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7Z8T

CAND1-SCF-SKP2 CAND1 engaged SCF rocked

Functional Information from GO Data
ChainGOidnamespacecontents
C0000045biological_processautophagosome assembly
C0000082biological_processG1/S transition of mitotic cell cycle
C0005515molecular_functionprotein binding
C0005634cellular_componentnucleus
C0005654cellular_componentnucleoplasm
C0005737cellular_componentcytoplasm
C0005829cellular_componentcytosol
C0005886cellular_componentplasma membrane
C0006511biological_processubiquitin-dependent protein catabolic process
C0006513biological_processprotein monoubiquitination
C0006915biological_processapoptotic process
C0007040biological_processlysosome organization
C0008283biological_processcell population proliferation
C0009887biological_processanimal organ morphogenesis
C0010507biological_processnegative regulation of autophagy
C0010508biological_processpositive regulation of autophagy
C0016567biological_processprotein ubiquitination
C0019005cellular_componentSCF ubiquitin ligase complex
C0030674molecular_functionprotein-macromolecule adaptor activity
C0031146biological_processSCF-dependent proteasomal ubiquitin-dependent protein catabolic process
C0031461cellular_componentcullin-RING ubiquitin ligase complex
C0031625molecular_functionubiquitin protein ligase binding
C0031669biological_processcellular response to nutrient levels
C0034599biological_processcellular response to oxidative stress
C0038202biological_processTORC1 signaling
C0043123biological_processpositive regulation of canonical NF-kappaB signal transduction
C0043124biological_processnegative regulation of canonical NF-kappaB signal transduction
C0043161biological_processproteasome-mediated ubiquitin-dependent protein catabolic process
C0070936biological_processprotein K48-linked ubiquitination
C0097193biological_processintrinsic apoptotic signaling pathway
C0140374biological_processantiviral innate immune response
C0160072molecular_functionubiquitin ligase complex scaffold activity
C1904037biological_processpositive regulation of epithelial cell apoptotic process
C1904262biological_processnegative regulation of TORC1 signaling
C1990452cellular_componentParkin-FBXW7-Cul1 ubiquitin ligase complex
D0000151cellular_componentubiquitin ligase complex
D0005515molecular_functionprotein binding
D0005576cellular_componentextracellular region
D0005634cellular_componentnucleus
D0005654cellular_componentnucleoplasm
D0005737cellular_componentcytoplasm
D0005794cellular_componentGolgi apparatus
D0005829cellular_componentcytosol
D0010265biological_processSCF complex assembly
D0016020cellular_componentmembrane
D0016567biological_processprotein ubiquitination
D0017025molecular_functionTBP-class protein binding
D0030154biological_processcell differentiation
D0031461cellular_componentcullin-RING ubiquitin ligase complex
D0034774cellular_componentsecretory granule lumen
D0043086biological_processnegative regulation of catalytic activity
D0045893biological_processpositive regulation of DNA-templated transcription
D0045899biological_processpositive regulation of RNA polymerase II transcription preinitiation complex assembly
D0070062cellular_componentextracellular exosome
D1904813cellular_componentficolin-1-rich granule lumen
F0000082biological_processG1/S transition of mitotic cell cycle
F0000086biological_processG2/M transition of mitotic cell cycle
F0000209biological_processprotein polyubiquitination
F0000729biological_processDNA double-strand break processing
F0002376biological_processimmune system process
F0005515molecular_functionprotein binding
F0005634cellular_componentnucleus
F0005654cellular_componentnucleoplasm
F0005730cellular_componentnucleolus
F0005737cellular_componentcytoplasm
F0005829cellular_componentcytosol
F0006511biological_processubiquitin-dependent protein catabolic process
F0016567biological_processprotein ubiquitination
F0019005cellular_componentSCF ubiquitin ligase complex
F0031146biological_processSCF-dependent proteasomal ubiquitin-dependent protein catabolic process
F0033148biological_processpositive regulation of intracellular estrogen receptor signaling pathway
F0042802molecular_functionidentical protein binding
F0042981biological_processregulation of apoptotic process
F0043161biological_processproteasome-mediated ubiquitin-dependent protein catabolic process
F0045087biological_processinnate immune response
F0048661biological_processpositive regulation of smooth muscle cell proliferation
F0051607biological_processdefense response to virus
F0051726biological_processregulation of cell cycle
F0070534biological_processprotein K63-linked ubiquitination
