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7ZES

Human SLFN11 dimer bound to ssDNA

Functional Information from GO Data
ChainGOidnamespacecontents
A0000049molecular_functiontRNA binding
A0002376biological_processimmune system process
A0003677molecular_functionDNA binding
A0004386molecular_functionhelicase activity
A0004519molecular_functionendonuclease activity
A0005515molecular_functionprotein binding
A0005524molecular_functionATP binding
A0005634cellular_componentnucleus
A0005654cellular_componentnucleoplasm
A0005694cellular_componentchromosome
A0005829cellular_componentcytosol
A0006338biological_processchromatin remodeling
A0006974biological_processDNA damage response
A0008156biological_processnegative regulation of DNA replication
A0016887molecular_functionATP hydrolysis activity
A0043111biological_processreplication fork arrest
A0051607biological_processdefense response to virus
A0090734cellular_componentsite of DNA damage
A2000134biological_processnegative regulation of G1/S transition of mitotic cell cycle
B0000049molecular_functiontRNA binding
B0002376biological_processimmune system process
B0003677molecular_functionDNA binding
B0004386molecular_functionhelicase activity
B0004519molecular_functionendonuclease activity
B0005515molecular_functionprotein binding
B0005524molecular_functionATP binding
B0005634cellular_componentnucleus
B0005654cellular_componentnucleoplasm
B0005694cellular_componentchromosome
B0005829cellular_componentcytosol
B0006338biological_processchromatin remodeling
B0006974biological_processDNA damage response
B0008156biological_processnegative regulation of DNA replication
B0016887molecular_functionATP hydrolysis activity
B0043111biological_processreplication fork arrest
B0051607biological_processdefense response to virus
B0090734cellular_componentsite of DNA damage
B2000134biological_processnegative regulation of G1/S transition of mitotic cell cycle
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues2
DetailsACT_SITE: ACT_SITE => ECO:0000269|PubMed:36115853
ChainResidueDetails
ALYS216
BLYS216

site_idSWS_FT_FI2
Number of Residues12
DetailsBINDING: BINDING => ECO:0000269|PubMed:36115853
ChainResidueDetails
AGLU209
BCYS287
BCYS321
BCYS322
AGLU214
AHIS285
ACYS287
ACYS321
ACYS322
BGLU209
BGLU214
BHIS285

site_idSWS_FT_FI3
Number of Residues2
DetailsBINDING: BINDING => ECO:0000255
ChainResidueDetails
AGLY599
BGLY599

226707

PDB entries from 2024-10-30

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