7Z4L
SpCas9 bound to 18-nucleotide complementary DNA substrate in the checkpoint state
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| B | 0003676 | molecular_function | nucleic acid binding |
| B | 0003677 | molecular_function | DNA binding |
| B | 0003723 | molecular_function | RNA binding |
| B | 0004519 | molecular_function | endonuclease activity |
| B | 0004520 | molecular_function | DNA endonuclease activity |
| B | 0004527 | molecular_function | exonuclease activity |
| B | 0008408 | molecular_function | 3'-5' exonuclease activity |
| B | 0043571 | biological_process | maintenance of CRISPR repeat elements |
| B | 0046872 | molecular_function | metal ion binding |
| B | 0051607 | biological_process | defense response to virus |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 1 |
| Details | ACT_SITE: For RuvC-like nuclease domain => ECO:0000305|PubMed:24529477 |
| Chain | Residue | Details |
| B | ASP10 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 1 |
| Details | ACT_SITE: Proton acceptor for HNH nuclease domain => ECO:0000305|PubMed:24529477 |
| Chain | Residue | Details |
| B | HIS840 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 6 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:24505130 |
| Chain | Residue | Details |
| B | ASP10 | |
| B | GLU762 | |
| B | GLU766 | |
| B | HIS983 | |
| B | HIS1297 | |
| B | ASP1328 |
