7ZES
Human SLFN11 dimer bound to ssDNA
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000049 | molecular_function | tRNA binding |
| A | 0002376 | biological_process | immune system process |
| A | 0003677 | molecular_function | DNA binding |
| A | 0004386 | molecular_function | helicase activity |
| A | 0004519 | molecular_function | endonuclease activity |
| A | 0005515 | molecular_function | protein binding |
| A | 0005524 | molecular_function | ATP binding |
| A | 0005634 | cellular_component | nucleus |
| A | 0005654 | cellular_component | nucleoplasm |
| A | 0005694 | cellular_component | chromosome |
| A | 0005829 | cellular_component | cytosol |
| A | 0006338 | biological_process | chromatin remodeling |
| A | 0006974 | biological_process | DNA damage response |
| A | 0008156 | biological_process | negative regulation of DNA replication |
| A | 0016887 | molecular_function | ATP hydrolysis activity |
| A | 0043111 | biological_process | replication fork arrest |
| A | 0051607 | biological_process | defense response to virus |
| A | 0090734 | cellular_component | site of DNA damage |
| A | 2000134 | biological_process | negative regulation of G1/S transition of mitotic cell cycle |
| B | 0000049 | molecular_function | tRNA binding |
| B | 0002376 | biological_process | immune system process |
| B | 0003677 | molecular_function | DNA binding |
| B | 0004386 | molecular_function | helicase activity |
| B | 0004519 | molecular_function | endonuclease activity |
| B | 0005515 | molecular_function | protein binding |
| B | 0005524 | molecular_function | ATP binding |
| B | 0005634 | cellular_component | nucleus |
| B | 0005654 | cellular_component | nucleoplasm |
| B | 0005694 | cellular_component | chromosome |
| B | 0005829 | cellular_component | cytosol |
| B | 0006338 | biological_process | chromatin remodeling |
| B | 0006974 | biological_process | DNA damage response |
| B | 0008156 | biological_process | negative regulation of DNA replication |
| B | 0016887 | molecular_function | ATP hydrolysis activity |
| B | 0043111 | biological_process | replication fork arrest |
| B | 0051607 | biological_process | defense response to virus |
| B | 0090734 | cellular_component | site of DNA damage |
| B | 2000134 | biological_process | negative regulation of G1/S transition of mitotic cell cycle |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 2 |
| Details | ACT_SITE: ACT_SITE => ECO:0000269|PubMed:36115853 |
| Chain | Residue | Details |
| A | LYS216 | |
| B | LYS216 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 12 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:36115853 |
| Chain | Residue | Details |
| A | GLU209 | |
| B | CYS287 | |
| B | CYS321 | |
| B | CYS322 | |
| A | GLU214 | |
| A | HIS285 | |
| A | CYS287 | |
| A | CYS321 | |
| A | CYS322 | |
| B | GLU209 | |
| B | GLU214 | |
| B | HIS285 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 2 |
| Details | BINDING: BINDING => ECO:0000255 |
| Chain | Residue | Details |
| A | GLY599 | |
| B | GLY599 |
