005515	molecular_function	protein binding
R	0005576	cellular_component	extracellular region
R	0005634	cellular_component	nucleus
R	0005737	cellular_component	cytoplasm
R	0005764	cellular_component	lysosome
R	0005776	cellular_component	autophagosome
R	0005829	cellular_component	cytosol
R	0006826	biological_process	iron ion transport
R	0006879	biological_process	intracellular iron ion homeostasis
R	0006955	biological_process	immune response
R	0008198	molecular_function	ferrous iron binding
R	0008199	molecular_function	ferric iron binding
R	0008285	biological_process	negative regulation of cell population proliferation
R	0016020	cellular_component	membrane
R	0016491	molecular_function	oxidoreductase activity
R	0031410	cellular_component	cytoplasmic vesicle
R	0042802	molecular_function	identical protein binding
R	0044754	cellular_component	autolysosome
R	0046872	molecular_function	metal ion binding
R	0048147	biological_process	negative regulation of fibroblast proliferation
R	0070062	cellular_component	extracellular exosome
R	0070288	cellular_component	ferritin complex
R	0110076	biological_process	negative regulation of ferroptosis
R	0140315	molecular_function	iron ion sequestering activity
R	1904724	cellular_component	tertiary granule lumen
R	1904813	cellular_component	ficolin-1-rich granule lumen
S	0004322	molecular_function	ferroxidase activity
S	0005506	molecular_function	iron ion binding
S	0005515	molecular_function	protein binding
S	0005576	cellular_component	extracellular region
S	0005634	cellular_component	nucleus
S	0005737	cellular_component	cytoplasm
S	0005764	cellular_component	lysosome
S	0005776	cellular_component	autophagosome
S	0005829	cellular_component	cytosol
S	0006826	biological_process	iron ion transport
S	0006879	biological_process	intracellular iron ion homeostasis
S	0006955	biological_process	immune response
S	0008198	molecular_function	ferrous iron binding
S	0008199	molecular_function	ferric iron binding
S	0008285	biological_process	negative regulation of cell population proliferation
S	0016020	cellular_component	membrane
S	0016491	molecular_function	oxidoreductase activity
S	0031410	cellular_component	cytoplasmic vesicle
S	0042802	molecular_function	identical protein binding
S	0044754	cellular_component	autolysosome
S	0046872	molecular_function	metal ion binding
S	0048147	biological_process	negative regulation of fibroblast proliferation
S	0070062	cellular_component	extracellular exosome
S	0070288	cellular_component	ferritin complex
S	0110076	biological_process	negative regulation of ferroptosis
S	0140315	molecular_function	iron ion sequestering activity
S	1904724	cellular_component	tertiary granule lumen
S	1904813	cellular_component	ficolin-1-rich granule lumen
T	0004322	molecular_function	ferroxidase activity
T	0005506	molecular_function	iron ion binding
T	0005515	molecular_function	protein binding
T	0005576	cellular_component	extracellular region
T	0005634	cellular_component	nucleus
T	0005737	cellular_component	cytoplasm
T	0005764	cellular_component	lysosome
T	0005776	cellular_component	autophagosome
T	0005829	cellular_component	cytosol
T	0006826	biological_process	iron ion transport
T	0006879	biological_process	intracellular iron ion homeostasis
T	0006955	biological_process	immune response
T	0008198	molecular_function	ferrous iron binding
T	0008199	molecular_function	ferric iron binding
T	0008285	biological_process	negative regulation of cell population proliferation
T	0016020	cellular_component	membrane
T	0016491	molecular_function	oxidoreductase activity
T	0031410	cellular_component	cytoplasmic vesicle
T	0042802	molecular_function	identical protein binding
T	0044754	cellular_component	autolysosome
T	0046872	molecular_function	metal ion binding
T	0048147	biological_process	negative regulation of fibroblast proliferation
T	0070062	cellular_component	extracellular exosome
T	0070288	cellular_component	ferritin complex
T	0110076	biological_process	negative regulation of ferroptosis
T	0140315	molecular_function	iron ion sequestering activity
T	1904724	cellular_component	tertiary granule lumen
T	1904813	cellular_component	ficolin-1-rich granule lumen
U	0004322	molecular_function	ferroxidase activity
U	0005506	molecular_function	iron ion binding
U	0005515	molecular_function	protein binding
U	0005576	cellular_component	extracellular region
U	0005634	cellular_component	nucleus
U	0005737	cellular_component	cytoplasm
U	0005764	cellular_component	lysosome
U	0005776	cellular_component	autophagosome
U	0005829	cellular_component	cytosol
U	0006826	biological_process	iron ion transport
U	0006879	biological_process	intracellular iron ion homeostasis
U	0006955	biological_process	immune response
U	0008198	molecular_function	ferrous iron binding
U	0008199	molecular_function	ferric iron binding
U	0008285	biological_process	negative regulation of cell population proliferation
U	0016020	cellular_component	membrane