F0070936biological_processprotein K48-linked ubiquitination
F0071460biological_processcellular response to cell-matrix adhesion
F1902916biological_processpositive regulation of protein polyubiquitination
F1905168biological_processpositive regulation of double-strand break repair via homologous recombination
F1990166biological_processprotein localization to site of double-strand break
F1990756molecular_functionubiquitin-like ligase-substrate adaptor activity
R0000045biological_processautophagosome assembly
R0000082biological_processG1/S transition of mitotic cell cycle
R0000165biological_processMAPK cascade
R0000209biological_processprotein polyubiquitination
R0000423biological_processmitophagy
R0001837biological_processepithelial to mesenchymal transition
R0004842molecular_functionubiquitin-protein transferase activity
R0005515molecular_functionprotein binding
R0005634cellular_componentnucleus
R0005654cellular_componentnucleoplasm
R0005737cellular_componentcytoplasm
R0005829cellular_componentcytosol
R0006281biological_processDNA repair
R0006283biological_processtranscription-coupled nucleotide-excision repair
R0006366biological_processtranscription by RNA polymerase II
R0006368biological_processtranscription elongation by RNA polymerase II
R0006511biological_processubiquitin-dependent protein catabolic process
R0006513biological_processprotein monoubiquitination
R0006915biological_processapoptotic process
R0006974biological_processDNA damage response
R0006979biological_processresponse to oxidative stress
R0007040biological_processlysosome organization
R0007283biological_processspermatogenesis
R0007346biological_processregulation of mitotic cell cycle
R0008270molecular_functionzinc ion binding
R0008286biological_processinsulin receptor signaling pathway
R0010507biological_processnegative regulation of autophagy
R0010508biological_processpositive regulation of autophagy
R0016567biological_processprotein ubiquitination
R0016740molecular_functiontransferase activity
R0019005cellular_componentSCF ubiquitin ligase complex
R0019221biological_processcytokine-mediated signaling pathway
R0019788molecular_functionNEDD8 transferase activity
R0030163biological_processprotein catabolic process
R0030330biological_processDNA damage response, signal transduction by p53 class mediator
R0030891cellular_componentVCB complex
R0031146biological_processSCF-dependent proteasomal ubiquitin-dependent protein catabolic process
R0031461cellular_componentcullin-RING ubiquitin ligase complex
R0031462cellular_componentCul2-RING ubiquitin ligase complex
R0031463cellular_componentCul3-RING ubiquitin ligase complex
R0031464cellular_componentCul4A-RING E3 ubiquitin ligase complex
R0031465cellular_componentCul4B-RING E3 ubiquitin ligase complex
R0031466cellular_componentCul5-RING ubiquitin ligase complex
R0031467cellular_componentCul7-RING ubiquitin ligase complex
R0031625molecular_functionubiquitin protein ligase binding
R0031669biological_processcellular response to nutrient levels
R0032435biological_processnegative regulation of proteasomal ubiquitin-dependent protein catabolic process
R0032436biological_processpositive regulation of proteasomal ubiquitin-dependent protein catabolic process
R0032480biological_processnegative regulation of type I interferon production
R0032481biological_processpositive regulation of type I interferon production
R0032869biological_processcellular response to insulin stimulus
R0034198biological_processcellular response to amino acid starvation
R0034450molecular_functionubiquitin-ubiquitin ligase activity
R0034599biological_processcellular response to oxidative stress
R0034644biological_processcellular response to UV
R0035279biological_processmiRNA-mediated gene silencing by mRNA destabilization
R0038066biological_processp38MAPK cascade
R0038202biological_processTORC1 signaling
R0042110biological_processT cell activation
R0042770biological_processsignal transduction in response to DNA damage
R0043123biological_processpositive regulation of canonical NF-kappaB signal transduction
R0043124biological_processnegative regulation of canonical NF-kappaB signal transduction
R0043161biological_processproteasome-mediated ubiquitin-dependent protein catabolic process
R0043687biological_processpost-translational protein modification
R0044877molecular_functionprotein-containing complex binding
R0045116biological_processprotein neddylation
R0045727biological_processpositive regulation of translation
R0045732biological_processpositive regulation of protein catabolic process
R0045944biological_processpositive regulation of transcription by RNA polymerase II
