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7ZEU

Crystal structure of human Clusterin, crystal form II

Functional Information from GO Data
ChainGOidnamespacecontents
A0000902biological_processcell morphogenesis
A0001540molecular_functionamyloid-beta binding
A0001774biological_processmicroglial cell activation
A0001836biological_processrelease of cytochrome c from mitochondria
A0002434biological_processimmune complex clearance
A0005102molecular_functionsignaling receptor binding
A0005515molecular_functionprotein binding
A0005576cellular_componentextracellular region
A0005615cellular_componentextracellular space
A0005634cellular_componentnucleus
A0005737cellular_componentcytoplasm
A0005739cellular_componentmitochondrion
A0005743cellular_componentmitochondrial inner membrane
A0005783cellular_componentendoplasmic reticulum
A0005794cellular_componentGolgi apparatus
A0005829cellular_componentcytosol
A0005856cellular_componentcytoskeleton
A0006629biological_processlipid metabolic process
A0006915biological_processapoptotic process
A0006956biological_processcomplement activation
A0006958biological_processcomplement activation, classical pathway
A0009615biological_processresponse to virus
A0009986cellular_componentcell surface
A0010628biological_processpositive regulation of gene expression
A0016020cellular_componentmembrane
A0016887molecular_functionATP hydrolysis activity
A0017038biological_processprotein import
A0031093cellular_componentplatelet alpha granule lumen
A0031333biological_processnegative regulation of protein-containing complex assembly
A0031334biological_processpositive regulation of protein-containing complex assembly
A0031410cellular_componentcytoplasmic vesicle
A0031625molecular_functionubiquitin protein ligase binding
A0031966cellular_componentmitochondrial membrane
A0032286biological_processcentral nervous system myelin maintenance
A0032436biological_processpositive regulation of proteasomal ubiquitin-dependent protein catabolic process
A0032760biological_processpositive regulation of tumor necrosis factor production
A0032991cellular_componentprotein-containing complex
A0034366cellular_componentspherical high-density lipoprotein particle
A0042127biological_processregulation of cell population proliferation
A0042583cellular_componentchromaffin granule
A0042981biological_processregulation of apoptotic process
A0043065biological_processpositive regulation of apoptotic process
A0043231cellular_componentintracellular membrane-bounded organelle
A0043524biological_processnegative regulation of neuron apoptotic process
A0043691biological_processreverse cholesterol transport
A0044877molecular_functionprotein-containing complex binding
A0045087biological_processinnate immune response
A0045202cellular_componentsynapse
A0045429biological_processpositive regulation of nitric oxide biosynthetic process
A0048018molecular_functionreceptor ligand activity
A0048156molecular_functiontau protein binding
A0048260biological_processpositive regulation of receptor-mediated endocytosis
A0048471cellular_componentperinuclear region of cytoplasm
A0050750molecular_functionlow-density lipoprotein particle receptor binding
A0050821biological_processprotein stabilization
A0051082molecular_functionunfolded protein binding
A0051087molecular_functionprotein-folding chaperone binding
A0051092biological_processpositive regulation of NF-kappaB transcription factor activity
A0051131biological_processchaperone-mediated protein complex assembly
A0051787molecular_functionmisfolded protein binding
A0051788biological_processresponse to misfolded protein
A0061077biological_processchaperone-mediated protein folding
A0061518biological_processmicroglial cell proliferation
A0061740biological_processprotein targeting to lysosome involved in chaperone-mediated autophagy
A0062023cellular_componentcollagen-containing extracellular matrix
A0070062cellular_componentextracellular exosome
A0071944cellular_componentcell periphery
A0072562cellular_componentblood microparticle
A0090201biological_processnegative regulation of release of cytochrome c from mitochondria
A0097242biological_processamyloid-beta clearance
A0097418cellular_componentneurofibrillary tangle
A0097440cellular_componentapical dendrite
A0099020cellular_componentperinuclear endoplasmic reticulum lumen
A0140597molecular_functionprotein carrier chaperone
A1900221biological_processregulation of amyloid-beta clearance
A1902004biological_processpositive regulation of amyloid-beta formation
A1902230biological_processnegative regulation of intrinsic apoptotic signaling pathway in response to DNA damage
A1902430biological_processnegative regulation of amyloid-beta formation
A1902847biological_processregulation of neuronal signal transduction
A1902998biological_processpositive regulation of neurofibrillary tangle assembly
A1903573biological_processnegative regulation of response to endoplasmic reticulum stress
A1905907biological_processnegative regulation of amyloid fibril formation
A1905908biological_processpositive regulation of amyloid fibril formation
A2000060biological_processpositive regulation of ubiquitin-dependent protein catabolic process
