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7ZAU

Fascin-1 in complex with Nb 3E11

Functional Information from GO Data
ChainGOidnamespacecontents
A0001725cellular_componentstress fiber
A0001726cellular_componentruffle
A0002102cellular_componentpodosome
A0003723molecular_functionRNA binding
A0003779molecular_functionactin binding
A0005515molecular_functionprotein binding
A0005737cellular_componentcytoplasm
A0005829cellular_componentcytosol
A0005856cellular_componentcytoskeleton
A0005902cellular_componentmicrovillus
A0005911cellular_componentcell-cell junction
A0005938cellular_componentcell cortex
A0007015biological_processactin filament organization
A0007043biological_processcell-cell junction assembly
A0007163biological_processestablishment or maintenance of cell polarity
A0008144molecular_functionobsolete drug binding
A0010592biological_processpositive regulation of lamellipodium assembly
A0015629cellular_componentactin cytoskeleton
A0016477biological_processcell migration
A0030027cellular_componentlamellipodium
A0030035biological_processmicrospike assembly
A0030036biological_processactin cytoskeleton organization
A0030046biological_processparallel actin filament bundle assembly
A0030175cellular_componentfilopodium
A0030426cellular_componentgrowth cone
A0030674molecular_functionprotein-macromolecule adaptor activity
A0031253cellular_componentcell projection membrane
A0032534biological_processregulation of microvillus assembly
A0032956biological_processregulation of actin cytoskeleton organization
A0035089biological_processestablishment of apical/basal cell polarity
A0042995cellular_componentcell projection
A0044393cellular_componentmicrospike
A0045296molecular_functioncadherin binding
A0048870biological_processcell motility
A0051015molecular_functionactin filament binding
A0051017biological_processactin filament bundle assembly
A0051491biological_processpositive regulation of filopodium assembly
A0070062cellular_componentextracellular exosome
A0070161cellular_componentanchoring junction
A0071803biological_processpositive regulation of podosome assembly
A0090091biological_processpositive regulation of extracellular matrix disassembly
C0001725cellular_componentstress fiber
C0001726cellular_componentruffle
C0002102cellular_componentpodosome
C0003723molecular_functionRNA binding
C0003779molecular_functionactin binding
C0005515molecular_functionprotein binding
C0005737cellular_componentcytoplasm
C0005829cellular_componentcytosol
C0005856cellular_componentcytoskeleton
C0005902cellular_componentmicrovillus
C0005911cellular_componentcell-cell junction
C0005938cellular_componentcell cortex
C0007015biological_processactin filament organization
C0007043biological_processcell-cell junction assembly
C0007163biological_processestablishment or maintenance of cell polarity
C0008144molecular_functionobsolete drug binding
C0010592biological_processpositive regulation of lamellipodium assembly
C0015629cellular_componentactin cytoskeleton
C0016477biological_processcell migration
C0030027cellular_componentlamellipodium
C0030035biological_processmicrospike assembly
C0030036biological_processactin cytoskeleton organization
C0030046biological_processparallel actin filament bundle assembly
C0030175cellular_componentfilopodium
C0030426cellular_componentgrowth cone
C0030674molecular_functionprotein-macromolecule adaptor activity
C0031253cellular_componentcell projection membrane
C0032534biological_processregulation of microvillus assembly
C0032956biological_processregulation of actin cytoskeleton organization
C0035089biological_processestablishment of apical/basal cell polarity
C0042995cellular_componentcell projection
C0044393cellular_componentmicrospike
C0045296molecular_functioncadherin binding
C0048870biological_processcell motility
C0051015molecular_functionactin filament binding
C0051017biological_processactin filament bundle assembly
C0051491biological_processpositive regulation of filopodium assembly
C0070062cellular_componentextracellular exosome
C0070161cellular_componentanchoring junction
C0071803biological_processpositive regulation of podosome assembly
C0090091biological_processpositive regulation of extracellular matrix disassembly
E0001725cellular_componentstress fiber
E0001726cellular_componentruffle
E0002102cellular_componentpodosome
E0003723molecular_functionRNA binding
E0003779molecular_functionactin binding
E0005515molecular_functionprotein binding
E0005737cellular_componentcytoplasm
E0005829cellular_componentcytosol
E0005856cellular_componentcytoskeleton
E0005902cellular_componentmicrovillus
E0005911cellular_componentcell-cell junction
E0005938cellular_componentcell cortex
E0007015biological_processactin filament organization
E0007043biological_processcell-cell junction assembly
E0007163biological_processestablishment or maintenance of cell polarity
E0008144molecular_functionobsolete drug binding
E0010592biological_processpositive regulation of lamellipodium assembly
E0015629cellular_componentactin cytoskeleton
E0016477biological_processcell migration
E0030027cellular_componentlamellipodium
E0030035biological_processmicrospike assembly
E0030036biological_processactin cytoskeleton organization
E0030046biological_processparallel actin filament bundle assembly
E0030175cellular_componentfilopodium
E0030426cellular_componentgrowth cone
E0030674molecular_functionprotein-macromolecule adaptor activity
E0031253cellular_componentcell projection membrane
E0032534biological_processregulation of microvillus assembly
E0032956biological_processregulation of actin cytoskeleton organization
E0035089biological_processestablishment of apical/basal cell polarity
E0042995cellular_componentcell projection
E0044393cellular_componentmicrospike
E0045296molecular_functioncadherin binding
E0048870biological_processcell motility
E0051015molecular_functionactin filament binding
E0051017biological_processactin filament bundle assembly
E0051491biological_processpositive regulation of filopodium assembly
E0070062cellular_componentextracellular exosome
E0070161cellular_componentanchoring junction
E0071803biological_processpositive regulation of podosome assembly
E0090091biological_processpositive regulation of extracellular matrix disassembly
G0001725cellular_componentstress fiber
G0001726cellular_componentruffle
G0002102cellular_componentpodosome
G0003723molecular_functionRNA binding
G0003779molecular_functionactin binding
G0005515molecular_functionprotein binding
G0005737cellular_componentcytoplasm
G0005829cellular_componentcytosol
G0005856cellular_componentcytoskeleton
G0005902cellular_componentmicrovillus
G0005911cellular_componentcell-cell junction
G0005938cellular_componentcell cortex
G0007015biological_processactin filament organization
G0007043biological_processcell-cell junction assembly
G0007163biological_processestablishment or maintenance of cell polarity
G0008144molecular_functionobsolete drug binding
G0010592biological_processpositive regulation of lamellipodium assembly
G0015629cellular_componentactin cytoskeleton
G0016477biological_processcell migration
G0030027cellular_componentlamellipodium
G0030035biological_processmicrospike assembly
G0030036biological_processactin cytoskeleton organization
G0030046biological_processparallel actin filament bundle assembly
G0030175cellular_componentfilopodium
G0030426cellular_componentgrowth cone
G0030674molecular_functionprotein-macromolecule adaptor activity
G0031253cellular_componentcell projection membrane
G0032534biological_processregulation of microvillus assembly
G0032956biological_processregulation of actin cytoskeleton organization
G0035089biological_processestablishment of apical/basal cell polarity
G0042995cellular_componentcell projection
G0044393cellular_componentmicrospike
G0045296molecular_functioncadherin binding
G0048870biological_processcell motility
G0051015molecular_functionactin filament binding
G0051017biological_processactin filament bundle assembly
G0051491biological_processpositive regulation of filopodium assembly
G0070062cellular_componentextracellular exosome
G0070161cellular_componentanchoring junction
G0071803biological_processpositive regulation of podosome assembly
G0090091biological_processpositive regulation of extracellular matrix disassembly
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues4
DetailsMOD_RES: N-acetylthreonine => ECO:0000269|Ref.9, ECO:0007744|PubMed:22223895
ChainResidueDetails
ATHR2
CTHR2
ETHR2
GTHR2

