Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

7Z9T

Crystal structure of p38alpha C162S in complex with ATPgS and CAS 2094667-81-7 (in catalytic site, Y35 out), P 1 21 1

This is a non-PDB format compatible entry.

Functional Information from GO Data

Chain	GOid	namespace	contents
AAA	0000077	biological_process	DNA damage checkpoint signaling
AAA	0000165	biological_process	MAPK cascade
AAA	0000166	molecular_function	nucleotide binding
AAA	0000902	biological_process	cell morphogenesis
AAA	0000922	cellular_component	spindle pole
AAA	0001502	biological_process	cartilage condensation
AAA	0001525	biological_process	angiogenesis
AAA	0001649	biological_process	osteoblast differentiation
AAA	0001890	biological_process	placenta development
AAA	0002021	biological_process	response to dietary excess
AAA	0002062	biological_process	chondrocyte differentiation
AAA	0004672	molecular_function	protein kinase activity
AAA	0004674	molecular_function	protein serine/threonine kinase activity
AAA	0004707	molecular_function	MAP kinase activity
AAA	0005515	molecular_function	protein binding
AAA	0005524	molecular_function	ATP binding
AAA	0005634	cellular_component	nucleus
AAA	0005654	cellular_component	nucleoplasm
AAA	0005737	cellular_component	cytoplasm
AAA	0005739	cellular_component	mitochondrion
AAA	0005829	cellular_component	cytosol
AAA	0006006	biological_process	glucose metabolic process
AAA	0006351	biological_process	DNA-templated transcription
AAA	0006355	biological_process	regulation of DNA-templated transcription
AAA	0006357	biological_process	regulation of transcription by RNA polymerase II
AAA	0006468	biological_process	protein phosphorylation
AAA	0006915	biological_process	apoptotic process
AAA	0006974	biological_process	DNA damage response
AAA	0007178	biological_process	cell surface receptor protein serine/threonine kinase signaling pathway
AAA	0007519	biological_process	skeletal muscle tissue development
AAA	0010628	biological_process	positive regulation of gene expression
AAA	0010831	biological_process	positive regulation of myotube differentiation
AAA	0016301	molecular_function	kinase activity
AAA	0016607	cellular_component	nuclear speck
AAA	0016740	molecular_function	transferase activity
AAA	0018105	biological_process	peptidyl-serine phosphorylation
AAA	0019395	biological_process	fatty acid oxidation
AAA	0019899	molecular_function	enzyme binding
AAA	0019903	molecular_function	protein phosphatase binding
AAA	0030278	biological_process	regulation of ossification
AAA	0030316	biological_process	osteoclast differentiation
AAA	0031098	biological_process	stress-activated protein kinase signaling cascade
AAA	0031281	biological_process	positive regulation of cyclase activity
AAA	0031663	biological_process	lipopolysaccharide-mediated signaling pathway
AAA	0032495	biological_process	response to muramyl dipeptide
AAA	0032496	biological_process	response to lipopolysaccharide
AAA	0032735	biological_process	positive regulation of interleukin-12 production
AAA	0032868	biological_process	response to insulin
AAA	0033209	biological_process	tumor necrosis factor-mediated signaling pathway
AAA	0035331	biological_process	negative regulation of hippo signaling
AAA	0035556	biological_process	intracellular signal transduction
AAA	0035924	biological_process	cellular response to vascular endothelial growth factor stimulus
AAA	0035994	biological_process	response to muscle stretch
AAA	0038066	biological_process	p38MAPK cascade
AAA	0042307	biological_process	positive regulation of protein import into nucleus
AAA	0042770	biological_process	signal transduction in response to DNA damage
AAA	0045648	biological_process	positive regulation of erythrocyte differentiation
AAA	0045663	biological_process	positive regulation of myoblast differentiation
AAA	0045944	biological_process	positive regulation of transcription by RNA polymerase II
AAA	0046326	biological_process	positive regulation of D-glucose import
AAA	0046777	biological_process	protein autophosphorylation
AAA	0048010	biological_process	vascular endothelial growth factor receptor signaling pathway
AAA	0048273	molecular_function	mitogen-activated protein kinase p38 binding
AAA	0051146	biological_process	striated muscle cell differentiation
AAA	0051403	biological_process	stress-activated MAPK cascade
AAA	0051525	molecular_function	NFAT protein binding
AAA	0051604	biological_process	protein maturation
AAA	0060043	biological_process	regulation of cardiac muscle cell proliferation
AAA	0060045	biological_process	positive regulation of cardiac muscle cell proliferation
AAA	0060348	biological_process	bone development
AAA	0070269	biological_process	pyroptotic inflammatory response
AAA	0071222	biological_process	cellular response to lipopolysaccharide
AAA	0071223	biological_process	cellular response to lipoteichoic acid
AAA	0071356	biological_process	cellular response to tumor necrosis factor
AAA	0071479	biological_process	cellular response to ionizing radiation
AAA	0071493	biological_process	cellular response to UV-B
AAA	0090090	biological_process	negative regulation of canonical Wnt signaling pathway
AAA	0090336	biological_process	positive regulation of brown fat cell differentiation
AAA	0090400	biological_process	stress-induced premature senescence
AAA	0098586	biological_process	cellular response to virus
AAA	0098978	cellular_component	glutamatergic synapse
AAA	0099179	biological_process	regulation of synaptic membrane adhesion
AAA	0106310	molecular_function	protein serine kinase activity
AAA	1900015	biological_process	regulation of cytokine production involved in inflammatory response
AAA	1901741	biological_process	positive regulation of myoblast fusion