R0046627biological_processnegative regulation of insulin receptor signaling pathway
R0046872molecular_functionmetal ion binding
R0060090molecular_functionmolecular adaptor activity
R0060337biological_processtype I interferon-mediated signaling pathway
R0061629molecular_functionRNA polymerase II-specific DNA-binding transcription factor binding
R0061630molecular_functionubiquitin protein ligase activity
R0061663molecular_functionNEDD8 ligase activity
R0062197biological_processcellular response to chemical stress
R0070294biological_processrenal sodium ion absorption
R0070936biological_processprotein K48-linked ubiquitination
R0071230biological_processcellular response to amino acid stimulus
R0080008cellular_componentCul4-RING E3 ubiquitin ligase complex
R0090090biological_processnegative regulation of canonical Wnt signaling pathway
R0090734cellular_componentsite of DNA damage
R0097510biological_processbase-excision repair, AP site formation via deaminated base removal
R0097602molecular_functioncullin family protein binding
R0140627biological_processubiquitin-dependent protein catabolic process via the C-end degron rule pathway
R0160240biological_processRNA polymerase II transcription initiation surveillance
R1900076biological_processregulation of cellular response to insulin stimulus
R1901525biological_processnegative regulation of mitophagy
R1901797biological_processnegative regulation of signal transduction by p53 class mediator
R1902499biological_processpositive regulation of protein autoubiquitination
R1902883biological_processnegative regulation of response to oxidative stress
R1904037biological_processpositive regulation of epithelial cell apoptotic process
R1904262biological_processnegative regulation of TORC1 signaling
R1904263biological_processpositive regulation of TORC1 signaling
R2000059biological_processnegative regulation of ubiquitin-dependent protein catabolic process
S0000209biological_processprotein polyubiquitination
S0005515molecular_functionprotein binding
S0005634cellular_componentnucleus
S0005654cellular_componentnucleoplasm
S0005737cellular_componentcytoplasm
S0005813cellular_componentcentrosome
S0005829cellular_componentcytosol
S0006338biological_processchromatin remodeling
S0006511biological_processubiquitin-dependent protein catabolic process
S0006513biological_processprotein monoubiquitination
S0006915biological_processapoptotic process
S0008013molecular_functionbeta-catenin binding
S0016567biological_processprotein ubiquitination
S0019005cellular_componentSCF ubiquitin ligase complex
S0019904molecular_functionprotein domain specific binding
S0031146biological_processSCF-dependent proteasomal ubiquitin-dependent protein catabolic process
S0031467cellular_componentCul7-RING ubiquitin ligase complex
S0031519cellular_componentPcG protein complex
S0043161biological_processproteasome-mediated ubiquitin-dependent protein catabolic process
S0051457biological_processmaintenance of protein location in nucleus
S0061564biological_processaxon development
S0070936biological_processprotein K48-linked ubiquitination
S0097602molecular_functioncullin family protein binding
S0140677molecular_functionmolecular function activator activity
S0160072molecular_functionubiquitin ligase complex scaffold activity
S1904037biological_processpositive regulation of epithelial cell apoptotic process
S1990444molecular_functionF-box domain binding
S1990756molecular_functionubiquitin-like ligase-substrate adaptor activity
S1990757molecular_functionubiquitin ligase activator activity
Functional Information from PROSITE/UniProt
site_idPS01256
Number of Residues28
DetailsCULLIN_1 Cullin family signature. IKkcIdiLIEKeYLeRvdgekdtYsYlA
ChainResidueDetails
CILE749-ALA776

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues1
DetailsMOD_RES: Phosphothreonine => ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:21406692
ChainResidueDetails
STHR131

site_idSWS_FT_FI2
Number of Residues2
DetailsCROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1) => ECO:0007744|PubMed:25114211
ChainResidueDetails
SLYS142
FLYS71
RCYS75
RHIS77
RHIS80
RCYS94
RASP97

site_idSWS_FT_FI3
Number of Residues2
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:23186163
ChainResidueDetails
FSER72
FSER75
RCYS68
RHIS82

site_idSWS_FT_FI4
Number of Residues1
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:18220336, ECO:0007744|PubMed:23186163
ChainResidueDetails
FSER179

site_idSWS_FT_FI5
Number of Residues1
DetailsMOD_RES: Phosphothreonine => ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:23186163
ChainResidueDetails
RTHR9

237992

PDB entries from 2025-06-25

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