D0000902biological_processcell morphogenesis
D0001540molecular_functionamyloid-beta binding
D0001774biological_processmicroglial cell activation
D0001836biological_processrelease of cytochrome c from mitochondria
D0002434biological_processimmune complex clearance
D0005102molecular_functionsignaling receptor binding
D0005515molecular_functionprotein binding
D0005576cellular_componentextracellular region
D0005615cellular_componentextracellular space
D0005634cellular_componentnucleus
D0005737cellular_componentcytoplasm
D0005739cellular_componentmitochondrion
D0005743cellular_componentmitochondrial inner membrane
D0005783cellular_componentendoplasmic reticulum
D0005794cellular_componentGolgi apparatus
D0005829cellular_componentcytosol
D0005856cellular_componentcytoskeleton
D0006629biological_processlipid metabolic process
D0006915biological_processapoptotic process
D0006956biological_processcomplement activation
D0006958biological_processcomplement activation, classical pathway
D0009615biological_processresponse to virus
D0009986cellular_componentcell surface
D0010628biological_processpositive regulation of gene expression
D0016020cellular_componentmembrane
D0016887molecular_functionATP hydrolysis activity
D0017038biological_processprotein import
D0031093cellular_componentplatelet alpha granule lumen
D0031333biological_processnegative regulation of protein-containing complex assembly
D0031334biological_processpositive regulation of protein-containing complex assembly
D0031410cellular_componentcytoplasmic vesicle
D0031625molecular_functionubiquitin protein ligase binding
D0031966cellular_componentmitochondrial membrane
D0032286biological_processcentral nervous system myelin maintenance
D0032436biological_processpositive regulation of proteasomal ubiquitin-dependent protein catabolic process
D0032760biological_processpositive regulation of tumor necrosis factor production
D0032991cellular_componentprotein-containing complex
D0034366cellular_componentspherical high-density lipoprotein particle
D0042127biological_processregulation of cell population proliferation
D0042583cellular_componentchromaffin granule
D0042981biological_processregulation of apoptotic process
D0043065biological_processpositive regulation of apoptotic process
D0043231cellular_componentintracellular membrane-bounded organelle
D0043524biological_processnegative regulation of neuron apoptotic process
D0043691biological_processreverse cholesterol transport
D0044877molecular_functionprotein-containing complex binding
D0045087biological_processinnate immune response
D0045202cellular_componentsynapse
D0045429biological_processpositive regulation of nitric oxide biosynthetic process
D0048018molecular_functionreceptor ligand activity
D0048156molecular_functiontau protein binding
D0048260biological_processpositive regulation of receptor-mediated endocytosis
D0048471cellular_componentperinuclear region of cytoplasm
D0050750molecular_functionlow-density lipoprotein particle receptor binding
D0050821biological_processprotein stabilization
D0051082molecular_functionunfolded protein binding
D0051087molecular_functionprotein-folding chaperone binding
D0051092biological_processpositive regulation of NF-kappaB transcription factor activity
D0051131biological_processchaperone-mediated protein complex assembly
D0051787molecular_functionmisfolded protein binding
D0051788biological_processresponse to misfolded protein
D0061077biological_processchaperone-mediated protein folding
D0061518biological_processmicroglial cell proliferation
D0061740biological_processprotein targeting to lysosome involved in chaperone-mediated autophagy
D0062023cellular_componentcollagen-containing extracellular matrix
D0070062cellular_componentextracellular exosome
D0071944cellular_componentcell periphery
D0072562cellular_componentblood microparticle
D0090201biological_processnegative regulation of release of cytochrome c from mitochondria
D0097242biological_processamyloid-beta clearance
D0097418cellular_componentneurofibrillary tangle
D0097440cellular_componentapical dendrite
D0099020cellular_componentperinuclear endoplasmic reticulum lumen
D0140597molecular_functionprotein carrier chaperone
D1900221biological_processregulation of amyloid-beta clearance
D1902004biological_processpositive regulation of amyloid-beta formation
D1902230biological_processnegative regulation of intrinsic apoptotic signaling pathway in response to DNA damage
D1902430biological_processnegative regulation of amyloid-beta formation
D1902847biological_processregulation of neuronal signal transduction
D1902998biological_processpositive regulation of neurofibrillary tangle assembly
D1903573biological_processnegative regulation of response to endoplasmic reticulum stress
D1905907biological_processnegative regulation of amyloid fibril formation
D1905908biological_processpositive regulation of amyloid fibril formation
D2000060biological_processpositive regulation of ubiquitin-dependent protein catabolic process
Functional Information from PROSITE/UniProt
site_idPS00492
Number of Residues9
DetailsCLUSTERIN_1 Clusterin signature 1. CKPCLKqTC
ChainResidueDetails
ACYS113-CYS121