U	0016491	molecular_function	oxidoreductase activity
U	0031410	cellular_component	cytoplasmic vesicle
U	0042802	molecular_function	identical protein binding
U	0044754	cellular_component	autolysosome
U	0046872	molecular_function	metal ion binding
U	0048147	biological_process	negative regulation of fibroblast proliferation
U	0070062	cellular_component	extracellular exosome
U	0070288	cellular_component	ferritin complex
U	0110076	biological_process	negative regulation of ferroptosis
U	0140315	molecular_function	iron ion sequestering activity
U	1904724	cellular_component	tertiary granule lumen
U	1904813	cellular_component	ficolin-1-rich granule lumen
V	0004322	molecular_function	ferroxidase activity
V	0005506	molecular_function	iron ion binding
V	0005515	molecular_function	protein binding
V	0005576	cellular_component	extracellular region
V	0005634	cellular_component	nucleus
V	0005737	cellular_component	cytoplasm
V	0005764	cellular_component	lysosome
V	0005776	cellular_component	autophagosome
V	0005829	cellular_component	cytosol
V	0006826	biological_process	iron ion transport
V	0006879	biological_process	intracellular iron ion homeostasis
V	0006955	biological_process	immune response
V	0008198	molecular_function	ferrous iron binding
V	0008199	molecular_function	ferric iron binding
V	0008285	biological_process	negative regulation of cell population proliferation
V	0016020	cellular_component	membrane
V	0016491	molecular_function	oxidoreductase activity
V	0031410	cellular_component	cytoplasmic vesicle
V	0042802	molecular_function	identical protein binding
V	0044754	cellular_component	autolysosome
V	0046872	molecular_function	metal ion binding
V	0048147	biological_process	negative regulation of fibroblast proliferation
V	0070062	cellular_component	extracellular exosome
V	0070288	cellular_component	ferritin complex
V	0110076	biological_process	negative regulation of ferroptosis
V	0140315	molecular_function	iron ion sequestering activity
V	1904724	cellular_component	tertiary granule lumen
V	1904813	cellular_component	ficolin-1-rich granule lumen
W	0004322	molecular_function	ferroxidase activity
W	0005506	molecular_function	iron ion binding
W	0005515	molecular_function	protein binding
W	0005576	cellular_component	extracellular region
W	0005634	cellular_component	nucleus
W	0005737	cellular_component	cytoplasm
W	0005764	cellular_component	lysosome
W	0005776	cellular_component	autophagosome
W	0005829	cellular_component	cytosol
W	0006826	biological_process	iron ion transport
W	0006879	biological_process	intracellular iron ion homeostasis
W	0006955	biological_process	immune response
W	0008198	molecular_function	ferrous iron binding
W	0008199	molecular_function	ferric iron binding
W	0008285	biological_process	negative regulation of cell population proliferation
W	0016020	cellular_component	membrane
W	0016491	molecular_function	oxidoreductase activity
W	0031410	cellular_component	cytoplasmic vesicle
W	0042802	molecular_function	identical protein binding
W	0044754	cellular_component	autolysosome
W	0046872	molecular_function	metal ion binding
W	0048147	biological_process	negative regulation of fibroblast proliferation
W	0070062	cellular_component	extracellular exosome
W	0070288	cellular_component	ferritin complex
W	0110076	biological_process	negative regulation of ferroptosis
W	0140315	molecular_function	iron ion sequestering activity
W	1904724	cellular_component	tertiary granule lumen
W	1904813	cellular_component	ficolin-1-rich granule lumen
X	0004322	molecular_function	ferroxidase activity
X	0005506	molecular_function	iron ion binding
X	0005515	molecular_function	protein binding
X	0005576	cellular_component	extracellular region
X	0005634	cellular_component	nucleus
X	0005737	cellular_component	cytoplasm
X	0005764	cellular_component	lysosome
X	0005776	cellular_component	autophagosome
X	0005829	cellular_component	cytosol
X	0006826	biological_process	iron ion transport
X	0006879	biological_process	intracellular iron ion homeostasis
X	0006955	biological_process	immune response
X	0008198	molecular_function	ferrous iron binding
X	0008199	molecular_function	ferric iron binding
X	0008285	biological_process	negative regulation of cell population proliferation
X	0016020	cellular_component	membrane
X	0016491	molecular_function	oxidoreductase activity
X	0031410	cellular_component	cytoplasmic vesicle
X	0042802	molecular_function	identical protein binding
X	0044754	cellular_component	autolysosome
X	0046872	molecular_function	metal ion binding
X	0048147	biological_process	negative regulation of fibroblast proliferation
X	0070062	cellular_component	extracellular exosome
X	0070288	cellular_component	ferritin complex
X	0110076	biological_process	negative regulation of ferroptosis
X	0140315	molecular_function	iron ion sequestering activity
X	1904724	cellular_component	tertiary granule lumen
X	1904813	cellular_component	ficolin-1-rich granule lumen