site_idSWS_FT_FI2
Number of Residues4
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:18669648
ChainResidueDetails
ASER38
CSER38
ESER38
GSER38

site_idSWS_FT_FI3
Number of Residues4
DetailsMOD_RES: Phosphoserine; by PKC => ECO:0000269|PubMed:8999969, ECO:0000305|PubMed:22155786
ChainResidueDetails
ASER39
CSER39
ESER39
GSER39

site_idSWS_FT_FI4
Number of Residues4
DetailsMOD_RES: N6-acetyllysine => ECO:0000250|UniProtKB:Q61553
ChainResidueDetails
ALYS74
CLYS74
ELYS74
GLYS74

site_idSWS_FT_FI5
Number of Residues8
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:23186163
ChainResidueDetails
ASER127
ASER234
CSER127
CSER234
ESER127
ESER234
GSER127
GSER234

site_idSWS_FT_FI6
Number of Residues4
DetailsMOD_RES: Phosphothreonine => ECO:0007744|PubMed:23186163
ChainResidueDetails
ATHR239
CTHR239
ETHR239
GTHR239

site_idSWS_FT_FI7
Number of Residues4
DetailsMOD_RES: Phosphothreonine => ECO:0000250|UniProtKB:P85845
ChainResidueDetails
ATHR403
CTHR403
ETHR403
GTHR403

site_idSWS_FT_FI8
Number of Residues8
DetailsCROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) => ECO:0007744|PubMed:25218447
ChainResidueDetails
ALYS399
CLYS399
ELYS399
GLYS399

221051

PDB entries from 2024-06-12

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