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7Z8K

Cytoplasmic dynein (A1) bound to BICDR1

Functional Information from GO Data
ChainGOidnamespacecontents
W0005515molecular_functionprotein binding
W0005737cellular_componentcytoplasm
W0005813cellular_componentcentrosome
W0005856cellular_componentcytoskeleton
W0007399biological_processnervous system development
W0031175biological_processneuron projection development
W0031267molecular_functionsmall GTPase binding
W0034452molecular_functiondynactin binding
W0047496biological_processvesicle transport along microtubule
W0055107biological_processGolgi to secretory granule transport
X0005515molecular_functionprotein binding
X0005737cellular_componentcytoplasm
X0005813cellular_componentcentrosome
X0005856cellular_componentcytoskeleton
X0007399biological_processnervous system development
X0031175biological_processneuron projection development
X0031267molecular_functionsmall GTPase binding
X0034452molecular_functiondynactin binding
X0047496biological_processvesicle transport along microtubule
X0055107biological_processGolgi to secretory granule transport
e0000166molecular_functionnucleotide binding
e0003723molecular_functionRNA binding
e0005515molecular_functionprotein binding
e0005524molecular_functionATP binding
e0005576cellular_componentextracellular region
e0005737cellular_componentcytoplasm
e0005813cellular_componentcentrosome
e0005829cellular_componentcytosol
e0005856cellular_componentcytoskeleton
e0005868cellular_componentcytoplasmic dynein complex
e0005874cellular_componentmicrotubule
e0005881cellular_componentcytoplasmic microtubule
e0005938cellular_componentcell cortex
e0007018biological_processmicrotubule-based movement
e0007052biological_processmitotic spindle organization
e0007097biological_processnuclear migration
e0008090biological_processretrograde axonal transport
e0008569molecular_functionminus-end-directed microtubule motor activity
e0016020cellular_componentmembrane
e0030175cellular_componentfilopodium
e0030286cellular_componentdynein complex
e0031122biological_processcytoplasmic microtubule organization
e0032388biological_processpositive regulation of intracellular transport
e0033962biological_processP-body assembly
e0034063biological_processstress granule assembly
e0035578cellular_componentazurophil granule lumen
e0042802molecular_functionidentical protein binding
e0045505molecular_functiondynein intermediate chain binding
e0051293biological_processestablishment of spindle localization
e0051301biological_processcell division
e0051959molecular_functiondynein light intermediate chain binding
e0060236biological_processregulation of mitotic spindle organization
e0070062cellular_componentextracellular exosome
e0090235biological_processregulation of metaphase plate congression
e0120162biological_processpositive regulation of cold-induced thermogenesis
e1904115cellular_componentaxon cytoplasm
e1905832biological_processpositive regulation of spindle assembly
f0000166molecular_functionnucleotide binding
f0003723molecular_functionRNA binding
f0005515molecular_functionprotein binding
f0005524molecular_functionATP binding
f0005576cellular_componentextracellular region
f0005737cellular_componentcytoplasm
f0005813cellular_componentcentrosome
f0005829cellular_componentcytosol
f0005856cellular_componentcytoskeleton
f0005868cellular_componentcytoplasmic dynein complex
f0005874cellular_componentmicrotubule
f0005881cellular_componentcytoplasmic microtubule
f0005938cellular_componentcell cortex
f0007018biological_processmicrotubule-based movement
f0007052biological_processmitotic spindle organization
f0007097biological_processnuclear migration
f0008090biological_processretrograde axonal transport
f0008569molecular_functionminus-end-directed microtubule motor activity
f0016020cellular_componentmembrane
f0030175cellular_componentfilopodium
f0030286cellular_componentdynein complex
f0031122biological_processcytoplasmic microtubule organization
f0032388biological_processpositive regulation of intracellular transport
f0033962biological_processP-body assembly
f0034063biological_processstress granule assembly
f0035578cellular_componentazurophil granule lumen
f0042802molecular_functionidentical protein binding
f0045505molecular_functiondynein intermediate chain binding
f0051293biological_processestablishment of spindle localization
f0051301biological_processcell division
f0051959molecular_functiondynein light intermediate chain binding
f0060236biological_processregulation of mitotic spindle organization
f0070062cellular_componentextracellular exosome
f0090235biological_processregulation of metaphase plate congression
f0120162biological_processpositive regulation of cold-induced thermogenesis
f1904115cellular_componentaxon cytoplasm
f1905832biological_processpositive regulation of spindle assembly
h0005868cellular_componentcytoplasmic dynein complex
h0007018biological_processmicrotubule-based movement
i0000166molecular_functionnucleotide binding
i0000226biological_processmicrotubule cytoskeleton organization
i0000776cellular_componentkinetochore
i0005524molecular_functionATP binding
i0005737cellular_componentcytoplasm
i0005770cellular_componentlate endosome
i0005813cellular_componentcentrosome
i0005829cellular_componentcytosol
i0005856cellular_componentcytoskeleton
i0005868cellular_componentcytoplasmic dynein complex
i0005874cellular_componentmicrotubule
i0007018biological_processmicrotubule-based movement
i0016020cellular_componentmembrane
i0030286cellular_componentdynein complex
i0032388biological_processpositive regulation of intracellular transport
i0042802molecular_functionidentical protein binding
i0045504molecular_functiondynein heavy chain binding
i0051642biological_processcentrosome localization
i1990090biological_processcellular response to nerve growth factor stimulus
w0005515molecular_functionprotein binding
w0005737cellular_componentcytoplasm
w0005813cellular_componentcentrosome
w0005856cellular_componentcytoskeleton
w0007399biological_processnervous system development
w0031175biological_processneuron projection development
w0031267molecular_functionsmall GTPase binding
w0034452molecular_functiondynactin binding
w0047496biological_processvesicle transport along microtubule
w0055107biological_processGolgi to secretory granule transport
x0005515molecular_functionprotein binding
x0005737cellular_componentcytoplasm
x0005813cellular_componentcentrosome
x0005856cellular_componentcytoskeleton
x0007399biological_processnervous system development
x0031175biological_processneuron projection development
x0031267molecular_functionsmall GTPase binding
x0034452molecular_functiondynactin binding
x0047496biological_processvesicle transport along microtubule
x0055107biological_processGolgi to secretory granule transport
Functional Information from PROSITE/UniProt
site_idPS00432
Number of Residues9
DetailsACTINS_2 Actins signature 2. WVSKkEYEE
ChainResidueDetails
FTRP357-GLU365