Functional Information from PROSITE/UniProt

site_id	PS00204
Number of Residues	21
Details	FERRITIN_2 Ferritin iron-binding regions signature 2. DphLCDFIEthYLneqvkaIK

Chain	Residue	Details
A	ASP126-LYS146

---

site_id	PS00540
Number of Residues	19
Details	FERRITIN_1 Ferritin iron-binding regions signature 1. EeREhaEKLMklQNqRgGR

Chain	Residue	Details
A	GLU61-ARG79

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	48
Details	BINDING: BINDING => ECO:0000269|PubMed:1992356, ECO:0007744|PDB:1FHA

Chain	Residue	Details
A	GLU27
E	HIS65
F	GLU27
F	HIS65
G	GLU27
G	HIS65
H	GLU27
H	HIS65
I	GLU27
I	HIS65
J	GLU27
A	HIS65
J	HIS65
K	GLU27
K	HIS65
L	GLU27
L	HIS65
M	GLU27
M	HIS65
N	GLU27
N	HIS65
O	GLU27
B	GLU27
O	HIS65
P	GLU27
P	HIS65
Q	GLU27
Q	HIS65
R	GLU27
R	HIS65
S	GLU27
S	HIS65
T	GLU27
B	HIS65
T	HIS65
U	GLU27
U	HIS65
V	GLU27
V	HIS65
W	GLU27
W	HIS65
X	GLU27
X	HIS65
C	GLU27
C	HIS65
D	GLU27
D	HIS65
E	GLU27

---

site_id	SWS_FT_FI2
Number of Residues	72
Details	BINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU00085

Chain	Residue	Details
A	GLU62
D	GLU62
D	GLU107
D	GLN141
E	GLU62
E	GLU107
E	GLN141
F	GLU62
F	GLU107
F	GLN141
G	GLU62
A	GLU107
G	GLU107
G	GLN141
H	GLU62
H	GLU107
H	GLN141
I	GLU62
I	GLU107
I	GLN141
J	GLU62
J	GLU107
A	GLN141
J	GLN141
K	GLU62
K	GLU107
K	GLN141
L	GLU62
L	GLU107
L	GLN141
M	GLU62
M	GLU107
M	GLN141
B	GLU62
N	GLU62
N	GLU107
N	GLN141
O	GLU62
O	GLU107
O	GLN141
P	GLU62
P	GLU107
P	GLN141
Q	GLU62
B	GLU107
Q	GLU107
Q	GLN141
R	GLU62
R	GLU107
R	GLN141
S	GLU62
S	GLU107
S	GLN141
T	GLU62
T	GLU107
B	GLN141
T	GLN141
U	GLU62
U	GLU107
U	GLN141
V	GLU62
V	GLU107
V	GLN141
W	GLU62
W	GLU107
W	GLN141
C	GLU62
X	GLU62
X	GLU107
X	GLN141
C	GLU107
C	GLN141

---

site_id	SWS_FT_FI3
Number of Residues	24
Details	SITE: Essential for association with cargo receptor NCOA4 => ECO:0000269|PubMed:26436293

Chain	Residue	Details
A	ARG22
J	ARG22
K	ARG22
L	ARG22
M	ARG22
N	ARG22
O	ARG22
P	ARG22
Q	ARG22
R	ARG22
S	ARG22
B	ARG22
T	ARG22
U	ARG22
V	ARG22
W	ARG22
X	ARG22
C	ARG22
D	ARG22
E	ARG22
F	ARG22
G	ARG22
H	ARG22
I	ARG22

---