AAA	1904784	biological_process	NLRP1 inflammasome complex assembly
AAA	2000379	biological_process	positive regulation of reactive oxygen species metabolic process
BBB	0000077	biological_process	DNA damage checkpoint signaling
BBB	0000165	biological_process	MAPK cascade
BBB	0000166	molecular_function	nucleotide binding
BBB	0000902	biological_process	cell morphogenesis
BBB	0000922	cellular_component	spindle pole
BBB	0001502	biological_process	cartilage condensation
BBB	0001525	biological_process	angiogenesis
BBB	0001649	biological_process	osteoblast differentiation
BBB	0001890	biological_process	placenta development
BBB	0002021	biological_process	response to dietary excess
BBB	0002062	biological_process	chondrocyte differentiation
BBB	0004672	molecular_function	protein kinase activity
BBB	0004674	molecular_function	protein serine/threonine kinase activity
BBB	0004707	molecular_function	MAP kinase activity
BBB	0005515	molecular_function	protein binding
BBB	0005524	molecular_function	ATP binding
BBB	0005634	cellular_component	nucleus
BBB	0005654	cellular_component	nucleoplasm
BBB	0005737	cellular_component	cytoplasm
BBB	0005739	cellular_component	mitochondrion
BBB	0005829	cellular_component	cytosol
BBB	0006006	biological_process	glucose metabolic process
BBB	0006351	biological_process	DNA-templated transcription
BBB	0006355	biological_process	regulation of DNA-templated transcription
BBB	0006357	biological_process	regulation of transcription by RNA polymerase II
BBB	0006468	biological_process	protein phosphorylation
BBB	0006915	biological_process	apoptotic process
BBB	0006974	biological_process	DNA damage response
BBB	0007178	biological_process	cell surface receptor protein serine/threonine kinase signaling pathway
BBB	0007519	biological_process	skeletal muscle tissue development
BBB	0010628	biological_process	positive regulation of gene expression
BBB	0010831	biological_process	positive regulation of myotube differentiation
BBB	0016301	molecular_function	kinase activity
BBB	0016607	cellular_component	nuclear speck
BBB	0016740	molecular_function	transferase activity
BBB	0018105	biological_process	peptidyl-serine phosphorylation
BBB	0019395	biological_process	fatty acid oxidation
BBB	0019899	molecular_function	enzyme binding
BBB	0019903	molecular_function	protein phosphatase binding
BBB	0030278	biological_process	regulation of ossification
BBB	0030316	biological_process	osteoclast differentiation
BBB	0031098	biological_process	stress-activated protein kinase signaling cascade
BBB	0031281	biological_process	positive regulation of cyclase activity
BBB	0031663	biological_process	lipopolysaccharide-mediated signaling pathway
BBB	0032495	biological_process	response to muramyl dipeptide
BBB	0032496	biological_process	response to lipopolysaccharide
BBB	0032735	biological_process	positive regulation of interleukin-12 production
BBB	0032868	biological_process	response to insulin
BBB	0033209	biological_process	tumor necrosis factor-mediated signaling pathway
BBB	0035331	biological_process	negative regulation of hippo signaling
BBB	0035556	biological_process	intracellular signal transduction
BBB	0035924	biological_process	cellular response to vascular endothelial growth factor stimulus
BBB	0035994	biological_process	response to muscle stretch
BBB	0038066	biological_process	p38MAPK cascade
BBB	0042307	biological_process	positive regulation of protein import into nucleus
BBB	0042770	biological_process	signal transduction in response to DNA damage
BBB	0045648	biological_process	positive regulation of erythrocyte differentiation
BBB	0045663	biological_process	positive regulation of myoblast differentiation
BBB	0045944	biological_process	positive regulation of transcription by RNA polymerase II
BBB	0046326	biological_process	positive regulation of D-glucose import
BBB	0046777	biological_process	protein autophosphorylation
BBB	0048010	biological_process	vascular endothelial growth factor receptor signaling pathway
BBB	0048273	molecular_function	mitogen-activated protein kinase p38 binding
BBB	0051146	biological_process	striated muscle cell differentiation
BBB	0051403	biological_process	stress-activated MAPK cascade
BBB	0051525	molecular_function	NFAT protein binding
BBB	0051604	biological_process	protein maturation
BBB	0060043	biological_process	regulation of cardiac muscle cell proliferation
BBB	0060045	biological_process	positive regulation of cardiac muscle cell proliferation
BBB	0060348	biological_process	bone development
BBB	0070269	biological_process	pyroptotic inflammatory response
BBB	0071222	biological_process	cellular response to lipopolysaccharide
BBB	0071223	biological_process	cellular response to lipoteichoic acid
BBB	0071356	biological_process	cellular response to tumor necrosis factor
BBB	0071479	biological_process	cellular response to ionizing radiation
BBB	0071493	biological_process	cellular response to UV-B
BBB	0090090	biological_process	negative regulation of canonical Wnt signaling pathway
BBB	0090336	biological_process	positive regulation of brown fat cell differentiation
BBB	0090400	biological_process	stress-induced premature senescence
BBB	0098586	biological_process	cellular response to virus
BBB	0098978	cellular_component	glutamatergic synapse
BBB	0099179	biological_process	regulation of synaptic membrane adhesion
BBB	0106310	molecular_function	protein serine kinase activity
BBB	1900015	biological_process	regulation of cytokine production involved in inflammatory response
BBB	1901741	biological_process	positive regulation of myoblast fusion
BBB	1904784	biological_process	NLRP1 inflammasome complex assembly
BBB	2000379	biological_process	positive regulation of reactive oxygen species metabolic process

