Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

7Z8R

CAND1-CUL1-RBX1

Functional Information from GO Data

Chain	GOid	namespace	contents
C	0000082	biological_process	G1/S transition of mitotic cell cycle
C	0005515	molecular_function	protein binding
C	0005634	cellular_component	nucleus
C	0005654	cellular_component	nucleoplasm
C	0005737	cellular_component	cytoplasm
C	0005829	cellular_component	cytosol
C	0005886	cellular_component	plasma membrane
C	0006511	biological_process	ubiquitin-dependent protein catabolic process
C	0006513	biological_process	protein monoubiquitination
C	0006915	biological_process	apoptotic process
C	0008283	biological_process	cell population proliferation
C	0009887	biological_process	animal organ morphogenesis
C	0010498	biological_process	proteasomal protein catabolic process
C	0016567	biological_process	protein ubiquitination
C	0019005	cellular_component	SCF ubiquitin ligase complex
C	0030674	molecular_function	protein-macromolecule adaptor activity
C	0031146	biological_process	SCF-dependent proteasomal ubiquitin-dependent protein catabolic process
C	0031461	cellular_component	cullin-RING ubiquitin ligase complex
C	0031625	molecular_function	ubiquitin protein ligase binding
C	0043123	biological_process	positive regulation of canonical NF-kappaB signal transduction
C	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
C	0070936	biological_process	protein K48-linked ubiquitination
C	0097193	biological_process	intrinsic apoptotic signaling pathway
C	0160072	molecular_function	ubiquitin ligase complex scaffold activity
C	1990452	cellular_component	Parkin-FBXW7-Cul1 ubiquitin ligase complex
D	0000151	cellular_component	ubiquitin ligase complex
D	0005515	molecular_function	protein binding
D	0005576	cellular_component	extracellular region
D	0005634	cellular_component	nucleus
D	0005654	cellular_component	nucleoplasm
D	0005737	cellular_component	cytoplasm
D	0005794	cellular_component	Golgi apparatus
D	0005829	cellular_component	cytosol
D	0010265	biological_process	SCF complex assembly
D	0016020	cellular_component	membrane
D	0016567	biological_process	protein ubiquitination
D	0017025	molecular_function	TBP-class protein binding
D	0030154	biological_process	cell differentiation
D	0031461	cellular_component	cullin-RING ubiquitin ligase complex
D	0034774	cellular_component	secretory granule lumen
D	0043086	biological_process	negative regulation of catalytic activity
D	0045893	biological_process	positive regulation of DNA-templated transcription
D	0045899	biological_process	positive regulation of RNA polymerase II transcription preinitiation complex assembly
D	0070062	cellular_component	extracellular exosome
D	1904813	cellular_component	ficolin-1-rich granule lumen
R	0000165	biological_process	MAPK cascade
R	0000209	biological_process	protein polyubiquitination
R	0004842	molecular_function	ubiquitin-protein transferase activity
R	0005515	molecular_function	protein binding
R	0005634	cellular_component	nucleus
R	0005654	cellular_component	nucleoplasm
R	0005737	cellular_component	cytoplasm
R	0005829	cellular_component	cytosol
R	0006281	biological_process	DNA repair
R	0006511	biological_process	ubiquitin-dependent protein catabolic process
R	0006513	biological_process	protein monoubiquitination
R	0006974	biological_process	DNA damage response
R	0007283	biological_process	spermatogenesis
R	0008270	molecular_function	zinc ion binding
R	0016567	biological_process	protein ubiquitination
R	0016740	molecular_function	transferase activity
R	0019005	cellular_component	SCF ubiquitin ligase complex
R	0019788	molecular_function	NEDD8 transferase activity
R	0030163	biological_process	protein catabolic process
R	0031146	biological_process	SCF-dependent proteasomal ubiquitin-dependent protein catabolic process
R	0031461	cellular_component	cullin-RING ubiquitin ligase complex
R	0031462	cellular_component	Cul2-RING ubiquitin ligase complex
R	0031463	cellular_component	Cul3-RING ubiquitin ligase complex
R	0031464	cellular_component	Cul4A-RING E3 ubiquitin ligase complex
R	0031465	cellular_component	Cul4B-RING E3 ubiquitin ligase complex
R	0031466	cellular_component	Cul5-RING ubiquitin ligase complex
R	0031467	cellular_component	Cul7-RING ubiquitin ligase complex
R	0031625	molecular_function	ubiquitin protein ligase binding
R	0032436	biological_process	positive regulation of proteasomal ubiquitin-dependent protein catabolic process
R	0032480	biological_process	negative regulation of type I interferon production
R	0034450	molecular_function	ubiquitin-ubiquitin ligase activity
R	0034599	biological_process	cellular response to oxidative stress
R	0034644	biological_process	cellular response to UV
R	0042110	biological_process	T cell activation
R	0043123	biological_process	positive regulation of canonical NF-kappaB signal transduction
R	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
R	0043687	biological_process	post-translational protein modification
R	0045116	biological_process	protein neddylation
R	0045732	biological_process	positive regulation of protein catabolic process
R	0046872	molecular_function	metal ion binding
R	0060090	molecular_function	molecular adaptor activity
R	0061629	molecular_function	RNA polymerase II-specific DNA-binding transcription factor binding
R	0061630	molecular_function	ubiquitin protein ligase activity
R	0061663	molecular_function	NEDD8 ligase activity
R	0062197	biological_process	cellular response to chemical stress
R	0070936	biological_process	protein K48-linked ubiquitination
R	0071230	biological_process	cellular response to amino acid stimulus
R	0090090	biological_process	negative regulation of canonical Wnt signaling pathway
R	0097602	molecular_function	cullin family protein binding
R	0140627	biological_process	ubiquitin-dependent protein catabolic process via the C-end degron rule pathway
R	1900076	biological_process	regulation of cellular response to insulin stimulus
R	1902499	biological_process	positive regulation of protein autoubiquitination
R	1902883	biological_process	negative regulation of response to oxidative stress
R	1904263	biological_process	positive regulation of TORC1 signaling

