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7ZDZ

Cryo-EM structure of the human inward-rectifier potassium 2.1 channel (Kir2.1)

Functional Information from GO Data
ChainGOidnamespacecontents
A0005242molecular_functioninward rectifier potassium channel activity
A0005515molecular_functionprotein binding
A0005546molecular_functionphosphatidylinositol-4,5-bisphosphate binding
A0005886cellular_componentplasma membrane
A0006813biological_processpotassium ion transport
A0008076cellular_componentvoltage-gated potassium channel complex
A0014704cellular_componentintercalated disc
A0014861biological_processregulation of skeletal muscle contraction via regulation of action potential
A0015693biological_processmagnesium ion transport
A0016020cellular_componentmembrane
A0030007biological_processintracellular potassium ion homeostasis
A0030315cellular_componentT-tubule
A0030425cellular_componentdendrite
A0034220biological_processmonoatomic ion transmembrane transport
A0034702cellular_componentmonoatomic ion channel complex
A0034765biological_processregulation of monoatomic ion transmembrane transport
A0042802molecular_functionidentical protein binding
A0043025cellular_componentneuronal cell body
A0043197cellular_componentdendritic spine
A0045211cellular_componentpostsynaptic membrane
A0051289biological_processprotein homotetramerization
A0055119biological_processrelaxation of cardiac muscle
A0060075biological_processregulation of resting membrane potential
A0060306biological_processregulation of membrane repolarization
A0071260biological_processcellular response to mechanical stimulus
A0071805biological_processpotassium ion transmembrane transport
A0086001biological_processcardiac muscle cell action potential
A0086002biological_processcardiac muscle cell action potential involved in contraction
A0086004biological_processregulation of cardiac muscle cell contraction
A0086008molecular_functionvoltage-gated potassium channel activity involved in cardiac muscle cell action potential repolarization
A0086011biological_processmembrane repolarization during action potential
A0086012biological_processmembrane depolarization during cardiac muscle cell action potential
A0086013biological_processmembrane repolarization during cardiac muscle cell action potential
A0086091biological_processregulation of heart rate by cardiac conduction
A0090076biological_processrelaxation of skeletal muscle
A0098978cellular_componentglutamatergic synapse
A1901381biological_processpositive regulation of potassium ion transmembrane transport
A1990573biological_processpotassium ion import across plasma membrane
B0005242molecular_functioninward rectifier potassium channel activity
B0005515molecular_functionprotein binding
B0005546molecular_functionphosphatidylinositol-4,5-bisphosphate binding
B0005886cellular_componentplasma membrane
B0006813biological_processpotassium ion transport
B0008076cellular_componentvoltage-gated potassium channel complex
B0014704cellular_componentintercalated disc
B0014861biological_processregulation of skeletal muscle contraction via regulation of action potential
B0015693biological_processmagnesium ion transport
B0016020cellular_componentmembrane
B0030007biological_processintracellular potassium ion homeostasis
B0030315cellular_componentT-tubule
B0030425cellular_componentdendrite
B0034220biological_processmonoatomic ion transmembrane transport
B0034702cellular_componentmonoatomic ion channel complex
B0034765biological_processregulation of monoatomic ion transmembrane transport
B0042802molecular_functionidentical protein binding
B0043025cellular_componentneuronal cell body
B0043197cellular_componentdendritic spine
B0045211cellular_componentpostsynaptic membrane
B0051289biological_processprotein homotetramerization
B0055119biological_processrelaxation of cardiac muscle
B0060075biological_processregulation of resting membrane potential
B0060306biological_processregulation of membrane repolarization
B0071260biological_processcellular response to mechanical stimulus
B0071805biological_processpotassium ion transmembrane transport
B0086001biological_processcardiac muscle cell action potential
B0086002biological_processcardiac muscle cell action potential involved in contraction
B0086004biological_processregulation of cardiac muscle cell contraction
B0086008molecular_functionvoltage-gated potassium channel activity involved in cardiac muscle cell action potential repolarization
B0086011biological_processmembrane repolarization during action potential
B0086012biological_processmembrane depolarization during cardiac muscle cell action potential
B0086013biological_processmembrane repolarization during cardiac muscle cell action potential
B0086091biological_processregulation of heart rate by cardiac conduction
B0090076biological_processrelaxation of skeletal muscle
B0098978cellular_componentglutamatergic synapse
B1901381biological_processpositive regulation of potassium ion transmembrane transport
B1990573biological_processpotassium ion import across plasma membrane
C0005242molecular_functioninward rectifier potassium channel activity
C0005515molecular_functionprotein binding
C0005546molecular_functionphosphatidylinositol-4,5-bisphosphate binding
C0005886cellular_componentplasma membrane
C0006813biological_processpotassium ion transport
C0008076cellular_componentvoltage-gated potassium channel complex
C0014704cellular_componentintercalated disc
C0014861biological_processregulation of skeletal muscle contraction via regulation of action potential
C0015693biological_processmagnesium ion transport
C0016020cellular_componentmembrane
C0030007biological_processintracellular potassium ion homeostasis
C0030315cellular_componentT-tubule
C0030425cellular_componentdendrite
C0034220biological_processmonoatomic ion transmembrane transport
C0034702cellular_componentmonoatomic ion channel complex
C0034765biological_processregulation of monoatomic ion transmembrane transport
C0042802molecular_functionidentical protein binding
C0043025cellular_componentneuronal cell body
C0043197cellular_componentdendritic spine
C0045211cellular_componentpostsynaptic membrane
C0051289biological_processprotein homotetramerization
C0055119biological_processrelaxation of cardiac muscle
C0060075biological_processregulation of resting membrane potential
C0060306biological_processregulation of membrane repolarization
C0071260biological_processcellular response to mechanical stimulus
C0071805biological_processpotassium ion transmembrane transport
C0086001biological_processcardiac muscle cell action potential
C0086002biological_processcardiac muscle cell action potential involved in contraction
C0086004biological_processregulation of cardiac muscle cell contraction
C0086008molecular_functionvoltage-gated potassium channel activity involved in cardiac muscle cell action potential repolarization
C0086011biological_processmembrane repolarization during action potential
C0086012biological_processmembrane depolarization during cardiac muscle cell action potential
C0086013biological_processmembrane repolarization during cardiac muscle cell action potential
C0086091biological_processregulation of heart rate by cardiac conduction
C0090076biological_processrelaxation of skeletal muscle
C0098978cellular_componentglutamatergic synapse
C1901381biological_processpositive regulation of potassium ion transmembrane transport
C1990573biological_processpotassium ion import across plasma membrane
D0005242molecular_functioninward rectifier potassium channel activity
D0005515molecular_functionprotein binding
D0005546molecular_functionphosphatidylinositol-4,5-bisphosphate binding
D0005886cellular_componentplasma membrane
D0006813biological_processpotassium ion transport
D0008076cellular_componentvoltage-gated potassium channel complex
D0014704cellular_componentintercalated disc
D0014861biological_processregulation of skeletal muscle contraction via regulation of action potential
D0015693biological_processmagnesium ion transport
D0016020cellular_componentmembrane
D0030007biological_processintracellular potassium ion homeostasis
D0030315cellular_componentT-tubule
D0030425cellular_componentdendrite
D0034220biological_processmonoatomic ion transmembrane transport
D0034702cellular_componentmonoatomic ion channel complex
D0034765biological_processregulation of monoatomic ion transmembrane transport
D0042802molecular_functionidentical protein binding
D0043025cellular_componentneuronal cell body
D0043197cellular_componentdendritic spine
D0045211cellular_componentpostsynaptic membrane
D0051289biological_processprotein homotetramerization
D0055119biological_processrelaxation of cardiac muscle
D0060075biological_processregulation of resting membrane potential
D0060306biological_processregulation of membrane repolarization
D0071260biological_processcellular response to mechanical stimulus
D0071805biological_processpotassium ion transmembrane transport
D0086001biological_processcardiac muscle cell action potential
D0086002biological_processcardiac muscle cell action potential involved in contraction
D0086004biological_processregulation of cardiac muscle cell contraction
D0086008molecular_functionvoltage-gated potassium channel activity involved in cardiac muscle cell action potential repolarization
D0086011biological_processmembrane repolarization during action potential
D0086012biological_processmembrane depolarization during cardiac muscle cell action potential
D0086013biological_processmembrane repolarization during cardiac muscle cell action potential
D0086091biological_processregulation of heart rate by cardiac conduction
D0090076biological_processrelaxation of skeletal muscle
D0098978cellular_componentglutamatergic synapse
D1901381biological_processpositive regulation of potassium ion transmembrane transport
D1990573biological_processpotassium ion import across plasma membrane
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues1308
DetailsTOPO_DOM: Cytoplasmic => ECO:0000250
ChainResidueDetails
AGLY2-TRP81
AVAL179-ILE427
BGLY2-TRP81
BVAL179-ILE427
CGLY2-TRP81
CVAL179-ILE427
DGLY2-TRP81
DVAL179-ILE427

