Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

7Z8K

Cytoplasmic dynein (A1) bound to BICDR1

Functional Information from GO Data

Chain	GOid	namespace	contents
W	0005515	molecular_function	protein binding
W	0005813	cellular_component	centrosome
W	0005856	cellular_component	cytoskeleton
W	0007399	biological_process	nervous system development
W	0031175	biological_process	neuron projection development
W	0031267	molecular_function	small GTPase binding
W	0034452	molecular_function	dynactin binding
W	0047496	biological_process	vesicle transport along microtubule
W	0055107	biological_process	Golgi to secretory granule transport
X	0005515	molecular_function	protein binding
X	0005813	cellular_component	centrosome
X	0005856	cellular_component	cytoskeleton
X	0007399	biological_process	nervous system development
X	0031175	biological_process	neuron projection development
X	0031267	molecular_function	small GTPase binding
X	0034452	molecular_function	dynactin binding
X	0047496	biological_process	vesicle transport along microtubule
X	0055107	biological_process	Golgi to secretory granule transport
e	0000166	molecular_function	nucleotide binding
e	0001673	cellular_component	male germ cell nucleus
e	0003723	molecular_function	RNA binding
e	0005515	molecular_function	protein binding
e	0005524	molecular_function	ATP binding
e	0005576	cellular_component	extracellular region
e	0005737	cellular_component	cytoplasm
e	0005813	cellular_component	centrosome
e	0005829	cellular_component	cytosol
e	0005856	cellular_component	cytoskeleton
e	0005868	cellular_component	cytoplasmic dynein complex
e	0005874	cellular_component	microtubule
e	0005881	cellular_component	cytoplasmic microtubule
e	0005938	cellular_component	cell cortex
e	0007018	biological_process	microtubule-based movement
e	0007052	biological_process	mitotic spindle organization
e	0007097	biological_process	nuclear migration
e	0008090	biological_process	retrograde axonal transport
e	0008569	molecular_function	minus-end-directed microtubule motor activity
e	0016020	cellular_component	membrane
e	0030175	cellular_component	filopodium
e	0030286	cellular_component	dynein complex
e	0031122	biological_process	cytoplasmic microtubule organization
e	0032388	biological_process	positive regulation of intracellular transport
e	0033962	biological_process	P-body assembly
e	0034063	biological_process	stress granule assembly
e	0035578	cellular_component	azurophil granule lumen
e	0042802	molecular_function	identical protein binding
e	0045505	molecular_function	dynein intermediate chain binding
e	0051293	biological_process	establishment of spindle localization
e	0051301	biological_process	cell division
e	0051959	molecular_function	dynein light intermediate chain binding
e	0060236	biological_process	regulation of mitotic spindle organization
e	0070062	cellular_component	extracellular exosome
e	0090235	biological_process	regulation of metaphase plate congression
e	0090267	biological_process	positive regulation of mitotic cell cycle spindle assembly checkpoint
e	0120162	biological_process	positive regulation of cold-induced thermogenesis
e	1904115	cellular_component	axon cytoplasm
e	1905832	biological_process	positive regulation of spindle assembly
f	0000166	molecular_function	nucleotide binding
f	0001673	cellular_component	male germ cell nucleus
f	0003723	molecular_function	RNA binding
f	0005515	molecular_function	protein binding
f	0005524	molecular_function	ATP binding
f	0005576	cellular_component	extracellular region
f	0005737	cellular_component	cytoplasm
f	0005813	cellular_component	centrosome
f	0005829	cellular_component	cytosol
f	0005856	cellular_component	cytoskeleton
f	0005868	cellular_component	cytoplasmic dynein complex
f	0005874	cellular_component	microtubule
f	0005881	cellular_component	cytoplasmic microtubule
f	0005938	cellular_component	cell cortex
f	0007018	biological_process	microtubule-based movement
f	0007052	biological_process	mitotic spindle organization
f	0007097	biological_process	nuclear migration
f	0008090	biological_process	retrograde axonal transport
f	0008569	molecular_function	minus-end-directed microtubule motor activity
f	0016020	cellular_component	membrane
f	0030175	cellular_component	filopodium
f	0030286	cellular_component	dynein complex
f	0031122	biological_process	cytoplasmic microtubule organization
f	0032388	biological_process	positive regulation of intracellular transport
f	0033962	biological_process	P-body assembly
f	0034063	biological_process	stress granule assembly
f	0035578	cellular_component	azurophil granule lumen
f	0042802	molecular_function	identical protein binding
f	0045505	molecular_function	dynein intermediate chain binding
f	0051293	biological_process	establishment of spindle localization
f	0051301	biological_process	cell division
f	0051959	molecular_function	dynein light intermediate chain binding
f	0060236	biological_process	regulation of mitotic spindle organization
f	0070062	cellular_component	extracellular exosome
f	0090235	biological_process	regulation of metaphase plate congression
f	0090267	biological_process	positive regulation of mitotic cell cycle spindle assembly checkpoint
f	0120162	biological_process	positive regulation of cold-induced thermogenesis
f	1904115	cellular_component	axon cytoplasm
f	1905832	biological_process	positive regulation of spindle assembly
h	0005868	cellular_component	cytoplasmic dynein complex
h	0007018	biological_process	microtubule-based movement
i	0000166	molecular_function	nucleotide binding
i	0000226	biological_process	microtubule cytoskeleton organization
i	0000776	cellular_component	kinetochore
i	0001673	cellular_component	male germ cell nucleus
i	0005515	molecular_function	protein binding
i	0005524	molecular_function	ATP binding
i	0005770	cellular_component	late endosome
i	0005813	cellular_component	centrosome
i	0005829	cellular_component	cytosol
i	0005856	cellular_component	cytoskeleton
i	0005868	cellular_component	cytoplasmic dynein complex
i	0005874	cellular_component	microtubule
i	0007018	biological_process	microtubule-based movement
i	0016020	cellular_component	membrane
i	0030286	cellular_component	dynein complex
i	0032388	biological_process	positive regulation of intracellular transport
i	0042802	molecular_function	identical protein binding
i	0045504	molecular_function	dynein heavy chain binding
i	1990090	biological_process	cellular response to nerve growth factor stimulus
w	0005515	molecular_function	protein binding
w	0005813	cellular_component	centrosome
w	0005856	cellular_component	cytoskeleton
w	0007399	biological_process	nervous system development
w	0031175	biological_process	neuron projection development
w	0031267	molecular_function	small GTPase binding
w	0034452	molecular_function	dynactin binding
w	0047496	biological_process	vesicle transport along microtubule
w	0055107	biological_process	Golgi to secretory granule transport
x	0005515	molecular_function	protein binding
x	0005813	cellular_component	centrosome
x	0005856	cellular_component	cytoskeleton
x	0007399	biological_process	nervous system development
x	0031175	biological_process	neuron projection development
x	0031267	molecular_function	small GTPase binding
x	0034452	molecular_function	dynactin binding
x	0047496	biological_process	vesicle transport along microtubule
x	0055107	biological_process	Golgi to secretory granule transport