Functional Information from PROSITE/UniProt

site_id	PS01256
Number of Residues	28
Details	CULLIN_1 Cullin family signature. IKkcIdiLIEKeYLeRvdgekdtYsYlA

Chain	Residue	Details
C	ILE749-ALA776

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	45
Details	ZN_FING: RING-type => ECO:0000255\|PROSITE-ProRule:PRU00175

Chain	Residue	Details
R	CYS53-ASN98

site_id	SWS_FT_FI2
Number of Residues	7
Details	BINDING: BINDING => ECO:0000269\|PubMed:11961546, ECO:0007744\|PDB:1LDJ, ECO:0007744\|PDB:1LDK, ECO:0007744\|PDB:1U6G, ECO:0007744\|PDB:2HYE, ECO:0007744\|PDB:3DPL, ECO:0007744\|PDB:3DQV, ECO:0007744\|PDB:3RTR, ECO:0007744\|PDB:4F52, ECO:0007744\|PDB:4P5O

Chain	Residue	Details
R	CYS42
R	CYS45
R	CYS75
R	HIS77
R	HIS80
R	CYS94
R	ASP97

site_id	SWS_FT_FI3
Number of Residues	4
Details	BINDING: BINDING => ECO:0000269\|PubMed:11961546, ECO:0007744\|PDB:1LDJ, ECO:0007744\|PDB:1LDK, ECO:0007744\|PDB:1U6G, ECO:0007744\|PDB:2HYE, ECO:0007744\|PDB:3DPL, ECO:0007744\|PDB:3DQV, ECO:0007744\|PDB:3RTR, ECO:0007744\|PDB:4F52, ECO:0007744\|PDB:4P5O, ECO:0007744\|PDB:7Z8B

Chain	Residue	Details
R	CYS53
R	CYS56
R	CYS68
R	HIS82

site_id	SWS_FT_FI4
Number of Residues	1
Details	BINDING: BINDING => ECO:0000269\|PubMed:11961546, ECO:0007744\|PDB:1LDJ, ECO:0007744\|PDB:1LDK, ECO:0007744\|PDB:1U6G, ECO:0007744\|PDB:2HYE, ECO:0007744\|PDB:3DQV, ECO:0007744\|PDB:3RTR, ECO:0007744\|PDB:4F52, ECO:0007744\|PDB:4P5O

Chain	Residue	Details
R	CYS83

site_id	SWS_FT_FI5
Number of Residues	1
Details	MOD_RES: Phosphothreonine => ECO:0007744\|PubMed:20068231, ECO:0007744\|PubMed:23186163

Chain	Residue	Details
R	THR9

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)