Functional Information from PROSITE/UniProt

site_id	PS00107
Number of Residues	25
Details	PROTEIN_KINASE_ATP Protein kinases ATP-binding region signature. VGSGAYGSVCaAfdtktghrv.........AVKK

Chain	Residue	Details
AAA	VAL30-LYS54

site_id	PS01351
Number of Residues	104
Details	MAPK MAP kinase signature. FqsiihakrtyRElrllkhmkhenviglldvftparsleefndvylvthlmgadlnnivkcqkltddhvqfliyqilrglkyihsadiih.........RDlKpsnlavnedS

Chain	Residue	Details
AAA	PHE59-SER162

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	568
Details	Domain: {"description":"Protein kinase","evidences":[{"source":"PROSITE-ProRule","id":"PRU00159","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI2
Number of Residues	4
Details	Motif: {"description":"TXY"}

Chain

Residue

Details

site_id	SWS_FT_FI3
Number of Residues	2
Details	Active site: {"description":"Proton acceptor","evidences":[{"source":"PROSITE-ProRule","id":"PRU00159","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI4
Number of Residues	18
Details	Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00159","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI5
Number of Residues	2
Details	Modified residue: {"description":"Phosphothreonine","evidences":[{"source":"UniProtKB","id":"Q16539","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI6
Number of Residues	4
Details	Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"UniProtKB","id":"Q16539","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI7
Number of Residues	2
Details	Modified residue: {"description":"Phosphothreonine; by MAP2K3, MAP2K4, MAP2K6 and autocatalysis","evidences":[{"evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI8
Number of Residues	2
Details	Modified residue: {"description":"Phosphotyrosine; by MAP2K3, MAP2K4, MAP2K6 and autocatalysis","evidences":[{"evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI9
Number of Residues	2
Details	Modified residue: {"description":"Phosphotyrosine; by ZAP70","evidences":[{"source":"UniProtKB","id":"Q16539","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)