Functional Information from PROSITE/UniProt

site_id	PS00432
Number of Residues	9
Details	ACTINS_2 Actins signature 2. WVSKkEYEE

Chain	Residue	Details
F	TRP357-GLU365

site_id	PS00639
Number of Residues	11
Details	THIOL_PROTEASE_HIS Eukaryotic thiol (cysteine) proteases histidine active site. INHGLMMVGPS

Chain	Residue	Details
e	ILE2216-SER2226

site_id	PS01132
Number of Residues	13
Details	ACTINS_ACT_LIKE Actins and actin-related proteins signature. LLTEApLNPrkNR

Chain	Residue	Details
F	LEU109-ARG121

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	151
Details	Region: {"description":"Interaction with DYNC1LI2","evidences":[{"evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI2
Number of Residues	92
Details	Coiled coil: {"evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI3
Number of Residues	49
Details	Repeat: {"description":"WD 1"}

Chain

Residue

Details

site_id	SWS_FT_FI4
Number of Residues	40
Details	Repeat: {"description":"WD 2"}

Chain

Residue

Details

site_id	SWS_FT_FI5
Number of Residues	41
Details	Repeat: {"description":"WD 3"}

Chain

Residue

Details

site_id	SWS_FT_FI6
Number of Residues	40
Details	Repeat: {"description":"WD 4"}

Chain

Residue

Details

site_id	SWS_FT_FI7
Number of Residues	45
Details	Repeat: {"description":"WD 5"}

Chain

Residue

Details

site_id	SWS_FT_FI8
Number of Residues	40
Details	Repeat: {"description":"WD 6"}

Chain

Residue

Details

site_id	SWS_FT_FI9
Number of Residues	39
Details	Repeat: {"description":"WD 7"}

Chain

Residue

Details

site_id	SWS_FT_FI10
Number of Residues	8
Details	Motif: {"description":"CC1 box","evidences":[{"source":"PubMed","id":"36071160","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)