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SummaryStructural detailsExperimental detailsFunctional detailsSequence NeighborHistoryDownloads

7ZDZ

Cryo-EM structure of the human inward-rectifier potassium 2.1 channel (Kir2.1)

Functional Information from GO Data
ChainGOidnamespacecontents
A0005242molecular_functioninward rectifier potassium channel activity
A0005515molecular_functionprotein binding
A0005546molecular_functionphosphatidylinositol-4,5-bisphosphate binding
A0005886cellular_componentplasma membrane
A0006811biological_processmonoatomic ion transport
A0006813biological_processpotassium ion transport
A0008076cellular_componentvoltage-gated potassium channel complex
A0014704cellular_componentintercalated disc
A0014861biological_processregulation of skeletal muscle contraction via regulation of action potential
A0016020cellular_componentmembrane
A0030007biological_processintracellular potassium ion homeostasis
A0030315cellular_componentT-tubule
A0030425cellular_componentdendrite
A0034220biological_processmonoatomic ion transmembrane transport
A0034702cellular_componentmonoatomic ion channel complex
A0042802molecular_functionidentical protein binding
A0043025cellular_componentneuronal cell body
A0043197cellular_componentdendritic spine
A0045211cellular_componentpostsynaptic membrane
A0051289biological_processprotein homotetramerization
A0055119biological_processrelaxation of cardiac muscle
A0060075biological_processregulation of resting membrane potential
A0060306biological_processregulation of membrane repolarization
A0071260biological_processcellular response to mechanical stimulus
A0071805biological_processpotassium ion transmembrane transport
A0086002biological_processcardiac muscle cell action potential involved in contraction
A0086004biological_processregulation of cardiac muscle cell contraction
A0086008molecular_functionvoltage-gated potassium channel activity involved in cardiac muscle cell action potential repolarization
A0086011biological_processmembrane repolarization during action potential
A0086012biological_processmembrane depolarization during cardiac muscle cell action potential
A0086013biological_processmembrane repolarization during cardiac muscle cell action potential
A0086091biological_processregulation of heart rate by cardiac conduction
A0090076biological_processrelaxation of skeletal muscle
A0098978cellular_componentglutamatergic synapse
A1901381biological_processpositive regulation of potassium ion transmembrane transport
A1990573biological_processpotassium ion import across plasma membrane
B0005242molecular_functioninward rectifier potassium channel activity
B0005515molecular_functionprotein binding
B0005546molecular_functionphosphatidylinositol-4,5-bisphosphate binding
B0005886cellular_componentplasma membrane
B0006811biological_processmonoatomic ion transport
B0006813biological_processpotassium ion transport
B0008076cellular_componentvoltage-gated potassium channel complex
B0014704cellular_componentintercalated disc
B0014861biological_processregulation of skeletal muscle contraction via regulation of action potential
B0016020cellular_componentmembrane
B0030007biological_processintracellular potassium ion homeostasis
B0030315cellular_componentT-tubule
B0030425cellular_componentdendrite
B0034220biological_processmonoatomic ion transmembrane transport
B0034702cellular_componentmonoatomic ion channel complex
B0042802molecular_functionidentical protein binding
B0043025cellular_componentneuronal cell body
B0043197cellular_componentdendritic spine
B0045211cellular_componentpostsynaptic membrane
B0051289biological_processprotein homotetramerization
B0055119biological_processrelaxation of cardiac muscle
B0060075biological_processregulation of resting membrane potential
B0060306biological_processregulation of membrane repolarization
B0071260biological_processcellular response to mechanical stimulus
B0071805biological_processpotassium ion transmembrane transport
B0086002biological_processcardiac muscle cell action potential involved in contraction
B0086004biological_processregulation of cardiac muscle cell contraction
B0086008molecular_functionvoltage-gated potassium channel activity involved in cardiac muscle cell action potential repolarization
B0086011biological_processmembrane repolarization during action potential
B0086012biological_processmembrane depolarization during cardiac muscle cell action potential
B0086013biological_processmembrane repolarization during cardiac muscle cell action potential
B0086091biological_processregulation of heart rate by cardiac conduction
B0090076biological_processrelaxation of skeletal muscle
B0098978cellular_componentglutamatergic synapse
B1901381biological_processpositive regulation of potassium ion transmembrane transport
B1990573biological_processpotassium ion import across plasma membrane
C0005242molecular_functioninward rectifier potassium channel activity
C0005515molecular_functionprotein binding
C0005546molecular_functionphosphatidylinositol-4,5-bisphosphate binding
C0005886cellular_componentplasma membrane
C0006811biological_processmonoatomic ion transport
C0006813biological_processpotassium ion transport
C0008076cellular_componentvoltage-gated potassium channel complex
C0014704cellular_componentintercalated disc
C0014861biological_processregulation of skeletal muscle contraction via regulation of action potential
C0016020cellular_componentmembrane
C0030007biological_processintracellular potassium ion homeostasis
C0030315cellular_componentT-tubule
C0030425cellular_componentdendrite
C0034220biological_processmonoatomic ion transmembrane transport