site_idPS00493
Number of Residues11
DetailsCLUSTERIN_2 Clusterin signature 2. CLRMKdQCDKC
ChainResidueDetails
ACYS295-CYS305

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues2
DetailsSITE: Cleavage => ECO:0000269|PubMed:25402950
ChainResidueDetails
AHIS252
DHIS252

site_idSWS_FT_FI2
Number of Residues4
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:24275569
ChainResidueDetails
ASER133
AVAL421
DSER133
DVAL421

site_idSWS_FT_FI3
Number of Residues2
DetailsCARBOHYD: N-linked (GlcNAc...) (complex) asparagine => ECO:0000269|PubMed:1551440, ECO:0000269|PubMed:16335952, ECO:0000269|PubMed:19139490, ECO:0000269|PubMed:19159218, ECO:0000269|PubMed:9336835
ChainResidueDetails
AASN86
DASN86

site_idSWS_FT_FI4
Number of Residues4
DetailsCARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:1551440, ECO:0000269|PubMed:16335952, ECO:0000269|PubMed:19159218, ECO:0000269|PubMed:2721499, ECO:0000269|PubMed:9336835
ChainResidueDetails
AASN103
AASN145
DASN103
DASN145

site_idSWS_FT_FI5
Number of Residues2
DetailsCARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:1551440, ECO:0000269|PubMed:16335952, ECO:0000269|PubMed:18780401, ECO:0000269|PubMed:2721499, ECO:0000269|PubMed:9336835
ChainResidueDetails
AASN316
DASN316

site_idSWS_FT_FI6
Number of Residues2
DetailsCARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:12754519, ECO:0000269|PubMed:14760718, ECO:0000269|PubMed:1551440, ECO:0000269|PubMed:16335952, ECO:0000269|PubMed:19159218, ECO:0000269|PubMed:9336835
ChainResidueDetails
AGLU379
DGLU379

site_idSWS_FT_FI7
Number of Residues2
DetailsCARBOHYD: N-linked (GlcNAc...) (complex) asparagine => ECO:0000269|PubMed:14760718, ECO:0000269|PubMed:1551440, ECO:0000269|PubMed:16263699, ECO:0000269|PubMed:16335952, ECO:0000269|PubMed:16740002, ECO:0000269|PubMed:18780401, ECO:0000269|PubMed:19139490, ECO:0000269|PubMed:19159218, ECO:0000269|PubMed:19838169, ECO:0000269|PubMed:9336835
ChainResidueDetails
APRO399
DPRO399

222624

PDB entries from 2024-07-17

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