site_idPS00639
Number of Residues11
DetailsTHIOL_PROTEASE_HIS Eukaryotic thiol (cysteine) proteases histidine active site. INHGLMMVGPS
ChainResidueDetails
eILE2216-SER2226

site_idPS01132
Number of Residues13
DetailsACTINS_ACT_LIKE Actins and actin-related proteins signature. LLTEApLNPrkNR
ChainResidueDetails
FLEU109-ARG121

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues1
DetailsMOD_RES: N-acetylmethionine => ECO:0000250|UniProtKB:P61163
ChainResidueDetails
FMET1
eGLY2224
eGLY2595
eGLY2937
fGLY1906
fGLY2224
fGLY2595
fGLY2937

site_idSWS_FT_FI2
Number of Residues1
DetailsMOD_RES: Phosphothreonine => ECO:0007744|PubMed:23186163
ChainResidueDetails
hTHR95
fSER2

site_idSWS_FT_FI3
Number of Residues1
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:23186163
ChainResidueDetails
hSER97
eSER4162
fSER70
fSER4162

site_idSWS_FT_FI4
Number of Residues1
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:21406692, ECO:0007744|PubMed:23186163
ChainResidueDetails
hSER101
eLYS3480
eLYS4283
fLYS1125
fLYS3480
fLYS4283

site_idSWS_FT_FI5
Number of Residues1
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:19690332, ECO:0007744|PubMed:23186163
ChainResidueDetails
hSER104
fSER1230

site_idSWS_FT_FI6
Number of Residues1
DetailsMOD_RES: Phosphothreonine => ECO:0007744|PubMed:20068231
ChainResidueDetails
iTHR441
fTHR4366

site_idSWS_FT_FI7
Number of Residues1
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:20068231
ChainResidueDetails
iSER443
fSER4368

site_idSWS_FT_FI8
Number of Residues1
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:16964243, ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:18691976, ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:23186163
ChainResidueDetails
iSER446

237423

PDB entries from 2025-06-11

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