C0034702cellular_componentmonoatomic ion channel complex
C0042802molecular_functionidentical protein binding
C0043025cellular_componentneuronal cell body
C0043197cellular_componentdendritic spine
C0045211cellular_componentpostsynaptic membrane
C0051289biological_processprotein homotetramerization
C0055119biological_processrelaxation of cardiac muscle
C0060075biological_processregulation of resting membrane potential
C0060306biological_processregulation of membrane repolarization
C0071260biological_processcellular response to mechanical stimulus
C0071805biological_processpotassium ion transmembrane transport
C0086002biological_processcardiac muscle cell action potential involved in contraction
C0086004biological_processregulation of cardiac muscle cell contraction
C0086008molecular_functionvoltage-gated potassium channel activity involved in cardiac muscle cell action potential repolarization
C0086011biological_processmembrane repolarization during action potential
C0086012biological_processmembrane depolarization during cardiac muscle cell action potential
C0086013biological_processmembrane repolarization during cardiac muscle cell action potential
C0086091biological_processregulation of heart rate by cardiac conduction
C0090076biological_processrelaxation of skeletal muscle
C0098978cellular_componentglutamatergic synapse
C1901381biological_processpositive regulation of potassium ion transmembrane transport
C1990573biological_processpotassium ion import across plasma membrane
D0005242molecular_functioninward rectifier potassium channel activity
D0005515molecular_functionprotein binding
D0005546molecular_functionphosphatidylinositol-4,5-bisphosphate binding
D0005886cellular_componentplasma membrane
D0006811biological_processmonoatomic ion transport
D0006813biological_processpotassium ion transport
D0008076cellular_componentvoltage-gated potassium channel complex
D0014704cellular_componentintercalated disc
D0014861biological_processregulation of skeletal muscle contraction via regulation of action potential
D0016020cellular_componentmembrane
D0030007biological_processintracellular potassium ion homeostasis
D0030315cellular_componentT-tubule
D0030425cellular_componentdendrite
D0034220biological_processmonoatomic ion transmembrane transport
D0034702cellular_componentmonoatomic ion channel complex
D0042802molecular_functionidentical protein binding
D0043025cellular_componentneuronal cell body
D0043197cellular_componentdendritic spine
D0045211cellular_componentpostsynaptic membrane
D0051289biological_processprotein homotetramerization
D0055119biological_processrelaxation of cardiac muscle
D0060075biological_processregulation of resting membrane potential
D0060306biological_processregulation of membrane repolarization
D0071260biological_processcellular response to mechanical stimulus
D0071805biological_processpotassium ion transmembrane transport
D0086002biological_processcardiac muscle cell action potential involved in contraction
D0086004biological_processregulation of cardiac muscle cell contraction
D0086008molecular_functionvoltage-gated potassium channel activity involved in cardiac muscle cell action potential repolarization
D0086011biological_processmembrane repolarization during action potential
D0086012biological_processmembrane depolarization during cardiac muscle cell action potential
D0086013biological_processmembrane repolarization during cardiac muscle cell action potential
D0086091biological_processregulation of heart rate by cardiac conduction
D0090076biological_processrelaxation of skeletal muscle
D0098978cellular_componentglutamatergic synapse
D1901381biological_processpositive regulation of potassium ion transmembrane transport
D1990573biological_processpotassium ion import across plasma membrane
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues96
DetailsTransmembrane: {"description":"Helical; Name=M1","evidences":[{"evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI2
Number of Residues116
DetailsTopological domain: {"description":"Extracellular","evidences":[{"evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI3
Number of Residues44
DetailsIntramembrane: {"description":"Helical; Pore-forming; Name=H5","evidences":[{"evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI4
Number of Residues24
DetailsIntramembrane: {"description":"Pore-forming","evidences":[{"evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI5
Number of Residues84
DetailsTransmembrane: {"description":"Helical; Name=M2","evidences":[{"evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI6
Number of Residues108
DetailsRegion: {"description":"Polyphosphoinositide (PIP2)-binding","evidences":[{"source":"UniProtKB","id":"Q64273","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI7
Number of Residues20
DetailsMotif: {"description":"Selectivity filter","evidences":[{"evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI8
Number of Residues4
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"36149965","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7ZDZ","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI9
Number of Residues4
DetailsSite: {"description":"Role in the control of polyamine-mediated channel gating and in the blocking by intracellular magnesium","evidences":[{"evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI10
Number of Residues4
DetailsModified residue: {"description":"S-nitrosocysteine","evidences":[{"source":"PubMed","id":"19608980","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails

247947

PDB entries from 2026-01-21

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