site_idSWS_FT_FI2
Number of Residues96
DetailsTRANSMEM: Helical; Name=M1 => ECO:0000250
ChainResidueDetails
AARG82-ILE106
BARG82-ILE106
CARG82-ILE106
DARG82-ILE106

site_idSWS_FT_FI3
Number of Residues116
DetailsTOPO_DOM: Extracellular => ECO:0000250
ChainResidueDetails
AALA107-SER128
AARG148-ILE156
BALA107-SER128
BARG148-ILE156
CALA107-SER128
CARG148-ILE156
DALA107-SER128
DARG148-ILE156

site_idSWS_FT_FI4
Number of Residues44
DetailsINTRAMEM: Helical; Pore-forming; Name=H5 => ECO:0000250
ChainResidueDetails
APHE129-GLN140
BPHE129-GLN140
CPHE129-GLN140
DPHE129-GLN140

site_idSWS_FT_FI5
Number of Residues24
DetailsINTRAMEM: Pore-forming => ECO:0000250
ChainResidueDetails
ATHR141-PHE147
BTHR141-PHE147
CTHR141-PHE147
DTHR141-PHE147

site_idSWS_FT_FI6
Number of Residues84
DetailsTRANSMEM: Helical; Name=M2 => ECO:0000250
ChainResidueDetails
AALA157-ALA178
BALA157-ALA178
CALA157-ALA178
DALA157-ALA178

site_idSWS_FT_FI7
Number of Residues4
DetailsBINDING: BINDING => ECO:0000269|PubMed:36149965, ECO:0007744|PDB:7ZDZ
ChainResidueDetails
AASP255
BASP255
CASP255
DASP255

site_idSWS_FT_FI8
Number of Residues4
DetailsSITE: Role in the control of polyamine-mediated channel gating and in the blocking by intracellular magnesium => ECO:0000250
ChainResidueDetails
AASP172
BASP172
CASP172
DASP172

site_idSWS_FT_FI9
Number of Residues4
DetailsMOD_RES: S-nitrosocysteine => ECO:0000269|PubMed:19608980
ChainResidueDetails
ACYS76
BCYS76
CCYS76
DCYS76

site_idSWS_FT_FI10
Number of Residues4
DetailsLIPID: N-myristoyl glycine => ECO:0000269|PubMed:25043870
ChainResidueDetails
AGLY2
BGLY2
CGLY2
DGLY2

221051

PDB entries from 2024-06-12

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